Balsalazide (sodium hydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.071232
ELL2 elongation factor, RNA polymerase II, 2 0.062783
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0549249
DTNA dystrobrevin, alpha 0.0525829
EXT1 exostosin glycosyltransferase 1 0.0514742
MYH9 myosin, heavy chain 9, non-muscle 0.0484242
EEF2 eukaryotic translation elongation factor 2 0.0430976
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0430065
ERRFI1 ERBB receptor feedback inhibitor 1 0.0401274
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0389676
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0372168
CORO1C coronin, actin binding protein, 1C 0.0364135
BCAR3 breast cancer anti-estrogen resistance 3 0.0357841
HSPA8 heat shock 70kDa protein 8 0.032582
KDM3A lysine (K)-specific demethylase 3A 0.0324781
NUP58 nucleoporin 58 0.0321003
PICALM phosphatidylinositol binding clathrin assembly protein 0.0318197
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.031656
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0316055
SPAG9 sperm associated antigen 9 0.0315521
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0313115
BDNF brain-derived neurotrophic factor 0.0309419
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0303679
SAMD4A sterile alpha motif domain containing 4A 0.0300758
MALT1 MALT1 paracaspase 0.029775
UBA6 ubiquitin-like modifier activating enzyme 6 0.0282525
PRKCE protein kinase C, epsilon 0.0275079
MYO10 myosin X 0.0270925
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0268059
MCTP1 multiple C2 domains, transmembrane 1 0.0265734
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0254676
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0251181
TAC4 tachykinin 4 (hemokinin) 0.0245864
CALD1 caldesmon 1 0.0243646
RUNX1 runt-related transcription factor 1 0.0243589
SMAD3 SMAD family member 3 0.0240829
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0237809
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.023173
HOOK2 hook microtubule-tethering protein 2 0.0231263
PCBP2 poly(rC) binding protein 2 0.0226082
ADAM19 ADAM metallopeptidase domain 19 0.022525
ATP13A3 ATPase type 13A3 0.0213061
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0212907
DNMBP dynamin binding protein 0.0212472
ADAM9 ADAM metallopeptidase domain 9 0.0209154
MARCHF6 membrane associated ring-CH-type finger 6 0.0208292
BHLHE40 basic helix-loop-helix family, member e40 0.0203272
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0201029
TRIO trio Rho guanine nucleotide exchange factor 0.0200652
RIGI RNA sensor RIG-I 0.0199922
TLN1 talin 1 0.0198782
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0198235
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0195478
SPRED1 sprouty-related, EVH1 domain containing 1 0.0194438
FMNL2 formin-like 2 0.0192592
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0190925
POM121 POM121 transmembrane nucleoporin 0.0183362
RASA2 RAS p21 protein activator 2 0.0182792
GRAMD1B GRAM domain containing 1B 0.0178473
DLC1 DLC1 Rho GTPase activating protein 0.017844
RPL3 ribosomal protein L3 0.017805
ZFAND3 zinc finger, AN1-type domain 3 0.0177059
EIF4B eukaryotic translation initiation factor 4B 0.0175573
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0175158
NAMPT nicotinamide phosphoribosyltransferase 0.0173865
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0172209
YAP1 Yes-associated protein 1 0.0172165
USP32 ubiquitin specific peptidase 32 0.0170115
CTBP2 C-terminal binding protein 2 0.016825
RPL38 ribosomal protein L38 0.016796
CCN2 cellular communication network factor 2 0.0167327
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0167316
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0166745
UGCG UDP-glucose ceramide glucosyltransferase 0.0166605
RPL4 ribosomal protein L4 0.0165843
ARHGAP21 Rho GTPase activating protein 21 0.0164013
KMT2C lysine (K)-specific methyltransferase 2C 0.0163408
ECPAS Ecm29 proteasome adaptor and scaffold 0.0162875
RNF145 ring finger protein 145 0.0162341
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0161218
FLNA filamin A, alpha 0.0159142
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0159062
PLEC plectin 0.0158878
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0158733
WDR45B WD repeat domain 45B 0.0156543
ATP11B ATPase, class VI, type 11B 0.0154233
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.015223
AGTPBP1 ATP/GTP binding protein 1 0.0151844
ANKRD11 ankyrin repeat domain 11 0.0149897
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0149634
DIAPH1 diaphanous-related formin 1 0.014791
RAB8B RAB8B, member RAS oncogene family 0.0146125
MCL1 myeloid cell leukemia 1 0.0145613
CFAP251 cilia and flagella associated protein 251 0.0144386
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0143516
RLF rearranged L-myc fusion 0.0143073
MSN moesin 0.0140184
CYRIB CYFIP related Rac1 interactor B 0.0139912
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0138366
