Belinostat_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.182793
DSPP dentin sialophosphoprotein 0.142848
APLP2 amyloid beta (A4) precursor-like protein 2 0.102985
SPTBN1 spectrin, beta, non-erythrocytic 1 0.094533
PEG3 paternally expressed 3 0.0875661
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0687398
APOA2 apolipoprotein A-II 0.0530027
MAML2 mastermind-like 2 (Drosophila) 0.0529721
EML4 echinoderm microtubule associated protein like 4 0.0519446
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0490378
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.047786
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0476457
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0463469
FNDC3B fibronectin type III domain containing 3B 0.0461346
VEGFA vascular endothelial growth factor A 0.0459557
NKD1 naked cuticle homolog 1 (Drosophila) 0.0457876
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0451097
EHBP1 EH domain binding protein 1 0.0443183
PTPRM protein tyrosine phosphatase, receptor type, M 0.0434268
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0430893
PTBP3 polypyrimidine tract binding protein 3 0.0423345
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0418429
TF transferrin 0.0416179
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0411737
NPAS2 neuronal PAS domain protein 2 0.0395976
FAT1 FAT atypical cadherin 1 0.0392704
MBNL2 muscleblind-like splicing regulator 2 0.0385013
RAI14 retinoic acid induced 14 0.0380902
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0379881
SFTPA2 surfactant protein A2 0.0366044
CTSB cathepsin B 0.0363053
CPE carboxypeptidase E 0.0353459
RPLP0 ribosomal protein, large, P0 0.0346696
INSIG2 insulin induced gene 2 0.0345969
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0344371
AKAP12 A kinase (PRKA) anchor protein 12 0.0340369
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0340364
DLC1 DLC1 Rho GTPase activating protein 0.0336903
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0336061
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0335465
AHSG alpha-2-HS-glycoprotein 0.0323251
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0314995
SOX5 SRY (sex determining region Y)-box 5 0.0312401
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0306038
TNS1 tensin 1 0.0303406
TMEM181 transmembrane protein 181 0.0303371
KPNB1 karyopherin (importin) beta 1 0.0297124
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0295571
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0267239
MTUS1 microtubule associated tumor suppressor 1 0.0264566
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0262468
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0261364
ESYT2 extended synaptotagmin-like protein 2 0.0261294
SBF2 SET binding factor 2 0.026035
CRY1 cryptochrome circadian clock 1 0.0259191
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0257148
RICTOR RPTOR independent companion of MTOR, complex 2 0.0254067
RSRC2 arginine/serine-rich coiled-coil 2 0.0253995
WNK1 WNK lysine deficient protein kinase 1 0.0253564
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0253556
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0252111
H1-0 H1.0 linker histone 0.0246759
KIZ kizuna centrosomal protein 0.0245458
CYTH1 cytohesin 1 0.024465
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0244472
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0244335
SCAF11 SR-related CTD-associated factor 11 0.0243571
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.024239
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0241111
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0240711
KDM7A lysine (K)-specific demethylase 7A 0.0235297
FAM13A family with sequence similarity 13, member A 0.0234425
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0227829
RAD21 RAD21 homolog (S. pombe) 0.0224638
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0224502
RPL11 ribosomal protein L11 0.0224129
FAM135A family with sequence similarity 135, member A 0.0223771
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0221824
PKP4 plakophilin 4 0.0219424
SETD5 SET domain containing 5 0.0216585
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0216094
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0215926
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0215707
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0215585
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0215269
TPM4 tropomyosin 4 0.0212843
ELOVL5 ELOVL fatty acid elongase 5 0.0212277
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0211429
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0209904
RPL7 ribosomal protein L7 0.0207572
SCARB1 scavenger receptor class B, member 1 0.020719
GK glycerol kinase 0.0206548
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0203912
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.020137
CCDC88A coiled-coil domain containing 88A 0.020023
SPRED2 sprouty-related, EVH1 domain containing 2 0.0199305
MYADM myeloid-associated differentiation marker 0.0198195
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0197771
