Balsalazide (sodium hydrate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.209136
ADGRG6 adhesion G protein-coupled receptor G6 0.140674
ZNF608 zinc finger protein 608 0.13448
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.10176
USP9X ubiquitin specific peptidase 9, X-linked 0.0877958
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0787995
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0767673
JMJD1C jumonji domain containing 1C 0.0757165
DST dystonin 0.0626285
VCL vinculin 0.0619202
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0579823
KMT2C lysine (K)-specific methyltransferase 2C 0.0578188
CABIN1 calcineurin binding protein 1 0.0493944
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0487556
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0484146
KMT2E lysine (K)-specific methyltransferase 2E 0.0479739
NALF1 NALCN channel auxiliary factor 1 0.0476732
TOX thymocyte selection-associated high mobility group box 0.0474227
EEF2 eukaryotic translation elongation factor 2 0.0456071
SHROOM3 shroom family member 3 0.0449518
SOX5 SRY (sex determining region Y)-box 5 0.0447603
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0441484
STAT1 signal transducer and activator of transcription 1, 91kDa 0.043742
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0433865
PCBP2 poly(rC) binding protein 2 0.0432898
NFIA nuclear factor I/A 0.0428181
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426263
PDE4D phosphodiesterase 4D, cAMP-specific 0.0426095
YAP1 Yes-associated protein 1 0.041786
OGA O-GlcNAcase 0.0415798
MED13L mediator complex subunit 13-like 0.0406359
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0398889
MKI67 marker of proliferation Ki-67 0.0393306
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0390481
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0388516
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0386472
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0385402
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0382887
FBXL7 F-box and leucine-rich repeat protein 7 0.0376798
NGLY1 N-glycanase 1 0.0371216
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0367975
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0367172
QKI QKI, KH domain containing, RNA binding 0.0366455
CHD7 chromodomain helicase DNA binding protein 7 0.0361553
PHF21A PHD finger protein 21A 0.0359017
ZNF292 zinc finger protein 292 0.035826
XPO1 exportin 1 0.034636
USP34 ubiquitin specific peptidase 34 0.0345928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0344102
SERTAD2 SERTA domain containing 2 0.0341411
GSK3B glycogen synthase kinase 3 beta 0.0335539
SRPK2 SRSF protein kinase 2 0.0334782
EFNA5 ephrin-A5 0.0328879
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0325783
PUM2 pumilio RNA-binding family member 2 0.0323614
RHOA ras homolog family member A 0.0320905
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0311674
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0299421
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0297015
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0296366
CENPF centromere protein F, 350/400kDa 0.0296202
TTC3 tetratricopeptide repeat domain 3 0.0295698
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292952
NFIB nuclear factor I/B 0.0292873
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0290591
NCKAP1 NCK-associated protein 1 0.0288089
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0287501
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.028541
RERE arginine-glutamic acid dipeptide (RE) repeats 0.028239
PDS5B PDS5 cohesin associated factor B 0.0280743
MBD5 methyl-CpG binding domain protein 5 0.0280708
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0280673
RIGI RNA sensor RIG-I 0.0280234
BCAS3 breast carcinoma amplified sequence 3 0.0279568
SRRM2 serine/arginine repetitive matrix 2 0.0278319
FERMT2 fermitin family member 2 0.0277461
TJP1 tight junction protein 1 0.0275311
UBA6 ubiquitin-like modifier activating enzyme 6 0.027388
KDM3A lysine (K)-specific demethylase 3A 0.0272925
ZNF638 zinc finger protein 638 0.0271241
MED13 mediator complex subunit 13 0.026891
SETD5 SET domain containing 5 0.0268242
ATRN attractin 0.0267811
CDC73 cell division cycle 73 0.0267361
NUP58 nucleoporin 58 0.0265706
HELZ helicase with zinc finger 0.026504
KIF1B kinesin family member 1B 0.0263685
PBX3 pre-B-cell leukemia homeobox 3 0.026364
DENND5A DENN/MADD domain containing 5A 0.0263027
PCM1 pericentriolar material 1 0.026089
ATXN7 ataxin 7 0.0259618
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0259096
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0257589
ADAR adenosine deaminase, RNA-specific 0.0257129
BMPR1A bone morphogenetic protein receptor, type IA 0.0256144
AUTS2 autism susceptibility candidate 2 0.0254565
