Balsalazide (sodium hydrate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0838277
COL5A1 collagen, type V, alpha 1 0.0756089
NAV2 neuron navigator 2 0.0704951
BHLHE40 basic helix-loop-helix family, member e40 0.0686116
COL7A1 collagen, type VII, alpha 1 0.0576188
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0548023
FHIT fragile histidine triad 0.0500743
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0493734
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0489955
IGFBP3 insulin-like growth factor binding protein 3 0.0482583
MYH9 myosin, heavy chain 9, non-muscle 0.0458694
SMAD3 SMAD family member 3 0.0454584
COL6A1 collagen, type VI, alpha 1 0.0407063
NRP1 neuropilin 1 0.0382525
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0380822
FTH1 ferritin, heavy polypeptide 1 0.036897
MLPH melanophilin 0.0366227
TMEM178B transmembrane protein 178B 0.03623
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0361841
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0360704
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0357975
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354547
MMP2 matrix metallopeptidase 2 0.0345228
FAT1 FAT atypical cadherin 1 0.0334327
TRIO trio Rho guanine nucleotide exchange factor 0.0329268
PLEC plectin 0.032919
ZNF638 zinc finger protein 638 0.0318937
ECE1 endothelin converting enzyme 1 0.031768
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0317068
FOSL1 FOS-like antigen 1 0.0307522
ANO6 anoctamin 6 0.0299563
HDAC9 histone deacetylase 9 0.0296993
RUNX1 runt-related transcription factor 1 0.0296916
GRB10 growth factor receptor-bound protein 10 0.0295181
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0287061
MYOF myoferlin 0.02833
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0282706
TGM2 transglutaminase 2 0.0282502
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0277339
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0273113
JARID2 jumonji, AT rich interactive domain 2 0.0270804
C1D C1D nuclear receptor corepressor 0.0269577
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.02658
EPAS1 endothelial PAS domain protein 1 0.0263848
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0262633
SH3PXD2A SH3 and PX domains 2A 0.0261378
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.025408
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0249426
IFI44L interferon-induced protein 44-like 0.0249319
AKAP9 A kinase (PRKA) anchor protein 9 0.0246213
SHB Src homology 2 domain containing adaptor protein B 0.0245576
MAML2 mastermind-like 2 (Drosophila) 0.0244576
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0243737
ZBTB38 zinc finger and BTB domain containing 38 0.024296
TENT5A terminal nucleotidyltransferase 5A 0.0237698
RNF213 ring finger protein 213 0.023755
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0235236
MACF1 microtubule-actin crosslinking factor 1 0.0230542
EEF2 eukaryotic translation elongation factor 2 0.0230252
SMYD3 SET and MYND domain containing 3 0.0228461
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.022658
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0221396
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0220037
TIMP2 TIMP metallopeptidase inhibitor 2 0.0219631
ESYT2 extended synaptotagmin-like protein 2 0.0216621
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0214953
KMT2C lysine (K)-specific methyltransferase 2C 0.0214753
SVIL supervillin 0.0213558
ATP13A3 ATPase type 13A3 0.0212414
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.02074
KLC1 kinesin light chain 1 0.020729
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.020583
FLNB filamin B, beta 0.0203603
GYS1 glycogen synthase 1 (muscle) 0.0202834
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0202055
UTRN utrophin 0.0199569
YEATS2 YEATS domain containing 2 0.0196624
EXOC4 exocyst complex component 4 0.0194068
ZHX2 zinc fingers and homeoboxes 2 0.0189288
ARRDC3 arrestin domain containing 3 0.0188278
ARHGAP32 Rho GTPase activating protein 32 0.0186636
KDM5B lysine (K)-specific demethylase 5B 0.0184575
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.018227
PRRC2B proline-rich coiled-coil 2B 0.018152
RNF144A ring finger protein 144A 0.0180472
SAMD4A sterile alpha motif domain containing 4A 0.0179752
SRRM2 serine/arginine repetitive matrix 2 0.0179187
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0178821
ZEB2 zinc finger E-box binding homeobox 2 0.0178718
PICALM phosphatidylinositol binding clathrin assembly protein 0.0177437
AEBP1 AE binding protein 1 0.0177311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.017707
MX1 MX dynamin-like GTPase 1 0.0177001
PDE8A phosphodiesterase 8A 0.0176186
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0176172
BBS9 Bardet-Biedl syndrome 9 0.0175195
PRELID2 PRELI domain containing 2 0.0172917
USP47 ubiquitin specific peptidase 47 0.0171903
DST dystonin 0.0170985
CADM1 cell adhesion molecule 1 0.0170027

