Baicalin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.083021
STC2 stanniocalcin 2 0.0799746
GRB10 growth factor receptor-bound protein 10 0.0700474
MYH9 myosin, heavy chain 9, non-muscle 0.0679176
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0674167
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0644714
VEGFA vascular endothelial growth factor A 0.0618355
ZSWIM6 zinc finger, SWIM-type containing 6 0.058379
EXT1 exostosin glycosyltransferase 1 0.0554604
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0509429
PDLIM5 PDZ and LIM domain 5 0.0506152
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0503959
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.048993
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0471216
RNF145 ring finger protein 145 0.0445396
ERRFI1 ERBB receptor feedback inhibitor 1 0.0405735
LOXL2 lysyl oxidase-like 2 0.0399596
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0397255
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0392385
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0391952
VCL vinculin 0.0388949
TXNIP thioredoxin interacting protein 0.0386219
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0367349
FNDC3A fibronectin type III domain containing 3A 0.0355017
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0354056
NTN4 netrin 4 0.0353983
HILPDA hypoxia inducible lipid droplet-associated 0.034642
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0330185
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0328341
HIPK2 homeodomain interacting protein kinase 2 0.0328118
NPAS2 neuronal PAS domain protein 2 0.0326197
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0324571
PER1 period circadian clock 1 0.0315631
SPAG9 sperm associated antigen 9 0.031542
FLNA filamin A, alpha 0.0308667
CEMIP2 cell migration inducing hyaluronidase 2 0.0307369
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0301095
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0300842
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0299702
AKAP13 A kinase (PRKA) anchor protein 13 0.0290182
PALLD palladin, cytoskeletal associated protein 0.02899
RASAL2 RAS protein activator like 2 0.0285392
JARID2 jumonji, AT rich interactive domain 2 0.0283092
CCNL1 cyclin L1 0.0278651
COPA coatomer protein complex, subunit alpha 0.0278323
MYOF myoferlin 0.0278242
AKAP12 A kinase (PRKA) anchor protein 12 0.0276898
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0274409
SMAD3 SMAD family member 3 0.0274253
AFDN afadin, adherens junction formation factor 0.0269098
SSBP2 single-stranded DNA binding protein 2 0.026886
CLIP2 CAP-GLY domain containing linker protein 2 0.0267449
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0266202
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0265003
APLP2 amyloid beta (A4) precursor-like protein 2 0.0257902
ABLIM1 actin binding LIM protein 1 0.0257285
ESYT2 extended synaptotagmin-like protein 2 0.0252473
ELL2 elongation factor, RNA polymerase II, 2 0.025105
LTBP1 latent transforming growth factor beta binding protein 1 0.0250347
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0245594
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0245536
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0245243
RAB8B RAB8B, member RAS oncogene family 0.0244824
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0242085
PLEC plectin 0.0239251
SHB Src homology 2 domain containing adaptor protein B 0.0239055
TTC19 tetratricopeptide repeat domain 19 0.0239026
TUFT1 tuftelin 1 0.0234689
SEC23A Sec23 homolog A (S. cerevisiae) 0.0233333
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0230064
PRKCA protein kinase C, alpha 0.0228509
RBPMS RNA binding protein with multiple splicing 0.0224397
NUP58 nucleoporin 58 0.0223521
NPTN neuroplastin 0.0223423
RYBP RING1 and YY1 binding protein 0.022086
UBASH3B ubiquitin associated and SH3 domain containing B 0.0216621
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0215925
SOX9 SRY (sex determining region Y)-box 9 0.0215816
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0213393
KMT2E lysine (K)-specific methyltransferase 2E 0.0212993
TGFB1 transforming growth factor, beta 1 0.0212536
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0211754
FOSL1 FOS-like antigen 1 0.0209441
INTS6 integrator complex subunit 6 0.0209069
LIMCH1 LIM and calponin homology domains 1 0.0208161
ACTN1 actinin, alpha 1 0.0206004
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0203579
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0198896
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0196463
GPATCH2L G patch domain containing 2-like 0.0195628
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0194912
MRTFA myocardin related transcription factor A 0.0194558
FERMT2 fermitin family member 2 0.0194213
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0193268
