Balsalazide (sodium hydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZSWIM6 zinc finger, SWIM-type containing 6 0.0675796
INTS6 integrator complex subunit 6 0.0665603
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0522343
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0488072
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.045934
CATSPERB catsper channel auxiliary subunit beta 0.0421211
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0406773
FAT1 FAT atypical cadherin 1 0.0387978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0374966
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0364011
CTBP2 C-terminal binding protein 2 0.0363463
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0356836
PTPRK protein tyrosine phosphatase, receptor type, K 0.0352223
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0346086
SP100 SP100 nuclear antigen 0.031398
PTPRG protein tyrosine phosphatase, receptor type, G 0.0313714
ARHGAP26 Rho GTPase activating protein 26 0.0311564
MYO1E myosin IE 0.031087
EXT1 exostosin glycosyltransferase 1 0.0309285
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0308488
PDE4D phosphodiesterase 4D, cAMP-specific 0.0300348
SFPQ splicing factor proline/glutamine-rich 0.0295024
PTPRB protein tyrosine phosphatase, receptor type, B 0.0287544
NABP1 nucleic acid binding protein 1 0.0278813
PDLIM5 PDZ and LIM domain 5 0.0265553
RCC1 regulator of chromosome condensation 1 0.025195
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0235352
MARCHF3 membrane associated ring-CH-type finger 3 0.0234361
GLS2 glutaminase 2 (liver, mitochondrial) 0.0230788
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0230204
MBNL1 muscleblind-like splicing regulator 1 0.0224545
APLP2 amyloid beta (A4) precursor-like protein 2 0.0224287
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0221621
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0221273
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0220335
LRRC23 leucine rich repeat containing 23 0.0218855
RIMKLB ribosomal modification protein rimK-like family member B 0.0218633
CCNYL1 cyclin Y-like 1 0.0215842
RAD51B RAD51 paralog B 0.0213116
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0212791
CEMIP2 cell migration inducing hyaluronidase 2 0.0210873
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0204832
EXOC4 exocyst complex component 4 0.0204496
SLC38A2 solute carrier family 38, member 2 0.0203667
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.020258
AEBP2 AE binding protein 2 0.0200233
LOC105378220 macrophage receptor MARCO-like 0.0195681
CEMIP cell migration inducing protein, hyaluronan binding 0.0195177
MSH4 mutS homolog 4 0.0188966
POTEF POTE ankyrin domain family, member F 0.0183749
LGALS12 lectin, galactoside-binding, soluble, 12 0.0183393
MYOF myoferlin 0.0181566
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0174438
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0174354
WWOX WW domain containing oxidoreductase 0.0174201
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0174005
UBAP2 ubiquitin associated protein 2 0.0172431
CNOT1 CCR4-NOT transcription complex, subunit 1 0.016879
ARL15 ADP-ribosylation factor-like 15 0.0168141
NCAPG2 non-SMC condensin II complex, subunit G2 0.0166662
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.0163019
DST dystonin 0.0162742
PEAK1 pseudopodium-enriched atypical kinase 1 0.0162623
TRAPPC9 trafficking protein particle complex 9 0.0159673
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0156341
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.015554
PLSCR1 phospholipid scramblase 1 0.0155072
SUMF1 sulfatase modifying factor 1 0.0154731
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0153467
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0152905
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.014967
FHIT fragile histidine triad 0.0149615
PCBP2 poly(rC) binding protein 2 0.0147131
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0146902
PARD3B par-3 family cell polarity regulator beta 0.0146166
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0145786
RABGAP1L RAB GTPase activating protein 1-like 0.014548
HOMER1 homer scaffolding protein 1 0.0145153
RPL3 ribosomal protein L3 0.014476
TRIM69 tripartite motif containing 69 0.0143774
EFNA5 ephrin-A5 0.0142876
YLPM1 YLP motif containing 1 0.0142218
KDM4C lysine (K)-specific demethylase 4C 0.014071
EFNB2 ephrin-B2 0.0140696
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.0138989
ADIPOR2 adiponectin receptor 2 0.013794
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0137871
TRIO trio Rho guanine nucleotide exchange factor 0.0136314
SMYD3 SET and MYND domain containing 3 0.0135658
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0135011
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0134957
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0134641
SHB Src homology 2 domain containing adaptor protein B 0.0134547
