Balsalazide (sodium hydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.164883
IGFBP3 insulin-like growth factor binding protein 3 0.105884
FAM13A family with sequence similarity 13, member A 0.0784942
HELZ helicase with zinc finger 0.0455685
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0440455
BACE2 beta-site APP-cleaving enzyme 2 0.0422504
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0418211
VEGFA vascular endothelial growth factor A 0.0393814
TRIO trio Rho guanine nucleotide exchange factor 0.0380233
AKAP12 A kinase (PRKA) anchor protein 12 0.0358925
BHLHE40 basic helix-loop-helix family, member e40 0.0337018
ERRFI1 ERBB receptor feedback inhibitor 1 0.0330663
FNDC3B fibronectin type III domain containing 3B 0.0330434
FAM219A family with sequence similarity 219, member A 0.0318621
HDAC9 histone deacetylase 9 0.030743
MMP12 matrix metallopeptidase 12 0.0307197
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0291811
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0291138
FNIP1 folliculin interacting protein 1 0.02898
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0288528
COPA coatomer protein complex, subunit alpha 0.0285892
SMAD3 SMAD family member 3 0.0276962
RNMT RNA (guanine-7-) methyltransferase 0.0274329
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272822
STC1 stanniocalcin 1 0.0272495
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0267249
DGKD diacylglycerol kinase, delta 130kDa 0.0267149
ANO6 anoctamin 6 0.0252309
SRP54 signal recognition particle 54kDa 0.0251369
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.024927
DCAF10 DDB1 and CUL4 associated factor 10 0.0246749
SNX13 sorting nexin 13 0.0242978
ATP13A3 ATPase type 13A3 0.0242553
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0234684
MACF1 microtubule-actin crosslinking factor 1 0.0234283
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0232735
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0231849
NGLY1 N-glycanase 1 0.0231166
YEATS2 YEATS domain containing 2 0.0231122
CD109 CD109 molecule 0.0230948
DTNA dystrobrevin, alpha 0.0228413
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0228084
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0226511
OSMR oncostatin M receptor 0.0223954
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0222191
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0221851
AHNAK AHNAK nucleoprotein 0.0221415
OGA O-GlcNAcase 0.0220474
AFF4 AF4/FMR2 family, member 4 0.0220182
MARCHF6 membrane associated ring-CH-type finger 6 0.021387
TENT5A terminal nucleotidyltransferase 5A 0.0206081
MON2 MON2 homolog (S. cerevisiae) 0.0205893
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0205264
POM121C POM121 transmembrane nucleoporin C 0.0205125
LOX lysyl oxidase 0.0204821
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0203783
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0202928
NPC1 Niemann-Pick disease, type C1 0.0202482
TPM3 tropomyosin 3 0.02008
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0199608
JARID2 jumonji, AT rich interactive domain 2 0.0196669
RPL3 ribosomal protein L3 0.0195658
FTH1 ferritin, heavy polypeptide 1 0.0194805
RIC1 RAB6A GEF complex partner 1 0.019411
USP37 ubiquitin specific peptidase 37 0.0191888
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.019046
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0189104
NAMPT nicotinamide phosphoribosyltransferase 0.0188933
BRWD3 bromodomain and WD repeat domain containing 3 0.0188454
HILPDA hypoxia inducible lipid droplet-associated 0.0188392
MYO1B myosin IB 0.0184462
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.01822
PTPRM protein tyrosine phosphatase, receptor type, M 0.0179172
ZC3H11A zinc finger CCCH-type containing 11A 0.0177687
C1D C1D nuclear receptor corepressor 0.0174517
POM121 POM121 transmembrane nucleoporin 0.0172936
TMEM39A transmembrane protein 39A 0.0171167
DNMBP dynamin binding protein 0.0170399
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0170183
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0167714
LCORL ligand dependent nuclear receptor corepressor-like 0.0164576
WWTR1 WW domain containing transcription regulator 1 0.0163731
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0162643
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0161649
ZNF841 zinc finger protein 841 0.0161187
SUCO SUN domain containing ossification factor 0.0160701
CADM1 cell adhesion molecule 1 0.0160688
KMT2C lysine (K)-specific methyltransferase 2C 0.0160597
MEF2A myocyte enhancer factor 2A 0.0160096
PYGL phosphorylase, glycogen, liver 0.0159426
CDK19 cyclin-dependent kinase 19 0.0158901
HSPA8 heat shock 70kDa protein 8 0.0158687
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0158475
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0158384
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0157866
DDIT4 DNA-damage-inducible transcript 4 0.0157302
