Balsalazide (sodium hydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TJP1 tight junction protein 1 0.118435
PDE4D phosphodiesterase 4D, cAMP-specific 0.0800798
ZEB1 zinc finger E-box binding homeobox 1 0.0763455
DSCAM Down syndrome cell adhesion molecule 0.0717803
VCL vinculin 0.071443
RTN4 reticulon 4 0.0671766
NCEH1 neutral cholesterol ester hydrolase 1 0.0620544
PDGFC platelet derived growth factor C 0.0595658
TMSB4X thymosin beta 4, X-linked 0.0592454
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0592454
EZR ezrin 0.0585704
GOLGA4 golgin A4 0.0511686
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0486707
RBM39 RNA binding motif protein 39 0.0485206
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0481569
ZFAND3 zinc finger, AN1-type domain 3 0.0478616
SAMD4A sterile alpha motif domain containing 4A 0.0477626
EGFR epidermal growth factor receptor 0.0473365
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.046055
EML4 echinoderm microtubule associated protein like 4 0.0452361
ZNF608 zinc finger protein 608 0.0445846
ZNF292 zinc finger protein 292 0.0443856
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0439501
KMT2E lysine (K)-specific methyltransferase 2E 0.04311
NCKAP1 NCK-associated protein 1 0.0428449
ADAM10 ADAM metallopeptidase domain 10 0.0423532
EXT1 exostosin glycosyltransferase 1 0.041864
SSBP2 single-stranded DNA binding protein 2 0.0418391
RHOA ras homolog family member A 0.040797
KDM3A lysine (K)-specific demethylase 3A 0.0393541
QKI QKI, KH domain containing, RNA binding 0.0390874
OGA O-GlcNAcase 0.0382244
STRN3 striatin, calmodulin binding protein 3 0.0379271
HDAC9 histone deacetylase 9 0.0376522
MED13 mediator complex subunit 13 0.0371376
WAC WW domain containing adaptor with coiled-coil 0.0366799
PYGB phosphorylase, glycogen; brain 0.0365633
EEF2 eukaryotic translation elongation factor 2 0.0363665
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0362439
BIRC6 baculoviral IAP repeat containing 6 0.0360097
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0356841
NAMPT nicotinamide phosphoribosyltransferase 0.0355211
ZFC3H1 zinc finger, C3H1-type containing 0.0354837
PRRC2C proline-rich coiled-coil 2C 0.0352665
SREBF2 sterol regulatory element binding transcription factor 2 0.0338486
ARID1A AT rich interactive domain 1A (SWI-like) 0.0338224
TXNRD1 thioredoxin reductase 1 0.0337862
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.033656
CHD1 chromodomain helicase DNA binding protein 1 0.0332294
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.033158
HSPA8 heat shock 70kDa protein 8 0.0327121
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0325308
CCNL1 cyclin L1 0.0318692
CDC73 cell division cycle 73 0.0316437
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0315258
CAMTA1 calmodulin binding transcription activator 1 0.0315155
BRWD1 bromodomain and WD repeat domain containing 1 0.0311136
YAP1 Yes-associated protein 1 0.031087
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0305501
MEF2A myocyte enhancer factor 2A 0.030122
NCOA3 nuclear receptor coactivator 3 0.0299935
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0297894
PDZD8 PDZ domain containing 8 0.0294535
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0290949
FXR1 fragile X mental retardation, autosomal homolog 1 0.028572
JMJD1C jumonji domain containing 1C 0.0282342
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0278138
EP300 E1A binding protein p300 0.0274114
NBAS neuroblastoma amplified sequence 0.0273449
ADAM9 ADAM metallopeptidase domain 9 0.0273357
UBC ubiquitin C 0.0272606
ARL15 ADP-ribosylation factor-like 15 0.0270639
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0270289
TOP2B topoisomerase (DNA) II beta 180kDa 0.0266977
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0266377
MACF1 microtubule-actin crosslinking factor 1 0.0263871
MYH9 myosin, heavy chain 9, non-muscle 0.0263089
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0263006
PDS5B PDS5 cohesin associated factor B 0.0261454
COG5 component of oligomeric golgi complex 5 0.0261391
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0261172
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0259533
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0259516
RB1CC1 RB1-inducible coiled-coil 1 0.0256806
UBE2H ubiquitin-conjugating enzyme E2H 0.0255674
ATP9B ATPase, class II, type 9B 0.0254316
KIAA0232 KIAA0232 0.0251834
KMT2C lysine (K)-specific methyltransferase 2C 0.0251697
AKAP9 A kinase (PRKA) anchor protein 9 0.025167
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0251212
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0251206
SNX9 sorting nexin 9 0.0251137
RHEB Ras homolog enriched in brain 0.025062
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0248141
TCF12 transcription factor 12 0.0247839
FOXP1 forkhead box P1 0.02478
HDLBP high density lipoprotein binding protein 0.0247776