RUNX1 runt-related transcription factor 1 0.0130091
WDR27 WD repeat domain 27 0.0129646
PRKCE protein kinase C, epsilon 0.0129279
RIGI RNA sensor RIG-I 0.0129207
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0128898
OXSR1 oxidative stress responsive 1 0.0128284
MX1 MX dynamin-like GTPase 1 0.0128055

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.194573
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.182137
RPLP1 ribosomal protein, large, P1 -0.170259
RPS6 ribosomal protein S6 -0.166596
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130221
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.107313
PTPRR protein tyrosine phosphatase, receptor type, R -0.104582
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100823
RPS8 ribosomal protein S8 -0.100477
RPL34 ribosomal protein L34 -0.0893106
RPLP0 ribosomal protein, large, P0 -0.0883151
GOLGA4 golgin A4 -0.0865821
TMSB10 thymosin beta 10 -0.0842351
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0818996
PTMA prothymosin, alpha -0.0745241
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0744291
RPL35A ribosomal protein L35a -0.0710047
CANX calnexin -0.0699051
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0634813
RPS19 ribosomal protein S19 -0.0615925
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0604346
RPL12 ribosomal protein L12 -0.0580239
CALB1 calbindin 1, 28kDa -0.0579007
RPL19 ribosomal protein L19 -0.057622
RRBP1 ribosome binding protein 1 -0.0567954
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0562452
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0549723
EZR ezrin -0.0540311
RPL26 ribosomal protein L26 -0.0539729
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0535521
RPS13 ribosomal protein S13 -0.0534349
RPL4 ribosomal protein L4 -0.0531928
PDIA3 protein disulfide isomerase family A, member 3 -0.0530572
RACK1 receptor for activated C kinase 1 -0.0516913
RPS24 ribosomal protein S24 -0.0512362
ESYT2 extended synaptotagmin-like protein 2 -0.05043
CALU calumenin -0.0490463
RPL37 ribosomal protein L37 -0.0485625
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0476187
DSG2 desmoglein 2 -0.0461002
TSPAN8 tetraspanin 8 -0.0458219
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0455532
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0451297
RPS25 ribosomal protein S25 -0.0445687
FLNB filamin B, beta -0.0443236
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0433165
ITPRID2 ITPR interacting domain containing 2 -0.0432155
RPS27A ribosomal protein S27a -0.0432
RPL37A ribosomal protein L37a -0.0424877
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0420352
PLAC8 placenta-specific 8 -0.0419643
HDLBP high density lipoprotein binding protein -0.0415477
SEC31A SEC31 homolog A (S. cerevisiae) -0.0407278
KRT18 keratin 18, type I -0.0405661
EIF1 eukaryotic translation initiation factor 1 -0.0405156
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0404459
HLA-B major histocompatibility complex, class I, B -0.0404065
RPL32 ribosomal protein L32 -0.0402116
RPL31 ribosomal protein L31 -0.039835
RPS3 ribosomal protein S3 -0.0397459
RPLP2 ribosomal protein, large, P2 -0.0394542
GARS1 glycyl-tRNA synthetase 1 -0.0390377
RPS16 ribosomal protein S16 -0.0387046
RPL27A ribosomal protein L27a -0.0385434
ACTG1 actin gamma 1 -0.0384639
LDHA lactate dehydrogenase A -0.0381645
AGR2 anterior gradient 2 -0.0378891
RPL8 ribosomal protein L8 -0.0375215
F3 coagulation factor III (thromboplastin, tissue factor) -0.0375035
FOXO1 forkhead box O1 -0.0369615
RPS21 ribosomal protein S21 -0.0369385
RPS14 ribosomal protein S14 -0.0367276
RPS27 ribosomal protein S27 -0.0364308
AKAP9 A kinase (PRKA) anchor protein 9 -0.0362908
CD2AP CD2-associated protein -0.0361513
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0361004
RPL11 ribosomal protein L11 -0.0360276
RPS12 ribosomal protein S12 -0.0357811
RPS29 ribosomal protein S29 -0.0354268
TTC3 tetratricopeptide repeat domain 3 -0.0351523
BACE2 beta-site APP-cleaving enzyme 2 -0.0348716
RPS23 ribosomal protein S23 -0.034712
ARHGAP5 Rho GTPase activating protein 5 -0.0347088
PGK1 phosphoglycerate kinase 1 -0.034373
GCC2 GRIP and coiled-coil domain containing 2 -0.0340718
RPL13A ribosomal protein L13a -0.0339915
CLINT1 clathrin interactor 1 -0.0339624
TPM4 tropomyosin 4 -0.0339411
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0338777
KLF5 Kruppel-like factor 5 (intestinal) -0.0337619
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0334188
SCAF11 SR-related CTD-associated factor 11 -0.0330366
S100A6 S100 calcium binding protein A6 -0.0329772
RAB1A RAB1A, member RAS oncogene family -0.0329584
RPL38 ribosomal protein L38 -0.0325779
LOC112694756 uncharaterized LOC112694756 -0.0322232
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0322051
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0319522
RPL36 ribosomal protein L36 -0.0316201
GNAS GNAS complex locus -0.0315354