Balsalazide (sodium hydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0935217
IGFBP3 insulin-like growth factor binding protein 3 0.0861972
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0831216
ESYT2 extended synaptotagmin-like protein 2 0.0688554
COPA coatomer protein complex, subunit alpha 0.0683427
NBAS neuroblastoma amplified sequence 0.0666179
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0657147
KMT2C lysine (K)-specific methyltransferase 2C 0.0634876
FMNL2 formin-like 2 0.0623986
FN1 fibronectin 1 0.0615269
BHLHE40 basic helix-loop-helix family, member e40 0.0604654
PTK2 protein tyrosine kinase 2 0.0603881
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0543757
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0537517
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0511908
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0487522
CABIN1 calcineurin binding protein 1 0.0487344
TMEM178B transmembrane protein 178B 0.0460814
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0455968
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0439952
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0432473
CD109 CD109 molecule 0.0429758
PRELID2 PRELI domain containing 2 0.0427699
ASPH aspartate beta-hydroxylase 0.0421467
KMT2E lysine (K)-specific methyltransferase 2E 0.0419275
VEGFA vascular endothelial growth factor A 0.0416414
TAC4 tachykinin 4 (hemokinin) 0.0412992
NLGN1 neuroligin 1 0.0410335
FLNB filamin B, beta 0.0408728
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0405362
ATXN1 ataxin 1 0.040074
FNDC3B fibronectin type III domain containing 3B 0.0391821
SETBP1 SET binding protein 1 0.0391138
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0390783
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0384944
MACF1 microtubule-actin crosslinking factor 1 0.0380289
ZMIZ1 zinc finger, MIZ-type containing 1 0.0379876
GPC6 glypican 6 0.0376975
MARK3 MAP/microtubule affinity-regulating kinase 3 0.037628
HELZ helicase with zinc finger 0.0367689
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0343896
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0343849
LEF1 lymphoid enhancer-binding factor 1 0.0343422
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0343422
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338513
PDIA4 protein disulfide isomerase family A, member 4 0.0335977
CTTNBP2 cortactin binding protein 2 0.0333913
IGFBP5 insulin-like growth factor binding protein 5 0.0322775
MAML3 mastermind-like 3 (Drosophila) 0.032262
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0321359
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0321173
SND1 staphylococcal nuclease and tudor domain containing 1 0.0319917
PTPRM protein tyrosine phosphatase, receptor type, M 0.0317685
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0317177
HILPDA hypoxia inducible lipid droplet-associated 0.031244
TBC1D22A TBC1 domain family, member 22A 0.031242
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0295962
RCOR1 REST corepressor 1 0.0294464
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286475
UBASH3B ubiquitin associated and SH3 domain containing B 0.0285463
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0279443
NUP58 nucleoporin 58 0.0274254
CALR calreticulin 0.0274078
CTBP2 C-terminal binding protein 2 0.0273735
PHF21A PHD finger protein 21A 0.0273219
FOSL1 FOS-like antigen 1 0.0272425
NOTCH2 notch 2 0.0270954
TRIM2 tripartite motif containing 2 0.0269887
SSBP3 single stranded DNA binding protein 3 0.0269157
EEF2 eukaryotic translation elongation factor 2 0.0266685
CDC73 cell division cycle 73 0.026653
MCL1 myeloid cell leukemia 1 0.0261149
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0260127
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0256671
GLS2 glutaminase 2 (liver, mitochondrial) 0.0254
ZSWIM6 zinc finger, SWIM-type containing 6 0.0251877
SMAD3 SMAD family member 3 0.0248466
PKM pyruvate kinase, muscle 0.0246264
SRRM2 serine/arginine repetitive matrix 2 0.0245673
UBA6 ubiquitin-like modifier activating enzyme 6 0.0244895
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0243628
ZNF638 zinc finger protein 638 0.0243207
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.024292
CLMN calmin (calponin-like, transmembrane) 0.0240804
ANO6 anoctamin 6 0.0240369
DST dystonin 0.0239996
HSPG2 heparan sulfate proteoglycan 2 0.0239244
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0238146
PICALM phosphatidylinositol binding clathrin assembly protein 0.0237823
MSN moesin 0.0233237
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0229239
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0228692
PDIA3 protein disulfide isomerase family A, member 3 0.022846
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0227806
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0226906
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0226575
