Balsalazide (sodium hydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.0651691
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0644779
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0470225
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0439561
PDE4D phosphodiesterase 4D, cAMP-specific 0.0432526
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.041929
BHLHE40 basic helix-loop-helix family, member e40 0.0391653
FN1 fibronectin 1 0.0389094
PCBP2 poly(rC) binding protein 2 0.0369774
ESYT2 extended synaptotagmin-like protein 2 0.0336964
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0327268
SMAD3 SMAD family member 3 0.030489
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0304459
SEPTIN9 septin 9 0.0292921
ANTXR2 anthrax toxin receptor 2 0.0277492
DOCK5 dedicator of cytokinesis 5 0.0277126
MACF1 microtubule-actin crosslinking factor 1 0.0275633
DST dystonin 0.0274313
NGLY1 N-glycanase 1 0.0273533
AOPEP aminopeptidase O (putative) 0.0269049
ZNF638 zinc finger protein 638 0.0267816
RAI14 retinoic acid induced 14 0.0264414
ANKRD36 ankyrin repeat domain 36 0.0260974
ATF7 activating transcription factor 7 0.0260056
TTC3 tetratricopeptide repeat domain 3 0.0255521
SOD2 superoxide dismutase 2, mitochondrial 0.0250296
DPYSL3 dihydropyrimidinase-like 3 0.0248853
MEF2A myocyte enhancer factor 2A 0.0238427
VEGFC vascular endothelial growth factor C 0.0237085
AHNAK AHNAK nucleoprotein 0.0235613
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0224137
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0223657
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0222187
ANO6 anoctamin 6 0.0214961
RUNX2 runt-related transcription factor 2 0.0214003
MAML2 mastermind-like 2 (Drosophila) 0.0213748
SYT1 synaptotagmin I 0.021369
CCDC68 coiled-coil domain containing 68 0.0212427
CEP250 centrosomal protein 250kDa 0.0206679
FBN1 fibrillin 1 0.0206302
PFKP phosphofructokinase, platelet 0.0204699
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0204123
IGFBP3 insulin-like growth factor binding protein 3 0.0202012
MLPH melanophilin 0.0198865
PSD3 pleckstrin and Sec7 domain containing 3 0.0197966
IRAK2 interleukin-1 receptor-associated kinase 2 0.0193677
ZEB2 zinc finger E-box binding homeobox 2 0.0188965
BMAL2 basic helix-loop-helix ARNT like 2 0.0188512
FAM219A family with sequence similarity 219, member A 0.0188224
BACE2 beta-site APP-cleaving enzyme 2 0.0186773
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0186094
ANKH ANKH inorganic pyrophosphate transport regulator 0.0184774
HDAC9 histone deacetylase 9 0.0183078
MAST4 microtubule associated serine/threonine kinase family member 4 0.0182586
OXSR1 oxidative stress responsive 1 0.0178344
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0176299
COL7A1 collagen, type VII, alpha 1 0.0175887
MECOM MDS1 and EVI1 complex locus 0.0175794
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0174803
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0174768
MAML3 mastermind-like 3 (Drosophila) 0.0171718
PTPRM protein tyrosine phosphatase, receptor type, M 0.0171671
PYGL phosphorylase, glycogen, liver 0.0171122
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0170656
CDH13 cadherin 13 0.017046
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0170028
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0170004
PICALM phosphatidylinositol binding clathrin assembly protein 0.016658
PIAS2 protein inhibitor of activated STAT, 2 0.0162648
EHBP1 EH domain binding protein 1 0.0159603
NEBL nebulette 0.0158472
ADD3 adducin 3 (gamma) 0.0158449
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0158214
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0157364
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0157241
ARHGAP21 Rho GTPase activating protein 21 0.015513
LOX lysyl oxidase 0.0154636
ITGAV integrin, alpha V 0.0154173
ZEB1 zinc finger E-box binding homeobox 1 0.0153184
GYS1 glycogen synthase 1 (muscle) 0.0152499
UBA6 ubiquitin-like modifier activating enzyme 6 0.0152461
COPA coatomer protein complex, subunit alpha 0.0151288
CD109 CD109 molecule 0.0150986
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0150851
SVIL supervillin 0.0149535
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0147886
TRIO trio Rho guanine nucleotide exchange factor 0.0147656
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0147006
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0145301
EEF2 eukaryotic translation elongation factor 2 0.0143325
EGFR epidermal growth factor receptor 0.0142171
LRMDA leucine rich melanocyte differentiation associated 0.0141403
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0140387
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0140141
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0139442
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0139162
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0139089
C1D C1D nuclear receptor corepressor 0.0137563
