Balsalazide (sodium hydrate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.132861
CEMIP cell migration inducing protein, hyaluronan binding 0.0805399
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0804141
FAM13A family with sequence similarity 13, member A 0.0747322
ELL2 elongation factor, RNA polymerase II, 2 0.0736702
LAMA4 laminin, alpha 4 0.0730404
MCL1 myeloid cell leukemia 1 0.0725743
SLTM SAFB-like, transcription modulator 0.0698703
SMAD3 SMAD family member 3 0.068789
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0673749
NAMPT nicotinamide phosphoribosyltransferase 0.066936
SAMD4A sterile alpha motif domain containing 4A 0.062445
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0604758
MYH9 myosin, heavy chain 9, non-muscle 0.0564315
THSD4 thrombospondin, type I, domain containing 4 0.0530488
CES1 carboxylesterase 1 0.0529445
BCAR3 breast cancer anti-estrogen resistance 3 0.0463971
GSK3B glycogen synthase kinase 3 beta 0.0443209
MACF1 microtubule-actin crosslinking factor 1 0.0435643
FTH1 ferritin, heavy polypeptide 1 0.0428176
TBC1D22A TBC1 domain family, member 22A 0.0427131
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0408793
MSN moesin 0.0393963
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.038961
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0387181
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0376061
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0375485
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0368006
BHLHE40 basic helix-loop-helix family, member e40 0.0365975
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0364475
OSMR oncostatin M receptor 0.0357704
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0356125
TSC22D2 TSC22 domain family, member 2 0.0354698
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0353688
RUNX1 runt-related transcription factor 1 0.0351202
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0342661
JMJD1C jumonji domain containing 1C 0.0330961
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.032867
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0328637
GRB10 growth factor receptor-bound protein 10 0.0327648
PLEC plectin 0.0325835
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0324468
OGA O-GlcNAcase 0.031912
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0314408
NGLY1 N-glycanase 1 0.0314017
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0306313
RNF149 ring finger protein 149 0.0305704
ZNF638 zinc finger protein 638 0.0304969
PM20D1 peptidase M20 domain containing 1 0.029671
ERRFI1 ERBB receptor feedback inhibitor 1 0.0295851
DTNA dystrobrevin, alpha 0.0294809
ANKRD11 ankyrin repeat domain 11 0.0288906
SRRM2 serine/arginine repetitive matrix 2 0.0288807
ATP13A3 ATPase type 13A3 0.028442
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0279665
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0276013
TMEM165 transmembrane protein 165 0.0265704
UBA6 ubiquitin-like modifier activating enzyme 6 0.0262973
RASA2 RAS p21 protein activator 2 0.0260785
YEATS2 YEATS domain containing 2 0.0260112
ANO6 anoctamin 6 0.0259975
PUM2 pumilio RNA-binding family member 2 0.0259026
STRN3 striatin, calmodulin binding protein 3 0.0253323
CUL4A cullin 4A 0.0250538
FNDC3B fibronectin type III domain containing 3B 0.0245878
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0244857
TOP1 topoisomerase (DNA) I 0.0242712
FBXL5 F-box and leucine-rich repeat protein 5 0.0239522
KDM2A lysine (K)-specific demethylase 2A 0.023952
USP34 ubiquitin specific peptidase 34 0.0239156
MREG melanoregulin 0.0238767
ATP11A ATPase, class VI, type 11A 0.0238024
EP300 E1A binding protein p300 0.0237052
DOCK5 dedicator of cytokinesis 5 0.0236753
SPRED1 sprouty-related, EVH1 domain containing 1 0.0235154
RNF145 ring finger protein 145 0.023396
CAMTA1 calmodulin binding transcription activator 1 0.0232668
NCKAP1 NCK-associated protein 1 0.0231182
HELZ helicase with zinc finger 0.023088
AGO2 argonaute RISC catalytic component 2 0.0229813
CDCP1 CUB domain containing protein 1 0.0229267
KMT2D lysine (K)-specific methyltransferase 2D 0.0228049
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0224755
KMT2E lysine (K)-specific methyltransferase 2E 0.0224
ZNF292 zinc finger protein 292 0.0222951
NBAS neuroblastoma amplified sequence 0.0222665
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0219757
DIAPH1 diaphanous-related formin 1 0.0218737
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0217724
EPAS1 endothelial PAS domain protein 1 0.0216463
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0216118
MARK3 MAP/microtubule affinity-regulating kinase 3 0.021459
MED13L mediator complex subunit 13-like 0.0212252
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0211487
KLC1 kinesin light chain 1 0.0210223
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0209602
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0209249
