Balsalazide (sodium hydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.149362
SMOC1 SPARC related modular calcium binding 1 0.112762
SNAP25 synaptosomal-associated protein, 25kDa 0.108225
MCL1 myeloid cell leukemia 1 0.0682539
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0627174
MYH9 myosin, heavy chain 9, non-muscle 0.0585727
VGF VGF nerve growth factor inducible 0.0576164
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0535144
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0493323
FNDC3A fibronectin type III domain containing 3A 0.0468908
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0426266
ELL2 elongation factor, RNA polymerase II, 2 0.0421942
FAT1 FAT atypical cadherin 1 0.0420658
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0414745
AHR aryl hydrocarbon receptor 0.0382518
VEGFA vascular endothelial growth factor A 0.0338888
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0332589
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.032292
BACE2 beta-site APP-cleaving enzyme 2 0.0322239
CHD7 chromodomain helicase DNA binding protein 7 0.0320979
LCOR ligand dependent nuclear receptor corepressor 0.0317812
EFNA5 ephrin-A5 0.0308823
TENT5A terminal nucleotidyltransferase 5A 0.0296949
ERRFI1 ERBB receptor feedback inhibitor 1 0.0286462
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0272771
RPH3AL rabphilin 3A-like (without C2 domains) 0.0272736
FAM13A family with sequence similarity 13, member A 0.0270521
NAV2 neuron navigator 2 0.0269829
BHLHE40 basic helix-loop-helix family, member e40 0.0268421
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0265606
RNF144A ring finger protein 144A 0.0263244
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0261038
PRPF8 pre-mRNA processing factor 8 0.0259498
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0247012
ZSWIM6 zinc finger, SWIM-type containing 6 0.0242701
DGKD diacylglycerol kinase, delta 130kDa 0.0241969
GRB10 growth factor receptor-bound protein 10 0.0240929
MPRIP myosin phosphatase Rho interacting protein 0.0240333
KDM2A lysine (K)-specific demethylase 2A 0.0240151
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0240128
SREBF2 sterol regulatory element binding transcription factor 2 0.0239052
IQSEC1 IQ motif and Sec7 domain 1 0.0223326
PAEP progestagen-associated endometrial protein 0.0219225
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0216496
BTBD3 BTB (POZ) domain containing 3 0.0214014
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0210186
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0209038
IGF1R insulin-like growth factor 1 receptor 0.0208915
SIK2 salt-inducible kinase 2 0.0207291
RIMBP2 RIMS binding protein 2 0.0202264
LRP5 low density lipoprotein receptor-related protein 5 0.0201714
FOXJ3 forkhead box J3 0.0199168
TMEM255B transmembrane protein 255B 0.0198915
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0196816
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0196229
DTNA dystrobrevin, alpha 0.0195688
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0193793
AOPEP aminopeptidase O (putative) 0.0193443
SYT13 synaptotagmin XIII 0.0192668
CA8 carbonic anhydrase VIII 0.0192469
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0191826
TENT4A terminal nucleotidyltransferase 4A 0.0191308
MBNL2 muscleblind-like splicing regulator 2 0.0190387
STC1 stanniocalcin 1 0.018949
SENP6 SUMO1/sentrin specific peptidase 6 0.0188836
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0188275
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0187495
SEC23B Sec23 homolog B (S. cerevisiae) 0.0183396
PCBP2 poly(rC) binding protein 2 0.0182915
TRIO trio Rho guanine nucleotide exchange factor 0.0182459
GRAMD4 GRAM domain containing 4 0.0181968
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0181878
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0181869
HYOU1 hypoxia up-regulated 1 0.0180598
EXT1 exostosin glycosyltransferase 1 0.0179791
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0178176
CHD1L chromodomain helicase DNA binding protein 1-like 0.0178135
FAF1 Fas (TNFRSF6) associated factor 1 0.0176909
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0176249
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0175796
CASC3 cancer susceptibility candidate 3 0.0175536
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.017471
ANKH ANKH inorganic pyrophosphate transport regulator 0.0174625
TSPAN9 tetraspanin 9 0.0174384
ZFHX3 zinc finger homeobox 3 0.0170956
CEMIP cell migration inducing protein, hyaluronan binding 0.0170184
KLHL29 kelch-like family member 29 0.0170033
TTC19 tetratricopeptide repeat domain 19 0.0169822
SDK1 sidekick cell adhesion molecule 1 0.0169337
ADAM10 ADAM metallopeptidase domain 10 0.0169144
RPL3 ribosomal protein L3 0.0168868
RPTOR regulatory associated protein of MTOR, complex 1 0.0167853
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0165066
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165006
