Balsalazide (sodium hydrate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.170496
FAT1 FAT atypical cadherin 1 0.141508
MUC6 mucin 6, oligomeric mucus/gel-forming 0.126327
VEGFA vascular endothelial growth factor A 0.116163
LMO7 LIM domain 7 0.0998422
TXNIP thioredoxin interacting protein 0.0977955
EZR ezrin 0.0798119
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0731502
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0605949
NDRG1 N-myc downstream regulated 1 0.0591813
EEF2 eukaryotic translation elongation factor 2 0.0590183
ITGA6 integrin, alpha 6 0.0565712
MUC13 mucin 13, cell surface associated 0.0541195
HSPA8 heat shock 70kDa protein 8 0.053179
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0528783
TSC22D2 TSC22 domain family, member 2 0.050284
PCBP2 poly(rC) binding protein 2 0.0500846
FTH1 ferritin, heavy polypeptide 1 0.0479022
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0475821
KMT2E lysine (K)-specific methyltransferase 2E 0.0454605
POTEF POTE ankyrin domain family, member F 0.0453241
RNF145 ring finger protein 145 0.0423682
SRRM2 serine/arginine repetitive matrix 2 0.0415716
MYO5B myosin VB 0.0415457
AFF1 AF4/FMR2 family, member 1 0.0409773
FAM13A family with sequence similarity 13, member A 0.0404021
DSPP dentin sialophosphoprotein 0.0403268
RPL3 ribosomal protein L3 0.0402082
ENO1 enolase 1, (alpha) 0.0401717
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0399064
GRB10 growth factor receptor-bound protein 10 0.039838
ESYT2 extended synaptotagmin-like protein 2 0.0397511
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0393214
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0389319
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.038091
MED13 mediator complex subunit 13 0.0380112
ERRFI1 ERBB receptor feedback inhibitor 1 0.0369215
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0367861
UGCG UDP-glucose ceramide glucosyltransferase 0.0361047
CCNY cyclin Y 0.0360783
EPS8 epidermal growth factor receptor pathway substrate 8 0.0355566
ANXA1 annexin A1 0.0351309
CALR calreticulin 0.0350127
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0349723
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0348728
CEMIP cell migration inducing protein, hyaluronan binding 0.0343851
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0343779
SVIL supervillin 0.0335523
TPM3 tropomyosin 3 0.0323425
WAC WW domain containing adaptor with coiled-coil 0.0322071
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308634
PSD3 pleckstrin and Sec7 domain containing 3 0.0307257
TRIO trio Rho guanine nucleotide exchange factor 0.0301424
RREB1 ras responsive element binding protein 1 0.03002
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0298304
COPA coatomer protein complex, subunit alpha 0.029542
RNF217 ring finger protein 217 0.0294312
CEMIP2 cell migration inducing hyaluronidase 2 0.0290428
FNBP1L formin binding protein 1-like 0.0289996
ARHGAP12 Rho GTPase activating protein 12 0.0288498
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0288304
SIK3 SIK family kinase 3 0.0284669
APLP2 amyloid beta (A4) precursor-like protein 2 0.0284201
EGFR epidermal growth factor receptor 0.0281525
MYH9 myosin, heavy chain 9, non-muscle 0.0279512
BRD2 bromodomain containing 2 0.0278268
HILPDA hypoxia inducible lipid droplet-associated 0.0273925
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0271175
SLTM SAFB-like, transcription modulator 0.0270931
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0269782
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0269475
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0268976
CENPF centromere protein F, 350/400kDa 0.0265684
PDIA6 protein disulfide isomerase family A, member 6 0.0264088
FOS FBJ murine osteosarcoma viral oncogene homolog 0.026294
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261185
AKAP13 A kinase (PRKA) anchor protein 13 0.0258189
EPHB2 EPH receptor B2 0.0252338
CLOCK clock circadian regulator 0.0251902
YBX1 Y box binding protein 1 0.025068
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.024964
FBXO11 F-box protein 11 0.0249237
RHOA ras homolog family member A 0.0247022
PARD3 par-3 family cell polarity regulator 0.0245726
PDIA3 protein disulfide isomerase family A, member 3 0.0244909
MYO1E myosin IE 0.0243769
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0243588
TFG TRK-fused gene 0.0243515
PELI1 pellino E3 ubiquitin protein ligase 1 0.0243222
KRT8 keratin 8, type II 0.0243052
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0242004
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0241612
KDM6A lysine (K)-specific demethylase 6A 0.0241603
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0238645
DIAPH3 diaphanous-related formin 3 0.0237292
BHLHE40 basic helix-loop-helix family, member e40 0.0236907
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0235106
