Balsalazide (sodium hydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.160958
IGFBP3 insulin-like growth factor binding protein 3 0.124099
NAV2 neuron navigator 2 0.0582141
BHLHE40 basic helix-loop-helix family, member e40 0.052151
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0513915
GPC6 glypican 6 0.0446095
TRIO trio Rho guanine nucleotide exchange factor 0.0395993
SMAD3 SMAD family member 3 0.028319
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0275973
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.025498
FTH1 ferritin, heavy polypeptide 1 0.0254488
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0250539
VEGFA vascular endothelial growth factor A 0.0241842
PLEC plectin 0.0234294
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0233692
FAM13A family with sequence similarity 13, member A 0.0225907
RNF213 ring finger protein 213 0.0220475
ATP13A3 ATPase type 13A3 0.0208043
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0195916
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0195594
COL5A1 collagen, type V, alpha 1 0.0187835
COL4A2 collagen, type IV, alpha 2 0.0185548
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0185191
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0179353
GPC5 glypican 5 0.0177645
DOCK5 dedicator of cytokinesis 5 0.0176261
EHBP1 EH domain binding protein 1 0.0174708
HPCAL1 hippocalcin-like 1 0.0173736
ABTB3 ankyrin repeat and BTB domain containing 3 0.0173068
NDRG1 N-myc downstream regulated 1 0.0172732
SFTPA2 surfactant protein A2 0.0172216
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0170592
APOL1 apolipoprotein L, 1 0.0167743
SOD2 superoxide dismutase 2, mitochondrial 0.0167174
CA12 carbonic anhydrase XII 0.0166914
ESYT2 extended synaptotagmin-like protein 2 0.0165824
AHNAK AHNAK nucleoprotein 0.0164785
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0161642
DAPK1 death-associated protein kinase 1 0.0160739
EIF4H eukaryotic translation initiation factor 4H 0.0159909
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0156854
FMNL2 formin-like 2 0.0156458
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0153098
RAI14 retinoic acid induced 14 0.0152822
MACF1 microtubule-actin crosslinking factor 1 0.0149614
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0147731
FSTL1 follistatin-like 1 0.0144839
TGM2 transglutaminase 2 0.0144375
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0144016
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0143805
ANO6 anoctamin 6 0.0140025
LOXL2 lysyl oxidase-like 2 0.0139397
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0139205
AUH AU RNA binding protein/enoyl-CoA hydratase 0.013612
EFNA5 ephrin-A5 0.0134427
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0133773
NEK6 NIMA-related kinase 6 0.0133509
UBE3C ubiquitin protein ligase E3C 0.0132709
ARHGAP21 Rho GTPase activating protein 21 0.0132
BNC2 basonuclin 2 0.0131001
PRKCA protein kinase C, alpha 0.0128446
DOCK1 dedicator of cytokinesis 1 0.0126656
EXOC4 exocyst complex component 4 0.0125997
MYOF myoferlin 0.012197
HDLBP high density lipoprotein binding protein 0.0121889
KDM3A lysine (K)-specific demethylase 3A 0.0121708
MYH9 myosin, heavy chain 9, non-muscle 0.0121602
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0121321
WDFY1 WD repeat and FYVE domain containing 1 0.0120825
KANK1 KN motif and ankyrin repeat domains 1 0.0119948
NFE2L1 nuclear factor, erythroid 2-like 1 0.0119919
COL4A1 collagen, type IV, alpha 1 0.0118517
FRMD5 FERM domain containing 5 0.0115278
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0114412
TCF12 transcription factor 12 0.0114335
PTK2 protein tyrosine kinase 2 0.0114258
RUNX2 runt-related transcription factor 2 0.0114245
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.0114121
HSPA8 heat shock 70kDa protein 8 0.0113656
CTBP2 C-terminal binding protein 2 0.0113109
FNIP1 folliculin interacting protein 1 0.0112747
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0112732
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0111998
FAM219A family with sequence similarity 219, member A 0.0111867
ERRFI1 ERBB receptor feedback inhibitor 1 0.0111381
SEPTIN9 septin 9 0.0110839
TNS1 tensin 1 0.0110319
C1D C1D nuclear receptor corepressor 0.0108463
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.0107885
TMEM65 transmembrane protein 65 0.0107839
SLC35F5 solute carrier family 35, member F5 0.0106341
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0105959
ZCCHC7 zinc finger, CCHC domain containing 7 0.0105032
FAT1 FAT atypical cadherin 1 0.0103248
SPIRE1 spire-type actin nucleation factor 1 0.0101943
RABGAP1L RAB GTPase activating protein 1-like 0.0101866
EGFR epidermal growth factor receptor 0.0101111
DST dystonin 0.0101005
SAMD4A sterile alpha motif domain containing 4A 0.0100318