decreased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 -0.262516
VIM vimentin -0.210127
TIMP3 TIMP metallopeptidase inhibitor 3 -0.140433
MT2A metallothionein 2A -0.135768
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130766
B2M beta-2-microglobulin -0.129584
NDRG1 N-myc downstream regulated 1 -0.108424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103519
COL1A2 collagen, type I, alpha 2 -0.0805214
TFPI2 tissue factor pathway inhibitor 2 -0.0799431
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0769533
ASPH aspartate beta-hydroxylase -0.0748495
IFI6 interferon, alpha-inducible protein 6 -0.0744597
TMSB10 thymosin beta 10 -0.0703083
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0646787
FN1 fibronectin 1 -0.0628005
PTMA prothymosin, alpha -0.0619886
GOLGA4 golgin A4 -0.0524519
PSD3 pleckstrin and Sec7 domain containing 3 -0.0513985
TPT1 tumor protein, translationally-controlled 1 -0.0511413
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0506797
PGK1 phosphoglycerate kinase 1 -0.0499524
ANGPTL4 angiopoietin-like 4 -0.0495586
CDH13 cadherin 13 -0.0494893
TPM4 tropomyosin 4 -0.0489431
HLA-B major histocompatibility complex, class I, B -0.0484798
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0476762
CEMIP cell migration inducing protein, hyaluronan binding -0.0453948
S100A6 S100 calcium binding protein A6 -0.0438863
RRBP1 ribosome binding protein 1 -0.0403277
NAMPT nicotinamide phosphoribosyltransferase -0.0394824
GLIS3 GLIS family zinc finger 3 -0.0389097
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0377434
CANX calnexin -0.0367068
RAD21 RAD21 homolog (S. pombe) -0.0352912
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0345912
GNAS GNAS complex locus -0.0325488
CAVIN1 caveolae associated protein 1 -0.032503
PDIA3 protein disulfide isomerase family A, member 3 -0.0325019
FRMD4A FERM domain containing 4A -0.0324757
LDHA lactate dehydrogenase A -0.0320279
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0319016
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0317804
SEPTIN7 septin 7 -0.0316894
EIF1 eukaryotic translation initiation factor 1 -0.030847
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0305268
RPS24 ribosomal protein S24 -0.0304147
IL1B interleukin 1, beta -0.0301333
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.030072
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0299815
RAB1A RAB1A, member RAS oncogene family -0.0299694
LMAN1 lectin, mannose-binding, 1 -0.0292804
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.028896
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0282146
NAP1L1 nucleosome assembly protein 1-like 1 -0.0278629
SBF2 SET binding factor 2 -0.0276879
CALU calumenin -0.027676
ANKRD12 ankyrin repeat domain 12 -0.0274546
EML5 echinoderm microtubule associated protein like 5 -0.0273818
IER3 immediate early response 3 -0.0273619
SAMD9 sterile alpha motif domain containing 9 -0.0271452
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0268403
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0265594
RPL31 ribosomal protein L31 -0.0262298
DSTN destrin (actin depolymerizing factor) -0.0260981
RPL12 ribosomal protein L12 -0.0260508
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0260269
TFG TRK-fused gene -0.0256863
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0254262
RPL23 ribosomal protein L23 -0.025405
ZBTB20 zinc finger and BTB domain containing 20 -0.0253608
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0252486
CENPF centromere protein F, 350/400kDa -0.0251013
NT5E 5'-nucleotidase, ecto (CD73) -0.0249945
FNDC3B fibronectin type III domain containing 3B -0.024983
DSCAM Down syndrome cell adhesion molecule -0.0248373
FTL ferritin, light polypeptide -0.0248162
TMEM263 transmembrane protein 263 -0.0246427
DNER delta/notch-like EGF repeat containing -0.0245314
RPL34 ribosomal protein L34 -0.0244039
NUMB numb homolog (Drosophila) -0.0242635
WSB1 WD repeat and SOCS box containing 1 -0.0240889
RPL26 ribosomal protein L26 -0.023877
AKAP12 A kinase (PRKA) anchor protein 12 -0.0238485
FAM162A family with sequence similarity 162, member A -0.0237945
CCDC138 coiled-coil domain containing 138 -0.0236608
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0236554
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0236451
KDM3A lysine (K)-specific demethylase 3A -0.023552
MT1E metallothionein 1E -0.0235252
HM13 histocompatibility (minor) 13 -0.0235138
CD44 CD44 molecule (Indian blood group) -0.0232437
BZW1 basic leucine zipper and W2 domains 1 -0.023022
RPS21 ribosomal protein S21 -0.0229712
S100A9 S100 calcium binding protein A9 -0.0228475
RPS27A ribosomal protein S27a -0.0228397
IGFBP7 insulin-like growth factor binding protein 7 -0.0227682
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0226805
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.022649
BLZF1 basic leucine zipper nuclear factor 1 -0.0225875