Balsalazide (sodium hydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0927859
SMAD3 SMAD family member 3 0.0744557
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0700747
PRELID2 PRELI domain containing 2 0.0656953
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0555441
FLNA filamin A, alpha 0.0501388
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0474518
HELZ helicase with zinc finger 0.0470417
PAX8 paired box 8 0.0421232
FNDC3B fibronectin type III domain containing 3B 0.0371641
PLEC plectin 0.0369382
FLNB filamin B, beta 0.0344787
ANKRD36 ankyrin repeat domain 36 0.0330933
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0313919
MPRIP myosin phosphatase Rho interacting protein 0.0287488
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0282573
ITGB8 integrin, beta 8 0.0276964
TRIO trio Rho guanine nucleotide exchange factor 0.027422
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0267028
PICALM phosphatidylinositol binding clathrin assembly protein 0.0262074
PCBP2 poly(rC) binding protein 2 0.0254467
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0249415
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0244532
WWC1 WW and C2 domain containing 1 0.0242558
NRIP1 nuclear receptor interacting protein 1 0.0238348
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0230215
CTBP2 C-terminal binding protein 2 0.0230052
RUNX1 runt-related transcription factor 1 0.0227033
MYEOV myeloma overexpressed 0.0224322
ATXN1 ataxin 1 0.022387
INTS6 integrator complex subunit 6 0.0220817
SHB Src homology 2 domain containing adaptor protein B 0.0219227
KDM6A lysine (K)-specific demethylase 6A 0.021742
EEF2 eukaryotic translation elongation factor 2 0.0214847
ECT2 epithelial cell transforming 2 0.0214663
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0214656
ESYT2 extended synaptotagmin-like protein 2 0.0214154
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0213094
BHLHE40 basic helix-loop-helix family, member e40 0.021244
USP9X ubiquitin specific peptidase 9, X-linked 0.0205896
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0201366
SPAG9 sperm associated antigen 9 0.0200896
RPL3 ribosomal protein L3 0.0199182
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0196067
AFDN afadin, adherens junction formation factor 0.0194547
NOTCH2 notch 2 0.0191282
APLP2 amyloid beta (A4) precursor-like protein 2 0.0190689
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0189842
ZNF638 zinc finger protein 638 0.0186882
FNIP1 folliculin interacting protein 1 0.0186814
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0186422
ERRFI1 ERBB receptor feedback inhibitor 1 0.018566
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0184801
ZNF292 zinc finger protein 292 0.0183651
YEATS2 YEATS domain containing 2 0.0183208
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0181936
EPHA2 EPH receptor A2 0.0177764
ATXN7 ataxin 7 0.0172001
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0171456
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0170828
NCKAP1 NCK-associated protein 1 0.0169867
PCLO piccolo presynaptic cytomatrix protein 0.0168623
VEGFA vascular endothelial growth factor A 0.0166529
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0165995
KDM4C lysine (K)-specific demethylase 4C 0.0163653
COPA coatomer protein complex, subunit alpha 0.0161766
TBCD tubulin folding cofactor D 0.0160089
SEPTIN9 septin 9 0.0158272
CORO1C coronin, actin binding protein, 1C 0.0157818
SLC35F5 solute carrier family 35, member F5 0.0156379
COG6 component of oligomeric golgi complex 6 0.0154866
MIDEAS mitotic deacetylase associated SANT domain protein 0.0154331
SLTM SAFB-like, transcription modulator 0.0153506
SRRM2 serine/arginine repetitive matrix 2 0.0152816
RCOR1 REST corepressor 1 0.015219
ANKRD33B ankyrin repeat domain 33B 0.0151513
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.014772
SNX9 sorting nexin 9 0.0147012
TUSC3 tumor suppressor candidate 3 0.014694
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0145698
HSPA8 heat shock 70kDa protein 8 0.0145229
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0145117
ADAM9 ADAM metallopeptidase domain 9 0.0145077
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0144766
ADARB1 adenosine deaminase, RNA-specific, B1 0.0144545
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0143188
AXL AXL receptor tyrosine kinase 0.0142981
RAD18 RAD18 E3 ubiquitin protein ligase 0.0142942
NUP58 nucleoporin 58 0.0142612
AFF1 AF4/FMR2 family, member 1 0.0141932
BCL2L1 BCL2-like 1 0.0140428
PRPF8 pre-mRNA processing factor 8 0.0139791
OGA O-GlcNAcase 0.0139623
ZSWIM6 zinc finger, SWIM-type containing 6 0.0138193
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0136571