DOCK5 dedicator of cytokinesis 5 0.016436
CADM1 cell adhesion molecule 1 0.0163431
FKBP9 FK506 binding protein 9, 63 kDa 0.0163121
FAM168A family with sequence similarity 168, member A 0.0161534
CORO1C coronin, actin binding protein, 1C 0.0161358
USP37 ubiquitin specific peptidase 37 0.0158488

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.175396
PTMA prothymosin, alpha -0.16484
FTL ferritin, light polypeptide -0.108988
ENO1 enolase 1, (alpha) -0.0898243
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0876948
MT2A metallothionein 2A -0.0871917
CALCA calcitonin-related polypeptide alpha -0.0847117
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0779465
NALF1 NALCN channel auxiliary factor 1 -0.0688756
RPL26 ribosomal protein L26 -0.0684711
RPS21 ribosomal protein S21 -0.0670149
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0634772
RPS3 ribosomal protein S3 -0.0614453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0580093
RPS8 ribosomal protein S8 -0.0575908
RPLP1 ribosomal protein, large, P1 -0.0567797
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0549908
IFI6 interferon, alpha-inducible protein 6 -0.0529802
S100A9 S100 calcium binding protein A9 -0.0525954
RIMS2 regulating synaptic membrane exocytosis 2 -0.0520105
RPL19 ribosomal protein L19 -0.0512021
GPC5 glypican 5 -0.0501612
TPT1 tumor protein, translationally-controlled 1 -0.0484489
RPL11 ribosomal protein L11 -0.0477017
RPS6 ribosomal protein S6 -0.0472348
TMSB10 thymosin beta 10 -0.0471159
PEG10 paternally expressed 10 -0.0467734
RPL37A ribosomal protein L37a -0.0464331
RPL8 ribosomal protein L8 -0.0453799
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0449161
RPS19 ribosomal protein S19 -0.0448437
TXNRD1 thioredoxin reductase 1 -0.0445521
SCG2 secretogranin II -0.044385
ATP5F1E ATP synthase F1 subunit epsilon -0.0433582
SYT1 synaptotagmin I -0.0430751
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0415632
ARB2A ARB2 cotranscriptional regulator A -0.0402753
RPL23 ribosomal protein L23 -0.0399651
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0398433
ISG15 ISG15 ubiquitin-like modifier -0.0398181
GNAS GNAS complex locus -0.0393616
RPS16 ribosomal protein S16 -0.0393522
RPL37 ribosomal protein L37 -0.038299
RPL32 ribosomal protein L32 -0.0380758
RPS12 ribosomal protein S12 -0.0371111
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0370509
ACTG1 actin gamma 1 -0.0366121
RPL12 ribosomal protein L12 -0.0363516
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0359241
RPL35 ribosomal protein L35 -0.0352439
RPS11 ribosomal protein S11 -0.0350036
RPL36 ribosomal protein L36 -0.0345166
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0341541
NAP1L1 nucleosome assembly protein 1-like 1 -0.0334406
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0333067
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.033218
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0331565
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0331353
RPL5 ribosomal protein L5 -0.0330072
IGFBP5 insulin-like growth factor binding protein 5 -0.0328874
RAD21 RAD21 homolog (S. pombe) -0.0321463
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0319237
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0314407
SOX4 SRY (sex determining region Y)-box 4 -0.0313536
NOVA1 neuro-oncological ventral antigen 1 -0.0309399
PNISR PNN-interacting serine/arginine-rich protein -0.0304062
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0300904
TUBB4B tubulin, beta 4B class IVb -0.0300726
CBX3 chromobox homolog 3 -0.0300612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0296755
RPL38 ribosomal protein L38 -0.0295612
GMDS GDP-mannose 4,6-dehydratase -0.0294288
RRBP1 ribosome binding protein 1 -0.0291849
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0290276
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0289692
MT1X metallothionein 1X -0.0288754
RPL30 ribosomal protein L30 -0.0288721
TMSB4X thymosin beta 4, X-linked -0.0287574
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0287314
B2M beta-2-microglobulin -0.0287142
RPS27A ribosomal protein S27a -0.0283642
SNTG1 syntrophin, gamma 1 -0.0281246
HMGB1 high mobility group box 1 -0.0279385
PHF14 PHD finger protein 14 -0.0278105
RPL7 ribosomal protein L7 -0.0276414
RPS5 ribosomal protein S5 -0.027603
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0275843
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0275694
SYT4 synaptotagmin IV -0.0274437
RPL35A ribosomal protein L35a -0.0273536
RPS29 ribosomal protein S29 -0.0273302
CENPF centromere protein F, 350/400kDa -0.0273214
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0270922
RPS25 ribosomal protein S25 -0.0270441
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.0268906
RIT2 Ras-like without CAAX 2 -0.0268714
RPL36A ribosomal protein L36a -0.0268676
KPNB1 karyopherin (importin) beta 1 -0.0268164
RPL31 ribosomal protein L31 -0.026612
FOXC1 forkhead box C1 -0.0265884