LAMA4 laminin, alpha 4 0.0135066
PRELID2 PRELI domain containing 2 0.0134015

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181315
TMSB10 thymosin beta 10 -0.170604
VIM vimentin -0.152858
CXCL8 chemokine (C-X-C motif) ligand 8 -0.114657
AKAP12 A kinase (PRKA) anchor protein 12 -0.0986688
NAMPT nicotinamide phosphoribosyltransferase -0.093277
FTL ferritin, light polypeptide -0.0883686
PTMA prothymosin, alpha -0.0753618
CD44 CD44 molecule (Indian blood group) -0.0700922
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0690921
TPT1 tumor protein, translationally-controlled 1 -0.0640921
RPLP1 ribosomal protein, large, P1 -0.0595328
MT2A metallothionein 2A -0.0583771
NDRG1 N-myc downstream regulated 1 -0.0548883
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0511879
RPL35A ribosomal protein L35a -0.0496302
EIF1 eukaryotic translation initiation factor 1 -0.0488678
RPS6 ribosomal protein S6 -0.0477561
RPS19 ribosomal protein S19 -0.0457306
NAP1L1 nucleosome assembly protein 1-like 1 -0.0454723
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0449594
RBM39 RNA binding motif protein 39 -0.0448892
S100A6 S100 calcium binding protein A6 -0.0441502
FNDC3B fibronectin type III domain containing 3B -0.0435997
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0434633
IER3 immediate early response 3 -0.0428669
TFPI2 tissue factor pathway inhibitor 2 -0.0425657
B2M beta-2-microglobulin -0.0422558
EGR1 early growth response 1 -0.0413006
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0412389
RPS12 ribosomal protein S12 -0.040961
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0401214
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0401082
HMGA1 high mobility group AT-hook 1 -0.0383849
RPL37A ribosomal protein L37a -0.0376249
RPS24 ribosomal protein S24 -0.0371842
RPL34 ribosomal protein L34 -0.0368503
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0367695
C15ORF48 chromosome 15 open reading frame 48 -0.0363963
NCOA7 nuclear receptor coactivator 7 -0.0353979
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0348507
RPS21 ribosomal protein S21 -0.0340448
SLC38A1 solute carrier family 38, member 1 -0.0337668
RPL36 ribosomal protein L36 -0.0336403
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0335728
TNNC1 troponin C type 1 (slow) -0.0335146
RAB1A RAB1A, member RAS oncogene family -0.0334332
RPLP2 ribosomal protein, large, P2 -0.0325618
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0325472
RPLP0 ribosomal protein, large, P0 -0.0324199
RPL23 ribosomal protein L23 -0.0323515
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0323229
ANXA2 annexin A2 -0.0315323
GOLGA4 golgin A4 -0.0311004
RPS8 ribosomal protein S8 -0.0310977
S100A10 S100 calcium binding protein A10 -0.0310569
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309147
LOC102724023 ES1 protein homolog, mitochondrial -0.0307626
TMSB4X thymosin beta 4, X-linked -0.0307177
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.030581
IFI6 interferon, alpha-inducible protein 6 -0.0304532
DDIT3 DNA-damage-inducible transcript 3 -0.0303626
BTG1 B-cell translocation gene 1, anti-proliferative -0.0301781
WSB1 WD repeat and SOCS box containing 1 -0.0300678
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0300332
GNAS GNAS complex locus -0.0286349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0279634
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0278667
EXT1 exostosin glycosyltransferase 1 -0.0277608
RPL32 ribosomal protein L32 -0.0275119
RPL12 ribosomal protein L12 -0.0273459
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0262361
ARID4B AT rich interactive domain 4B (RBP1-like) -0.026191
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0261652
RPL11 ribosomal protein L11 -0.0261227
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0260858
RPS23 ribosomal protein S23 -0.0254205
RPL37 ribosomal protein L37 -0.0253697
STC1 stanniocalcin 1 -0.0251029
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.025072
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0249325
PLAUR plasminogen activator, urokinase receptor -0.0245699
RPS25 ribosomal protein S25 -0.023663
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0236326
RPL31 ribosomal protein L31 -0.0234754
LMAN1 lectin, mannose-binding, 1 -0.0233798
KLF6 Kruppel-like factor 6 -0.022932
RPS5 ribosomal protein S5 -0.0228876
PRRC2C proline-rich coiled-coil 2C -0.0227032
TOP1 topoisomerase (DNA) I -0.0226723
RPS29 ribosomal protein S29 -0.0225809
TAS2R14 taste receptor, type 2, member 14 -0.0225382
RPL9 ribosomal protein L9 -0.022418
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0223189
RAP1B RAP1B, member of RAS oncogene family -0.0222896
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0219513
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0219087
BASP1 brain abundant, membrane attached signal protein 1 -0.021778
RPS3 ribosomal protein S3 -0.0215437
SOX4 SRY (sex determining region Y)-box 4 -0.021508