Balsalazide (sodium hydrate)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.22895
SMAD3 SMAD family member 3 0.123271
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.105488
EXT1 exostosin glycosyltransferase 1 0.0916909
TXNRD1 thioredoxin reductase 1 0.0862817
EZR ezrin 0.0815618
NTN4 netrin 4 0.0768929
BCL2L1 BCL2-like 1 0.0673949
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0667601
PDZD8 PDZ domain containing 8 0.0658758
CTBP2 C-terminal binding protein 2 0.0648318
ARHGAP23 Rho GTPase activating protein 23 0.0570182
PICALM phosphatidylinositol binding clathrin assembly protein 0.0558742
PDLIM5 PDZ and LIM domain 5 0.0552737
STK24 serine/threonine kinase 24 0.0544402
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0537931
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0522012
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.049797
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0484247
MYH9 myosin, heavy chain 9, non-muscle 0.0473172
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.04663
ARHGAP29 Rho GTPase activating protein 29 0.0459672
NCEH1 neutral cholesterol ester hydrolase 1 0.0444226
ATXN1 ataxin 1 0.0429446
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0417789
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0402101
MYO1E myosin IE 0.0401206
FAT1 FAT atypical cadherin 1 0.0397669
DPP4 dipeptidyl-peptidase 4 0.0393243
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0385806
ITPRID2 ITPR interacting domain containing 2 0.0379932
TJP1 tight junction protein 1 0.0379697
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0378488
FHL2 four and a half LIM domains 2 0.0377987
EPS8 epidermal growth factor receptor pathway substrate 8 0.0375037
ADGRG6 adhesion G protein-coupled receptor G6 0.0374313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0371336
WWC1 WW and C2 domain containing 1 0.0369707
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0367535
PDE10A phosphodiesterase 10A 0.036729
LATS2 large tumor suppressor kinase 2 0.0366575
CCNYL1 cyclin Y-like 1 0.036395
GCLC glutamate-cysteine ligase, catalytic subunit 0.0359178
DST dystonin 0.0358452
LCOR ligand dependent nuclear receptor corepressor 0.0354695
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0353384
UTRN utrophin 0.0350711
ANXA11 annexin A11 0.0347349
AFF1 AF4/FMR2 family, member 1 0.0346458
VCL vinculin 0.0339897
PPL periplakin 0.0339069
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0338089
MBNL1 muscleblind-like splicing regulator 1 0.0332208
CTNND1 catenin (cadherin-associated protein), delta 1 0.0330027
MYOF myoferlin 0.0326182
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0325497
MBNL2 muscleblind-like splicing regulator 2 0.0321252
OSBPL10 oxysterol binding protein-like 10 0.0319934
VEGFA vascular endothelial growth factor A 0.0314383
FOXO1 forkhead box O1 0.0310553
EEF2 eukaryotic translation elongation factor 2 0.0308839
CLIC5 chloride intracellular channel 5 0.0308563
PELI1 pellino E3 ubiquitin protein ligase 1 0.0307193
MYEOV myeloma overexpressed 0.0299335
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0297987
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0297501
PGCKA1 PDCD10 and GCKIII kinases associated 1 0.0294553
ESYT2 extended synaptotagmin-like protein 2 0.0288956
SEPTIN9 septin 9 0.0287249
KRT18 keratin 18, type I 0.0285619
KDM6A lysine (K)-specific demethylase 6A 0.0281921
DIAPH1 diaphanous-related formin 1 0.0278599
PCBP2 poly(rC) binding protein 2 0.0278525
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0275357
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274863
SRRM2 serine/arginine repetitive matrix 2 0.0271485
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0266855
SPRED2 sprouty-related, EVH1 domain containing 2 0.0263892
SLTM SAFB-like, transcription modulator 0.026283
AKAP13 A kinase (PRKA) anchor protein 13 0.0262056
PRR5L proline rich 5 like 0.0260944
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0260218
PUM2 pumilio RNA-binding family member 2 0.025833
YAP1 Yes-associated protein 1 0.0257825
RHEB Ras homolog enriched in brain 0.0256952
EPS8L1 EPS8-like 1 0.025639
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0245411
RPL3 ribosomal protein L3 0.0243443
DSCAM Down syndrome cell adhesion molecule 0.0240537
TES testin LIM domain protein 0.0240391
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0237789
ARHGAP42 Rho GTPase activating protein 42 0.0236706
TPM3 tropomyosin 3 0.0231273
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0230203
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0228562
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0227888
NFE2L2 nuclear factor, erythroid 2-like 2 0.0226744
CHD7 chromodomain helicase DNA binding protein 7 0.022324
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0222459