OSBPL10 oxysterol binding protein-like 10 0.0224392
ENO2 enolase 2 (gamma, neuronal) 0.0220497
UTRN utrophin 0.021992
FAT1 FAT atypical cadherin 1 0.0217406

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.282686
IFI16 interferon, gamma-inducible protein 16 -0.215286
VIM vimentin -0.196741
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.189854
FMN1 formin 1 -0.138161
ACTG1 actin gamma 1 -0.0824285
MT2A metallothionein 2A -0.0787456
TNNC1 troponin C type 1 (slow) -0.0621666
TMSB10 thymosin beta 10 -0.05872
IER3 immediate early response 3 -0.056496
COL19A1 collagen, type XIX, alpha 1 -0.056418
S100A6 S100 calcium binding protein A6 -0.0553402
NPC1 Niemann-Pick disease, type C1 -0.052798
HLA-B major histocompatibility complex, class I, B -0.0495919
TPT1 tumor protein, translationally-controlled 1 -0.0468619
RPLP1 ribosomal protein, large, P1 -0.0463606
DCT dopachrome tautomerase -0.0449331
TM4SF1 transmembrane 4 L six family member 1 -0.0427634
LOC112694756 uncharaterized LOC112694756 -0.0395351
HMCN1 hemicentin 1 -0.0394426
A2M alpha-2-macroglobulin -0.0387504
NAMPT nicotinamide phosphoribosyltransferase -0.0385917
NCOA7 nuclear receptor coactivator 7 -0.0384147
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0382113
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0376149
MT1X metallothionein 1X -0.0353291
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0338974
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0338042
PDE10A phosphodiesterase 10A -0.0326139
IFI6 interferon, alpha-inducible protein 6 -0.0325527
FRMD4A FERM domain containing 4A -0.032534
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.032162
VCL vinculin -0.0309634
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0306348
CALD1 caldesmon 1 -0.0306063
RAD21 RAD21 homolog (S. pombe) -0.0302002
ICAM1 intercellular adhesion molecule 1 -0.0291337
LMNA lamin A/C -0.0288019
ZMYND8 zinc finger, MYND-type containing 8 -0.0287486
PGK1 phosphoglycerate kinase 1 -0.0286257
RRBP1 ribosome binding protein 1 -0.0283891
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0269129
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0262828
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0260345
OXR1 oxidation resistance 1 -0.0259862
WSB1 WD repeat and SOCS box containing 1 -0.0249788
RPLP0 ribosomal protein, large, P0 -0.0248218
CAVIN1 caveolae associated protein 1 -0.0244717
MTPN myotrophin -0.0243345
CD59 CD59 molecule, complement regulatory protein -0.0243075
RHOJ ras homolog family member J -0.0242481
BACE2 beta-site APP-cleaving enzyme 2 -0.0237285
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0236766
FRMD5 FERM domain containing 5 -0.0236014
CD63 CD63 molecule -0.0232498
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0230037
GNAS GNAS complex locus -0.0228231
OSMR oncostatin M receptor -0.022746
RPL12 ribosomal protein L12 -0.0224311
NAV3 neuron navigator 3 -0.0224005
ARHGAP5 Rho GTPase activating protein 5 -0.0221879
SYPL1 synaptophysin-like 1 -0.0219402
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0216219
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0213474
INPP5F inositol polyphosphate-5-phosphatase F -0.0213461
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0212209
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0211051
RHOBTB3 Rho-related BTB domain containing 3 -0.0210501
NAP1L1 nucleosome assembly protein 1-like 1 -0.0210264
ANKRD28 ankyrin repeat domain 28 -0.0209976
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0209889
RPL34 ribosomal protein L34 -0.0209048
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0208708
WWTR1 WW domain containing transcription regulator 1 -0.0208181
DUSP6 dual specificity phosphatase 6 -0.020808
RPL19 ribosomal protein L19 -0.0207735
S100A10 S100 calcium binding protein A10 -0.0206315
VDAC1 voltage-dependent anion channel 1 -0.0204054
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0202892
IFITM1 interferon induced transmembrane protein 1 -0.02003
RPL30 ribosomal protein L30 -0.0199047
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0198043
RTN4 reticulon 4 -0.0197678
RPS8 ribosomal protein S8 -0.019645
BZW1 basic leucine zipper and W2 domains 1 -0.0195706
GSN gelsolin -0.0194174
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0193985
IFITM3 interferon induced transmembrane protein 3 -0.0192601
RPL26 ribosomal protein L26 -0.0191664
HLA-E major histocompatibility complex, class I, E -0.018951
RPL35A ribosomal protein L35a -0.0189021
RPS19 ribosomal protein S19 -0.0188874
CRYBG1 crystallin beta-gamma domain containing 1 -0.0188553
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.018574
EHBP1 EH domain binding protein 1 -0.0184744
MTDH metadherin -0.0182898
YBX3 Y box binding protein 3 -0.0180953
RPS12 ribosomal protein S12 -0.0176879
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0176667
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.017397