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02331
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0233085
NUP58 nucleoporin 58 0.0233069

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.155957
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.116779
PTMA prothymosin, alpha -0.103901
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0902978
NPSR1 neuropeptide S receptor 1 -0.0876586
TMSB10 thymosin beta 10 -0.0814549
NALF1 NALCN channel auxiliary factor 1 -0.0708986
RPS24 ribosomal protein S24 -0.066501
GCC2 GRIP and coiled-coil domain containing 2 -0.0607581
VCL vinculin -0.0601991
RPS6 ribosomal protein S6 -0.0578062
ARHGAP5 Rho GTPase activating protein 5 -0.0566789
GPHN gephyrin -0.0537201
GOLGA4 golgin A4 -0.0535892
RPL26 ribosomal protein L26 -0.0531252
RPL34 ribosomal protein L34 -0.0519036
NFIA nuclear factor I/A -0.0511192
RNF43 ring finger protein 43 -0.0505103
BTBD9 BTB (POZ) domain containing 9 -0.0491919
RPL9 ribosomal protein L9 -0.0476199
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.04732
S100A6 S100 calcium binding protein A6 -0.0469688
MON2 MON2 homolog (S. cerevisiae) -0.0451832
RPL12 ribosomal protein L12 -0.0448604
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0431854
IER3 immediate early response 3 -0.0422229
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0414731
EPCAM epithelial cell adhesion molecule -0.0411942
TNS4 tensin 4 -0.0407862
MBD5 methyl-CpG binding domain protein 5 -0.040695
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0391987
PATJ PATJ crumbs cell polarity complex component -0.0390076
CADPS Ca++-dependent secretion activator -0.0387858
FRMD5 FERM domain containing 5 -0.0387576
DLG1 discs, large homolog 1 (Drosophila) -0.0385085
KLF6 Kruppel-like factor 6 -0.0376866
RPLP2 ribosomal protein, large, P2 -0.0370238
AREG amphiregulin -0.0368145
TAS2R14 taste receptor, type 2, member 14 -0.0363048
RPLP1 ribosomal protein, large, P1 -0.0362781
RPS27A ribosomal protein S27a -0.036262
ALCAM activated leukocyte cell adhesion molecule -0.0355729
AKAP9 A kinase (PRKA) anchor protein 9 -0.0354698
CANX calnexin -0.035416
PNISR PNN-interacting serine/arginine-rich protein -0.0353876
ANTXR2 anthrax toxin receptor 2 -0.0353524
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0350991
RPL35A ribosomal protein L35a -0.0350724
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0343623
ETNK1 ethanolamine kinase 1 -0.0340251
RAB10 RAB10, member RAS oncogene family -0.0339485
RPLP0 ribosomal protein, large, P0 -0.0338763
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0332554
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0332517
RBM25 RNA binding motif protein 25 -0.0331643
RRBP1 ribosome binding protein 1 -0.032968
NCOR1 nuclear receptor corepressor 1 -0.0323867
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0323749
KIF5B kinesin family member 5B -0.0322575
CHD9 chromodomain helicase DNA binding protein 9 -0.032023
PERP PERP, TP53 apoptosis effector -0.0318101
IGFL2 IGF-like family member 2 -0.0317411
PRSS3 protease, serine, 3 -0.0316553
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0316371
RPS12 ribosomal protein S12 -0.0314065
SMYD3 SET and MYND domain containing 3 -0.0313605
METTL15 methyltransferase like 15 -0.0311633
USP34 ubiquitin specific peptidase 34 -0.0309435
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0307558
RPS8 ribosomal protein S8 -0.0306553
RPL11 ribosomal protein L11 -0.0305513
RPL31 ribosomal protein L31 -0.0301682
ANKRD10 ankyrin repeat domain 10 -0.030114
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0299163
EIF1 eukaryotic translation initiation factor 1 -0.0297836
ACTN4 actinin, alpha 4 -0.0294798
RAD21 RAD21 homolog (S. pombe) -0.029016
CCSER1 coiled-coil serine-rich protein 1 -0.0288912
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0288426
RESF1 retroelement silencing factor 1 -0.0286969
TBC1D5 TBC1 domain family, member 5 -0.0286814
RPL13A ribosomal protein L13a -0.028549
FERMT1 fermitin family member 1 -0.0284802
CCND1 cyclin D1 -0.0284462
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0283776
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0283212
ARHGAP32 Rho GTPase activating protein 32 -0.0282493
SOS1 son of sevenless homolog 1 (Drosophila) -0.0280559
HDLBP high density lipoprotein binding protein -0.0279385
PCNP PEST proteolytic signal containing nuclear protein -0.0276981
PCDHB16 protocadherin beta 16 -0.0276355
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0274018
TMEM45B transmembrane protein 45B -0.0273689
TXNRD1 thioredoxin reductase 1 -0.0271573
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0270857
BTG1 B-cell translocation gene 1, anti-proliferative -0.0270229
BIRC6 baculoviral IAP repeat containing 6 -0.0267337
VDAC1 voltage-dependent anion channel 1 -0.026733
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0266131
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.026447