Balsalazide (sodium hydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.118186
NDRG1 N-myc downstream regulated 1 0.103792
TRIO trio Rho guanine nucleotide exchange factor 0.0809271
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0722498
ELL2 elongation factor, RNA polymerase II, 2 0.0697964
RNF145 ring finger protein 145 0.0675415
UBA6 ubiquitin-like modifier activating enzyme 6 0.0672532
ADAM9 ADAM metallopeptidase domain 9 0.0633436
FNDC3B fibronectin type III domain containing 3B 0.0628842
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0614388
ASPH aspartate beta-hydroxylase 0.0583733
KMT2E lysine (K)-specific methyltransferase 2E 0.0572215
CCNL1 cyclin L1 0.0552481
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0543549
BHLHE40 basic helix-loop-helix family, member e40 0.0483993
VEGFA vascular endothelial growth factor A 0.0482737
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0482151
MSN moesin 0.0475878
FAM13A family with sequence similarity 13, member A 0.0465849
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0464024
POTEF POTE ankyrin domain family, member F 0.0463475
TFG TRK-fused gene 0.0461209
COPA coatomer protein complex, subunit alpha 0.0458529
EZR ezrin 0.045787
MARCHF6 membrane associated ring-CH-type finger 6 0.0449402
MYH9 myosin, heavy chain 9, non-muscle 0.0447461
FAM3C family with sequence similarity 3, member C 0.044412
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0432193
FXR1 fragile X mental retardation, autosomal homolog 1 0.0426106
PCBP2 poly(rC) binding protein 2 0.0419044
GRB10 growth factor receptor-bound protein 10 0.0418471
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0413613
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0403867
DUSP10 dual specificity phosphatase 10 0.03997
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0389944
RBM39 RNA binding motif protein 39 0.03803
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0376534
PTK2 protein tyrosine kinase 2 0.0374479
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0365929
MYO5B myosin VB 0.0357213
SLMAP sarcolemma associated protein 0.0356823
USP3 ubiquitin specific peptidase 3 0.0353033
KDM6A lysine (K)-specific demethylase 6A 0.0351615
MYO6 myosin VI 0.0348777
WAC WW domain containing adaptor with coiled-coil 0.034487
RICTOR RPTOR independent companion of MTOR, complex 2 0.0339385
CDC73 cell division cycle 73 0.033442
NPEPPS aminopeptidase puromycin sensitive 0.0329636
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0328836
ATP13A3 ATPase type 13A3 0.0324373
YTHDC1 YTH domain containing 1 0.0320378
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0316491
CDK17 cyclin-dependent kinase 17 0.0309673
ARHGAP29 Rho GTPase activating protein 29 0.0303398
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0301749
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0300139
UGCG UDP-glucose ceramide glucosyltransferase 0.029759
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0296906
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.029558
STRN3 striatin, calmodulin binding protein 3 0.0294537
PUM1 pumilio RNA-binding family member 1 0.0293696
MACF1 microtubule-actin crosslinking factor 1 0.0293431
SPAG9 sperm associated antigen 9 0.0289871
NAMPT nicotinamide phosphoribosyltransferase 0.0286014
NUP58 nucleoporin 58 0.0281789
ANXA5 annexin A5 0.0281533
APLP2 amyloid beta (A4) precursor-like protein 2 0.0280782
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0279583
RHOA ras homolog family member A 0.0277544
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0277063
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0276126
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0275242
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0274225
TPM3 tropomyosin 3 0.0273136
HELZ helicase with zinc finger 0.0272193
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0271853
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0271049
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.027017
QKI QKI, KH domain containing, RNA binding 0.0269627
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.026758
PLEC plectin 0.0264834
DTNA dystrobrevin, alpha 0.0262537
ZNF292 zinc finger protein 292 0.0258963
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.025881
ITCH itchy E3 ubiquitin protein ligase 0.0258404
NCKAP1 NCK-associated protein 1 0.0257618
PPARD peroxisome proliferator-activated receptor delta 0.0256515
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0252222
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0248324
CORO1C coronin, actin binding protein, 1C 0.0247453
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.024624
EEF2 eukaryotic translation elongation factor 2 0.024367
IGFBP3 insulin-like growth factor binding protein 3 0.0243082
