Balsalazide (sodium hydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Balsalazide (sodium hydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Balsalazide (sodium hydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.151929
AKAP12 A kinase (PRKA) anchor protein 12 0.130652
NALF1 NALCN channel auxiliary factor 1 0.114691
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111409
CXCL8 chemokine (C-X-C motif) ligand 8 0.102244
ELL2 elongation factor, RNA polymerase II, 2 0.097487
CD44 CD44 molecule (Indian blood group) 0.0794702
FNDC3B fibronectin type III domain containing 3B 0.0782044
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0779546
MYO10 myosin X 0.0756467
ASPH aspartate beta-hydroxylase 0.0655354
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0654924
NAMPT nicotinamide phosphoribosyltransferase 0.0617202
MT2A metallothionein 2A 0.0614539
FMNL2 formin-like 2 0.0600731
JARID2 jumonji, AT rich interactive domain 2 0.058638
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0582281
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0574475
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0562995
TRIO trio Rho guanine nucleotide exchange factor 0.0548752
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0539019
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0490242
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0486872
SOD2 superoxide dismutase 2, mitochondrial 0.046796
MYH9 myosin, heavy chain 9, non-muscle 0.0446531
RASA2 RAS p21 protein activator 2 0.043864
RPLP1 ribosomal protein, large, P1 0.0435259
TPT1 tumor protein, translationally-controlled 1 0.0429651
ABI3BP ABI family, member 3 (NESH) binding protein 0.0411799
RPL23 ribosomal protein L23 0.0394938
GLIS3 GLIS family zinc finger 3 0.0392227
TIMP1 TIMP metallopeptidase inhibitor 1 0.0383249
FTH1 ferritin, heavy polypeptide 1 0.0378602
POTEF POTE ankyrin domain family, member F 0.0367954
BHLHE40 basic helix-loop-helix family, member e40 0.0360594
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0355901
B2M beta-2-microglobulin 0.0339468
RNF145 ring finger protein 145 0.0333736
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0326861
ZSWIM6 zinc finger, SWIM-type containing 6 0.0321786
LTBP1 latent transforming growth factor beta binding protein 1 0.0316824
EXT1 exostosin glycosyltransferase 1 0.0309173
ENO1 enolase 1, (alpha) 0.0308588
FAM13A family with sequence similarity 13, member A 0.0306586
TOP1 topoisomerase (DNA) I 0.0305109
RPS6 ribosomal protein S6 0.0300203
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.029987
IER3 immediate early response 3 0.0295477
RPS8 ribosomal protein S8 0.0294616
ANO6 anoctamin 6 0.0294103
PRKG1 protein kinase, cGMP-dependent, type I 0.0293516
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0289081
RPL12 ribosomal protein L12 0.0288969
PTK2 protein tyrosine kinase 2 0.0276687
RPLP0 ribosomal protein, large, P0 0.0276047
MMP2 matrix metallopeptidase 2 0.0274913
NAP1L1 nucleosome assembly protein 1-like 1 0.0274819
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0272642
NAV1 neuron navigator 1 0.0268304
HSPA8 heat shock 70kDa protein 8 0.0265734
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0262502
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262237
SNX9 sorting nexin 9 0.0256901
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0251856
GPHN gephyrin 0.0251311
PRELID2 PRELI domain containing 2 0.025084
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.024754
RPS12 ribosomal protein S12 0.0246983
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0242748
FLNA filamin A, alpha 0.0241384
RYBP RING1 and YY1 binding protein 0.0240966
COL6A3 collagen, type VI, alpha 3 0.0239125
JAK1 Janus kinase 1 0.0239109
EEF2 eukaryotic translation elongation factor 2 0.0237873
COL5A2 collagen, type V, alpha 2 0.0236809
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236111
VCL vinculin 0.0233752
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0232076
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0229824
LIMS1 LIM and senescent cell antigen-like domains 1 0.0228694
ANXA5 annexin A5 0.0226283
ACTG1 actin gamma 1 0.0224903
RACK1 receptor for activated C kinase 1 0.0219808
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0219704
RPL37A ribosomal protein L37a 0.0218814
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0218755
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.0218518
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0218316
RLF rearranged L-myc fusion 0.0217658
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.021749
RPL26 ribosomal protein L26 0.0216763
MACF1 microtubule-actin crosslinking factor 1 0.0215378
MMP1 matrix metallopeptidase 1 0.0213984
ZEB2 zinc finger E-box binding homeobox 2 0.0212614
WTAP Wilms tumor 1 associated protein 0.0210253
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0209335
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0207367
QKI QKI, KH domain containing, RNA binding 0.0204495
FNDC3A fibronectin type III domain containing 3A 0.0203216
IGFBP7 insulin-like growth factor binding protein 7 0.0202984

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.189506