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0156892
CRYBG3 beta-gamma crystallin domain containing 3 0.0156575
FOSL1 FOS-like antigen 1 0.0156191
MARCHF7 membrane associated ring-CH-type finger 7 0.0155837

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.260846
VIM vimentin -0.181935
TMSB10 thymosin beta 10 -0.177419
MT2A metallothionein 2A -0.164828
PTMA prothymosin, alpha -0.143746
FTL ferritin, light polypeptide -0.131442
HLA-B major histocompatibility complex, class I, B -0.0958685
TPT1 tumor protein, translationally-controlled 1 -0.0938731
RPL35A ribosomal protein L35a -0.0838849
NALF1 NALCN channel auxiliary factor 1 -0.0837399
B2M beta-2-microglobulin -0.0771015
PDE4D phosphodiesterase 4D, cAMP-specific -0.0667949
RPS13 ribosomal protein S13 -0.0609264
TPM4 tropomyosin 4 -0.0605258
RPS8 ribosomal protein S8 -0.0600719
RPLP1 ribosomal protein, large, P1 -0.0586008
RPS6 ribosomal protein S6 -0.057755
RPL31 ribosomal protein L31 -0.0532424
VCL vinculin -0.0521803
RPL37A ribosomal protein L37a -0.0488541
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.048848
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.048695
RPLP2 ribosomal protein, large, P2 -0.0463642
RPL28 ribosomal protein L28 -0.0460026
RPL9 ribosomal protein L9 -0.0459951
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0450722
ACTG1 actin gamma 1 -0.0444339
ENO1 enolase 1, (alpha) -0.0439309
RPS23 ribosomal protein S23 -0.0437206
ENO2 enolase 2 (gamma, neuronal) -0.0433241
RPL23 ribosomal protein L23 -0.0432401
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.043081
EIF1 eukaryotic translation initiation factor 1 -0.0422402
RPS24 ribosomal protein S24 -0.041265
ANKRD11 ankyrin repeat domain 11 -0.0412594
WSB1 WD repeat and SOCS box containing 1 -0.0409336
PSD3 pleckstrin and Sec7 domain containing 3 -0.0408711
RPS25 ribosomal protein S25 -0.0405492
RPL7A ribosomal protein L7a -0.0403531
RPL34 ribosomal protein L34 -0.0402576
SEC61G Sec61 gamma subunit -0.0394375
CAVIN1 caveolae associated protein 1 -0.038051
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0376859
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0368469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0365336
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0364826
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0364231
NLGN1 neuroligin 1 -0.036421
RPS27A ribosomal protein S27a -0.0360187
PGK1 phosphoglycerate kinase 1 -0.035417
RPL38 ribosomal protein L38 -0.0351783
IGF2 insulin-like growth factor 2 -0.0350835
RPL27A ribosomal protein L27a -0.0350197
FBXO11 F-box protein 11 -0.0335697
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0335645
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0334049
RPL11 ribosomal protein L11 -0.0331686
TGFBI transforming growth factor, beta-induced, 68kDa -0.0329077
PLAUR plasminogen activator, urokinase receptor -0.0327254
HLA-C major histocompatibility complex, class I, C -0.0317097
RAB1A RAB1A, member RAS oncogene family -0.0313502
EGR1 early growth response 1 -0.0312637
RPS16 ribosomal protein S16 -0.0311969
S100A10 S100 calcium binding protein A10 -0.030865
DGKI diacylglycerol kinase, iota -0.0306109
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0299942
S100A6 S100 calcium binding protein A6 -0.0298404
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0297911
RPS29 ribosomal protein S29 -0.0296752
KPNB1 karyopherin (importin) beta 1 -0.0296716
NAP1L1 nucleosome assembly protein 1-like 1 -0.0296045
RAN RAN, member RAS oncogene family -0.0295665
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.029454
ATXN1 ataxin 1 -0.0291365
RPL36 ribosomal protein L36 -0.0290314
RPS11 ribosomal protein S11 -0.028911
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0288459
RACK1 receptor for activated C kinase 1 -0.028764
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0287229
H3-3B H3.3 histone B -0.028399
EIF5B eukaryotic translation initiation factor 5B -0.0283698
RPS5 ribosomal protein S5 -0.0281596
RPS12 ribosomal protein S12 -0.0280633
EXT1 exostosin glycosyltransferase 1 -0.0280451
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0280287
ZBTB20 zinc finger and BTB domain containing 20 -0.027913
LAMB3 laminin, beta 3 -0.0274782
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0274731
PRSS23 protease, serine, 23 -0.0273738
FAM162A family with sequence similarity 162, member A -0.0273475
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0272264
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0271627
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0271494
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0270218
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0268627
CKAP4 cytoskeleton-associated protein 4 -0.0263663
AHCYL1 adenosylhomocysteinase-like 1 -0.0262953
RPL37 ribosomal protein L37 -0.0262032
HLA-A major histocompatibility complex, class I, A -0.025726
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0256893