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0195888
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0195597

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.211712
RPS27A ribosomal protein S27a -0.143737
UBC ubiquitin C -0.13208
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.125218
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106453
TMSB10 thymosin beta 10 -0.104452
ENO1 enolase 1, (alpha) -0.103501
EEF2 eukaryotic translation elongation factor 2 -0.102279
IGFBP1 insulin-like growth factor binding protein 1 -0.0970015
RPS24 ribosomal protein S24 -0.0941589
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0846028
IGF2 insulin-like growth factor 2 -0.0763702
RPL23 ribosomal protein L23 -0.0763603
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.076286
RPL37A ribosomal protein L37a -0.0751125
RPS12 ribosomal protein S12 -0.071549
KRT8 keratin 8, type II -0.0683013
JUN jun proto-oncogene -0.066734
SDC4 syndecan 4 -0.0661305
LRMDA leucine rich melanocyte differentiation associated -0.0658821
SVIL supervillin -0.0647784
SOD2 superoxide dismutase 2, mitochondrial -0.0626787
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0619515
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0599947
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.058192
RPS19 ribosomal protein S19 -0.0573478
FTL ferritin, light polypeptide -0.0556017
TRIM26 tripartite motif containing 26 -0.0539712
NAP1L1 nucleosome assembly protein 1-like 1 -0.0529972
TPT1 tumor protein, translationally-controlled 1 -0.0527053
GPC3 glypican 3 -0.0521326
CFB complement factor B -0.0505091
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0492441
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0478174
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0477813
TM4SF1 transmembrane 4 L six family member 1 -0.0454007
CRLS1 cardiolipin synthase 1 -0.0450618
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0428186
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0424786
LOC112694756 uncharaterized LOC112694756 -0.0415645
AHNAK AHNAK nucleoprotein -0.0410716
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0397189
EIF1 eukaryotic translation initiation factor 1 -0.039485
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0394795
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0392661
VCL vinculin -0.0387998
RPLP1 ribosomal protein, large, P1 -0.0352483
RPL5 ribosomal protein L5 -0.0350428
RPL31 ribosomal protein L31 -0.0346499
MCL1 myeloid cell leukemia 1 -0.0343485
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0341245
MRTFA myocardin related transcription factor A -0.0337684
ELL2 elongation factor, RNA polymerase II, 2 -0.033599
RPL34 ribosomal protein L34 -0.0334884
APOE apolipoprotein E -0.0327534
TRIO trio Rho guanine nucleotide exchange factor -0.0326197
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0319474
MT2A metallothionein 2A -0.0315309
RPL35A ribosomal protein L35a -0.0314241
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0313651
ANO6 anoctamin 6 -0.0313346
PDGFB platelet-derived growth factor beta polypeptide -0.0310372
RPS25 ribosomal protein S25 -0.030678
RPL4 ribosomal protein L4 -0.0304559
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0301624
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0297872
IFI6 interferon, alpha-inducible protein 6 -0.0296666
RPLP2 ribosomal protein, large, P2 -0.0292314
SERINC3 serine incorporator 3 -0.0290806
FAM107B family with sequence similarity 107, member B -0.0287622
RPL36A ribosomal protein L36a -0.0287318
PDIA3 protein disulfide isomerase family A, member 3 -0.0285613
RPS17 ribosomal protein S17 -0.0285089
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0283641
USP34 ubiquitin specific peptidase 34 -0.0283063
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -0.0282445
CCL20 chemokine (C-C motif) ligand 20 -0.0280929
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0265082
UBASH3B ubiquitin associated and SH3 domain containing B -0.0264433
EGR1 early growth response 1 -0.0264292
NF1 neurofibromin 1 -0.0263657
RPL10A ribosomal protein L10a -0.0263448
PKM pyruvate kinase, muscle -0.0262839
RPS8 ribosomal protein S8 -0.0261581
PDE4D phosphodiesterase 4D, cAMP-specific -0.0257237
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0256811
SPDYA speedy/RINGO cell cycle regulator family member A -0.0256754
MED13L mediator complex subunit 13-like -0.0256323
YAP1 Yes-associated protein 1 -0.0255491
IGF1R insulin-like growth factor 1 receptor -0.025494
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0252083
IER3 immediate early response 3 -0.0251135
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0250285
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248565
GLG1 golgi glycoprotein 1 -0.0246839
PTMA prothymosin, alpha -0.0244649
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0242803
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0238596
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0238231
LPP LIM domain containing preferred translocation partner in lipoma -0.0234425