Balsalazide (sodium hydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0962956
MYH9 myosin, heavy chain 9, non-muscle 0.0837439
TRIO trio Rho guanine nucleotide exchange factor 0.0744257
SMAD3 SMAD family member 3 0.0662783
PDE10A phosphodiesterase 10A 0.0622922
FNDC3B fibronectin type III domain containing 3B 0.0581642
NAMPT nicotinamide phosphoribosyltransferase 0.0574826
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.055289
FRMD4A FERM domain containing 4A 0.0542629
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0514812
NAV2 neuron navigator 2 0.0502097
ELL2 elongation factor, RNA polymerase II, 2 0.0499008
VEGFA vascular endothelial growth factor A 0.0477963
TENT5A terminal nucleotidyltransferase 5A 0.046784
MYOF myoferlin 0.0427407
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0407259
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0388602
MSN moesin 0.0337798
UBA6 ubiquitin-like modifier activating enzyme 6 0.0322093
ZMIZ1 zinc finger, MIZ-type containing 1 0.0317931
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316577
FN1 fibronectin 1 0.0311789
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030984
RTN4 reticulon 4 0.0303302
USP9X ubiquitin specific peptidase 9, X-linked 0.0292319
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0290553
JMJD1C jumonji domain containing 1C 0.0286348
SOD2 superoxide dismutase 2, mitochondrial 0.0281034
EXT1 exostosin glycosyltransferase 1 0.0272233
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0267709
RUNX1 runt-related transcription factor 1 0.0267371
ARRDC3 arrestin domain containing 3 0.0265238
ATP13A3 ATPase type 13A3 0.0256859
UGCG UDP-glucose ceramide glucosyltransferase 0.0248819
ATXN1 ataxin 1 0.0241876
CADM1 cell adhesion molecule 1 0.0240404
ERBIN erbb2 interacting protein 0.0231769
HDAC9 histone deacetylase 9 0.0213593
FMNL2 formin-like 2 0.0213238
SBF2 SET binding factor 2 0.0212433
DST dystonin 0.0210661
BHLHE40 basic helix-loop-helix family, member e40 0.0208816
ANO6 anoctamin 6 0.0207881
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0204411
IL1RAP interleukin 1 receptor accessory protein 0.0203415
HELZ helicase with zinc finger 0.019913
FLNA filamin A, alpha 0.0193851
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.01923
ESYT2 extended synaptotagmin-like protein 2 0.0189724
PPARD peroxisome proliferator-activated receptor delta 0.0187439
OGA O-GlcNAcase 0.0185526
EPAS1 endothelial PAS domain protein 1 0.018439
ZNF608 zinc finger protein 608 0.018333
MED13L mediator complex subunit 13-like 0.0182097
ZNF292 zinc finger protein 292 0.0182028
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.018134
FOXO3 forkhead box O3 0.0180972
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0179631
NOTCH2 notch 2 0.0177183
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0175542
AHR aryl hydrocarbon receptor 0.017536
SHB Src homology 2 domain containing adaptor protein B 0.0171471
MLPH melanophilin 0.0170968
TSC22D2 TSC22 domain family, member 2 0.0170474
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0166104
MACF1 microtubule-actin crosslinking factor 1 0.0165628
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0165487
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0165451
ZFC3H1 zinc finger, C3H1-type containing 0.0165003
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0164764
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0164485
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0164275
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.01635
FLNB filamin B, beta 0.0162474
MX1 MX dynamin-like GTPase 1 0.0161096
SPAG9 sperm associated antigen 9 0.0160112
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0159459
KMT2C lysine (K)-specific methyltransferase 2C 0.0157001
DUSP10 dual specificity phosphatase 10 0.0153099
CD109 CD109 molecule 0.0151746
SRRM2 serine/arginine repetitive matrix 2 0.0150734
CEP250 centrosomal protein 250kDa 0.0150727
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.015008
TGM2 transglutaminase 2 0.014985
TNIP1 TNFAIP3 interacting protein 1 0.014929
ACTN1 actinin, alpha 1 0.0148071
PTBP2 polypyrimidine tract binding protein 2 0.0146104
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0145958
MKI67 marker of proliferation Ki-67 0.0144999
CDK19 cyclin-dependent kinase 19 0.014472
FNIP1 folliculin interacting protein 1 0.0144518
ANXA2 annexin A2 0.0142551
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.014193
ANKRD36 ankyrin repeat domain 36 0.0141673
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0138422
TJP2 tight junction protein 2 0.0137466
PICALM phosphatidylinositol binding clathrin assembly protein 0.0136698
