Balsalazide (sodium hydrate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.139046
COL5A1 collagen, type V, alpha 1 0.115148
COL6A3 collagen, type VI, alpha 3 0.0748331
HMGA2 high mobility group AT-hook 2 0.0743404
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0696054
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0680558
MYO10 myosin X 0.0630224
ERRFI1 ERBB receptor feedback inhibitor 1 0.0610262
PDE10A phosphodiesterase 10A 0.0573477
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0567384
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0539828
BHLHE40 basic helix-loop-helix family, member e40 0.0529567
IGFBP3 insulin-like growth factor binding protein 3 0.0521371
VEGFA vascular endothelial growth factor A 0.0518981
PLEC plectin 0.048275
GRAMD1B GRAM domain containing 1B 0.0482405
SEPTIN9 septin 9 0.0453929
AHNAK AHNAK nucleoprotein 0.0453652
CLMP CXADR-like membrane protein 0.0449519
JARID2 jumonji, AT rich interactive domain 2 0.0435797
RAI14 retinoic acid induced 14 0.040298
NAV1 neuron navigator 1 0.0383723
MYH9 myosin, heavy chain 9, non-muscle 0.0381265
AKAP12 A kinase (PRKA) anchor protein 12 0.0373572
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0356043
COL6A1 collagen, type VI, alpha 1 0.034651
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0336238
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0336077
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0317189
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0309607
TNS1 tensin 1 0.0302802
STC1 stanniocalcin 1 0.0302149
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0298522
PRELID2 PRELI domain containing 2 0.0295452
EPAS1 endothelial PAS domain protein 1 0.0291167
SMAD3 SMAD family member 3 0.0290462
MAP1B microtubule-associated protein 1B 0.0289484
GLIS3 GLIS family zinc finger 3 0.0288119
AFF3 AF4/FMR2 family, member 3 0.0283453
EGFR epidermal growth factor receptor 0.0283071
EFNA5 ephrin-A5 0.0271498
AXL AXL receptor tyrosine kinase 0.0269655
PCBP3 poly(rC) binding protein 3 0.0268753
LOXL2 lysyl oxidase-like 2 0.0265395
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0262019
COL7A1 collagen, type VII, alpha 1 0.0257634
MPRIP myosin phosphatase Rho interacting protein 0.025597
ZBTB38 zinc finger and BTB domain containing 38 0.0251468
IGF1R insulin-like growth factor 1 receptor 0.0248897
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0245817
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0244633
PPARD peroxisome proliferator-activated receptor delta 0.0241906
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0238749
HSPA8 heat shock 70kDa protein 8 0.0237152
EXT1 exostosin glycosyltransferase 1 0.0232823
DOCK5 dedicator of cytokinesis 5 0.0223795
VEGFC vascular endothelial growth factor C 0.0217279
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0217188
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0215965
DNMBP dynamin binding protein 0.0215457
JAG1 jagged 1 0.0204047
MACF1 microtubule-actin crosslinking factor 1 0.0203922
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.0202951
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0201491
DST dystonin 0.0199508
TRIO trio Rho guanine nucleotide exchange factor 0.019916
SAMD4A sterile alpha motif domain containing 4A 0.0195762
RUNX1 runt-related transcription factor 1 0.0190984
BACE2 beta-site APP-cleaving enzyme 2 0.0187143
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0182701
YEATS2 YEATS domain containing 2 0.0181739
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0181365
CDH13 cadherin 13 0.0179476
MAMLD1 mastermind-like domain containing 1 0.0178031
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0177866
ABLIM3 actin binding LIM protein family, member 3 0.0176749
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0176127
DSPP dentin sialophosphoprotein 0.0175742
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0174154
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0172388
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0168488
GRB10 growth factor receptor-bound protein 10 0.0167432
ANTXR1 anthrax toxin receptor 1 0.0167383
MLPH melanophilin 0.0165606
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0165404
MAML3 mastermind-like 3 (Drosophila) 0.0163695
SFTPA2 surfactant protein A2 0.0160366
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0159824
WWTR1 WW domain containing transcription regulator 1 0.0156813
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0156727
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0156558
TPM3 tropomyosin 3 0.015576
DUSP12 dual specificity phosphatase 12 0.0155131
GPC5 glypican 5 0.0152445
LOX lysyl oxidase 0.014911
RPL3 ribosomal protein L3 0.0148452
NCOR2 nuclear receptor corepressor 2 0.0148146
