Belinostat_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.241363
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.17776
AHNAK AHNAK nucleoprotein 0.0882945
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0862066
CANX calnexin 0.0666584
SULF1 sulfatase 1 0.0664565
RAI14 retinoic acid induced 14 0.065409
DOCK5 dedicator of cytokinesis 5 0.0648776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0632926
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.062952
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0619194
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0615484
NRIP1 nuclear receptor interacting protein 1 0.0586978
PDLIM5 PDZ and LIM domain 5 0.0568211
LMO7 LIM domain 7 0.0549132
PSD3 pleckstrin and Sec7 domain containing 3 0.0531819
EMP1 epithelial membrane protein 1 0.0518627
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0511822
RBM39 RNA binding motif protein 39 0.0502602
PALM2AKAP2 PALM2 and AKAP2 fusion 0.050174
DPYD dihydropyrimidine dehydrogenase 0.0474478
ANXA2 annexin A2 0.046722
MECOM MDS1 and EVI1 complex locus 0.0463139
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0462958
TIMP3 TIMP metallopeptidase inhibitor 3 0.0450673
ITCH itchy E3 ubiquitin protein ligase 0.0439191
HDLBP high density lipoprotein binding protein 0.0435353
PLEC plectin 0.0433533
MYH9 myosin, heavy chain 9, non-muscle 0.0432795
FOXO1 forkhead box O1 0.0430449
BLCAP bladder cancer associated protein 0.0416352
RASAL2 RAS protein activator like 2 0.0414247
OSMR oncostatin M receptor 0.0400874
AMOTL1 angiomotin like 1 0.0397459
MTSS1 metastasis suppressor 1 0.0395185
ZEB1 zinc finger E-box binding homeobox 1 0.038462
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0380355
FN1 fibronectin 1 0.0377567
LAMC2 laminin, gamma 2 0.0374153
ANO1 anoctamin 1, calcium activated chloride channel 0.037071
CEMIP cell migration inducing protein, hyaluronan binding 0.037032
EZR ezrin 0.0358535
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.035511
MCL1 myeloid cell leukemia 1 0.0350237
ITSN1 intersectin 1 (SH3 domain protein) 0.0345128
TSC22D1 TSC22 domain family, member 1 0.0344958
ANKRD33B ankyrin repeat domain 33B 0.0343794
RAB22A RAB22A, member RAS oncogene family 0.0341021
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0340766
GOLGA2 golgin A2 0.033947
GRB10 growth factor receptor-bound protein 10 0.0339463
FNIP1 folliculin interacting protein 1 0.0337495
MPRIP myosin phosphatase Rho interacting protein 0.0332837
CAPRIN2 caprin family member 2 0.0331759
TRIO trio Rho guanine nucleotide exchange factor 0.0331209
BMAL2 basic helix-loop-helix ARNT like 2 0.0328438
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0328367
COPA coatomer protein complex, subunit alpha 0.0326544
EFHD2 EF-hand domain family, member D2 0.0323732
BZW1 basic leucine zipper and W2 domains 1 0.0321108
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0319125
GOLGB1 golgin B1 0.0318363
MACF1 microtubule-actin crosslinking factor 1 0.0318282
ESYT2 extended synaptotagmin-like protein 2 0.0317973
APP amyloid beta (A4) precursor protein 0.0315391
SLC35F3 solute carrier family 35, member F3 0.0314552
COPB1 coatomer protein complex, subunit beta 1 0.0314334
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0313731
IQGAP1 IQ motif containing GTPase activating protein 1 0.0310056
C4BPB complement component 4 binding protein, beta 0.0309787
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0309618
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0303066
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0297096
TTC3 tetratricopeptide repeat domain 3 0.0296677
OGA O-GlcNAcase 0.0292375
KRT6A keratin 6A, type II 0.0289428
THSD4 thrombospondin, type I, domain containing 4 0.0286641
FNDC3B fibronectin type III domain containing 3B 0.0284649
NAV2 neuron navigator 2 0.0282878
EHBP1 EH domain binding protein 1 0.0280995
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0280443
ZCCHC7 zinc finger, CCHC domain containing 7 0.0279107
UTRN utrophin 0.027795
NCOA3 nuclear receptor coactivator 3 0.0277632
CTNND1 catenin (cadherin-associated protein), delta 1 0.0277304
EXOC4 exocyst complex component 4 0.0276024
ITGA6 integrin, alpha 6 0.0274593
LUZP1 leucine zipper protein 1 0.0272723
MYOF myoferlin 0.0272468
EXOC6B exocyst complex component 6B 0.0271685
RIN2 Ras and Rab interactor 2 0.0270573
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0269706
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0266547
CDK13 cyclin-dependent kinase 13 0.0264671
TJP1 tight junction protein 1 0.0263499
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0262285
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0260348