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254454
USP32 ubiquitin specific peptidase 32 0.0254025
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0253855
ESYT2 extended synaptotagmin-like protein 2 0.0253768

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162073
SLIT2 slit homolog 2 (Drosophila) -0.136022
NPAS3 neuronal PAS domain protein 3 -0.109098
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0976425
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0896778
RPL11 ribosomal protein L11 -0.0778206
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0777007
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0773423
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0736347
RPS8 ribosomal protein S8 -0.0703586
RPS21 ribosomal protein S21 -0.0703011
PTMA prothymosin, alpha -0.0698262
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0697074
RPS24 ribosomal protein S24 -0.0666816
TMSB10 thymosin beta 10 -0.0659674
TENM3 teneurin transmembrane protein 3 -0.0646016
RPS6 ribosomal protein S6 -0.0641256
RPLP1 ribosomal protein, large, P1 -0.06159
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0592453
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0551165
RCC1 regulator of chromosome condensation 1 -0.0510798
RPL26 ribosomal protein L26 -0.050201
ACTG1 actin gamma 1 -0.0499361
RPLP2 ribosomal protein, large, P2 -0.0486151
RPL31 ribosomal protein L31 -0.0483929
RPL34 ribosomal protein L34 -0.0475911
NAP1L1 nucleosome assembly protein 1-like 1 -0.0465801
HMGA1 high mobility group AT-hook 1 -0.0462064
RPL37A ribosomal protein L37a -0.0423768
TPT1 tumor protein, translationally-controlled 1 -0.0421365
HMGB1 high mobility group box 1 -0.0411909
ARHGAP32 Rho GTPase activating protein 32 -0.0405147
RSL1D1 ribosomal L1 domain containing 1 -0.0404598
RPL27A ribosomal protein L27a -0.0401341
RPL9 ribosomal protein L9 -0.040088
SOX4 SRY (sex determining region Y)-box 4 -0.0391001
RPS29 ribosomal protein S29 -0.038992
RAD51B RAD51 paralog B -0.0388405
RPL35A ribosomal protein L35a -0.0386562
RPL23 ribosomal protein L23 -0.0359044
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0353506
RPL18 ribosomal protein L18 -0.0351908
RPL28 ribosomal protein L28 -0.0349592
RPL12 ribosomal protein L12 -0.0347873
RPL13A ribosomal protein L13a -0.0344359
RPS27A ribosomal protein S27a -0.0342927
PRICKLE1 prickle homolog 1 (Drosophila) -0.0339681
OSBPL10 oxysterol binding protein-like 10 -0.033619
KPNB1 karyopherin (importin) beta 1 -0.0333351
RPS12 ribosomal protein S12 -0.0329344
LDHA lactate dehydrogenase A -0.0326863
RPL37 ribosomal protein L37 -0.0324219
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.032361
RPS11 ribosomal protein S11 -0.0322519
TOM1L2 target of myb1-like 2 (chicken) -0.0322206
RPS25 ribosomal protein S25 -0.0319958
RPLP0 ribosomal protein, large, P0 -0.0315071
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0314857
RPS19 ribosomal protein S19 -0.0310476
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0309345
GNAS GNAS complex locus -0.0308493
DENND1A DENN/MADD domain containing 1A -0.0306632
RPL7A ribosomal protein L7a -0.0301023
RPL36A ribosomal protein L36a -0.0298118
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0295449
CADM2 cell adhesion molecule 2 -0.0291263
RPS5 ribosomal protein S5 -0.0289367
RPL36 ribosomal protein L36 -0.0288033
RPL19 ribosomal protein L19 -0.0287816
PFN1 profilin 1 -0.0284484
RPS15 ribosomal protein S15 -0.0284401
RPL38 ribosomal protein L38 -0.028411
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0275938
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0275454
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0273078
ITSN1 intersectin 1 (SH3 domain protein) -0.0272455
SOX2 SRY (sex determining region Y)-box 2 -0.0271977
PTPRG protein tyrosine phosphatase, receptor type, G -0.0271166
ACACA acetyl-CoA carboxylase alpha -0.0271099
RPS28 ribosomal protein S28 -0.0268094
TAS2R14 taste receptor, type 2, member 14 -0.0262732
ATP9A ATPase, class II, type 9A -0.0258917
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0255036
IARS1 isoleucyl-tRNA synthetase 1 -0.0254322
LARS1 leucyl-tRNA synthetase 1 -0.0253905
TBC1D22A TBC1 domain family, member 22A -0.0250834
RPS20 ribosomal protein S20 -0.0250033
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0249711
RPL8 ribosomal protein L8 -0.0248725
RPS10 ribosomal protein S10 -0.0246427
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0243692
PARD3 par-3 family cell polarity regulator -0.0243086
CCSER1 coiled-coil serine-rich protein 1 -0.0242625
CCDC138 coiled-coil domain containing 138 -0.0238469
MYL12B myosin, light chain 12B, regulatory -0.023558
RPL35 ribosomal protein L35 -0.0235219
RPL32 ribosomal protein L32 -0.0232352
RPS3 ribosomal protein S3 -0.0231229
RPS13 ribosomal protein S13 -0.0231
TMEM178B transmembrane protein 178B -0.0221866