Balsalazide (sodium hydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.130055
SAMD4A sterile alpha motif domain containing 4A 0.10369
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0931532
DTNA dystrobrevin, alpha 0.069089
TGM2 transglutaminase 2 0.0688333
LMO7 LIM domain 7 0.0686963
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0658514
VEGFA vascular endothelial growth factor A 0.0647838
GRB10 growth factor receptor-bound protein 10 0.0596444
FTH1 ferritin, heavy polypeptide 1 0.0591249
PPARD peroxisome proliferator-activated receptor delta 0.0539389
APLP2 amyloid beta (A4) precursor-like protein 2 0.0533454
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.050695
RCOR1 REST corepressor 1 0.0504677
TSC22D2 TSC22 domain family, member 2 0.0469515
BRD2 bromodomain containing 2 0.0431326
MACF1 microtubule-actin crosslinking factor 1 0.0413759
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0411291
ESYT2 extended synaptotagmin-like protein 2 0.0388976
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0385159
MCL1 myeloid cell leukemia 1 0.0380106
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0375303
ZSWIM6 zinc finger, SWIM-type containing 6 0.037089
MYO1E myosin IE 0.0358475
HLA-A major histocompatibility complex, class I, A 0.0342861
RIMKLB ribosomal modification protein rimK-like family member B 0.0337157
PCBP2 poly(rC) binding protein 2 0.0335113
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0334873
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.031594
MX1 MX dynamin-like GTPase 1 0.0315682
STC1 stanniocalcin 1 0.0314314
SRP54 signal recognition particle 54kDa 0.0307196
JUP junction plakoglobin 0.0298594
DST dystonin 0.0295365
ELL2 elongation factor, RNA polymerase II, 2 0.0291013
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0287538
SGMS2 sphingomyelin synthase 2 0.0286362
ZMIZ1 zinc finger, MIZ-type containing 1 0.0285919
POTEF POTE ankyrin domain family, member F 0.0274821
PLEC plectin 0.0265303
PRSS8 protease, serine, 8 0.0265004
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0251208
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.024973
MYH9 myosin, heavy chain 9, non-muscle 0.024872
PLS3 plastin 3 0.0244074
HELZ helicase with zinc finger 0.0240359
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0239357
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0236795
SVIL supervillin 0.023656
COPA coatomer protein complex, subunit alpha 0.0228991
AKAP12 A kinase (PRKA) anchor protein 12 0.0228244
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0227956
MSN moesin 0.0227576
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0225624
BCAR3 breast cancer anti-estrogen resistance 3 0.0224905
NOTCH2 notch 2 0.0224423
SPAG9 sperm associated antigen 9 0.0222819
BHLHE40 basic helix-loop-helix family, member e40 0.0222604
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0221792
UBASH3B ubiquitin associated and SH3 domain containing B 0.0221169
UBC ubiquitin C 0.0211886
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0209605
TIMP2 TIMP metallopeptidase inhibitor 2 0.0208302
INTS6 integrator complex subunit 6 0.0208067
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.020773
NPAS2 neuronal PAS domain protein 2 0.0206323
ITGA6 integrin, alpha 6 0.0205429
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.0204181
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0203073
EPAS1 endothelial PAS domain protein 1 0.0201374
UBA6 ubiquitin-like modifier activating enzyme 6 0.020128
PARD3 par-3 family cell polarity regulator 0.0200036
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0199627
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0199436
ARHGAP42 Rho GTPase activating protein 42 0.0197639
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0196775
SEC24A SEC24 family member A 0.0192971
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0190843
MYO5B myosin VB 0.0189839
MAML3 mastermind-like 3 (Drosophila) 0.0188748
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0188228
TMC5 transmembrane channel-like 5 0.0184839
NCOR2 nuclear receptor corepressor 2 0.0181363
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0180917
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0179156
MAST4 microtubule associated serine/threonine kinase family member 4 0.0178971
CTBP2 C-terminal binding protein 2 0.0178392
PICALM phosphatidylinositol binding clathrin assembly protein 0.0177199
SEPTIN9 septin 9 0.0176111
AHNAK2 AHNAK nucleoprotein 2 0.0175185
TGFB1 transforming growth factor, beta 1 0.0172405
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0170815
RREB1 ras responsive element binding protein 1 0.0170619
ZFYVE28 zinc finger, FYVE domain containing 28 0.0170416
KDM5B lysine (K)-specific demethylase 5B 0.0169302
CIB1 calcium and integrin binding 1 (calmyrin) 0.0168201
ATF3 activating transcription factor 3 0.0167622
EEF2 eukaryotic translation elongation factor 2 0.0166656
