| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135564787 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Bay 60-7550 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRDM16 | PR domain containing 16 | 1.63 |
| PDE7A | phosphodiesterase 7A | 1.02 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.9 |
| NGFR | nerve growth factor receptor | 0.82 |
| ZSCAN29 | zinc finger and SCAN domain containing 29 | 0.77 |
| PARD6A | par-6 family cell polarity regulator alpha | 0.72 |
| C6ORF141 | chromosome 6 open reading frame 141 | 0.71 |
| SEPTIN5 | septin 5 | 0.64 |
| MIDN | midnolin | 0.63 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.61 |
| POF1B | premature ovarian failure, 1B | 0.59 |
| PLXNB1 | plexin B1 | 0.58 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.55 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.54 |
| B2M | beta-2-microglobulin | 0.51 |
| TULP4 | tubby like protein 4 | 0.51 |
| GCH1 | GTP cyclohydrolase 1 | 0.5 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.5 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.49 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.49 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.49 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.48 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.47 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.46 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.45 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.45 |
| RWDD2A | RWD domain containing 2A | 0.44 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.44 |
| ANKRD36 | ankyrin repeat domain 36 | 0.44 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.43 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.43 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.42 |
| TMC6 | transmembrane channel-like 6 | 0.41 |
| USP19 | ubiquitin specific peptidase 19 | 0.41 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.4 |
| ABHD4 | abhydrolase domain containing 4 | 0.4 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | 0.39 |
| NAA80 | N-alpha-acetyltransferase 80, NatH catalytic subunit | 0.39 |
| CD81 | CD81 molecule | 0.39 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.39 |
| CAPN5 | calpain 5 | 0.39 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.39 |
| INO80D | INO80 complex subunit D | 0.39 |
| WWC3 | WWC family member 3 | 0.38 |
| SLC16A6 | solute carrier family 16, member 6 | 0.38 |
| CES2 | carboxylesterase 2 | 0.38 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.38 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.37 |
| CFD | complement factor D (adipsin) | 0.37 |
| TMEM14C | transmembrane protein 14C | 0.37 |
| SLC41A1 | solute carrier family 41 (magnesium transporter), member 1 | 0.37 |
| MAGEA2 | melanoma antigen family A2 | 0.36 |
| YBEY | ybeY metallopeptidase (putative) | 0.36 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.36 |
| METTL7A | methyltransferase like 7A | 0.36 |
| TRIM62 | tripartite motif containing 62 | 0.36 |
| AGTRAP | angiotensin II receptor-associated protein | 0.35 |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.35 |
| ELL3 | elongation factor RNA polymerase II-like 3 | 0.35 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.35 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | 0.35 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 0.35 |
| TUFT1 | tuftelin 1 | 0.35 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.34 |
| TBX3 | T-box 3 | 0.34 |
| TCTN3 | tectonic family member 3 | 0.34 |
| ZNF226 | zinc finger protein 226 | 0.34 |
| MSX2 | msh homeobox 2 | 0.33 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.33 |
| FOXO1 | forkhead box O1 | 0.33 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.33 |
| ABHD2 | abhydrolase domain containing 2 | 0.33 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.33 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.33 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.33 |
| SEC61B | Sec61 beta subunit | 0.33 |
| XIRP2 | xin actin binding repeat containing 2 | 0.33 |
| AREG | amphiregulin | 0.33 |
| HMGB2 | high mobility group box 2 | 0.32 |
| GDF15 | growth differentiation factor 15 | 0.32 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.32 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.32 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.32 |
| SDF2 | stromal cell-derived factor 2 | 0.32 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | 0.32 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.31 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.31 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.31 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.31 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | 0.31 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.31 |
| ANO8 | anoctamin 8 | 0.31 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.3 |
| DLEC1 | deleted in lung and esophageal cancer 1 | 0.3 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | 0.3 |
| PARL | presenilin associated, rhomboid-like | 0.3 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | 0.3 |
| MTIF3 | mitochondrial translational initiation factor 3 | 0.3 |
| RNF167 | ring finger protein 167 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN5 | tetraspanin 5 | -0.84 |
