Balsalazide (sodium hydrate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.246155
ELL2 elongation factor, RNA polymerase II, 2 0.088061
MYH9 myosin, heavy chain 9, non-muscle 0.0821448
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0644441
FTH1 ferritin, heavy polypeptide 1 0.0598044
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0593615
PRELID2 PRELI domain containing 2 0.0587849
NRXN3 neurexin 3 0.0582658
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0578275
BHLHE40 basic helix-loop-helix family, member e40 0.0501698
SOD2 superoxide dismutase 2, mitochondrial 0.0478228
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0473669
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0451214
CLIP2 CAP-GLY domain containing linker protein 2 0.0449311
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0440381
HOOK2 hook microtubule-tethering protein 2 0.0439985
ESYT2 extended synaptotagmin-like protein 2 0.0438959
KYNU kynureninase 0.0427281
RUNX1 runt-related transcription factor 1 0.0419622
VEGFA vascular endothelial growth factor A 0.0399897
MACF1 microtubule-actin crosslinking factor 1 0.0395914
CD44 CD44 molecule (Indian blood group) 0.0394372
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0376149
XPO1 exportin 1 0.0359276
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0355944
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0345643
VEGFC vascular endothelial growth factor C 0.0343461
TPM3 tropomyosin 3 0.0338405
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0338156
TENT5A terminal nucleotidyltransferase 5A 0.0329642
MTREX Mtr4 exosome RNA helicase 0.0328466
JARID2 jumonji, AT rich interactive domain 2 0.0325774
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0325745
AKAP13 A kinase (PRKA) anchor protein 13 0.0324367
FNDC3B fibronectin type III domain containing 3B 0.0319745
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315552
NCAPG2 non-SMC condensin II complex, subunit G2 0.031505
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0309618
DIAPH3 diaphanous-related formin 3 0.0309498
FNDC3A fibronectin type III domain containing 3A 0.0307773
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0306308
CTSB cathepsin B 0.0300568
FAM13A family with sequence similarity 13, member A 0.0296236
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0294156
CLTC clathrin, heavy chain (Hc) 0.0291589
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0289345
COPA coatomer protein complex, subunit alpha 0.0288582
MATR3 matrin 3 0.0286093
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0284256
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0283571
SAMD4A sterile alpha motif domain containing 4A 0.0279445
CDK6 cyclin-dependent kinase 6 0.0277193
SEPTIN9 septin 9 0.0275287
MARCHF7 membrane associated ring-CH-type finger 7 0.0269843
COL7A1 collagen, type VII, alpha 1 0.0268792
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0266997
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0266232
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0263221
CTNND1 catenin (cadherin-associated protein), delta 1 0.0262306
MSN moesin 0.0262056
POT1 protection of telomeres 1 0.0261304
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0259748
BACE2 beta-site APP-cleaving enzyme 2 0.0259569
PTPRM protein tyrosine phosphatase, receptor type, M 0.0254253
RSAD2 radical S-adenosyl methionine domain containing 2 0.025421
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.0251964
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.024933
CADM1 cell adhesion molecule 1 0.0249213
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0248897
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246335
TAPBP TAP binding protein (tapasin) 0.0245035
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0241866
TOP1 topoisomerase (DNA) I 0.0237859
ZNF638 zinc finger protein 638 0.023783
TNIP1 TNFAIP3 interacting protein 1 0.0237001
USP47 ubiquitin specific peptidase 47 0.0236835
PCM1 pericentriolar material 1 0.0235026
RAP1B RAP1B, member of RAS oncogene family 0.023471
COL5A1 collagen, type V, alpha 1 0.0233868
NDRG1 N-myc downstream regulated 1 0.0233655
DENND4C DENN/MADD domain containing 4C 0.0233445
SHB Src homology 2 domain containing adaptor protein B 0.0230203
FLNA filamin A, alpha 0.0229583
ARB2A ARB2 cotranscriptional regulator A 0.0228201
GSE1 Gse1 coiled-coil protein 0.022754
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0227006
ATP13A3 ATPase type 13A3 0.0226868
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0226217
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0223852
SMAD3 SMAD family member 3 0.0218128
COL4A2 collagen, type IV, alpha 2 0.0216942
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0216383
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0216061
ERBIN erbb2 interacting protein 0.0215425
TXNDC11 thioredoxin domain containing 11 0.0215118
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0214819