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.016512
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0164753

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.190271
PTMA prothymosin, alpha -0.176672
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.137289
TPT1 tumor protein, translationally-controlled 1 -0.13584
TMSB4X thymosin beta 4, X-linked -0.131497
MT2A metallothionein 2A -0.115052
NAMPT nicotinamide phosphoribosyltransferase -0.113488
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.110337
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.1029
ACTG1 actin gamma 1 -0.0998618
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0974897
RPL23 ribosomal protein L23 -0.0927964
ASPH aspartate beta-hydroxylase -0.0923864
HLA-B major histocompatibility complex, class I, B -0.0863669
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0838475
MMP7 matrix metallopeptidase 7 -0.0837093
LAMB3 laminin, beta 3 -0.08188
KLF6 Kruppel-like factor 6 -0.0816619
RPS24 ribosomal protein S24 -0.0782803
VIM vimentin -0.0766068
RPS8 ribosomal protein S8 -0.0726974
PGK1 phosphoglycerate kinase 1 -0.0723967
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.072276
RPLP1 ribosomal protein, large, P1 -0.0721641
EIF1 eukaryotic translation initiation factor 1 -0.0695256
RPL35A ribosomal protein L35a -0.06929
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0669379
RPL19 ribosomal protein L19 -0.0658626
SLC38A1 solute carrier family 38, member 1 -0.0646877
RPL34 ribosomal protein L34 -0.0645725
CD2AP CD2-associated protein -0.0627847
RTN4 reticulon 4 -0.0610514
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0604352
IER3 immediate early response 3 -0.0595089
RPS21 ribosomal protein S21 -0.059404
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0591296
S100A6 S100 calcium binding protein A6 -0.0582916
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0565023
RPL11 ribosomal protein L11 -0.0545163
RPL9 ribosomal protein L9 -0.0540972
ISG15 ISG15 ubiquitin-like modifier -0.0532559
C15ORF48 chromosome 15 open reading frame 48 -0.0522821
ANXA2 annexin A2 -0.0520726
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0518179
RPLP0 ribosomal protein, large, P0 -0.0516626
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0506722
KRT19 keratin 19, type I -0.0505357
ALCAM activated leukocyte cell adhesion molecule -0.0497864
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0465961
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0458616
PLAU plasminogen activator, urokinase -0.0457567
FAM162A family with sequence similarity 162, member A -0.0456661
RPS27A ribosomal protein S27a -0.0455843
TM4SF1 transmembrane 4 L six family member 1 -0.0444246
LAMC2 laminin, gamma 2 -0.0443286
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.0437381
RPS3 ribosomal protein S3 -0.0436921
GCC2 GRIP and coiled-coil domain containing 2 -0.0435325
RPS6 ribosomal protein S6 -0.0432831
IFI16 interferon, gamma-inducible protein 16 -0.0425834
F3 coagulation factor III (thromboplastin, tissue factor) -0.0420151
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0412092
KPNB1 karyopherin (importin) beta 1 -0.0410333
EREG epiregulin -0.0393549
CANX calnexin -0.038116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.03805
RPL37A ribosomal protein L37a -0.0377617
NT5C2 5'-nucleotidase, cytosolic II -0.0377595
RRBP1 ribosome binding protein 1 -0.0375927
RACK1 receptor for activated C kinase 1 -0.037587
RPS19 ribosomal protein S19 -0.0373935
CD46 CD46 molecule, complement regulatory protein -0.0372749
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0371566
PLAUR plasminogen activator, urokinase receptor -0.0371117
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.036732
EPCAM epithelial cell adhesion molecule -0.0365738
RPL37 ribosomal protein L37 -0.0364906
B2M beta-2-microglobulin -0.03644
VDAC1 voltage-dependent anion channel 1 -0.0360923
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0357968
TPM1 tropomyosin 1 (alpha) -0.0355887
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0353577
S100A10 S100 calcium binding protein A10 -0.0352981
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0352424
RPS23 ribosomal protein S23 -0.0352269
KDM3A lysine (K)-specific demethylase 3A -0.0350425
RPL31 ribosomal protein L31 -0.0345164
MT1X metallothionein 1X -0.0344208
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.03425
CP ceruloplasmin (ferroxidase) -0.0341628
RPS29 ribosomal protein S29 -0.0340553
NDRG1 N-myc downstream regulated 1 -0.0337055
GNAS GNAS complex locus -0.0336762
RPL12 ribosomal protein L12 -0.0335007
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0332988
PHF3 PHD finger protein 3 -0.0332717
RPS16 ribosomal protein S16 -0.0330806
TOP1 topoisomerase (DNA) I -0.0323006
ZMYND8 zinc finger, MYND-type containing 8 -0.0322659
NPEPPS aminopeptidase puromycin sensitive -0.0319917