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0247743
HEG1 heart development protein with EGF-like domains 1 0.0247341
MARS1 methionyl-tRNA synthetase 1 0.0246577

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204893
PTMA prothymosin, alpha -0.154115
CPED1 cadherin-like and PC-esterase domain containing 1 -0.139732
BMP10 bone morphogenetic protein 10 -0.134456
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.13425
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.129105
PDE4B phosphodiesterase 4B, cAMP-specific -0.111291
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0852355
RPS6 ribosomal protein S6 -0.0783507
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0738339
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0726988
AHNAK AHNAK nucleoprotein -0.0652075
TM4SF1 transmembrane 4 L six family member 1 -0.0644131
SDK1 sidekick cell adhesion molecule 1 -0.0609261
CCND1 cyclin D1 -0.0568172
NPAS2 neuronal PAS domain protein 2 -0.0565632
RPS8 ribosomal protein S8 -0.0558518
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0554016
TPT1 tumor protein, translationally-controlled 1 -0.0547727
RFC3 replication factor C (activator 1) 3, 38kDa -0.0545884
PRELID2 PRELI domain containing 2 -0.0513167
DIAPH3 diaphanous-related formin 3 -0.0483612
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0476496
TTC28 tetratricopeptide repeat domain 28 -0.046297
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0459045
RPLP1 ribosomal protein, large, P1 -0.045679
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0436344
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0430788
RRBP1 ribosome binding protein 1 -0.0427485
MKI67 marker of proliferation Ki-67 -0.0407838
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0407624
CENPF centromere protein F, 350/400kDa -0.0400482
RPL12 ribosomal protein L12 -0.0385787
FHIT fragile histidine triad -0.0385175
RPS19 ribosomal protein S19 -0.0384793
RPLP0 ribosomal protein, large, P0 -0.0383612
GSE1 Gse1 coiled-coil protein -0.0381917
RPLP2 ribosomal protein, large, P2 -0.0378384
DLG1 discs, large homolog 1 (Drosophila) -0.0363302
HJURP Holliday junction recognition protein -0.0359208
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0357698
RPL31 ribosomal protein L31 -0.0355263
UNC13A unc-13 homolog A (C. elegans) -0.0354699
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0345494
ENO1 enolase 1, (alpha) -0.0331537
RPL23 ribosomal protein L23 -0.0330268
GLI3 GLI family zinc finger 3 -0.0319739
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0318775
MACROD2 MACRO domain containing 2 -0.031418
NAP1L1 nucleosome assembly protein 1-like 1 -0.0309578
RPS13 ribosomal protein S13 -0.0307126
SMC4 structural maintenance of chromosomes 4 -0.030424
RPL8 ribosomal protein L8 -0.0303887
RPL9 ribosomal protein L9 -0.0302883
RPS3 ribosomal protein S3 -0.0298843
RPS23 ribosomal protein S23 -0.0298127
NBEA neurobeachin -0.0297244
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0294533
CENPE centromere protein E, 312kDa -0.0292928
RPL36 ribosomal protein L36 -0.029214
S100A9 S100 calcium binding protein A9 -0.0288674
ASPH aspartate beta-hydroxylase -0.028649
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0285259
CAMKMT calmodulin-lysine N-methyltransferase -0.0285062
RPL34 ribosomal protein L34 -0.0282936
MEIS2 Meis homeobox 2 -0.0282532
ZNF438 zinc finger protein 438 -0.0282289
DIAPH2 diaphanous-related formin 2 -0.0281868
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0281051
TMSB10 thymosin beta 10 -0.0275008
PATJ PATJ crumbs cell polarity complex component -0.0274864
RPL26 ribosomal protein L26 -0.0273026
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0272831
PDE7B phosphodiesterase 7B -0.027262
TAS2R14 taste receptor, type 2, member 14 -0.0271419
GPHN gephyrin -0.0269432
NEBL nebulette -0.0267754
RPL19 ribosomal protein L19 -0.0266661
PFN1 profilin 1 -0.0266417
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.026512
RPL37 ribosomal protein L37 -0.0263976
RPS21 ribosomal protein S21 -0.0263507
RPS25 ribosomal protein S25 -0.0263235
ARL4C ADP-ribosylation factor-like 4C -0.0262564
COMMD10 COMM domain containing 10 -0.0257772
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0257376
NOP56 NOP56 ribonucleoprotein -0.0257239
PTPRG protein tyrosine phosphatase, receptor type, G -0.0250151
RPS12 ribosomal protein S12 -0.0250125
RPL35A ribosomal protein L35a -0.0250093
NAV2 neuron navigator 2 -0.0244867
RPL28 ribosomal protein L28 -0.0242795
FUS FUS RNA binding protein -0.0239442
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0238858
RPL37A ribosomal protein L37a -0.0234169
TUBB4B tubulin, beta 4B class IVb -0.0231626
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.02283
RPL32 ribosomal protein L32 -0.0228192
PRH1 proline-rich protein HaeIII subfamily 1 -0.0227292
AEBP2 AE binding protein 2 -0.0225046