Balsalazide (sodium hydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.135162
ELL2 elongation factor, RNA polymerase II, 2 0.124082
STC1 stanniocalcin 1 0.0866933
FRMD4A FERM domain containing 4A 0.0800908
DLC1 DLC1 Rho GTPase activating protein 0.0777583
NAV3 neuron navigator 3 0.0747722
AGO2 argonaute RISC catalytic component 2 0.0691207
RPL7 ribosomal protein L7 0.0678846
ZEB1 zinc finger E-box binding homeobox 1 0.0579195
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0538092
C2CD2 C2 calcium-dependent domain containing 2 0.0534353
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0533192
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0515158
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0502342
EEF2 eukaryotic translation elongation factor 2 0.0487556
SGMS2 sphingomyelin synthase 2 0.0460989
PDIA3 protein disulfide isomerase family A, member 3 0.0459258
RPL4 ribosomal protein L4 0.0444321
ZNF438 zinc finger protein 438 0.0439432
HMGA2 high mobility group AT-hook 2 0.0430511
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.042277
ARHGAP22 Rho GTPase activating protein 22 0.0421321
PGK1 phosphoglycerate kinase 1 0.0411529
KPNB1 karyopherin (importin) beta 1 0.0411084
SRRM2 serine/arginine repetitive matrix 2 0.0404175
BHLHE40 basic helix-loop-helix family, member e40 0.0401669
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0400371
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.039359
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0376257
UPP1 uridine phosphorylase 1 0.0352868
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0337056
ZFP36L1 ZFP36 ring finger protein-like 1 0.0335426
RPL7A ribosomal protein L7a 0.0334943
TTR transthyretin 0.0333447
RASA2 RAS p21 protein activator 2 0.0331584
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0329464
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0316534
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.031633
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0314965
AKAP9 A kinase (PRKA) anchor protein 9 0.0299333
POTEF POTE ankyrin domain family, member F 0.0298345
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0293444
FRMD6 FERM domain containing 6 0.0291812
FOSL1 FOS-like antigen 1 0.029095
RPLP0 ribosomal protein, large, P0 0.028458
SETX senataxin 0.0282996
SLC38A2 solute carrier family 38, member 2 0.0280621
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0276792
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0276293
CORO1C coronin, actin binding protein, 1C 0.0274091
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0273223
TAS2R14 taste receptor, type 2, member 14 0.0269485
SFTPA2 surfactant protein A2 0.026653
CDK6 cyclin-dependent kinase 6 0.0266198
AKAP12 A kinase (PRKA) anchor protein 12 0.0261546
ANXA2 annexin A2 0.0260102
GLRX glutaredoxin (thioltransferase) 0.025961
BCL10 B-cell CLL/lymphoma 10 0.0256457
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0243332
ADTRP androgen-dependent TFPI-regulating protein 0.0242326
EXT1 exostosin glycosyltransferase 1 0.0236652
SQSTM1 sequestosome 1 0.0236451
EGR1 early growth response 1 0.0236164
DEK DEK proto-oncogene 0.0231281
LDHA lactate dehydrogenase A 0.0231015
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0228464
NEMP2 nuclear envelope integral membrane protein 2 0.0228439
SEC24D SEC24 family member D 0.0228072
CLTC clathrin, heavy chain (Hc) 0.0225855
ZBTB38 zinc finger and BTB domain containing 38 0.0223665
TPM4 tropomyosin 4 0.0222423
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0220882
FLNB filamin B, beta 0.0219479
PPP1R3B protein phosphatase 1, regulatory subunit 3B 0.0216143
FHL2 four and a half LIM domains 2 0.0214097
TUBB4B tubulin, beta 4B class IVb 0.0213874
MAST4 microtubule associated serine/threonine kinase family member 4 0.0210239
GDI2 GDP dissociation inhibitor 2 0.0209086
SLC38A1 solute carrier family 38, member 1 0.0204763
MKI67 marker of proliferation Ki-67 0.0202835
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0201172
FHIT fragile histidine triad 0.0198652
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.0197919
THRAP3 thyroid hormone receptor associated protein 3 0.0196355
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0196281
NRIP1 nuclear receptor interacting protein 1 0.0195619
YBX1 Y box binding protein 1 0.0193637
NDRG1 N-myc downstream regulated 1 0.0193465
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0193091
RAB3IP RAB3A interacting protein 0.0191712
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0188352
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0.0187277
TOMM34 translocase of outer mitochondrial membrane 34 0.0187059
RPS2 ribosomal protein S2 0.0186798
ATP5F1B ATP synthase F1 subunit beta 0.0186635
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0185429
TTC17 tetratricopeptide repeat domain 17 0.0185085
TM4SF19 transmembrane 4 L six family member 19 0.0183001
NUP188 nucleoporin 188kDa 0.0180354
BICD1 bicaudal D homolog 1 (Drosophila) 0.0179458

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.11742