UBA6 ubiquitin-like modifier activating enzyme 6 0.0135616
CAMTA1 calmodulin binding transcription activator 1 0.0135577
LAMA5 laminin, alpha 5 0.0134868
RNF145 ring finger protein 145 0.0133073
GLS2 glutaminase 2 (liver, mitochondrial) 0.0130792

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.207484
MT2A metallothionein 2A -0.185105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162838
PTMA prothymosin, alpha -0.145611
TPT1 tumor protein, translationally-controlled 1 -0.125983
FTL ferritin, light polypeptide -0.0951659
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0913598
RPL35A ribosomal protein L35a -0.0905581
RPS6 ribosomal protein S6 -0.0879304
ACTG1 actin gamma 1 -0.083566
ENO1 enolase 1, (alpha) -0.0814924
CCND1 cyclin D1 -0.0805592
RPS8 ribosomal protein S8 -0.0776393
RPL12 ribosomal protein L12 -0.074871
B2M beta-2-microglobulin -0.0718999
TPM4 tropomyosin 4 -0.0704341
RPL23 ribosomal protein L23 -0.0656812
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.065661
RPL19 ribosomal protein L19 -0.0637747
RPS19 ribosomal protein S19 -0.0628612
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0620812
S100A6 S100 calcium binding protein A6 -0.0620209
TMSB4X thymosin beta 4, X-linked -0.0591221
HMGA1 high mobility group AT-hook 1 -0.0585018
MKI67 marker of proliferation Ki-67 -0.0575766
RPL34 ribosomal protein L34 -0.0568689
S100A10 S100 calcium binding protein A10 -0.055583
RPLP1 ribosomal protein, large, P1 -0.0533641
RPL26 ribosomal protein L26 -0.0516425
RPL31 ribosomal protein L31 -0.0516105
LAMB3 laminin, beta 3 -0.0507831
RPS24 ribosomal protein S24 -0.0504186
RPL9 ribosomal protein L9 -0.0500997
RPS27A ribosomal protein S27a -0.0497347
ASPH aspartate beta-hydroxylase -0.049037
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0487858
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0477629
CBX3 chromobox homolog 3 -0.0470022
HMGB1 high mobility group box 1 -0.046888
ALCAM activated leukocyte cell adhesion molecule -0.0464732
RPL32 ribosomal protein L32 -0.0462123
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0461828
RPS12 ribosomal protein S12 -0.0460668
EIF1 eukaryotic translation initiation factor 1 -0.0458867
RPL11 ribosomal protein L11 -0.0452014
KRT7 keratin 7, type II -0.0437685
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0432631
TPI1 triosephosphate isomerase 1 -0.0428118
AHNAK AHNAK nucleoprotein -0.0428022
RPL37A ribosomal protein L37a -0.0423392
VDAC1 voltage-dependent anion channel 1 -0.0413149
RPS3 ribosomal protein S3 -0.0408562
RPLP2 ribosomal protein, large, P2 -0.0407788
RACK1 receptor for activated C kinase 1 -0.0407277
CD44 CD44 molecule (Indian blood group) -0.0406651
RPL5 ribosomal protein L5 -0.0398676
SH3KBP1 SH3-domain kinase binding protein 1 -0.0396277
RPLP0 ribosomal protein, large, P0 -0.0393419
LDHA lactate dehydrogenase A -0.0392171
RPS14 ribosomal protein S14 -0.0385041
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0378998
DLC1 DLC1 Rho GTPase activating protein -0.0364007
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0362813
RPL35 ribosomal protein L35 -0.0361208
DEK DEK proto-oncogene -0.0357612
RPL7A ribosomal protein L7a -0.0350958
RPL37 ribosomal protein L37 -0.0348104
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0347421
GNAS GNAS complex locus -0.0347389
RPS29 ribosomal protein S29 -0.0337183
SEPTIN7 septin 7 -0.0336175
DSG2 desmoglein 2 -0.033282
BICD1 bicaudal D homolog 1 (Drosophila) -0.0331676
RPS25 ribosomal protein S25 -0.0321954
PKM pyruvate kinase, muscle -0.0319232
RPS13 ribosomal protein S13 -0.0316776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.031616
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0307873
H1-0 H1.0 linker histone -0.0306079
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0303758
RPS16 ribosomal protein S16 -0.03021
TUBA1B tubulin, alpha 1b -0.0301863
TUBB4B tubulin, beta 4B class IVb -0.030091
KPNB1 karyopherin (importin) beta 1 -0.0298238
RPS17 ribosomal protein S17 -0.0297997
SET SET nuclear proto-oncogene -0.0295826
EIF5B eukaryotic translation initiation factor 5B -0.0295645
RPS11 ribosomal protein S11 -0.0294398
TUBB tubulin, beta class I -0.0294321
LMNA lamin A/C -0.0294004
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0292356
RPL18 ribosomal protein L18 -0.0289102
ANXA2 annexin A2 -0.0288981
RPL15 ribosomal protein L15 -0.0287481
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0286418
SMC4 structural maintenance of chromosomes 4 -0.0286372
MAP4 microtubule-associated protein 4 -0.0286273
S100A4 S100 calcium binding protein A4 -0.0283973
LAMA4 laminin, alpha 4 -0.0282723
MYL12B myosin, light chain 12B, regulatory -0.0274785