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0221712

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.160337
NDRG1 N-myc downstream regulated 1 -0.129068
MYH14 myosin, heavy chain 14, non-muscle -0.109738
KRT20 keratin 20, type I -0.0983053
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0982912
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0963779
GMDS GDP-mannose 4,6-dehydratase -0.0875313
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0875279
LAMA4 laminin, alpha 4 -0.084022
SLC45A4 solute carrier family 45, member 4 -0.0826038
DIAPH2 diaphanous-related formin 2 -0.0807331
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0793386
FRY furry homolog (Drosophila) -0.0769521
INTS6 integrator complex subunit 6 -0.0695457
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0685431
EGR1 early growth response 1 -0.0657142
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0656049
TMSB10 thymosin beta 10 -0.0655046
AHNAK AHNAK nucleoprotein -0.0625983
PTMA prothymosin, alpha -0.0589841
PRELID2 PRELI domain containing 2 -0.058111
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0563672
SAMD12 sterile alpha motif domain containing 12 -0.056193
PGK1 phosphoglycerate kinase 1 -0.0560839
MCL1 myeloid cell leukemia 1 -0.0560349
KRT19 keratin 19, type I -0.0554913
SQSTM1 sequestosome 1 -0.0550132
LOC102724023 ES1 protein homolog, mitochondrial -0.0549265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.054342
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0535409
AGR2 anterior gradient 2 -0.0521363
CCSER1 coiled-coil serine-rich protein 1 -0.0518033
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0516201
ANXA2 annexin A2 -0.0494054
JUN jun proto-oncogene -0.0491612
ZBTB20 zinc finger and BTB domain containing 20 -0.0489899
RPS24 ribosomal protein S24 -0.0484006
RPS6 ribosomal protein S6 -0.0447526
MMP7 matrix metallopeptidase 7 -0.0445987
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0431464
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0426948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0426546
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0418358
SDCBP syndecan binding protein (syntenin) -0.0411139
LDHA lactate dehydrogenase A -0.0408682
ASPH aspartate beta-hydroxylase -0.0398291
ACACA acetyl-CoA carboxylase alpha -0.0391531
PCED1B PC-esterase domain containing 1B -0.0364898
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0362559
ACTG1 actin gamma 1 -0.0346056
EXOC4 exocyst complex component 4 -0.0343829
MAML2 mastermind-like 2 (Drosophila) -0.0341026
RPS3 ribosomal protein S3 -0.0339966
RPS12 ribosomal protein S12 -0.0334033
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0330854
KRT8 keratin 8, type II -0.0326584
LOC112694756 uncharaterized LOC112694756 -0.0324543
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0321822
AEBP2 AE binding protein 2 -0.0321773
RPL23 ribosomal protein L23 -0.0319103
RPLP0 ribosomal protein, large, P0 -0.031834
S100A10 S100 calcium binding protein A10 -0.0318137
S100A6 S100 calcium binding protein A6 -0.0313636
PRKCA protein kinase C, alpha -0.0308537
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0307584
DGKH diacylglycerol kinase, eta -0.0306132
TFRC transferrin receptor -0.0305173
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0304184
GOLGB1 golgin B1 -0.0302128
RPS8 ribosomal protein S8 -0.0299732
POF1B premature ovarian failure, 1B -0.0296251
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0294049
GSN gelsolin -0.029137
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0291221
ADARB1 adenosine deaminase, RNA-specific, B1 -0.029016
MBD5 methyl-CpG binding domain protein 5 -0.0288643
RRBP1 ribosome binding protein 1 -0.0285947
FTL ferritin, light polypeptide -0.0284614
LARP1B La ribonucleoprotein domain family, member 1B -0.0283102
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0280132
KLF10 Kruppel-like factor 10 -0.0276369
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.027527
ZMYND8 zinc finger, MYND-type containing 8 -0.0272967
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0271701
SNX14 sorting nexin 14 -0.0268931
B2M beta-2-microglobulin -0.0267131
CCDC91 coiled-coil domain containing 91 -0.0267033
DDIT3 DNA-damage-inducible transcript 3 -0.0266515
SPDYA speedy/RINGO cell cycle regulator family member A -0.0262297
RPL13A ribosomal protein L13a -0.0260197
NPC1 Niemann-Pick disease, type C1 -0.0258708
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0258219
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0257405
WASF2 WAS protein family, member 2 -0.0255924
TRPS1 trichorhinophalangeal syndrome I -0.0253874
CAPN8 calpain 8 -0.0252234
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0250618
RPL34 ribosomal protein L34 -0.025035
SLC38A2 solute carrier family 38, member 2 -0.0250146
FNDC3B fibronectin type III domain containing 3B -0.0249865