Belinostat_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.211353
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0971201
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0969944
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0959983
VCL vinculin 0.0939017
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0908247
LPIN1 lipin 1 0.0875603
CENPF centromere protein F, 350/400kDa 0.0749194
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0742449
ZSWIM6 zinc finger, SWIM-type containing 6 0.0726873
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0722472
SEPTIN9 septin 9 0.0671883
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0661757
NALF1 NALCN channel auxiliary factor 1 0.060763
PCBP2 poly(rC) binding protein 2 0.059474
CANX calnexin 0.0582047
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0546222
SLITRK6 SLIT and NTRK-like family, member 6 0.0526276
DCAF7 DDB1 and CUL4 associated factor 7 0.0509257
MYH9 myosin, heavy chain 9, non-muscle 0.0496333
MCL1 myeloid cell leukemia 1 0.0481652
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0481434
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0456184
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0428896
ENAH enabled homolog (Drosophila) 0.0419887
SMYD3 SET and MYND domain containing 3 0.041806
PKM pyruvate kinase, muscle 0.0408533
VEGFA vascular endothelial growth factor A 0.0406252
MKI67 marker of proliferation Ki-67 0.0391247
PTMA prothymosin, alpha 0.0390841
CLTC clathrin, heavy chain (Hc) 0.03822
PCDH9 protocadherin 9 0.0379904
RPL7 ribosomal protein L7 0.0377961
EEF1G eukaryotic translation elongation factor 1 gamma 0.0376654
TIMP3 TIMP metallopeptidase inhibitor 3 0.0371801
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0364076
AKAP12 A kinase (PRKA) anchor protein 12 0.0363381
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0357172
ENO1 enolase 1, (alpha) 0.0355379
LIMCH1 LIM and calponin homology domains 1 0.0354619
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.035117
TPM3 tropomyosin 3 0.0347674
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0342094
APLP2 amyloid beta (A4) precursor-like protein 2 0.0341605
DTNA dystrobrevin, alpha 0.0339193
VMP1 vacuole membrane protein 1 0.0334743
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0329803
TPR translocated promoter region, nuclear basket protein 0.0329496
TIMP2 TIMP metallopeptidase inhibitor 2 0.0326237
INTS6 integrator complex subunit 6 0.0325901
AKAP13 A kinase (PRKA) anchor protein 13 0.032263
CPED1 cadherin-like and PC-esterase domain containing 1 0.0322619
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.031316
DST dystonin 0.0311587
RABGAP1L RAB GTPase activating protein 1-like 0.0304168
RPS27 ribosomal protein S27 0.0301193
ATXN1 ataxin 1 0.0298028
ZMIZ1 zinc finger, MIZ-type containing 1 0.0296705
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0290127
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0290017
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0287098
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0278204
PTPRM protein tyrosine phosphatase, receptor type, M 0.0275593
ANXA2 annexin A2 0.0274961
FN1 fibronectin 1 0.0274908
BRD2 bromodomain containing 2 0.0268841
MSI2 musashi RNA-binding protein 2 0.0265695
UHMK1 U2AF homology motif (UHM) kinase 1 0.0263687
ZNF638 zinc finger protein 638 0.0263431
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0261228
SET SET nuclear proto-oncogene 0.0259404
SPAG9 sperm associated antigen 9 0.0255341
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.024986
DACH2 dachshund family transcription factor 2 0.0248005
ACTG1 actin gamma 1 0.0247748
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0247333
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0247276
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0246377
CCDC88A coiled-coil domain containing 88A 0.0245876
NFE2L1 nuclear factor, erythroid 2-like 1 0.0245202
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242905
FXR1 fragile X mental retardation, autosomal homolog 1 0.0241577
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0241502
INSIG2 insulin induced gene 2 0.024092
MLEC malectin 0.0240687
NBEA neurobeachin 0.0239509
FNBP1 formin binding protein 1 0.0238207
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0237558
LRP6 low density lipoprotein receptor-related protein 6 0.0236599
VIM vimentin 0.0235378
UBAP2 ubiquitin associated protein 2 0.0235024
RBMX RNA binding motif protein, X-linked 0.0234663
CDH13 cadherin 13 0.0233608
S100A9 S100 calcium binding protein A9 0.0232964
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0231682
RPL37A ribosomal protein L37a 0.0231547
PRR11 proline rich 11 0.0231378
ARRDC3 arrestin domain containing 3 0.0229245
ZCCHC7 zinc finger, CCHC domain containing 7 0.022895

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.229582
TPST1 tyrosylprotein sulfotransferase 1 -0.0915463
