Balsalazide (sodium hydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.127301
ERRFI1 ERBB receptor feedback inhibitor 1 0.102909
BHLHE40 basic helix-loop-helix family, member e40 0.0863745
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0853795
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0827868
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0774757
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0680034
TNS1 tensin 1 0.0560549
SAMD4A sterile alpha motif domain containing 4A 0.0499744
VEGFA vascular endothelial growth factor A 0.0494058
AFDN afadin, adherens junction formation factor 0.0462204
DSPP dentin sialophosphoprotein 0.0450353
KDM3A lysine (K)-specific demethylase 3A 0.0444964
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0439711
ELL2 elongation factor, RNA polymerase II, 2 0.0423855
DTNA dystrobrevin, alpha 0.0421169
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.04174
FAM13A family with sequence similarity 13, member A 0.038088
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.037728
INSIG2 insulin induced gene 2 0.0377216
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.037666
TRIO trio Rho guanine nucleotide exchange factor 0.0370346
FNDC3B fibronectin type III domain containing 3B 0.0367595
ESYT2 extended synaptotagmin-like protein 2 0.0362371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0346527
MACF1 microtubule-actin crosslinking factor 1 0.0336313
ASPH aspartate beta-hydroxylase 0.033198
ARFGEF3 ARFGEF family member 3 0.032471
NDRG1 N-myc downstream regulated 1 0.0318568
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0316378
KIAA1217 KIAA1217 0.0314113
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0313319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0311042
EEF2 eukaryotic translation elongation factor 2 0.030219
RPL3 ribosomal protein L3 0.0299524
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0298517
NGLY1 N-glycanase 1 0.0297012
ANO6 anoctamin 6 0.0285123
FBXO42 F-box protein 42 0.0272908
MYH9 myosin, heavy chain 9, non-muscle 0.0272764
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0271195
HOOK2 hook microtubule-tethering protein 2 0.0266601
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0264319
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0259688
ZNF292 zinc finger protein 292 0.0246706
TBC1D22A TBC1 domain family, member 22A 0.0245004
ARHGAP21 Rho GTPase activating protein 21 0.0244706
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0239485
SPAG9 sperm associated antigen 9 0.0238906
DDIT4 DNA-damage-inducible transcript 4 0.0238636
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0236211
NCKAP1 NCK-associated protein 1 0.0232077
ARRDC3 arrestin domain containing 3 0.023016
CCNY cyclin Y 0.0227537
FMNL2 formin-like 2 0.0227388
SMAD3 SMAD family member 3 0.0227022
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0226571
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0225046
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0224189
EIF4B eukaryotic translation initiation factor 4B 0.0223155
KDM7A lysine (K)-specific demethylase 7A 0.0223125
ATXN1 ataxin 1 0.0221263
GRB10 growth factor receptor-bound protein 10 0.0220077
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0219794
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0219394
MTSS1 metastasis suppressor 1 0.0216152
YEATS2 YEATS domain containing 2 0.0204247
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0203189
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0199423
KCMF1 potassium channel modulatory factor 1 0.0199192
SVIL supervillin 0.0193822
FRMD5 FERM domain containing 5 0.0191108
RICTOR RPTOR independent companion of MTOR, complex 2 0.0189565
USP47 ubiquitin specific peptidase 47 0.018932
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0187757
TPD52 tumor protein D52 0.0187165
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0185005
PIAS2 protein inhibitor of activated STAT, 2 0.0183722
CCDC93 coiled-coil domain containing 93 0.0180243
PDE8A phosphodiesterase 8A 0.0179555
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0178507
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0178325
STRN3 striatin, calmodulin binding protein 3 0.0178205
HELZ helicase with zinc finger 0.0177662
MYO1B myosin IB 0.017614
MXI1 MAX interactor 1, dimerization protein 0.0175646
IGF2 insulin-like growth factor 2 0.0174561
PCGF5 polycomb group ring finger 5 0.017426
KIF1B kinesin family member 1B 0.0173332
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0170946
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0168767
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0167706
NBAS neuroblastoma amplified sequence 0.0167044
MAP2K1 mitogen-activated protein kinase kinase 1 0.0165125