RIOK3 RIO kinase 3 0.0242469
MATR3 matrin 3 0.0242335
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0242312
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0241802
RLF rearranged L-myc fusion 0.0241088
TP53BP2 tumor protein p53 binding protein 2 0.0237943
FOSL1 FOS-like antigen 1 0.0236846

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183453
ACTG1 actin gamma 1 -0.135613
TPT1 tumor protein, translationally-controlled 1 -0.12457
TMSB10 thymosin beta 10 -0.124152
FTL ferritin, light polypeptide -0.112123
PTMA prothymosin, alpha -0.106502
LPP LIM domain containing preferred translocation partner in lipoma -0.092279
RPL35A ribosomal protein L35a -0.0903913
RPL34 ribosomal protein L34 -0.0841032
EXT1 exostosin glycosyltransferase 1 -0.0768532
FBXO32 F-box protein 32 -0.0701357
RPLP1 ribosomal protein, large, P1 -0.0701023
EIF1 eukaryotic translation initiation factor 1 -0.0666766
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.062245
RPL23 ribosomal protein L23 -0.0610893
IFI6 interferon, alpha-inducible protein 6 -0.0608093
S100A6 S100 calcium binding protein A6 -0.0602796
TMSB4X thymosin beta 4, X-linked -0.059778
RPS8 ribosomal protein S8 -0.0596054
IFI27 interferon, alpha-inducible protein 27 -0.0584914
LIMCH1 LIM and calponin homology domains 1 -0.0580703
IFI16 interferon, gamma-inducible protein 16 -0.0579594
EFNA5 ephrin-A5 -0.0575475
VCL vinculin -0.0562414
ISG15 ISG15 ubiquitin-like modifier -0.0526565
SQSTM1 sequestosome 1 -0.0524528
RPL9 ribosomal protein L9 -0.0521476
S100A10 S100 calcium binding protein A10 -0.0515421
RPS13 ribosomal protein S13 -0.0498777
RPS23 ribosomal protein S23 -0.0495768
RPLP2 ribosomal protein, large, P2 -0.0495733
RPS24 ribosomal protein S24 -0.0483204
FBXO34 F-box protein 34 -0.0462509
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0458473
GNAS GNAS complex locus -0.045774
RACK1 receptor for activated C kinase 1 -0.0456399
RPL37 ribosomal protein L37 -0.045252
RPL37A ribosomal protein L37a -0.0452415
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0450681
RPS25 ribosomal protein S25 -0.0450094
FN1 fibronectin 1 -0.04491
RPS19 ribosomal protein S19 -0.0439704
RPS29 ribosomal protein S29 -0.0439643
RPL30 ribosomal protein L30 -0.0428395
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0426513
RPLP0 ribosomal protein, large, P0 -0.0425887
HLA-B major histocompatibility complex, class I, B -0.0419165
SOX4 SRY (sex determining region Y)-box 4 -0.0416465
CCND1 cyclin D1 -0.0416275
RPL12 ribosomal protein L12 -0.0416176
RPL19 ribosomal protein L19 -0.040953
CSTB cystatin B (stefin B) -0.0406453
RPS3 ribosomal protein S3 -0.0391331
ARHGAP5 Rho GTPase activating protein 5 -0.0374329
PALLD palladin, cytoskeletal associated protein -0.037242
CANX calnexin -0.0371097
RPL8 ribosomal protein L8 -0.0369422
SAMD4A sterile alpha motif domain containing 4A -0.0368195
RPS12 ribosomal protein S12 -0.036518
ARHGAP20 Rho GTPase activating protein 20 -0.0363893
RPS27A ribosomal protein S27a -0.0358372
FNIP1 folliculin interacting protein 1 -0.0357957
TPM4 tropomyosin 4 -0.0351714
RPL11 ribosomal protein L11 -0.0345911
RPL31 ribosomal protein L31 -0.0342015
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0341909
RPS6 ribosomal protein S6 -0.0338637
RPS17 ribosomal protein S17 -0.0336512
MYO1E myosin IE -0.0334466
TTC3 tetratricopeptide repeat domain 3 -0.03252
RPS16 ribosomal protein S16 -0.0323503
RPL32 ribosomal protein L32 -0.0322821
IFIH1 interferon induced with helicase C domain 1 -0.0317672
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.031348
HLA-E major histocompatibility complex, class I, E -0.0311636
ALCAM activated leukocyte cell adhesion molecule -0.0311248
BZW1 basic leucine zipper and W2 domains 1 -0.0309
IFITM3 interferon induced transmembrane protein 3 -0.0305267
RPL15 ribosomal protein L15 -0.0303155
RPL27A ribosomal protein L27a -0.0301677
CEP350 centrosomal protein 350kDa -0.0293028
GOLGB1 golgin B1 -0.0292818
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0287865
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0287761
WSB1 WD repeat and SOCS box containing 1 -0.0286726
RPL26 ribosomal protein L26 -0.028451
C15ORF48 chromosome 15 open reading frame 48 -0.0283834
RPS10 ribosomal protein S10 -0.0282415
IFITM1 interferon induced transmembrane protein 1 -0.0281686
TBCA tubulin folding cofactor A -0.0281683
WARS1 tryptophanyl-tRNA synthetase 1 -0.0279157
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0278335
RPS14 ribosomal protein S14 -0.027816
RPS20 ribosomal protein S20 -0.0277322
CAVIN1 caveolae associated protein 1 -0.0274925
RPS21 ribosomal protein S21 -0.0274912
VIM vimentin -0.0274386
HLA-A major histocompatibility complex, class I, A -0.0271862
CDK13 cyclin-dependent kinase 13 -0.0271265
RPS27 ribosomal protein S27 -0.0267464