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0888222
SYT1 synaptotagmin I -0.0783465
TRIO trio Rho guanine nucleotide exchange factor -0.0645106
FMN1 formin 1 -0.0622708
FRMD4A FERM domain containing 4A -0.0527559
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0521696
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0521065
CEMIP cell migration inducing protein, hyaluronan binding -0.0485542
RNF213 ring finger protein 213 -0.0481022
KLHL13 kelch-like family member 13 -0.0466229
COL1A1 collagen, type I, alpha 1 -0.0454892
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0421228
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0420641
SP100 SP100 nuclear antigen -0.0393543
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0377081
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0370337
NRP1 neuropilin 1 -0.0369319
RIGI RNA sensor RIG-I -0.0363204
ANGPT1 angiopoietin 1 -0.0340293
RPL38 ribosomal protein L38 -0.0336795
AOPEP aminopeptidase O (putative) -0.0333211
RPS24 ribosomal protein S24 -0.0329319
MBD5 methyl-CpG binding domain protein 5 -0.0326214
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0321887
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.031222
COL3A1 collagen, type III, alpha 1 -0.0310279
IFI16 interferon, gamma-inducible protein 16 -0.030876
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0306437
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0301878
PDE10A phosphodiesterase 10A -0.0295804
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0295078
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0294053
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0282982
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0282498
TMSB10 thymosin beta 10 -0.0278829
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0276175
COL4A5 collagen, type IV, alpha 5 -0.0275675
TRPS1 trichorhinophalangeal syndrome I -0.0273484
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0270799
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0265407
HMBOX1 homeobox containing 1 -0.0260223
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0258298
JMJD1C jumonji domain containing 1C -0.0257215
EXT1 exostosin glycosyltransferase 1 -0.0250373
USP15 ubiquitin specific peptidase 15 -0.0243257
THSD4 thrombospondin, type I, domain containing 4 -0.0241982
KIF21A kinesin family member 21A -0.0240127
DENND4A DENN/MADD domain containing 4A -0.0239027
KMT2C lysine (K)-specific methyltransferase 2C -0.0237255
PTPRK protein tyrosine phosphatase, receptor type, K -0.0236789
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0231417
ZFAND3 zinc finger, AN1-type domain 3 -0.0228689
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0228321
SIK2 salt-inducible kinase 2 -0.022649
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0224922
ZFC3H1 zinc finger, C3H1-type containing -0.0224121
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0222571
WSB1 WD repeat and SOCS box containing 1 -0.0221979
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0221769
STRN3 striatin, calmodulin binding protein 3 -0.0218413
CDK6 cyclin-dependent kinase 6 -0.0217316
RBM20 RNA binding motif protein 20 -0.0217163
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0216819
IARS1 isoleucyl-tRNA synthetase 1 -0.0216262
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0215325
AKAP9 A kinase (PRKA) anchor protein 9 -0.0214376
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0213144
SEPTIN2 septin 2 -0.0212633
NPEPPS aminopeptidase puromycin sensitive -0.0212494
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0211743
LONRF2 LON peptidase N-terminal domain and ring finger 2 -0.0211459
ZNF804A zinc finger protein 804A -0.0211244
PTPRD protein tyrosine phosphatase, receptor type, D -0.0209426
PTPRE protein tyrosine phosphatase, receptor type, E -0.0207354
FAM107B family with sequence similarity 107, member B -0.0206896
IER3 immediate early response 3 -0.0203747
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0201514
UBB ubiquitin B -0.0201161
GAB2 GRB2-associated binding protein 2 -0.0200167
NCAM2 neural cell adhesion molecule 2 -0.019826
MYO9A myosin IXA -0.0197933
MAP1B microtubule-associated protein 1B -0.0197888
WAC WW domain containing adaptor with coiled-coil -0.0196551
YME1L1 YME1-like 1 ATPase -0.0196007
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0193273
TBCK TBC1 domain containing kinase -0.0192795
MX1 MX dynamin-like GTPase 1 -0.0192252
H1-0 H1.0 linker histone -0.0191456
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0191171
TRIM24 tripartite motif containing 24 -0.0191036
ARF1 ADP-ribosylation factor 1 -0.0188668
AFF4 AF4/FMR2 family, member 4 -0.0186496
KDM2A lysine (K)-specific demethylase 2A -0.0186489
IFIH1 interferon induced with helicase C domain 1 -0.0185421
ZFR zinc finger RNA binding protein -0.0184534
RPL6 ribosomal protein L6 -0.0184443
TMEM108 transmembrane protein 108 -0.0183756
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0182359