GDNF glial cell derived neurotrophic factor 0.0193173
RCOR1 REST corepressor 1 0.0192735
NDRG1 N-myc downstream regulated 1 0.0192652
FXR1 fragile X mental retardation, autosomal homolog 1 0.0192612
AHRR aryl-hydrocarbon receptor repressor 0.0191905
SUCO SUN domain containing ossification factor 0.0191194

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.228115
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.150665
SQSTM1 sequestosome 1 -0.134038
HLA-B major histocompatibility complex, class I, B -0.0995693
TPT1 tumor protein, translationally-controlled 1 -0.0957088
ITGA1 integrin, alpha 1 -0.0942271
PTMA prothymosin, alpha -0.0881929
VIM vimentin -0.0824752
TMSB10 thymosin beta 10 -0.0765782
RPL35A ribosomal protein L35a -0.0706633
OSMR oncostatin M receptor -0.0695256
GLIS3 GLIS family zinc finger 3 -0.0648895
MT2A metallothionein 2A -0.0634445
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0621119
NAMPT nicotinamide phosphoribosyltransferase -0.0608029
ETV1 ets variant 1 -0.0579148
IFI27 interferon, alpha-inducible protein 27 -0.0575229
FTL ferritin, light polypeptide -0.0568108
RPL9 ribosomal protein L9 -0.0554039
RPL37A ribosomal protein L37a -0.0531758
RPS6 ribosomal protein S6 -0.0495192
RPL31 ribosomal protein L31 -0.0483356
RPS8 ribosomal protein S8 -0.0483007
EIF1 eukaryotic translation initiation factor 1 -0.0481384
FN1 fibronectin 1 -0.0462699
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0459743
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0455617
ZMYND8 zinc finger, MYND-type containing 8 -0.0450694
ENO1 enolase 1, (alpha) -0.0449775
ZBTB20 zinc finger and BTB domain containing 20 -0.044595
RPL23 ribosomal protein L23 -0.0433812
NRG1 neuregulin 1 -0.0433402
RPS27A ribosomal protein S27a -0.0433028
RPS24 ribosomal protein S24 -0.0429475
NAP1L1 nucleosome assembly protein 1-like 1 -0.0428957
MBD5 methyl-CpG binding domain protein 5 -0.0423433
IFI16 interferon, gamma-inducible protein 16 -0.0422066
CD44 CD44 molecule (Indian blood group) -0.0412643
S100A6 S100 calcium binding protein A6 -0.0408481
RPL26 ribosomal protein L26 -0.0401751
MCTP2 multiple C2 domains, transmembrane 2 -0.0398169
FOXP1 forkhead box P1 -0.039417
RPL34 ribosomal protein L34 -0.0387758
RPL37 ribosomal protein L37 -0.0383386
RPS29 ribosomal protein S29 -0.0382094
RPL38 ribosomal protein L38 -0.0376389
EFNA5 ephrin-A5 -0.0376117
TAS2R14 taste receptor, type 2, member 14 -0.0372939
RPS12 ribosomal protein S12 -0.0370072
TMEM165 transmembrane protein 165 -0.0364678
IFI6 interferon, alpha-inducible protein 6 -0.0362709
SYT1 synaptotagmin I -0.03547
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0350252
PDE4D phosphodiesterase 4D, cAMP-specific -0.035007
ETV6 ets variant 6 -0.0349435
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0339663
CDCP1 CUB domain containing protein 1 -0.0338508
RPS21 ribosomal protein S21 -0.0336982
RPS3 ribosomal protein S3 -0.0334301
RPL12 ribosomal protein L12 -0.0332552
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0330671
B2M beta-2-microglobulin -0.0329338
KLHL5 kelch-like family member 5 -0.0323394
GCC2 GRIP and coiled-coil domain containing 2 -0.0322984
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0321832
TMSB4X thymosin beta 4, X-linked -0.0315837
MKI67 marker of proliferation Ki-67 -0.031207
RPLP0 ribosomal protein, large, P0 -0.0310333
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0309123
CENPF centromere protein F, 350/400kDa -0.0304248
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303247
RPS27 ribosomal protein S27 -0.0301798
HMGA2 high mobility group AT-hook 2 -0.0301648
RPS25 ribosomal protein S25 -0.0299385
RPLP1 ribosomal protein, large, P1 -0.029383
NPC1 Niemann-Pick disease, type C1 -0.0286439
ACTG1 actin gamma 1 -0.0283545
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.028049
RPL11 ribosomal protein L11 -0.0276647
RRBP1 ribosome binding protein 1 -0.0270548
RPS23 ribosomal protein S23 -0.0268581
CD63 CD63 molecule -0.0268071
ANKRD12 ankyrin repeat domain 12 -0.0262841
RSF1 remodeling and spacing factor 1 -0.026038
RPS16 ribosomal protein S16 -0.0259514
TXNRD1 thioredoxin reductase 1 -0.0256787
RACK1 receptor for activated C kinase 1 -0.0255596
RPLP2 ribosomal protein, large, P2 -0.0255454
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0254802
COG5 component of oligomeric golgi complex 5 -0.0254679
RPS11 ribosomal protein S11 -0.0254571
CANX calnexin -0.0252718
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0252539
TM4SF1 transmembrane 4 L six family member 1 -0.0252016
IER3 immediate early response 3 -0.0251615
PRRC2C proline-rich coiled-coil 2C -0.0248595
RPL36 ribosomal protein L36 -0.0243417
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0242389
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0241741
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0241338