Balsalazide (sodium hydrate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.132831
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0786659
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0738783
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.06359
SMAD3 SMAD family member 3 0.0611169
MACC1 metastasis associated in colon cancer 1 0.0529573
ITGA6 integrin, alpha 6 0.0515097
RUNX1 runt-related transcription factor 1 0.0435608
MLPH melanophilin 0.0411145
ATP10B ATPase, class V, type 10B 0.0401402
VEGFA vascular endothelial growth factor A 0.0379207
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0377285
ABHD2 abhydrolase domain containing 2 0.037152
EPSTI1 epithelial stromal interaction 1 (breast) 0.0367289
SH3PXD2A SH3 and PX domains 2A 0.0341248
MYO1E myosin IE 0.0337499
TOX3 TOX high mobility group box family member 3 0.0329659
FAT1 FAT atypical cadherin 1 0.0316952
SRRM2 serine/arginine repetitive matrix 2 0.030685
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0306094
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0302261
MSI2 musashi RNA-binding protein 2 0.0301643
DST dystonin 0.0300921
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0297911
MBNL2 muscleblind-like splicing regulator 2 0.0282437
RBM47 RNA binding motif protein 47 0.0282313
ZMYND8 zinc finger, MYND-type containing 8 0.0280736
ARHGAP26 Rho GTPase activating protein 26 0.0280056
SORBS1 sorbin and SH3 domain containing 1 0.0278852
CEMIP cell migration inducing protein, hyaluronan binding 0.0278384
PADI1 peptidyl arginine deiminase, type I 0.0266407
TRIM2 tripartite motif containing 2 0.0265924
RNF43 ring finger protein 43 0.0263541
MECOM MDS1 and EVI1 complex locus 0.0261799
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0260864
XDH xanthine dehydrogenase 0.0260342
MYH9 myosin, heavy chain 9, non-muscle 0.0258668
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0255741
KIAA1217 KIAA1217 0.0254028
DUSP16 dual specificity phosphatase 16 0.0250812
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0248198
PRSS3 protease, serine, 3 0.0247807
KIF16B kinesin family member 16B 0.0245167
YAP1 Yes-associated protein 1 0.0241962
TMC5 transmembrane channel-like 5 0.0241799
CDHR2 cadherin-related family member 2 0.0239415
PDZD8 PDZ domain containing 8 0.0237938
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0228799
PRSS22 protease, serine, 22 0.0225583
AFF1 AF4/FMR2 family, member 1 0.0224341
ALPK1 alpha-kinase 1 0.0224274
PROX1 prospero homeobox 1 0.022072
SAMD4A sterile alpha motif domain containing 4A 0.021992
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208579
ETV6 ets variant 6 0.0206053
NEBL nebulette 0.0200382
FNIP2 folliculin interacting protein 2 0.0199853
ZNRF3 zinc and ring finger 3 0.0197958
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0197056
BHLHE40 basic helix-loop-helix family, member e40 0.0196893
IL20RA interleukin 20 receptor, alpha 0.0193076
PTBP3 polypyrimidine tract binding protein 3 0.01911
TJP2 tight junction protein 2 0.0190994
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0189479
SPATA6L spermatogenesis associated 6-like 0.0188749
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0187703
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0187448
CCNL1 cyclin L1 0.018508
DHFR dihydrofolate reductase 0.018474
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0183631
CEMIP2 cell migration inducing hyaluronidase 2 0.0181819
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0181075
STK24 serine/threonine kinase 24 0.0180496
MYO5B myosin VB 0.0176861
CORIN corin, serine peptidase 0.0176537
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0174915
CATSPERB catsper channel auxiliary subunit beta 0.0174796
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0174531
FAM120A family with sequence similarity 120A 0.0172378
TMEM62 transmembrane protein 62 0.0169493
EPHB2 EPH receptor B2 0.0168007
SLK STE20-like kinase 0.0166427
NCOR2 nuclear receptor corepressor 2 0.0166345
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0165412
MAP2K6 mitogen-activated protein kinase kinase 6 0.016262
MACF1 microtubule-actin crosslinking factor 1 0.0159953
ESYT2 extended synaptotagmin-like protein 2 0.0158144
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0157956
ETNK1 ethanolamine kinase 1 0.0157109
FOSL2 FOS-like antigen 2 0.0156107
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.015565
TRAK1 trafficking protein, kinesin binding 1 0.0155631
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0154764
KLF3 Kruppel-like factor 3 (basic) 0.0154291
MYO10 myosin X 0.015374
TC2N tandem C2 domains, nuclear 0.0152773
MEIS2 Meis homeobox 2 0.015237
ARGLU1 arginine and glutamate rich 1 0.015222
PELI1 pellino E3 ubiquitin protein ligase 1 0.0150718
