Belinostat_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.167057
LMO7 LIM domain 7 0.1344
SPTBN1 spectrin, beta, non-erythrocytic 1 0.112013
P4HB prolyl 4-hydroxylase, beta polypeptide 0.102879
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0898909
MYO1E myosin IE 0.0841097
VMP1 vacuole membrane protein 1 0.0840044
EGR1 early growth response 1 0.081619
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0765871
ERBIN erbb2 interacting protein 0.0751168
INTS6 integrator complex subunit 6 0.0627934
ANXA2 annexin A2 0.0560884
AKAP13 A kinase (PRKA) anchor protein 13 0.0557983
EZR ezrin 0.0542063
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.053514
GOLGB1 golgin B1 0.0520598
SPAG9 sperm associated antigen 9 0.0519116
CCNL1 cyclin L1 0.0498604
MBNL2 muscleblind-like splicing regulator 2 0.0490917
N4BP2L2 NEDD4 binding protein 2-like 2 0.0489596
DSPP dentin sialophosphoprotein 0.0457713
TMC5 transmembrane channel-like 5 0.0446499
APLP2 amyloid beta (A4) precursor-like protein 2 0.0444073
PTBP3 polypyrimidine tract binding protein 3 0.0443156
TJP1 tight junction protein 1 0.0440001
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0438623
BCLAF1 BCL2-associated transcription factor 1 0.0426214
SFTPA2 surfactant protein A2 0.0418717
AREG amphiregulin 0.04184
MYH9 myosin, heavy chain 9, non-muscle 0.0417171
B2M beta-2-microglobulin 0.041507
EML4 echinoderm microtubule associated protein like 4 0.0412964
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.041202
STK24 serine/threonine kinase 24 0.0409967
NCOR2 nuclear receptor corepressor 2 0.0408032
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0399019
RAB7A RAB7A, member RAS oncogene family 0.039693
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0396158
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0393123
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0382425
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0379901
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0376801
SHB Src homology 2 domain containing adaptor protein B 0.0375208
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0373762
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0369053
TUFT1 tuftelin 1 0.0368659
MACC1 metastasis associated in colon cancer 1 0.0368291
COPA coatomer protein complex, subunit alpha 0.036508
EPS8 epidermal growth factor receptor pathway substrate 8 0.0360984
PCBP2 poly(rC) binding protein 2 0.0360678
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0357498
ANKRD17 ankyrin repeat domain 17 0.0352912
OARD1 O-acyl-ADP-ribose deacylase 1 0.0346499
VEGFA vascular endothelial growth factor A 0.0344798
SMAD3 SMAD family member 3 0.0342016
CTBP2 C-terminal binding protein 2 0.0336701
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0333948
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.03285
PKM pyruvate kinase, muscle 0.0325238
DSCAM Down syndrome cell adhesion molecule 0.0324241
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0313413
CLDN4 claudin 4 0.0311283
DDIT3 DNA-damage-inducible transcript 3 0.0308828
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0308701
CANX calnexin 0.0303588
LOC102724023 ES1 protein homolog, mitochondrial 0.0300533
AFF1 AF4/FMR2 family, member 1 0.0300068
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0298671
FOXO3 forkhead box O3 0.02976
DIAPH1 diaphanous-related formin 1 0.0295842
WASF2 WAS protein family, member 2 0.0295214
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0293029
RBM47 RNA binding motif protein 47 0.0292484
FNIP1 folliculin interacting protein 1 0.0291193
FTH1 ferritin, heavy polypeptide 1 0.0289629
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0288767
FOSL2 FOS-like antigen 2 0.028782
PADI1 peptidyl arginine deiminase, type I 0.028517
MLPH melanophilin 0.0280613
PHACTR4 phosphatase and actin regulator 4 0.0279261
ITGA6 integrin, alpha 6 0.0279156
COG6 component of oligomeric golgi complex 6 0.0277201
TOX3 TOX high mobility group box family member 3 0.0275401
DUSP10 dual specificity phosphatase 10 0.0273639
SEC31A SEC31 homolog A (S. cerevisiae) 0.0271634
PDZD8 PDZ domain containing 8 0.0271388
BRD2 bromodomain containing 2 0.0268299
RPL21 ribosomal protein L21 0.0266403
TTC3 tetratricopeptide repeat domain 3 0.0265273
CD9 CD9 molecule 0.026345
BAIAP2L1 BAI1-associated protein 2-like 1 0.0263042
SLK STE20-like kinase 0.0261795
UBA6 ubiquitin-like modifier activating enzyme 6 0.0261008
ADIPOR2 adiponectin receptor 2 0.0259386
AKAP9 A kinase (PRKA) anchor protein 9 0.0259336
KRT19 keratin 19, type I 0.0257674
CYSTM1 cysteine-rich transmembrane module containing 1 0.0256435
CENPF centromere protein F, 350/400kDa 0.025573
MCTP1 multiple C2 domains, transmembrane 1 0.0255721
SPRED2 sprouty-related, EVH1 domain containing 2 0.0253916

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146781
TPT1 tumor protein, translationally-controlled 1 -0.143865
LCN2 lipocalin 2 -0.0800383