TGM2 transglutaminase 2 0.0146115
ANXA2 annexin A2 0.0144023
ZNF185 zinc finger protein 185 (LIM domain) 0.0143935

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.374985
VIM vimentin -0.248502
TMSB10 thymosin beta 10 -0.191737
EGR1 early growth response 1 -0.0975116
PTMA prothymosin, alpha -0.0871556
MT2A metallothionein 2A -0.0861623
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0750462
ACTG1 actin gamma 1 -0.0645994
TPT1 tumor protein, translationally-controlled 1 -0.0583691
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0564993
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0560116
IGF2 insulin-like growth factor 2 -0.0548476
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0545605
ASPH aspartate beta-hydroxylase -0.0539055
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0484593
RTN4 reticulon 4 -0.04798
UBC ubiquitin C -0.0451011
ANKRD12 ankyrin repeat domain 12 -0.0401512
COL1A1 collagen, type I, alpha 1 -0.040002
IER3 immediate early response 3 -0.0394094
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.038975
RPS27A ribosomal protein S27a -0.0383017
VCL vinculin -0.0373894
ENO1 enolase 1, (alpha) -0.0351172
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0339287
FTL ferritin, light polypeptide -0.0330192
RPL35A ribosomal protein L35a -0.0325368
MYL12B myosin, light chain 12B, regulatory -0.032529
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0314162
PLAUR plasminogen activator, urokinase receptor -0.0310696
RAB7A RAB7A, member RAS oncogene family -0.0308576
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.030072
CALU calumenin -0.029232
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0292314
RPLP1 ribosomal protein, large, P1 -0.0291903
JUN jun proto-oncogene -0.0289977
S100A10 S100 calcium binding protein A10 -0.0284689
RPL9 ribosomal protein L9 -0.0283888
NDRG1 N-myc downstream regulated 1 -0.0277107
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270957
DUSP6 dual specificity phosphatase 6 -0.0268548
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0267142
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0262591
LMNA lamin A/C -0.0259901
GOLGA4 golgin A4 -0.0254797
RRBP1 ribosome binding protein 1 -0.0250402
RPS24 ribosomal protein S24 -0.0246107
RPLP2 ribosomal protein, large, P2 -0.024405
VMP1 vacuole membrane protein 1 -0.0242882
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0242461
SMC4 structural maintenance of chromosomes 4 -0.0241831
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0238583
RPS19 ribosomal protein S19 -0.023658
RAB1A RAB1A, member RAS oncogene family -0.0234198
H3-3B H3.3 histone B -0.0233327
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0231232
RPL11 ribosomal protein L11 -0.022992
WDR45B WD repeat domain 45B -0.0227738
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0227064
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0226855
MT1X metallothionein 1X -0.0225433
NALF1 NALCN channel auxiliary factor 1 -0.0225415
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0224115
WSB1 WD repeat and SOCS box containing 1 -0.0222533
SPAG9 sperm associated antigen 9 -0.0221365
RPL23 ribosomal protein L23 -0.0217623
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0212306
RAD21 RAD21 homolog (S. pombe) -0.0210637
ZFAND3 zinc finger, AN1-type domain 3 -0.0209912
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0209625
VDAC1 voltage-dependent anion channel 1 -0.0205745
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0205016
RAP1B RAP1B, member of RAS oncogene family -0.0203805
MORF4L2 mortality factor 4 like 2 -0.02028
RPL32 ribosomal protein L32 -0.0201717
EMP1 epithelial membrane protein 1 -0.0201058
GNAS GNAS complex locus -0.0200486
S100A6 S100 calcium binding protein A6 -0.0199294
TOP1 topoisomerase (DNA) I -0.0198648
RPS13 ribosomal protein S13 -0.0197719
PRRC2C proline-rich coiled-coil 2C -0.0197493
CCNI cyclin I -0.0197026
RPL34 ribosomal protein L34 -0.0195284
VASP vasodilator-stimulated phosphoprotein -0.0192487
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0190587
RPL19 ribosomal protein L19 -0.0188664
MCL1 myeloid cell leukemia 1 -0.0186625
TM9SF3 transmembrane 9 superfamily member 3 -0.0186362
ACTN1 actinin, alpha 1 -0.0185953
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0183655
RPL37A ribosomal protein L37a -0.0183225
SFPQ splicing factor proline/glutamine-rich -0.0181507
RPS21 ribosomal protein S21 -0.018124
HMGA1 high mobility group AT-hook 1 -0.0180096
NABP1 nucleic acid binding protein 1 -0.0179839
PFN1 profilin 1 -0.0179219
TPX2 TPX2, microtubule-associated -0.0176496
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0175127
IGFBP4 insulin-like growth factor binding protein 4 -0.0174845
S100A9 S100 calcium binding protein A9 -0.0170786