| ANKRD22 | ankyrin repeat domain 22 | -0.81 |
| HHEX | hematopoietically expressed homeobox | -0.81 |
| ZNF839 | zinc finger protein 839 | -0.73 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.72 |
| PROS1 | protein S (alpha) | -0.68 |
| CPA4 | carboxypeptidase A4 | -0.65 |
| CCN3 | cellular communication network factor 3 | -0.62 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.62 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.62 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.61 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.61 |
| BDNF | brain-derived neurotrophic factor | -0.6 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.58 |
| PRKD3 | protein kinase D3 | -0.57 |
| ATE1 | arginyltransferase 1 | -0.56 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -0.55 |
| MNT | MAX network transcriptional repressor | -0.52 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.52 |
| DENND4B | DENN/MADD domain containing 4B | -0.51 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.51 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.49 |
| TRIM15 | tripartite motif containing 15 | -0.49 |
| ELK1 | ELK1, member of ETS oncogene family | -0.49 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.48 |
| TMEM200A | transmembrane protein 200A | -0.48 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.47 |
| MAST3 | microtubule associated serine/threonine kinase 3 | -0.47 |
| CORO2B | coronin, actin binding protein, 2B | -0.46 |
| TMEM40 | transmembrane protein 40 | -0.46 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.45 |
| KLK6 | kallikrein-related peptidase 6 | -0.44 |
| USP27X | ubiquitin specific peptidase 27, X-linked | -0.44 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.44 |
| IL17RB | interleukin 17 receptor B | -0.44 |
| PLA2G12A | phospholipase A2, group XIIA | -0.43 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.43 |
| BPTF | bromodomain PHD finger transcription factor | -0.43 |
| NABP1 | nucleic acid binding protein 1 | -0.43 |
| TRIB1 | tribbles pseudokinase 1 | -0.43 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.42 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.42 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.42 |
| ZNF451 | zinc finger protein 451 | -0.42 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.42 |
| SLC38A2 | solute carrier family 38, member 2 | -0.41 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.41 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -0.41 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | -0.4 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.4 |
| ZNF564 | zinc finger protein 564 | -0.4 |
| NRP1 | neuropilin 1 | -0.4 |
| STK19 | serine/threonine kinase 19 | -0.39 |
| TRAF5 | TNF receptor-associated factor 5 | -0.39 |
| TOX2 | TOX high mobility group box family member 2 | -0.39 |
| ZNF431 | zinc finger protein 431 | -0.39 |
| DUSP5 | dual specificity phosphatase 5 | -0.39 |
| AMOT | angiomotin | -0.39 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.38 |
| LAMA3 | laminin, alpha 3 | -0.38 |
| MFF | mitochondrial fission factor | -0.38 |
| WNT16 | wingless-type MMTV integration site family, member 16 | -0.38 |
| UNC5B | unc-5 homolog B (C. elegans) | -0.38 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.37 |
| FOSL1 | FOS-like antigen 1 | -0.37 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.37 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.37 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.36 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.36 |
| SYTL3 | synaptotagmin-like 3 | -0.36 |
| MRAS | muscle RAS oncogene homolog | -0.35 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.35 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.35 |
| ZG16B | zymogen granule protein 16B | -0.35 |
| GAS6 | growth arrest-specific 6 | -0.35 |
| ELFN2 | extracellular leucine-rich repeat and fibronectin type III domain containing 2 | -0.34 |
| DNAH8 | dynein, axonemal, heavy chain 8 | -0.34 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | -0.34 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.34 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.34 |
| BCO2 | beta-carotene oxygenase 2 | -0.34 |
| BAIAP2 | BAI1-associated protein 2 | -0.34 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.34 |
| CCPG1 | cell cycle progression 1 | -0.34 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.34 |
| HDAC7 | histone deacetylase 7 | -0.34 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.33 |
| APOBEC3D | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | -0.33 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | -0.33 |
| HBA1 | hemoglobin, alpha 1 | -0.33 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.33 |
| ANKRD36C | ankyrin repeat domain 36C | -0.33 |
| WLS | wntless Wnt ligand secretion mediator | -0.32 |
| UBAP1 | ubiquitin associated protein 1 | -0.32 |
| DPY19L2 | dpy-19-like 2 (C. elegans) | -0.32 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.32 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -0.32 |
| ICK | intestinal cell (MAK-like) kinase | -0.31 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.31 |
| C12ORF73 | chromosome 12 open reading frame 73 | -0.31 |