RPL35A ribosomal protein L35a 0.0137562

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.230249
PRKG1 protein kinase, cGMP-dependent, type I -0.11812
TMSB10 thymosin beta 10 -0.112837
MMP12 matrix metallopeptidase 12 -0.10961
AKAP12 A kinase (PRKA) anchor protein 12 -0.101304
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0960738
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0814788
LSAMP limbic system-associated membrane protein -0.0699034
PTCHD4 patched domain containing 4 -0.0675026
SAMD3 sterile alpha motif domain containing 3 -0.063314
GPC6 glypican 6 -0.0557423
MT2A metallothionein 2A -0.0549676
PHACTR1 phosphatase and actin regulator 1 -0.0540406
NAP1L1 nucleosome assembly protein 1-like 1 -0.0516414
YBX3 Y box binding protein 3 -0.0506915
PTPRG protein tyrosine phosphatase, receptor type, G -0.0500658
EFNA5 ephrin-A5 -0.0499118
EGR1 early growth response 1 -0.0492791
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0492164
FTL ferritin, light polypeptide -0.0490393
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0471661
CDH13 cadherin 13 -0.0471496
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.043861
RPL23 ribosomal protein L23 -0.0424551
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0403199
HMGA2 high mobility group AT-hook 2 -0.0396784
RPLP0 ribosomal protein, large, P0 -0.0383596
ALCAM activated leukocyte cell adhesion molecule -0.037127
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0349295
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0333571
HDAC9 histone deacetylase 9 -0.0327837
ZNF804A zinc finger protein 804A -0.0324851
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0304898
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0303688
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0297883
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291752
NTM neurotrimin -0.0289099
PTPRK protein tyrosine phosphatase, receptor type, K -0.0288312
PHF3 PHD finger protein 3 -0.0279071
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0275736
TPI1 triosephosphate isomerase 1 -0.0273872
RPS4X ribosomal protein S4, X-linked -0.0264174
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0263879
TPT1 tumor protein, translationally-controlled 1 -0.0262257
NABP1 nucleic acid binding protein 1 -0.0261138
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0259886
KIAA1217 KIAA1217 -0.0257575
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0250682
ZFP36L1 ZFP36 ring finger protein-like 1 -0.024903
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0247244
FOXP1 forkhead box P1 -0.0246653
RPS12 ribosomal protein S12 -0.0242287
RPL12 ribosomal protein L12 -0.0238478
DPYD dihydropyrimidine dehydrogenase -0.0233996
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0233833
MBD5 methyl-CpG binding domain protein 5 -0.0232956
PTMA prothymosin, alpha -0.0230627
RPL18 ribosomal protein L18 -0.022632
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0224615
GNAS GNAS complex locus -0.0223357
TRPS1 trichorhinophalangeal syndrome I -0.0221691
RPL32 ribosomal protein L32 -0.0221323
CUX1 cut-like homeobox 1 -0.0213644
HMGA1 high mobility group AT-hook 1 -0.0212052
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0210588
VCAN versican -0.0210273
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0209352
CD109 CD109 molecule -0.0208521
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.020669
BLZF1 basic leucine zipper nuclear factor 1 -0.0202882
SBF2 SET binding factor 2 -0.0202574
BNC2 basonuclin 2 -0.0202482
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0201025
SERBP1 SERPINE1 mRNA binding protein 1 -0.0199582
PCNX4 pecanex 4 -0.01988
DGKI diacylglycerol kinase, iota -0.0197682
SLC38A2 solute carrier family 38, member 2 -0.0195901
SDCCAG8 serologically defined colon cancer antigen 8 -0.0194174
BPTF bromodomain PHD finger transcription factor -0.019356
MAP4 microtubule-associated protein 4 -0.0188539
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0186562
RAD21 RAD21 homolog (S. pombe) -0.0184929
BZW1 basic leucine zipper and W2 domains 1 -0.0184645
CTSB cathepsin B -0.0184153
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0182772
CENPF centromere protein F, 350/400kDa -0.0182674
TNNC1 troponin C type 1 (slow) -0.0182483
FER fer (fps/fes related) tyrosine kinase -0.0179826
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0178692
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0178593
RPS19 ribosomal protein S19 -0.0178425
PDE4D phosphodiesterase 4D, cAMP-specific -0.0178004
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0177361
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0176817
SCFD1 sec1 family domain containing 1 -0.0176084
ASTN2 astrotactin 2 -0.0175946
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.017522
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.017171
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0171021
NAV1 neuron navigator 1 -0.0170328