Balsalazide (sodium hydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0875769
BCL2L1 BCL2-like 1 0.0828303
SAMD4A sterile alpha motif domain containing 4A 0.0749909
NEBL nebulette 0.0737918
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0726725
SMAD3 SMAD family member 3 0.0592815
TJP1 tight junction protein 1 0.0564226
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0528585
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0526103
EPS8 epidermal growth factor receptor pathway substrate 8 0.0523141
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0522423
WWC1 WW and C2 domain containing 1 0.052083
EZR ezrin 0.0511428
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0498902
AKAP13 A kinase (PRKA) anchor protein 13 0.049281
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.045915
NCEH1 neutral cholesterol ester hydrolase 1 0.0445051
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0427815
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0417473
MYO1E myosin IE 0.0415598
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0375506
DIAPH1 diaphanous-related formin 1 0.0368428
VCL vinculin 0.0366903
BRD2 bromodomain containing 2 0.0362957
PICALM phosphatidylinositol binding clathrin assembly protein 0.0348667
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.033486
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0327067
CPNE1 copine I 0.0323886
MACF1 microtubule-actin crosslinking factor 1 0.0320808
HSPA8 heat shock 70kDa protein 8 0.0316973
PDLIM5 PDZ and LIM domain 5 0.0316918
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0314187
FLNA filamin A, alpha 0.031306
FAM3C family with sequence similarity 3, member C 0.0312305
FHL2 four and a half LIM domains 2 0.0311988
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0309681
RAB7A RAB7A, member RAS oncogene family 0.0300015
APLP2 amyloid beta (A4) precursor-like protein 2 0.0296791
COPA coatomer protein complex, subunit alpha 0.0290624
AKAP9 A kinase (PRKA) anchor protein 9 0.0288924
SVIL supervillin 0.0285376
RHOA ras homolog family member A 0.0281403
UBE2H ubiquitin-conjugating enzyme E2H 0.0278829
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0276461
CEMIP2 cell migration inducing hyaluronidase 2 0.0272282
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0269429
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268648
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0267712
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0262121
EGFR epidermal growth factor receptor 0.0261541
TSC22D2 TSC22 domain family, member 2 0.0261415
NUP98 nucleoporin 98kDa 0.0256667
DOCK5 dedicator of cytokinesis 5 0.0255629
NXF1 nuclear RNA export factor 1 0.0254952
KMT2E lysine (K)-specific methyltransferase 2E 0.0252731
EXT1 exostosin glycosyltransferase 1 0.0251294
SPAG9 sperm associated antigen 9 0.0250996
YAP1 Yes-associated protein 1 0.0249986
ANKRD11 ankyrin repeat domain 11 0.0247123
SHB Src homology 2 domain containing adaptor protein B 0.024645
LRRC1 leucine rich repeat containing 1 0.0245533
ARHGAP42 Rho GTPase activating protein 42 0.0244851
TES testin LIM domain protein 0.0243413
DST dystonin 0.0242385
KDM6A lysine (K)-specific demethylase 6A 0.0241809
RTN4 reticulon 4 0.0240884
CKAP5 cytoskeleton associated protein 5 0.0240577
VEGFA vascular endothelial growth factor A 0.0240162
STK24 serine/threonine kinase 24 0.0238768
PPARD peroxisome proliferator-activated receptor delta 0.0236975
AMOTL2 angiomotin like 2 0.0235014
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0233043
ATP13A3 ATPase type 13A3 0.0228537
BCL9L B-cell CLL/lymphoma 9-like 0.0227781
GSK3B glycogen synthase kinase 3 beta 0.0222336
RASAL2 RAS protein activator like 2 0.0217775
KIAA0232 KIAA0232 0.0217308
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0217052
POTEF POTE ankyrin domain family, member F 0.021687
TOP1 topoisomerase (DNA) I 0.0216635
SGMS2 sphingomyelin synthase 2 0.0214463
ZFC3H1 zinc finger, C3H1-type containing 0.0212621
NAMPT nicotinamide phosphoribosyltransferase 0.0211299
STX3 syntaxin 3 0.0209329
TUFT1 tuftelin 1 0.0205613
NEK7 NIMA-related kinase 7 0.020496
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0204806
SND1 staphylococcal nuclease and tudor domain containing 1 0.0203716
USP47 ubiquitin specific peptidase 47 0.0202889
SIK3 SIK family kinase 3 0.0202301
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0200006
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0199564
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0199257
INO80 INO80 complex subunit 0.0198055
EIF5 eukaryotic translation initiation factor 5 0.0197267
MON2 MON2 homolog (S. cerevisiae) 0.0195866
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.019541
MALT1 MALT1 paracaspase 0.0193637
GDI2 GDP dissociation inhibitor 2 0.019343