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0100174

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.158714
VIM vimentin -0.148926
CXCL8 chemokine (C-X-C motif) ligand 8 -0.136436
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125172
TMSB10 thymosin beta 10 -0.113374
CCL2 chemokine (C-C motif) ligand 2 -0.0995655
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0885434
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0785701
B2M beta-2-microglobulin -0.0763658
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0748538
CSF1 colony stimulating factor 1 (macrophage) -0.0734445
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0701371
PFN1 profilin 1 -0.0693382
ASPH aspartate beta-hydroxylase -0.0680685
PTMA prothymosin, alpha -0.0640198
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0623691
RPS6 ribosomal protein S6 -0.0608581
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0601018
MT2A metallothionein 2A -0.0594339
TXNRD1 thioredoxin reductase 1 -0.0534738
RPL23 ribosomal protein L23 -0.0525586
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0515639
HSPB1 heat shock 27kDa protein 1 -0.0509587
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.046975
RPL35A ribosomal protein L35a -0.0466781
RPS8 ribosomal protein S8 -0.0464796
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0450792
UBC ubiquitin C -0.0438548
RTN4 reticulon 4 -0.0435119
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0434009
RPLP2 ribosomal protein, large, P2 -0.0408772
MAP1B microtubule-associated protein 1B -0.0401205
PKM pyruvate kinase, muscle -0.0393377
CBX3 chromobox homolog 3 -0.0391561
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.038229
S100A10 S100 calcium binding protein A10 -0.0380554
PRRC2C proline-rich coiled-coil 2C -0.0375019
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0371691
TUBA1B tubulin, alpha 1b -0.0370732
TPT1 tumor protein, translationally-controlled 1 -0.0369365
ACBD3 acyl-CoA binding domain containing 3 -0.0369183
RPS19 ribosomal protein S19 -0.0361151
CENPF centromere protein F, 350/400kDa -0.0349422
RPL9 ribosomal protein L9 -0.0347969
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0339841
HLA-B major histocompatibility complex, class I, B -0.0339721
G0S2 G0/G1 switch 2 -0.0328621
RPS5 ribosomal protein S5 -0.0328403
RPLP1 ribosomal protein, large, P1 -0.032247
LITAF lipopolysaccharide-induced TNF factor -0.03128
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0312107
CD44 CD44 molecule (Indian blood group) -0.0309702
POTEF POTE ankyrin domain family, member F -0.0308736
RPS24 ribosomal protein S24 -0.0308688
RPL12 ribosomal protein L12 -0.0307029
RPL19 ribosomal protein L19 -0.0306562
GLS2 glutaminase 2 (liver, mitochondrial) -0.0304759
RPS13 ribosomal protein S13 -0.0304198
MGST1 microsomal glutathione S-transferase 1 -0.0302338
UGCG UDP-glucose ceramide glucosyltransferase -0.0291732
RPS27A ribosomal protein S27a -0.0291556
MYADM myeloid-associated differentiation marker -0.0289356
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.028834
NOP58 NOP58 ribonucleoprotein -0.0286144
NAP1L1 nucleosome assembly protein 1-like 1 -0.0285221
SON SON DNA binding protein -0.0280782
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0274262
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0273894
RPL8 ribosomal protein L8 -0.0272509
TPM4 tropomyosin 4 -0.0267862
TAGLN2 transgelin 2 -0.0266923
CYB5R3 cytochrome b5 reductase 3 -0.0264437
KTN1 kinectin 1 (kinesin receptor) -0.0262851
SEPTIN7 septin 7 -0.0259584
DDIT4 DNA-damage-inducible transcript 4 -0.0257596
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0255158
CXXC1 CXXC finger protein 1 -0.0254251
DSTN destrin (actin depolymerizing factor) -0.0252043
EIF1 eukaryotic translation initiation factor 1 -0.0247932
RPL34 ribosomal protein L34 -0.0245906
HMGB1 high mobility group box 1 -0.0244112
RPS12 ribosomal protein S12 -0.0243662
S100A6 S100 calcium binding protein A6 -0.0243537
GDF15 growth differentiation factor 15 -0.0243498
RPL31 ribosomal protein L31 -0.0241631
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0240977
H3-3B H3.3 histone B -0.0239094
RPL26 ribosomal protein L26 -0.0237543
PLK2 polo-like kinase 2 -0.023366
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0233534
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0233406
NUCB2 nucleobindin 2 -0.0231371
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0230381
EIF5B eukaryotic translation initiation factor 5B -0.0227545
RPS23 ribosomal protein S23 -0.0227227
NAMPT nicotinamide phosphoribosyltransferase -0.022666
RPL28 ribosomal protein L28 -0.0226272
JUN jun proto-oncogene -0.0224267
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0224265
RBM25 RNA binding motif protein 25 -0.0223635