FAM117B family with sequence similarity 117, member B 0.0163246
HSPA8 heat shock 70kDa protein 8 0.0162913
FAM219A family with sequence similarity 219, member A 0.0162647
SLC35F5 solute carrier family 35, member F5 0.0162109
RAD51B RAD51 paralog B 0.0162036
SPOPL speckle-type POZ protein-like 0.0160002

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.250562
APOB apolipoprotein B -0.156039
MT2A metallothionein 2A -0.146221
TPT1 tumor protein, translationally-controlled 1 -0.114723
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.111678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109673
APOA2 apolipoprotein A-II -0.0947448
SLC38A2 solute carrier family 38, member 2 -0.0903348
GPC3 glypican 3 -0.0871511
FTL ferritin, light polypeptide -0.0846227
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0790654
TMSB10 thymosin beta 10 -0.0769074
RPS24 ribosomal protein S24 -0.0752489
VCL vinculin -0.069414
RPS8 ribosomal protein S8 -0.0664724
RPL37A ribosomal protein L37a -0.0657345
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0639194
RPS6 ribosomal protein S6 -0.059734
RPL11 ribosomal protein L11 -0.0587452
ITGAV integrin, alpha V -0.0578466
RPS19 ribosomal protein S19 -0.057553
NKD1 naked cuticle homolog 1 (Drosophila) -0.0573642
RPL31 ribosomal protein L31 -0.0546218
RPLP1 ribosomal protein, large, P1 -0.0543269
TM4SF1 transmembrane 4 L six family member 1 -0.0538639
TRIM26 tripartite motif containing 26 -0.0519497
RPL35A ribosomal protein L35a -0.0500049
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0471417
RPL9 ribosomal protein L9 -0.0466747
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0459142
PTCHD4 patched domain containing 4 -0.045756
EGR1 early growth response 1 -0.0449282
RPS12 ribosomal protein S12 -0.0441133
RPL34 ribosomal protein L34 -0.0440099
A2M alpha-2-macroglobulin -0.0439922
RPLP0 ribosomal protein, large, P0 -0.0430226
AMBP alpha-1-microglobulin/bikunin precursor -0.0425851
RPLP2 ribosomal protein, large, P2 -0.0418462
RPL23 ribosomal protein L23 -0.0409165
IGFBP1 insulin-like growth factor binding protein 1 -0.0409034
FBF1 Fas (TNFRSF6) binding factor 1 -0.0397631
RPS21 ribosomal protein S21 -0.0386624
APOE apolipoprotein E -0.0376291
RPL12 ribosomal protein L12 -0.0374917
GNAS GNAS complex locus -0.0374205
C3 complement component 3 -0.0372306
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0365827
IFI6 interferon, alpha-inducible protein 6 -0.0359404
DLC1 DLC1 Rho GTPase activating protein -0.0356801
GPC6 glypican 6 -0.0355171
RPS23 ribosomal protein S23 -0.0340327
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0331888
RPS13 ribosomal protein S13 -0.0331113
RPS29 ribosomal protein S29 -0.0321562
PTMA prothymosin, alpha -0.031789
RPS27A ribosomal protein S27a -0.0317778
RPL26 ribosomal protein L26 -0.0317311
RPS3 ribosomal protein S3 -0.0312502
CP ceruloplasmin (ferroxidase) -0.0307776
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0307169
RACK1 receptor for activated C kinase 1 -0.0306156
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0301733
RPS14 ribosomal protein S14 -0.0298784
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0295152
NPAS2 neuronal PAS domain protein 2 -0.0294899
RPL19 ribosomal protein L19 -0.0293545
HMGA1 high mobility group AT-hook 1 -0.029256
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0291534
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.029078
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0285445
PTPRK protein tyrosine phosphatase, receptor type, K -0.0284656
RPS5 ribosomal protein S5 -0.0283926
RPL32 ribosomal protein L32 -0.0280561
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0276802
B2M beta-2-microglobulin -0.0273848
APOA1 apolipoprotein A-I -0.0270531
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0270056
PDLIM5 PDZ and LIM domain 5 -0.0269089
ZBTB20 zinc finger and BTB domain containing 20 -0.0268501
RPL5 ribosomal protein L5 -0.0266593
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0263586
ZNF644 zinc finger protein 644 -0.0257666
MYO1E myosin IE -0.0257662
RPL36 ribosomal protein L36 -0.0257433
RPL30 ribosomal protein L30 -0.0251769
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0249569
INTS6 integrator complex subunit 6 -0.024751
KLF6 Kruppel-like factor 6 -0.0247481
KIF21A kinesin family member 21A -0.0244756
RRBP1 ribosome binding protein 1 -0.0244278
LYZ lysozyme -0.0244077
RPS17 ribosomal protein S17 -0.0242639
IER3 immediate early response 3 -0.0242558
PERP PERP, TP53 apoptosis effector -0.0240914
STK17A serine/threonine kinase 17a -0.0238109
DNAH17 dynein, axonemal, heavy chain 17 -0.0236035
NAP1L1 nucleosome assembly protein 1-like 1 -0.0235041
RPS25 ribosomal protein S25 -0.0234473
AHSG alpha-2-HS-glycoprotein -0.0233649
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0232391