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.171409
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.131003
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.112535
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0953172
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0646139
PDE4D phosphodiesterase 4D, cAMP-specific -0.0588673
COL1A1 collagen, type I, alpha 1 -0.055864
ARHGAP21 Rho GTPase activating protein 21 -0.0535149
ANKRD28 ankyrin repeat domain 28 -0.0518687
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0496329
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0466461
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0464843
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0459297
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0448163
MON2 MON2 homolog (S. cerevisiae) -0.041603
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0408332
AFF3 AF4/FMR2 family, member 3 -0.039431
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0392779
COL1A2 collagen, type I, alpha 2 -0.0386989
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0383095
DST dystonin -0.0382635
BIRC6 baculoviral IAP repeat containing 6 -0.0377997
FBN1 fibrillin 1 -0.0367354
GOLGA4 golgin A4 -0.0356188
NDRG1 N-myc downstream regulated 1 -0.0351614
APOLD1 apolipoprotein L domain containing 1 -0.033925
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0332785
PIBF1 progesterone immunomodulatory binding factor 1 -0.0331764
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0330448
MBD5 methyl-CpG binding domain protein 5 -0.0328937
SASH1 SAM and SH3 domain containing 1 -0.0324007
NBEAL1 neurobeachin-like 1 -0.032201
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0316381
AKAP9 A kinase (PRKA) anchor protein 9 -0.0303389
GREM1 gremlin 1, DAN family BMP antagonist -0.0302073
ATM ATM serine/threonine kinase -0.0298833
SRP54 signal recognition particle 54kDa -0.0295791
S100A6 S100 calcium binding protein A6 -0.0294046
LMAN1 lectin, mannose-binding, 1 -0.0292866
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0287066
NF1 neurofibromin 1 -0.0285293
INHBA inhibin, beta A -0.0274666
IGFBP4 insulin-like growth factor binding protein 4 -0.0273874
SEC24D SEC24 family member D -0.0273857
LIMCH1 LIM and calponin homology domains 1 -0.0273306
USP34 ubiquitin specific peptidase 34 -0.027069
TMEM165 transmembrane protein 165 -0.0261328
TTC3 tetratricopeptide repeat domain 3 -0.0255571
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0254872
SEC31A SEC31 homolog A (S. cerevisiae) -0.0243559
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0240015
SCFD1 sec1 family domain containing 1 -0.0239846
CALR calreticulin -0.023699
MMP12 matrix metallopeptidase 12 -0.0233928
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0232179
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0231647
CEP95 centrosomal protein 95kDa -0.022418
MYADM myeloid-associated differentiation marker -0.0224035
TMF1 TATA element modulatory factor 1 -0.0221711
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0220881
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -0.0219438
CHD9 chromodomain helicase DNA binding protein 9 -0.0218206
LCORL ligand dependent nuclear receptor corepressor-like -0.0215823
GCC2 GRIP and coiled-coil domain containing 2 -0.0213458
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0210759
LOX lysyl oxidase -0.0210307
NKTR natural killer cell triggering receptor -0.0209244
TCF12 transcription factor 12 -0.0207806
COG6 component of oligomeric golgi complex 6 -0.0207548
HDLBP high density lipoprotein binding protein -0.020753
VMP1 vacuole membrane protein 1 -0.0206993
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0206435
IARS1 isoleucyl-tRNA synthetase 1 -0.0206123
FRMPD4 FERM and PDZ domain containing 4 -0.0205995
DNER delta/notch-like EGF repeat containing -0.0202255
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0201447
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0199439
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0198787
ARHGAP24 Rho GTPase activating protein 24 -0.0198001
ARHGAP35 Rho GTPase activating protein 35 -0.0196143
MAP1B microtubule-associated protein 1B -0.0195757
BPTF bromodomain PHD finger transcription factor -0.0194682
PDIA3 protein disulfide isomerase family A, member 3 -0.0194119
ZMAT3 zinc finger, matrin-type 3 -0.0193827
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0193558
TM4SF1 transmembrane 4 L six family member 1 -0.0193289
CENPE centromere protein E, 312kDa -0.0191818
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0191121
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0189755
TRAM2 translocation associated membrane protein 2 -0.0187588
ARF4 ADP-ribosylation factor 4 -0.0186662
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0186495
RB1 retinoblastoma 1 -0.018589
ZEB1 zinc finger E-box binding homeobox 1 -0.0185291
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0183967
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0183515
WASF2 WAS protein family, member 2 -0.0182152
TBC1D23 TBC1 domain family, member 23 -0.0180857
PRSS23 protease, serine, 23 -0.0178603