Balsalazide (sodium hydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.123679
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0991354
HELZ helicase with zinc finger 0.0974443
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0794154
CDH10 cadherin 10, type 2 (T2-cadherin) 0.075841
KDM3A lysine (K)-specific demethylase 3A 0.0695534
TLE4 transducin-like enhancer of split 4 0.0637889
HILPDA hypoxia inducible lipid droplet-associated 0.0627709
MEF2A myocyte enhancer factor 2A 0.0626289
WDR45B WD repeat domain 45B 0.058163
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0550424
NDRG1 N-myc downstream regulated 1 0.052918
AKAP12 A kinase (PRKA) anchor protein 12 0.0523089
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0508503
NAMPT nicotinamide phosphoribosyltransferase 0.0480675
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0473365
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0464117
TRA2A transformer 2 alpha homolog (Drosophila) 0.0463822
ZMIZ1 zinc finger, MIZ-type containing 1 0.0431125
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0431111
KMT2E lysine (K)-specific methyltransferase 2E 0.042788
ZNF292 zinc finger protein 292 0.0413686
TRIO trio Rho guanine nucleotide exchange factor 0.0397289
XPO1 exportin 1 0.0392282
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0383295
FNBP1 formin binding protein 1 0.0382303
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0376843
TRIB2 tribbles pseudokinase 2 0.0374116
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0368758
KDM5B lysine (K)-specific demethylase 5B 0.0364055
WAC WW domain containing adaptor with coiled-coil 0.0362195
NPEPPS aminopeptidase puromycin sensitive 0.0361299
PTK2 protein tyrosine kinase 2 0.0360404
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0358961
SOX9 SRY (sex determining region Y)-box 9 0.0358364
DDIT4 DNA-damage-inducible transcript 4 0.0355534
MYH9 myosin, heavy chain 9, non-muscle 0.0354213
PICALM phosphatidylinositol binding clathrin assembly protein 0.0353877
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0351758
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0348667
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0342416
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0342379
RARA retinoic acid receptor, alpha 0.0341478
C1ORF21 chromosome 1 open reading frame 21 0.0340728
PHIP pleckstrin homology domain interacting protein 0.0335212
OGA O-GlcNAcase 0.0333346
RBM39 RNA binding motif protein 39 0.0333313
QKI QKI, KH domain containing, RNA binding 0.0330351
SDK1 sidekick cell adhesion molecule 1 0.0311443
MACF1 microtubule-actin crosslinking factor 1 0.0310645
RNF213 ring finger protein 213 0.0291334
FXR1 fragile X mental retardation, autosomal homolog 1 0.0286858
PCM1 pericentriolar material 1 0.0281326
RNF24 ring finger protein 24 0.0277828
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0277494
CXXC5 CXXC finger protein 5 0.0276901
ZNF148 zinc finger protein 148 0.0274502
TIMP3 TIMP metallopeptidase inhibitor 3 0.0274283
HOOK2 hook microtubule-tethering protein 2 0.0273841
KTN1 kinectin 1 (kinesin receptor) 0.0273811
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0273666
DNMBP dynamin binding protein 0.0273362
ASPH aspartate beta-hydroxylase 0.0272357
KDM4C lysine (K)-specific demethylase 4C 0.0270294
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0267353
CSNK1A1 casein kinase 1, alpha 1 0.0266418
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.026501
RYBP RING1 and YY1 binding protein 0.0261129
FAM162A family with sequence similarity 162, member A 0.0260706
SEPTIN7 septin 7 0.0260606
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0259734
MYH10 myosin, heavy chain 10, non-muscle 0.0259327
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0259265
LCORL ligand dependent nuclear receptor corepressor-like 0.0252317
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0248282
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0246624
DTNA dystrobrevin, alpha 0.0244399
RLF rearranged L-myc fusion 0.0243561
SMAD3 SMAD family member 3 0.0243485
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0239534
HDAC5 histone deacetylase 5 0.0237059
LIMCH1 LIM and calponin homology domains 1 0.023571
TSC22D2 TSC22 domain family, member 2 0.0235525
CEMIP2 cell migration inducing hyaluronidase 2 0.0235184
SEPTIN9 septin 9 0.0234678
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0233701
ATXN1 ataxin 1 0.0230629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0229242
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0224903
KMT2C lysine (K)-specific methyltransferase 2C 0.0223627
ANXA2 annexin A2 0.0222357
ACTN1 actinin, alpha 1 0.0221426
SSBP3 single stranded DNA binding protein 3 0.0217148
SKIC3 SKI3 subunit of superkiller complex 0.0216392
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0214386
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213402
PELI1 pellino E3 ubiquitin protein ligase 1 0.0213335
