Basal Cell Carcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471). (Experimental Factor Ontology, EFO_0004193)
External Link https://www.disgenet.org/browser/0/1/0/C1854245
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Genes

109 genes associated with the disease Basal Cell Carcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
ASIP agouti signaling protein
ATF2 activating transcription factor 2
ATP11A ATPase, class VI, type 11A
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BRCA2 breast cancer 2, early onset
C7ORF72 chromosome 7 open reading frame 72
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC88B coiled-coil domain containing 88B
CCL5 chemokine (C-C motif) ligand 5
CCNH cyclin H
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CLPTM1L CLPTM1-like
COLEC10 collectin sub-family member 10 (C-type lectin)
CPVL carboxypeptidase, vitellogenic-like
CTSH cathepsin H
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
EDN1 endothelin 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGFR epidermal growth factor receptor
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
EXO1 exonuclease 1
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FRMD4A FERM domain containing 4A
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GPR183 G protein-coupled receptor 183
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
HAL histidine ammonia-lyase
HAUS6 HAUS augmin-like complex, subunit 6
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HLA-B major histocompatibility complex, class I, B
HPGDS hematopoietic prostaglandin D synthase
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
IRF4 interferon regulatory factor 4
ITGAV integrin, alpha V
JDP2 Jun dimerization protein 2
KANK1 KN motif and ankyrin repeat domains 1
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LGALS7 lectin, galactoside-binding, soluble, 7
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPP LIM domain containing preferred translocation partner in lipoma
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MLANA melan-A
MMP9 matrix metallopeptidase 9
MSH3 mutS homolog 3
MUC1 mucin 1, cell surface associated
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PADI6 peptidyl arginine deiminase, type VI
PLAGL1 pleiomorphic adenoma gene-like 1
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKCA protein kinase C, alpha
PTCH1 patched 1
PTCH2 patched 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALY RALY heterogeneous nuclear ribonucleoprotein
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCC2 regulator of chromosome condensation 2
RGS22 regulator of G-protein signaling 22
RTL1 retrotransposon-like 1
RUNX3 runt-related transcription factor 3
S100A6 S100 calcium binding protein A6
SCAF1 SR-related CTD-associated factor 1
SLC45A2 solute carrier family 45, member 2
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17
SMC2 structural maintenance of chromosomes 2
SMO smoothened, frizzled class receptor
SOX10 SRY (sex determining region Y)-box 10
SOX9 SRY (sex determining region Y)-box 9
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM3 transglutaminase 3
TNF tumor necrosis factor
TNS3 tensin 3
TP53 tumor protein p53
TP63 tumor protein p63
TRPS1 trichorhinophalangeal syndrome I
TYMP thymidine phosphorylase
TYR tyrosinase
UBAC2 UBA domain containing 2
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
ZBTB7B zinc finger and BTB domain containing 7B
ZNF365 zinc finger protein 365