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0192545

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.207234
MAML2 mastermind-like 2 (Drosophila) -0.163359
TMSB10 thymosin beta 10 -0.146184
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.101048
SDK1 sidekick cell adhesion molecule 1 -0.0955378
FTL ferritin, light polypeptide -0.0878607
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0849343
KRT8 keratin 8, type II -0.0804777
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0769869
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0768138
CCND1 cyclin D1 -0.0750448
NFIA nuclear factor I/A -0.0745865
TPT1 tumor protein, translationally-controlled 1 -0.0713493
EHBP1 EH domain binding protein 1 -0.0638883
RPS6 ribosomal protein S6 -0.0608183
NDRG1 N-myc downstream regulated 1 -0.0607767
UBC ubiquitin C -0.0604166
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0600299
ZBTB20 zinc finger and BTB domain containing 20 -0.0597474
AHNAK AHNAK nucleoprotein -0.0592768
RPLP1 ribosomal protein, large, P1 -0.0587199
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0556563
TMEM123 transmembrane protein 123 -0.0554799
GNAS GNAS complex locus -0.0542652
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.053605
PERP PERP, TP53 apoptosis effector -0.0523339
RPS21 ribosomal protein S21 -0.051636
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0515979
IER3 immediate early response 3 -0.0512174
RPL35A ribosomal protein L35a -0.049904
EPCAM epithelial cell adhesion molecule -0.0493501
ZMYND8 zinc finger, MYND-type containing 8 -0.0477705
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0477591
RPS27A ribosomal protein S27a -0.0476031
CADPS Ca++-dependent secretion activator -0.0475834
GMDS GDP-mannose 4,6-dehydratase -0.0473699
EXOC4 exocyst complex component 4 -0.0468362
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0451699
SQSTM1 sequestosome 1 -0.0448915
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.044867
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0447057
LOC112694756 uncharaterized LOC112694756 -0.0436638
RPS24 ribosomal protein S24 -0.0427748
RPL12 ribosomal protein L12 -0.0425771
KDM3A lysine (K)-specific demethylase 3A -0.0414311
RPLP2 ribosomal protein, large, P2 -0.0413823
MACC1 metastasis associated in colon cancer 1 -0.0400865
KRT19 keratin 19, type I -0.039776
S100A6 S100 calcium binding protein A6 -0.0389048
RPS12 ribosomal protein S12 -0.0384899
RAD51B RAD51 paralog B -0.0378687
SLC38A1 solute carrier family 38, member 1 -0.0378424
RPS25 ribosomal protein S25 -0.0378295
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0373404
H1-0 H1.0 linker histone -0.0372582
TPM4 tropomyosin 4 -0.0365005
ACTN4 actinin, alpha 4 -0.0362601
PGK1 phosphoglycerate kinase 1 -0.0362278
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0362134
S100A10 S100 calcium binding protein A10 -0.0361836
RPL31 ribosomal protein L31 -0.0356544
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0356095
DENND1A DENN/MADD domain containing 1A -0.0350012
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0348748
RPS3 ribosomal protein S3 -0.0348338
RPL23 ribosomal protein L23 -0.0346131
SPDYA speedy/RINGO cell cycle regulator family member A -0.0344616
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0343915
SERINC5 serine incorporator 5 -0.034386
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0341786
KRT18 keratin 18, type I -0.0336856
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0335195
SOX4 SRY (sex determining region Y)-box 4 -0.0331634
B2M beta-2-microglobulin -0.0328133
ZMYM2 zinc finger, MYM-type 2 -0.0324985
SRRM3 serine/arginine repetitive matrix 3 -0.0323383
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0321039
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0318983
RPL18 ribosomal protein L18 -0.0318495
RPLP0 ribosomal protein, large, P0 -0.0314098
XYLT1 xylosyltransferase I -0.0310457
RPL37A ribosomal protein L37a -0.0308969
MSI2 musashi RNA-binding protein 2 -0.0308885
HMGA2 high mobility group AT-hook 2 -0.0308672
CEMIP cell migration inducing protein, hyaluronan binding -0.0306903
ANO1 anoctamin 1, calcium activated chloride channel -0.0306101
CANX calnexin -0.0305161
RAD21 RAD21 homolog (S. pombe) -0.0296775
ARHGAP5 Rho GTPase activating protein 5 -0.0294701
RSL1D1 ribosomal L1 domain containing 1 -0.0291671
RPS11 ribosomal protein S11 -0.0288293
PKM pyruvate kinase, muscle -0.0288264
RPS13 ribosomal protein S13 -0.0288092
RPL32 ribosomal protein L32 -0.0287048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0282661
CBX3 chromobox homolog 3 -0.028069
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0280278
RPL36A ribosomal protein L36a -0.027709
PATJ PATJ crumbs cell polarity complex component -0.0276668
RPS5 ribosomal protein S5 -0.0272989