HSPA8 heat shock 70kDa protein 8 0.0212737
NEK7 NIMA-related kinase 7 0.0212577
MRTFA myocardin related transcription factor A 0.0212092

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.155257
IGF2 insulin-like growth factor 2 -0.12998
LSAMP limbic system-associated membrane protein -0.119677
SYT1 synaptotagmin I -0.078886
PTMA prothymosin, alpha -0.0605353
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0572369
ZBTB20 zinc finger and BTB domain containing 20 -0.0569537
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0524718
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0520035
TENT5A terminal nucleotidyltransferase 5A -0.0501525
VMP1 vacuole membrane protein 1 -0.0486087
TPST1 tyrosylprotein sulfotransferase 1 -0.044685
MEIS2 Meis homeobox 2 -0.0444329
TPT1 tumor protein, translationally-controlled 1 -0.0438356
RPS24 ribosomal protein S24 -0.0435723
COL4A5 collagen, type IV, alpha 5 -0.0424231
FNDC3A fibronectin type III domain containing 3A -0.0412517
RPL31 ribosomal protein L31 -0.0412198
CADM2 cell adhesion molecule 2 -0.0410425
LINGO2 leucine rich repeat and Ig domain containing 2 -0.03905
FRMD4A FERM domain containing 4A -0.0389846
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0384835
SIK2 salt-inducible kinase 2 -0.0382121
PCNX4 pecanex 4 -0.0372649
RPL23 ribosomal protein L23 -0.0370882
EXT1 exostosin glycosyltransferase 1 -0.0369652
SLC38A2 solute carrier family 38, member 2 -0.0367157
RPL34 ribosomal protein L34 -0.0342176
GLCCI1 glucocorticoid induced 1 -0.0342023
GREM2 gremlin 2, DAN family BMP antagonist -0.0340658
RO60 Ro60, Y RNA binding protein -0.0338724
BCAS3 breast carcinoma amplified sequence 3 -0.0334748
GAB2 GRB2-associated binding protein 2 -0.0329852
PRRC2C proline-rich coiled-coil 2C -0.0314346
NRG1 neuregulin 1 -0.0309513
ADGRB3 adhesion G protein-coupled receptor B3 -0.0307277
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0302451
RHOBTB3 Rho-related BTB domain containing 3 -0.0301822
MAPK10 mitogen-activated protein kinase 10 -0.0298872
FMN1 formin 1 -0.0294887
PSD3 pleckstrin and Sec7 domain containing 3 -0.0291962
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0290108
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0288763
RPTOR regulatory associated protein of MTOR, complex 1 -0.0287958
RPS6 ribosomal protein S6 -0.0287764
ATRNL1 attractin-like 1 -0.028479
ACTG1 actin gamma 1 -0.0278637
MAP1B microtubule-associated protein 1B -0.0276613
PDE4D phosphodiesterase 4D, cAMP-specific -0.0269667
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0264252
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0257282
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0255109
IARS1 isoleucyl-tRNA synthetase 1 -0.0246419
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0246309
LPP LIM domain containing preferred translocation partner in lipoma -0.02447
TMEM165 transmembrane protein 165 -0.0244609
LRRC7 leucine rich repeat containing 7 -0.0242645
CRH corticotropin releasing hormone -0.0241643
GOLGB1 golgin B1 -0.0238864
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0238732
AEBP2 AE binding protein 2 -0.0237434
CALD1 caldesmon 1 -0.0236617
RPS12 ribosomal protein S12 -0.0235708
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0232455
IER3 immediate early response 3 -0.023077
EGR1 early growth response 1 -0.0227546
NBEA neurobeachin -0.0226631
SVIL supervillin -0.0223787
RBBP6 retinoblastoma binding protein 6 -0.0223158
SMC5 structural maintenance of chromosomes 5 -0.0222481
RPL19 ribosomal protein L19 -0.0222246
POTEF POTE ankyrin domain family, member F -0.0221383
TBX2 T-box 2 -0.0219505
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0218994
RAI14 retinoic acid induced 14 -0.0218717
MEX3A mex-3 RNA binding family member A -0.0217442
RPS14 ribosomal protein S14 -0.0217354
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0215091
VIM vimentin -0.021493
RPS17 ribosomal protein S17 -0.0214826
ZNF804A zinc finger protein 804A -0.0213701
PCDH9 protocadherin 9 -0.0213214
RAP1B RAP1B, member of RAS oncogene family -0.0212452
CNTN4 contactin 4 -0.0211814
IGFBP3 insulin-like growth factor binding protein 3 -0.0210608
STK38L serine/threonine kinase 38 like -0.0209436
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0209377
IGFBP5 insulin-like growth factor binding protein 5 -0.0209163
FNBP4 formin binding protein 4 -0.02068
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0206654
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0200314
ENAH enabled homolog (Drosophila) -0.019973
DNAH14 dynein, axonemal, heavy chain 14 -0.019893
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0198193
SH3PXD2B SH3 and PX domains 2B -0.0197823
RPLP0 ribosomal protein, large, P0 -0.0197793
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0197678
THOC2 THO complex 2 -0.019401
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0193864
PIBF1 progesterone immunomodulatory binding factor 1 -0.0192093