Balsalazide (sodium hydrate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.212924
FTH1 ferritin, heavy polypeptide 1 0.110415
FLNB filamin B, beta 0.0870695
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0722612
EFNA5 ephrin-A5 0.0715865
POTEF POTE ankyrin domain family, member F 0.0701089
MCL1 myeloid cell leukemia 1 0.0659874
NDRG1 N-myc downstream regulated 1 0.0639893
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0632288
HSPA8 heat shock 70kDa protein 8 0.0576134
APLP2 amyloid beta (A4) precursor-like protein 2 0.0565533
TGM2 transglutaminase 2 0.0507524
ZSWIM6 zinc finger, SWIM-type containing 6 0.0502946
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0499449
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0491311
TPM3 tropomyosin 3 0.0489967
PLEC plectin 0.0481868
MSN moesin 0.0480229
ERRFI1 ERBB receptor feedback inhibitor 1 0.0477097
PPARD peroxisome proliferator-activated receptor delta 0.0473546
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0459097
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0443724
BMP6 bone morphogenetic protein 6 0.0442706
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0431474
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0430008
ABTB3 ankyrin repeat and BTB domain containing 3 0.0424678
CDCP1 CUB domain containing protein 1 0.0413984
SRRM2 serine/arginine repetitive matrix 2 0.04139
DIAPH1 diaphanous-related formin 1 0.040247
EGFR epidermal growth factor receptor 0.0393729
PICALM phosphatidylinositol binding clathrin assembly protein 0.0385932
UBA6 ubiquitin-like modifier activating enzyme 6 0.0383425
UBC ubiquitin C 0.0380121
SMAD3 SMAD family member 3 0.0379922
MYH9 myosin, heavy chain 9, non-muscle 0.0370514
DOCK5 dedicator of cytokinesis 5 0.0361097
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0356957
BHLHE40 basic helix-loop-helix family, member e40 0.0341159
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0331716
DSPP dentin sialophosphoprotein 0.0310499
VEGFA vascular endothelial growth factor A 0.0298023
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0287409
UPP1 uridine phosphorylase 1 0.0280743
ARHGAP42 Rho GTPase activating protein 42 0.0279757
MPRIP myosin phosphatase Rho interacting protein 0.0272614
FMNL2 formin-like 2 0.0271175
ATP13A3 ATPase type 13A3 0.0271144
PSD3 pleckstrin and Sec7 domain containing 3 0.0269189
RUNX1 runt-related transcription factor 1 0.0266078
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0257849
MMP1 matrix metallopeptidase 1 0.0254605
CORO1C coronin, actin binding protein, 1C 0.0248002
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0245793
CLMP CXADR-like membrane protein 0.0245116
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.024328
TRRAP transformation/transcription domain-associated protein 0.0235642
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0232323
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.022865
EEF2 eukaryotic translation elongation factor 2 0.0227519
NCOR2 nuclear receptor corepressor 2 0.0215543
TMCC3 transmembrane and coiled-coil domain family 3 0.0211641
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0211156
SACK1A scaffolding CK1 anchoring protein A 0.0207467
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0205066
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.020367
CAPRIN2 caprin family member 2 0.0201635
THSD4 thrombospondin, type I, domain containing 4 0.0201561
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0200596
GRB10 growth factor receptor-bound protein 10 0.0198459
MACF1 microtubule-actin crosslinking factor 1 0.0195905
BCL9L B-cell CLL/lymphoma 9-like 0.0192169
RHOA ras homolog family member A 0.01917
TXNIP thioredoxin interacting protein 0.0191596
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0190932
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0190842
PCDH1 protocadherin 1 0.0188374
PELI1 pellino E3 ubiquitin protein ligase 1 0.0184697
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0183901
MARCHF3 membrane associated ring-CH-type finger 3 0.0183363
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0182916
ZMIZ1 zinc finger, MIZ-type containing 1 0.0181984
ESYT2 extended synaptotagmin-like protein 2 0.0180583
GLS2 glutaminase 2 (liver, mitochondrial) 0.0179725
MBNL1 muscleblind-like splicing regulator 1 0.0177377
CCNY cyclin Y 0.0177088
EIF4B eukaryotic translation initiation factor 4B 0.017479
RNPS1 RNA binding protein S1, serine-rich domain 0.0173757
AKAP13 A kinase (PRKA) anchor protein 13 0.0173653
KDM7A lysine (K)-specific demethylase 7A 0.0172313
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0171633
COPA coatomer protein complex, subunit alpha 0.0171549
FLNA filamin A, alpha 0.0171469
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0169398
ITPRID2 ITPR interacting domain containing 2 0.0169125
PTK2B protein tyrosine kinase 2 beta 0.0169118
SAMD4A sterile alpha motif domain containing 4A 0.0168727