EGFR epidermal growth factor receptor 0.0149975

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.284808
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143963
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142703
PTMA prothymosin, alpha -0.125766
B2M beta-2-microglobulin -0.115244
INTS6 integrator complex subunit 6 -0.112027
HLA-B major histocompatibility complex, class I, B -0.103504
VCL vinculin -0.0973711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0874408
RPL35A ribosomal protein L35a -0.0799536
IFI6 interferon, alpha-inducible protein 6 -0.078548
SQSTM1 sequestosome 1 -0.0728042
ANKRD10 ankyrin repeat domain 10 -0.0694401
PLSCR2 phospholipid scramblase 2 -0.0689784
FTL ferritin, light polypeptide -0.0684275
PHF3 PHD finger protein 3 -0.067864
PERP PERP, TP53 apoptosis effector -0.0658313
ANXA2 annexin A2 -0.0639497
RPL34 ribosomal protein L34 -0.0623039
TM4SF1 transmembrane 4 L six family member 1 -0.0622776
LYZ lysozyme -0.0620278
RPS6 ribosomal protein S6 -0.0613843
XAF1 XIAP associated factor 1 -0.0611177
AHI1 Abelson helper integration site 1 -0.060708
TMSB10 thymosin beta 10 -0.0596805
AREG amphiregulin -0.0585284
RAB7A RAB7A, member RAS oncogene family -0.0563113
EIF1 eukaryotic translation initiation factor 1 -0.0557824
SP100 SP100 nuclear antigen -0.0549306
RPS24 ribosomal protein S24 -0.0546735
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0536269
RPL7L1 ribosomal protein L7-like 1 -0.0531024
MUC20 mucin 20, cell surface associated -0.0520917
RPS8 ribosomal protein S8 -0.0509744
RPL23 ribosomal protein L23 -0.0506594
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0504148
MORF4L2 mortality factor 4 like 2 -0.0494409
CANX calnexin -0.0491099
ACTG1 actin gamma 1 -0.0478741
GOLGB1 golgin B1 -0.047679
TM4SF19 transmembrane 4 L six family member 19 -0.0473582
RPLP1 ribosomal protein, large, P1 -0.0469654
HLA-E major histocompatibility complex, class I, E -0.045095
MAP7 microtubule-associated protein 7 -0.0442097
C6ORF132 chromosome 6 open reading frame 132 -0.0436999
MT2A metallothionein 2A -0.0429932
LCN2 lipocalin 2 -0.0424617
HLA-C major histocompatibility complex, class I, C -0.042408
GCLC glutamate-cysteine ligase, catalytic subunit -0.0423145
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0422879
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0420279
BTBD9 BTB (POZ) domain containing 9 -0.0417835
TXNIP thioredoxin interacting protein -0.0406876
TM9SF2 transmembrane 9 superfamily member 2 -0.0399106
RPL26 ribosomal protein L26 -0.0396806
RPL19 ribosomal protein L19 -0.0395892
S100A10 S100 calcium binding protein A10 -0.0392259
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0385664
GOLGA4 golgin A4 -0.0385293
NF1 neurofibromin 1 -0.0382982
EGR1 early growth response 1 -0.0377216
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0376276
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0375032
SLC38A1 solute carrier family 38, member 1 -0.0374022
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0373484
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0369329
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0369293
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0368559
RPL37A ribosomal protein L37a -0.0368369
SEC31A SEC31 homolog A (S. cerevisiae) -0.0366861
POU2F2 POU class 2 homeobox 2 -0.0360832
GNAS GNAS complex locus -0.0359923
RPL12 ribosomal protein L12 -0.0359007
PKM pyruvate kinase, muscle -0.0356316
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0353023
PRRC2C proline-rich coiled-coil 2C -0.0350555
UFM1 ubiquitin-fold modifier 1 -0.035027
RAB1A RAB1A, member RAS oncogene family -0.0349848
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0348407
RRBP1 ribosome binding protein 1 -0.0347652
S100A6 S100 calcium binding protein A6 -0.0341694
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.034074
RPLP0 ribosomal protein, large, P0 -0.0340699
IRS2 insulin receptor substrate 2 -0.0336912
RPL37 ribosomal protein L37 -0.0336707
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0333596
HM13 histocompatibility (minor) 13 -0.0333539
RPL11 ribosomal protein L11 -0.0329051
EPCAM epithelial cell adhesion molecule -0.032386
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0323484
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0323143
KDM3A lysine (K)-specific demethylase 3A -0.032052
H3-3B H3.3 histone B -0.0319425
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.031815
RPL31 ribosomal protein L31 -0.0318031
NIPBL Nipped-B homolog (Drosophila) -0.0316781
TJP1 tight junction protein 1 -0.0316771
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0316547
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0316345
KPNB1 karyopherin (importin) beta 1 -0.0315046