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0209183
POTEF POTE ankyrin domain family, member F 0.0208602
BMP6 bone morphogenetic protein 6 0.0205265

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.345497
TMSB10 thymosin beta 10 -0.179866
TPT1 tumor protein, translationally-controlled 1 -0.119306
CAV1 caveolin 1, caveolae protein, 22kDa -0.110481
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.109513
S100A10 S100 calcium binding protein A10 -0.0903513
INTS6 integrator complex subunit 6 -0.0802865
ACTG1 actin gamma 1 -0.0794443
ASPH aspartate beta-hydroxylase -0.0787244
PTMA prothymosin, alpha -0.0710072
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0707923
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.069919
RPS24 ribosomal protein S24 -0.0669955
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0633612
IFI6 interferon, alpha-inducible protein 6 -0.0598951
LDHA lactate dehydrogenase A -0.058651
CST3 cystatin C -0.0580733
BIRC3 baculoviral IAP repeat containing 3 -0.0548795
FTL ferritin, light polypeptide -0.0535362
PTPRM protein tyrosine phosphatase, receptor type, M -0.0529221
RPL35A ribosomal protein L35a -0.0521434
SEC61G Sec61 gamma subunit -0.051671
KRT7 keratin 7, type II -0.0491123
HLA-B major histocompatibility complex, class I, B -0.0491097
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.048667
EGR1 early growth response 1 -0.0485497
B2M beta-2-microglobulin -0.0482589
SP100 SP100 nuclear antigen -0.0477564
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.047682
RPS25 ribosomal protein S25 -0.0465462
LRP1B low density lipoprotein receptor-related protein 1B -0.0463937
RPL34 ribosomal protein L34 -0.046167
CCND1 cyclin D1 -0.0456514
RPLP1 ribosomal protein, large, P1 -0.0451996
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.045073
HOMER1 homer scaffolding protein 1 -0.0445178
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0441763
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0440854
AKR1C1 aldo-keto reductase family 1, member C1 -0.0432312
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0430964
GM2A GM2 ganglioside activator -0.0426225
RPS3 ribosomal protein S3 -0.0421742
PATJ PATJ crumbs cell polarity complex component -0.0421412
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0420888
NABP1 nucleic acid binding protein 1 -0.0403638
RPS8 ribosomal protein S8 -0.0394275
RPL37A ribosomal protein L37a -0.0392993
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.039067
RPL31 ribosomal protein L31 -0.0380807
S100A6 S100 calcium binding protein A6 -0.0379573
SLC38A2 solute carrier family 38, member 2 -0.0373521
KRT18 keratin 18, type I -0.0367997
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0364508
TRIM56 tripartite motif containing 56 -0.0361858
RPS27A ribosomal protein S27a -0.0360761
BZW1 basic leucine zipper and W2 domains 1 -0.0358278
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0354838
SLC38A1 solute carrier family 38, member 1 -0.0354261
MT2A metallothionein 2A -0.0349118
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0348611
NSUN6 NOP2/Sun domain family, member 6 -0.0346208
IER3 immediate early response 3 -0.0339694
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0333656
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0332008
EFNA5 ephrin-A5 -0.0328412
S100P S100 calcium binding protein P -0.0326232
CATSPERB catsper channel auxiliary subunit beta -0.0326231
EIF1 eukaryotic translation initiation factor 1 -0.0326131
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0325062
GNAS GNAS complex locus -0.0324912
EGFR epidermal growth factor receptor -0.0319257
CUX1 cut-like homeobox 1 -0.0315135
RPL11 ribosomal protein L11 -0.0309241
AHNAK AHNAK nucleoprotein -0.0306109
RPL37 ribosomal protein L37 -0.0304255
RPL12 ribosomal protein L12 -0.0304003
ANXA2 annexin A2 -0.0303644
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0300126
RPS12 ribosomal protein S12 -0.0299551
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.029536
FBXO11 F-box protein 11 -0.0293337
TNS3 tensin 3 -0.0290407
RPL19 ribosomal protein L19 -0.0290272
KRT19 keratin 19, type I -0.0289606
SQSTM1 sequestosome 1 -0.0288808
RPL30 ribosomal protein L30 -0.0277507
RPS23 ribosomal protein S23 -0.027232
ANKRD10 ankyrin repeat domain 10 -0.027175
NCOA7 nuclear receptor coactivator 7 -0.0271645
BTG1 B-cell translocation gene 1, anti-proliferative -0.0270347
RPLP0 ribosomal protein, large, P0 -0.0269236
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0269148
AGR2 anterior gradient 2 -0.0266299
SPTSSA serine palmitoyltransferase, small subunit A -0.0266111
IRF1 interferon regulatory factor 1 -0.0261925
ANKRD12 ankyrin repeat domain 12 -0.0254509
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0249491
UGDH UDP-glucose 6-dehydrogenase -0.0248978
MORF4L2 mortality factor 4 like 2 -0.0248069
FUS FUS RNA binding protein -0.0247534