ECE1 endothelin converting enzyme 1 0.0212325
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0211913
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0211785
COL4A1 collagen, type IV, alpha 1 0.0211767

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.210324
TMSB10 thymosin beta 10 -0.181118
VIM vimentin -0.178104
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142891
FTL ferritin, light polypeptide -0.121398
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106781
MT1X metallothionein 1X -0.099441
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0872906
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0852417
CALD1 caldesmon 1 -0.0835656
F3 coagulation factor III (thromboplastin, tissue factor) -0.0709514
B2M beta-2-microglobulin -0.0693712
TPT1 tumor protein, translationally-controlled 1 -0.0679384
PRSS23 protease, serine, 23 -0.0623128
HLA-B major histocompatibility complex, class I, B -0.0603764
S100A6 S100 calcium binding protein A6 -0.0577365
TNS3 tensin 3 -0.056273
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0561763
ZMYND8 zinc finger, MYND-type containing 8 -0.0560737
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.055824
FN1 fibronectin 1 -0.0533431
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.052149
TPM4 tropomyosin 4 -0.051201
RPL34 ribosomal protein L34 -0.0506288
ACTG1 actin gamma 1 -0.0473304
TGFBI transforming growth factor, beta-induced, 68kDa -0.0456196
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0454991
CALU calumenin -0.0452417
CAVIN1 caveolae associated protein 1 -0.0450472
RPL26 ribosomal protein L26 -0.0441403
KAZN kazrin, periplakin interacting protein -0.043387
CALR calreticulin -0.0431651
MAP1B microtubule-associated protein 1B -0.0429625
HLA-C major histocompatibility complex, class I, C -0.0424617
CANX calnexin -0.0407882
CAV1 caveolin 1, caveolae protein, 22kDa -0.0404092
GNAS GNAS complex locus -0.0400129
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0398588
RRBP1 ribosome binding protein 1 -0.039351
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.03648
RAI14 retinoic acid induced 14 -0.0362946
RPS6 ribosomal protein S6 -0.0357594
VDAC1 voltage-dependent anion channel 1 -0.0356729
CBX3 chromobox homolog 3 -0.0355555
S100A10 S100 calcium binding protein A10 -0.0355521
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0346715
H3-3B H3.3 histone B -0.0344953
RPS14 ribosomal protein S14 -0.0339364
COL1A1 collagen, type I, alpha 1 -0.0329105
CDK13 cyclin-dependent kinase 13 -0.0321459
COL1A2 collagen, type I, alpha 2 -0.0316817
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0315452
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0313222
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.03113
RPL35A ribosomal protein L35a -0.0310106
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0308264
MED13L mediator complex subunit 13-like -0.0298773
BIRC6 baculoviral IAP repeat containing 6 -0.0298405
STC1 stanniocalcin 1 -0.0297835
RPL11 ribosomal protein L11 -0.0290412
S100A9 S100 calcium binding protein A9 -0.029001
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0289105
SEPTIN7 septin 7 -0.028697
MYADM myeloid-associated differentiation marker -0.0282791
PKM pyruvate kinase, muscle -0.0282369
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0281422
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0280676
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0279275
GLG1 golgi glycoprotein 1 -0.0272759
RPLP1 ribosomal protein, large, P1 -0.0271321
AKAP12 A kinase (PRKA) anchor protein 12 -0.027072
TM9SF3 transmembrane 9 superfamily member 3 -0.027005
RPL28 ribosomal protein L28 -0.0269654
PDE4D phosphodiesterase 4D, cAMP-specific -0.0266897
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0265029
OSMR oncostatin M receptor -0.0264574
SDC4 syndecan 4 -0.0264063
PTPRF protein tyrosine phosphatase, receptor type, F -0.0263522
TM4SF1 transmembrane 4 L six family member 1 -0.026051
CD63 CD63 molecule -0.0255853
GARS1 glycyl-tRNA synthetase 1 -0.0255308
PSD3 pleckstrin and Sec7 domain containing 3 -0.0255218
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0253973
PDIA3 protein disulfide isomerase family A, member 3 -0.0253915
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.025366
RAB31 RAB31, member RAS oncogene family -0.0253162
GCC2 GRIP and coiled-coil domain containing 2 -0.025154
HSPB1 heat shock 27kDa protein 1 -0.0250273
RPS21 ribosomal protein S21 -0.0248639
RPS23 ribosomal protein S23 -0.0248625
KRIT1 KRIT1, ankyrin repeat containing -0.0246486
ANXA2 annexin A2 -0.0242999
USP34 ubiquitin specific peptidase 34 -0.0241754
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0240891
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0239277
RPS27A ribosomal protein S27a -0.0239189
YIPF5 Yip1 domain family, member 5 -0.0234752
TFPI2 tissue factor pathway inhibitor 2 -0.0233894
LAMB3 laminin, beta 3 -0.0232198