RUNX1 runt-related transcription factor 1 -0.0760557
HLA-B major histocompatibility complex, class I, B -0.0693357
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0591608
GMDS GDP-mannose 4,6-dehydratase -0.0588153
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0549069
ZMYND8 zinc finger, MYND-type containing 8 -0.0538919
XAF1 XIAP associated factor 1 -0.0538231
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0535999
ARHGAP26 Rho GTPase activating protein 26 -0.0513922
LYZ lysozyme -0.0512241
RPL35A ribosomal protein L35a -0.0510939
RPS24 ribosomal protein S24 -0.0507186
MUC20 mucin 20, cell surface associated -0.0505327
STS steroid sulfatase (microsomal), isozyme S -0.0501586
PTMA prothymosin, alpha -0.0494517
TMSB10 thymosin beta 10 -0.048896
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0481963
TRIO trio Rho guanine nucleotide exchange factor -0.0456717
MSI2 musashi RNA-binding protein 2 -0.0456231
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0435534
GCLC glutamate-cysteine ligase, catalytic subunit -0.0400557
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0388827
SAMD12 sterile alpha motif domain containing 12 -0.0387309
WWOX WW domain containing oxidoreductase -0.0348126
H1-0 H1.0 linker histone -0.0342551
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0336104
NPSR1 neuropeptide S receptor 1 -0.0335682
PRELID2 PRELI domain containing 2 -0.0333376
S100A6 S100 calcium binding protein A6 -0.0332059
RPL34 ribosomal protein L34 -0.0329372
ANKRD10 ankyrin repeat domain 10 -0.0327277
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0322496
XRN1 5'-3' exoribonuclease 1 -0.0315267
STK39 serine threonine kinase 39 -0.0315151
NCOA7 nuclear receptor coactivator 7 -0.0313012
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0310764
RNF43 ring finger protein 43 -0.0309538
BTBD9 BTB (POZ) domain containing 9 -0.0305763
TAS2R14 taste receptor, type 2, member 14 -0.0302578
PTGR1 prostaglandin reductase 1 -0.0296518
PHF3 PHD finger protein 3 -0.0291339
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0287798
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0287269
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.027985
EPSTI1 epithelial stromal interaction 1 (breast) -0.0279327
MUC13 mucin 13, cell surface associated -0.0277368
TXNRD1 thioredoxin reductase 1 -0.0273398
NF1 neurofibromin 1 -0.0272217
RPLP1 ribosomal protein, large, P1 -0.0263469
LPP LIM domain containing preferred translocation partner in lipoma -0.0261437
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0261048
EPHB2 EPH receptor B2 -0.0259867
PATJ PATJ crumbs cell polarity complex component -0.0258433
RPL7L1 ribosomal protein L7-like 1 -0.0255778
KPNB1 karyopherin (importin) beta 1 -0.0253918
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0252612
ARF1 ADP-ribosylation factor 1 -0.0250586
APOL1 apolipoprotein L, 1 -0.025023
HMGB1 high mobility group box 1 -0.0248682
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0248616
HLA-C major histocompatibility complex, class I, C -0.0248182
ATP10B ATPase, class V, type 10B -0.0247728
CLYBL citrate lyase beta like -0.0246874
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0246829
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0246636
ANXA4 annexin A4 -0.0242147
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0238406
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0238316
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0238289
SPIDR scaffolding protein involved in DNA repair -0.023443
DLG1 discs, large homolog 1 (Drosophila) -0.0233767
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0233601
IFIH1 interferon induced with helicase C domain 1 -0.0232659
SENP5 SUMO1/sentrin specific peptidase 5 -0.0228399
DENND1A DENN/MADD domain containing 1A -0.0227321
RIGI RNA sensor RIG-I -0.0227226
PRKCA protein kinase C, alpha -0.0225566
PDE4D phosphodiesterase 4D, cAMP-specific -0.0224705
TM4SF1 transmembrane 4 L six family member 1 -0.0224193
KDM3A lysine (K)-specific demethylase 3A -0.0219461
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -0.0217957
FTL ferritin, light polypeptide -0.0217638
IGF1R insulin-like growth factor 1 receptor -0.0210763
SAMD9 sterile alpha motif domain containing 9 -0.0209804
PRRC2B proline-rich coiled-coil 2B -0.0209327
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -0.0208831
TMCC1 transmembrane and coiled-coil domain family 1 -0.0208514
TNRC6B trinucleotide repeat containing 6B -0.020744
BCL2L11 BCL2-like 11 (apoptosis facilitator) -0.0207171
GNAS GNAS complex locus -0.0206607
MAP2K6 mitogen-activated protein kinase kinase 6 -0.0205268
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0205195
CD2AP CD2-associated protein -0.0205093
PCED1B PC-esterase domain containing 1B -0.0202941
ARHGAP5 Rho GTPase activating protein 5 -0.0201699
DOCK1 dedicator of cytokinesis 1 -0.020164
DIAPH2 diaphanous-related formin 2 -0.0201549