ACTG1 actin gamma 1 -0.0758267
RBM25 RNA binding motif protein 25 -0.0712102
RPL23 ribosomal protein L23 -0.0695992
PTK2 protein tyrosine kinase 2 -0.0687327
RPS27A ribosomal protein S27a -0.0650767
TMSB10 thymosin beta 10 -0.0633815
JUN jun proto-oncogene -0.0623222
MT2A metallothionein 2A -0.0533946
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.052981
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0524638
SFPQ splicing factor proline/glutamine-rich -0.0510179
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0497983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0494577
PRRC2C proline-rich coiled-coil 2C -0.049354
NABP1 nucleic acid binding protein 1 -0.0489992
ZFAND3 zinc finger, AN1-type domain 3 -0.0475739
PRRC2B proline-rich coiled-coil 2B -0.0447873
DSCAM Down syndrome cell adhesion molecule -0.0443554
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0433437
BIRC6 baculoviral IAP repeat containing 6 -0.0425317
MCTP1 multiple C2 domains, transmembrane 1 -0.0424877
INTS6 integrator complex subunit 6 -0.0397737
SAMD4A sterile alpha motif domain containing 4A -0.0393786
RPL26 ribosomal protein L26 -0.0381785
TOP1 topoisomerase (DNA) I -0.0378891
PUM1 pumilio RNA-binding family member 1 -0.0377625
PHIP pleckstrin homology domain interacting protein -0.0368579
S100A6 S100 calcium binding protein A6 -0.036395
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0363484
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0362565
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0361985
DENND1A DENN/MADD domain containing 1A -0.0361636
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0359115
NAV2 neuron navigator 2 -0.0356456
RBM39 RNA binding motif protein 39 -0.0354997
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0352606
RPS12 ribosomal protein S12 -0.0347107
WSB1 WD repeat and SOCS box containing 1 -0.034355
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0342652
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0341028
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0340983
DIAPH3 diaphanous-related formin 3 -0.0339915
PTMA prothymosin, alpha -0.0338375
CALD1 caldesmon 1 -0.0336662
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0335782
GIGYF2 GRB10 interacting GYF protein 2 -0.0333278
TIMP1 TIMP metallopeptidase inhibitor 1 -0.033265
PCBP2 poly(rC) binding protein 2 -0.0332201
RPS3 ribosomal protein S3 -0.0328646
TRIO trio Rho guanine nucleotide exchange factor -0.032712
OGA O-GlcNAcase -0.0325184
AHNAK AHNAK nucleoprotein -0.0323276
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0322641
VMP1 vacuole membrane protein 1 -0.0318597
TPT1 tumor protein, translationally-controlled 1 -0.0316123
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0312864
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0311333
ZNF609 zinc finger protein 609 -0.0311195
MED27 mediator complex subunit 27 -0.0309488
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0305594
NAP1L1 nucleosome assembly protein 1-like 1 -0.0298866
EIF5B eukaryotic translation initiation factor 5B -0.0297408
RBM33 RNA binding motif protein 33 -0.0293974
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.02909
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0288176
FNBP4 formin binding protein 4 -0.0287693
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.028326
ZNF207 zinc finger protein 207 -0.0282621
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.028109
SPAG9 sperm associated antigen 9 -0.0277899
LOC112694756 uncharaterized LOC112694756 -0.0275615
SET SET nuclear proto-oncogene -0.0271621
FUBP3 far upstream element (FUSE) binding protein 3 -0.0270352
CHD7 chromodomain helicase DNA binding protein 7 -0.0269867
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0269662
NF1 neurofibromin 1 -0.0267334
PNISR PNN-interacting serine/arginine-rich protein -0.0265458
MYL12B myosin, light chain 12B, regulatory -0.0265011
MCL1 myeloid cell leukemia 1 -0.0264814
TM9SF3 transmembrane 9 superfamily member 3 -0.0261044
MIS18BP1 MIS18 binding protein 1 -0.0260038
RSRC1 arginine/serine-rich coiled-coil 1 -0.0258202
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0256703
IFRD1 interferon-related developmental regulator 1 -0.0255754
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0255254
KDM3A lysine (K)-specific demethylase 3A -0.0253528
BBX bobby sox homolog (Drosophila) -0.0253122
CAST calpastatin -0.0252085
RPL37A ribosomal protein L37a -0.0250031
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0249811
ADAM17 ADAM metallopeptidase domain 17 -0.0248398
ZCCHC7 zinc finger, CCHC domain containing 7 -0.024731
LPP LIM domain containing preferred translocation partner in lipoma -0.0244041
RPS21 ribosomal protein S21 -0.024245
NBAS neuroblastoma amplified sequence -0.0242066
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0240876
NIPBL Nipped-B homolog (Drosophila) -0.0240416
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0239614
PIBF1 progesterone immunomodulatory binding factor 1 -0.0238024