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0136174
SETD5 SET domain containing 5 0.0135676
CKAP5 cytoskeleton associated protein 5 0.013546

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.22932
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148703
HLA-B major histocompatibility complex, class I, B -0.108604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0952127
TPT1 tumor protein, translationally-controlled 1 -0.0892044
TMSB10 thymosin beta 10 -0.0884952
MT2A metallothionein 2A -0.0878323
FTL ferritin, light polypeptide -0.0823123
RPS12 ribosomal protein S12 -0.0723793
RPS6 ribosomal protein S6 -0.0636991
EIF1 eukaryotic translation initiation factor 1 -0.0597499
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0551258
HLA-A major histocompatibility complex, class I, A -0.055055
RPS8 ribosomal protein S8 -0.0541837
RPS24 ribosomal protein S24 -0.0540084
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0525718
AKAP12 A kinase (PRKA) anchor protein 12 -0.0524983
RPS3 ribosomal protein S3 -0.0494279
HMGA2 high mobility group AT-hook 2 -0.0486202
RPL23 ribosomal protein L23 -0.0479934
IER3 immediate early response 3 -0.0476398
NAP1L1 nucleosome assembly protein 1-like 1 -0.0458656
RPL37A ribosomal protein L37a -0.0455615
PTMA prothymosin, alpha -0.0444986
B2M beta-2-microglobulin -0.0434401
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0433559
RPL19 ribosomal protein L19 -0.0412854
RPL26 ribosomal protein L26 -0.0408477
RPLP2 ribosomal protein, large, P2 -0.0404956
RPLP1 ribosomal protein, large, P1 -0.0390247
RPS23 ribosomal protein S23 -0.0387174
BTG1 B-cell translocation gene 1, anti-proliferative -0.0381758
RPLP0 ribosomal protein, large, P0 -0.0379638
RPL35A ribosomal protein L35a -0.0371884
CDH13 cadherin 13 -0.037041
RPS19 ribosomal protein S19 -0.036764
RPL9 ribosomal protein L9 -0.0365846
CANX calnexin -0.0360978
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0358871
RPL36A ribosomal protein L36a -0.0357894
RPL12 ribosomal protein L12 -0.0351018
PLIN2 perilipin 2 -0.0334442
RPS13 ribosomal protein S13 -0.0331444
LDHA lactate dehydrogenase A -0.0322837
RPS25 ribosomal protein S25 -0.0319869
GNAS GNAS complex locus -0.0311671
RPL7A ribosomal protein L7a -0.0300453
HLA-E major histocompatibility complex, class I, E -0.0300006
RACK1 receptor for activated C kinase 1 -0.0284046
RPL11 ribosomal protein L11 -0.0280657
RPL34 ribosomal protein L34 -0.0280045
RPL5 ribosomal protein L5 -0.027795
ACTG1 actin gamma 1 -0.0266905
RPS10 ribosomal protein S10 -0.0266738
RPS4X ribosomal protein S4, X-linked -0.0258472
TMSB4X thymosin beta 4, X-linked -0.0256697
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0253176
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0251776
RPL36 ribosomal protein L36 -0.0250414
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0249915
LOC112694756 uncharaterized LOC112694756 -0.0248499
ADM adrenomedullin -0.0246978
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0245033
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0243269
SLC38A1 solute carrier family 38, member 1 -0.0241919
RPL37 ribosomal protein L37 -0.0241581
IFITM3 interferon induced transmembrane protein 3 -0.0241097
RPL32 ribosomal protein L32 -0.0240098
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0239977
RPL31 ribosomal protein L31 -0.0238307
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0236668
INTS6 integrator complex subunit 6 -0.0235923
RPL10A ribosomal protein L10a -0.0235633
IFI6 interferon, alpha-inducible protein 6 -0.0234631
BASP1 brain abundant, membrane attached signal protein 1 -0.0234598
DDIT3 DNA-damage-inducible transcript 3 -0.0234259
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0232177
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0229448
SQSTM1 sequestosome 1 -0.0228827
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228824
CALR calreticulin -0.0228733
NDRG1 N-myc downstream regulated 1 -0.0224178
GDF15 growth differentiation factor 15 -0.0222777
GLIS3 GLIS family zinc finger 3 -0.0220155
RPL27A ribosomal protein L27a -0.0219618
CD44 CD44 molecule (Indian blood group) -0.0219394
SPDYA speedy/RINGO cell cycle regulator family member A -0.0216785
ENO1 enolase 1, (alpha) -0.0214275
FRMPD4 FERM and PDZ domain containing 4 -0.0213485
RPL15 ribosomal protein L15 -0.0211638
RPS17 ribosomal protein S17 -0.0210262
RPL30 ribosomal protein L30 -0.020992
AFF3 AF4/FMR2 family, member 3 -0.0209736
RPS14 ribosomal protein S14 -0.0204723
RPS27A ribosomal protein S27a -0.0200799
RPS21 ribosomal protein S21 -0.0199968
S100A9 S100 calcium binding protein A9 -0.0198456
FTH1 ferritin, heavy polypeptide 1 -0.0194527
RPL8 ribosomal protein L8 -0.0191926
TPM4 tropomyosin 4 -0.0191689