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0253753
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0249877
MYO10 myosin X 0.0248984

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140051
RPS6 ribosomal protein S6 -0.102602
MT2A metallothionein 2A -0.0950016
RPS8 ribosomal protein S8 -0.0699898
B2M beta-2-microglobulin -0.0692047
RPLP2 ribosomal protein, large, P2 -0.0663005
RPS21 ribosomal protein S21 -0.0645738
RPLP1 ribosomal protein, large, P1 -0.0570449
RPS13 ribosomal protein S13 -0.0549875
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0531858
TPT1 tumor protein, translationally-controlled 1 -0.0491985
RPS12 ribosomal protein S12 -0.0488147
IFITM3 interferon induced transmembrane protein 3 -0.0481951
RPL11 ribosomal protein L11 -0.0474586
RPS19 ribosomal protein S19 -0.0474191
RPL23 ribosomal protein L23 -0.0459193
RPS3 ribosomal protein S3 -0.0458324
RPS25 ribosomal protein S25 -0.04561
RPL35A ribosomal protein L35a -0.0454391
CLU clusterin -0.0449889
RPL12 ribosomal protein L12 -0.0445187
PTMA prothymosin, alpha -0.0435482
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0426082
TMSB10 thymosin beta 10 -0.0424245
S100A10 S100 calcium binding protein A10 -0.0422442
MT1X metallothionein 1X -0.0418966
RPL37 ribosomal protein L37 -0.0406799
RPS24 ribosomal protein S24 -0.038823
RPL34 ribosomal protein L34 -0.036724
RPL37A ribosomal protein L37a -0.0364438
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0354986
RPL36 ribosomal protein L36 -0.0352339
FTH1 ferritin, heavy polypeptide 1 -0.0347134
RPL35 ribosomal protein L35 -0.0346738
FTL ferritin, light polypeptide -0.0346015
RPLP0 ribosomal protein, large, P0 -0.0344318
TOP2A topoisomerase (DNA) II alpha 170kDa -0.033603
RPL8 ribosomal protein L8 -0.0335159
RPL9 ribosomal protein L9 -0.0329644
RPL31 ribosomal protein L31 -0.0324535
DSTN destrin (actin depolymerizing factor) -0.0324311
RPS23 ribosomal protein S23 -0.0321946
S100A6 S100 calcium binding protein A6 -0.031754
RPL32 ribosomal protein L32 -0.0310343
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0309817
RPL28 ribosomal protein L28 -0.0304128
ATP5F1E ATP synthase F1 subunit epsilon -0.0303765
RPL26 ribosomal protein L26 -0.0295558
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0295373
RPS20 ribosomal protein S20 -0.0294399
STC1 stanniocalcin 1 -0.0292228
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0288026
RPS27 ribosomal protein S27 -0.0287677
RPS29 ribosomal protein S29 -0.0286064
ANGPTL4 angiopoietin-like 4 -0.0279301
RPS15 ribosomal protein S15 -0.0278319
CAV1 caveolin 1, caveolae protein, 22kDa -0.0266338
RPL19 ribosomal protein L19 -0.0265353
RACK1 receptor for activated C kinase 1 -0.0264951
RPL7A ribosomal protein L7a -0.0263976
RPS4X ribosomal protein S4, X-linked -0.0262246
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0261669
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0260897
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0259304
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0257349
RPL5 ribosomal protein L5 -0.0256808
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0256185
RPS14 ribosomal protein S14 -0.0254238
PLAT plasminogen activator, tissue -0.0253611
SLK STE20-like kinase -0.0253544
RPS11 ribosomal protein S11 -0.0250673
S100A11 S100 calcium binding protein A11 -0.0242978
NDRG1 N-myc downstream regulated 1 -0.0242976
RPS16 ribosomal protein S16 -0.0241378
RPS27A ribosomal protein S27a -0.0238006
CYB5R3 cytochrome b5 reductase 3 -0.023557
TXNIP thioredoxin interacting protein -0.0233694
PKM pyruvate kinase, muscle -0.023302
UBE2B ubiquitin-conjugating enzyme E2B -0.0230654
IFI6 interferon, alpha-inducible protein 6 -0.0230428
HLA-B major histocompatibility complex, class I, B -0.0225819
RPS17 ribosomal protein S17 -0.0223645
S100A2 S100 calcium binding protein A2 -0.0220938
RPS2 ribosomal protein S2 -0.0213037
PA2G4 proliferation-associated 2G4, 38kDa -0.0212244
CD44 CD44 molecule (Indian blood group) -0.02114
POTEF POTE ankyrin domain family, member F -0.0210297
RPL7 ribosomal protein L7 -0.0210163
RPL27A ribosomal protein L27a -0.0208154
PFN1 profilin 1 -0.0206197
ACTG1 actin gamma 1 -0.0206129
IFITM1 interferon induced transmembrane protein 1 -0.0205341
RPL27 ribosomal protein L27 -0.0203479
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0200656
CENPF centromere protein F, 350/400kDa -0.0198731
RPS5 ribosomal protein S5 -0.0197635
CNRIP1 cannabinoid receptor interacting protein 1 -0.0193338
RPL36A ribosomal protein L36a -0.0192224
EIF5B eukaryotic translation initiation factor 5B -0.0190483
PDIA3 protein disulfide isomerase family A, member 3 -0.0189355