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0168396
RCOR1 REST corepressor 1 0.0168336
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0167623
SGMS2 sphingomyelin synthase 2 0.0165448

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.246776
TMSB10 thymosin beta 10 -0.244569
TPT1 tumor protein, translationally-controlled 1 -0.226322
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.16669
PTMA prothymosin, alpha -0.11917
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.102388
S100A10 S100 calcium binding protein A10 -0.0949329
LMO7 LIM domain 7 -0.0877925
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0867029
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0795755
VIM vimentin -0.0777676
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0725805
RPL35A ribosomal protein L35a -0.0701054
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0670488
FTL ferritin, light polypeptide -0.066573
F3 coagulation factor III (thromboplastin, tissue factor) -0.0642409
HMGA1 high mobility group AT-hook 1 -0.0591526
B2M beta-2-microglobulin -0.0575508
SQSTM1 sequestosome 1 -0.0569503
S100A6 S100 calcium binding protein A6 -0.0561479
RPL34 ribosomal protein L34 -0.0561382
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0539488
RPS24 ribosomal protein S24 -0.0503235
PLAUR plasminogen activator, urokinase receptor -0.0491668
CD2AP CD2-associated protein -0.0487811
ACTG1 actin gamma 1 -0.0485873
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0484993
LAMA4 laminin, alpha 4 -0.0484537
RPLP1 ribosomal protein, large, P1 -0.0474176
RPS8 ribosomal protein S8 -0.047337
S100A4 S100 calcium binding protein A4 -0.0466583
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0455171
RPL31 ribosomal protein L31 -0.0446773
RPL37A ribosomal protein L37a -0.0437343
ANXA2 annexin A2 -0.0434631
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0430762
GCC2 GRIP and coiled-coil domain containing 2 -0.0425222
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.042374
MYL12B myosin, light chain 12B, regulatory -0.04138
RBM39 RNA binding motif protein 39 -0.0413658
GNAS GNAS complex locus -0.0413047
RPL8 ribosomal protein L8 -0.0411801
IER3 immediate early response 3 -0.0403866
RPL26 ribosomal protein L26 -0.0403373
EIF1 eukaryotic translation initiation factor 1 -0.0400873
TRA2A transformer 2 alpha homolog (Drosophila) -0.0389806
RPLP2 ribosomal protein, large, P2 -0.0388987
PERP PERP, TP53 apoptosis effector -0.0385934
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0381832
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.038087
RPS21 ribosomal protein S21 -0.0379584
VCL vinculin -0.0375432
WSB1 WD repeat and SOCS box containing 1 -0.0374605
RAB1A RAB1A, member RAS oncogene family -0.0373133
RPS27A ribosomal protein S27a -0.037248
SDC4 syndecan 4 -0.0367056
RPS13 ribosomal protein S13 -0.0367013
KLF6 Kruppel-like factor 6 -0.0362336
RPL30 ribosomal protein L30 -0.0361036
RRBP1 ribosome binding protein 1 -0.0359497
GOLGA4 golgin A4 -0.0359341
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0358764
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0356172
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0353726
ASPH aspartate beta-hydroxylase -0.0352998
EPCAM epithelial cell adhesion molecule -0.0347618
RPL11 ribosomal protein L11 -0.0343959
NAMPT nicotinamide phosphoribosyltransferase -0.0341728
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0340305
EIF5B eukaryotic translation initiation factor 5B -0.03399
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0335902
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0335683
KDM3A lysine (K)-specific demethylase 3A -0.0333753
RPS25 ribosomal protein S25 -0.0321711
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0316856
RPS6 ribosomal protein S6 -0.0316647
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0316285
RPL37 ribosomal protein L37 -0.0313577
TM4SF1 transmembrane 4 L six family member 1 -0.031228
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311914
BZW1 basic leucine zipper and W2 domains 1 -0.0310133
RAD21 RAD21 homolog (S. pombe) -0.0307058
RPS3 ribosomal protein S3 -0.0307021
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0306478
RPS23 ribosomal protein S23 -0.0305696
RPL12 ribosomal protein L12 -0.0303723
RPL9 ribosomal protein L9 -0.0301446
RPS29 ribosomal protein S29 -0.0293582
EMP1 epithelial membrane protein 1 -0.0292926
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0290676
TXNRD1 thioredoxin reductase 1 -0.0288616
PTPRR protein tyrosine phosphatase, receptor type, R -0.0284475
LY6E lymphocyte antigen 6 complex, locus E -0.0283618
KDM5B lysine (K)-specific demethylase 5B -0.0280673
FUS FUS RNA binding protein -0.0280361
ATG12 autophagy related 12 -0.0279582
MORF4L2 mortality factor 4 like 2 -0.0276776
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.027462
SLC38A2 solute carrier family 38, member 2 -0.027458
TOP1 topoisomerase (DNA) I -0.0272603