Belinostat_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.153914
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0924878
CANX calnexin 0.07595
CEMIP cell migration inducing protein, hyaluronan binding 0.0720789
LMO7 LIM domain 7 0.0687369
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0672228
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0596055
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0585823
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0578063
GOLGA4 golgin A4 0.0574653
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0538465
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0521477
ITGA6 integrin, alpha 6 0.0478693
RNF43 ring finger protein 43 0.0455057
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.045056
DSPP dentin sialophosphoprotein 0.0448855
EREG epiregulin 0.0437628
TXNIP thioredoxin interacting protein 0.0432005
KIF5B kinesin family member 5B 0.0431817
BIRC6 baculoviral IAP repeat containing 6 0.0415036
FAM13A family with sequence similarity 13, member A 0.0406027
OGA O-GlcNAcase 0.039545
ANXA2 annexin A2 0.03947
DSCAM Down syndrome cell adhesion molecule 0.0388146
ITPRID2 ITPR interacting domain containing 2 0.0387909
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0369305
ATXN1 ataxin 1 0.0361346
EZR ezrin 0.0356162
MACF1 microtubule-actin crosslinking factor 1 0.0348298
BTBD9 BTB (POZ) domain containing 9 0.0343835
SOS1 son of sevenless homolog 1 (Drosophila) 0.0342688
KLF5 Kruppel-like factor 5 (intestinal) 0.0339952
APLP2 amyloid beta (A4) precursor-like protein 2 0.0338916
ASPH aspartate beta-hydroxylase 0.0328451
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328392
VEGFA vascular endothelial growth factor A 0.0325373
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0324114
MBNL2 muscleblind-like splicing regulator 2 0.0323494
ANTXR2 anthrax toxin receptor 2 0.0323273
PCBP2 poly(rC) binding protein 2 0.0317926
CSNK1A1 casein kinase 1, alpha 1 0.0302194
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0299653
CEMIP2 cell migration inducing hyaluronidase 2 0.0295645
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0295418
PTEN phosphatase and tensin homolog 0.0290242
AFDN afadin, adherens junction formation factor 0.0290233
MED13L mediator complex subunit 13-like 0.028824
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0288069
HDLBP high density lipoprotein binding protein 0.028516
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0274837
NCOR1 nuclear receptor corepressor 1 0.0274233
CADPS Ca++-dependent secretion activator 0.0272749
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0272571
NEBL nebulette 0.0271955
CALR calreticulin 0.0271915
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0271912
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0268788
PIGR polymeric immunoglobulin receptor 0.0268141
TTC3 tetratricopeptide repeat domain 3 0.0265972
ONECUT3 one cut homeobox 3 0.025822
ESYT2 extended synaptotagmin-like protein 2 0.0256674
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0255879
USP34 ubiquitin specific peptidase 34 0.0254997
KDM7A lysine (K)-specific demethylase 7A 0.0251481
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.025116
ANKRD17 ankyrin repeat domain 17 0.0249857
NBAS neuroblastoma amplified sequence 0.0247882
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0247197
TBC1D5 TBC1 domain family, member 5 0.0245905
ERBIN erbb2 interacting protein 0.0243812
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0243448
TM9SF3 transmembrane 9 superfamily member 3 0.0243444
GSK3B glycogen synthase kinase 3 beta 0.0242185
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0239388
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0238841
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0238238
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0237222
UBE2H ubiquitin-conjugating enzyme E2H 0.0234925
ZFAND3 zinc finger, AN1-type domain 3 0.0234259
SHB Src homology 2 domain containing adaptor protein B 0.0234236
EIF4B eukaryotic translation initiation factor 4B 0.0233368
YTHDC1 YTH domain containing 1 0.0233257
PPARG peroxisome proliferator-activated receptor gamma 0.0231789
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0231469
SETD5 SET domain containing 5 0.0230515
ACBD3 acyl-CoA binding domain containing 3 0.0229935
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.022874
MYH9 myosin, heavy chain 9, non-muscle 0.0227787
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0227278
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0225503
USP6NL USP6 N-terminal like 0.022509
CCNY cyclin Y 0.0224308
SEC31A SEC31 homolog A (S. cerevisiae) 0.0223824
EIF4A2 eukaryotic translation initiation factor 4A2 0.0223401
HSPA8 heat shock 70kDa protein 8 0.0222841
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0222255
RREB1 ras responsive element binding protein 1 0.0220695
SPRED2 sprouty-related, EVH1 domain containing 2 0.0220335
NCKAP1 NCK-associated protein 1 0.0218932
AFF1 AF4/FMR2 family, member 1 0.0217497

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.250303
NPSR1 neuropeptide S receptor 1 -0.125718
RPS6 ribosomal protein S6 -0.106914
TPT1 tumor protein, translationally-controlled 1 -0.102921
RPL35A ribosomal protein L35a -0.101745
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0954661
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.088644
PTMA prothymosin, alpha -0.0853276
ACTG1 actin gamma 1 -0.0784779
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0729154
RPS19 ribosomal protein S19 -0.0693849
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.06675
MT2A metallothionein 2A -0.0516637
RPS8 ribosomal protein S8 -0.0490383
RPL34 ribosomal protein L34 -0.0462117
POTEF POTE ankyrin domain family, member F -0.045473
RPLP1 ribosomal protein, large, P1 -0.0447386
RPS24 ribosomal protein S24 -0.0436639
RPS12 ribosomal protein S12 -0.0434493
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0425132
HMGA1 high mobility group AT-hook 1 -0.0421414
RPL9 ribosomal protein L9 -0.040883
RPL37A ribosomal protein L37a -0.0408103
RPL23 ribosomal protein L23 -0.0388222
ALCAM activated leukocyte cell adhesion molecule -0.0386126
RPS25 ribosomal protein S25 -0.0371491
TUBB4B tubulin, beta 4B class IVb -0.0364053
S100A6 S100 calcium binding protein A6 -0.0358727
FTL ferritin, light polypeptide -0.0343353
RPLP2 ribosomal protein, large, P2 -0.0339792
TUBA1B tubulin, alpha 1b -0.0338836
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0337982
RPL31 ribosomal protein L31 -0.0325709
SOX4 SRY (sex determining region Y)-box 4 -0.0324811
RPL32 ribosomal protein L32 -0.0311129
RPL36 ribosomal protein L36 -0.030889
PFN1 profilin 1 -0.0304899
S100A10 S100 calcium binding protein A10 -0.030422
LMNA lamin A/C -0.0293948
SLC35F3 solute carrier family 35, member F3 -0.0290548
TFF1 trefoil factor 1 -0.0287381
RPS21 ribosomal protein S21 -0.0284243
RPS14 ribosomal protein S14 -0.027551
RPS17 ribosomal protein S17 -0.0271569
IER3 immediate early response 3 -0.0261141
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0248301
CBX3 chromobox homolog 3 -0.0246336
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0246289
RPL28 ribosomal protein L28 -0.0237774
RPS3 ribosomal protein S3 -0.023671
RPL7A ribosomal protein L7a -0.0231955
GREB1L growth regulation by estrogen in breast cancer-like -0.0230679
TFF3 trefoil factor 3 (intestinal) -0.0230197
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0229374
RPL36A ribosomal protein L36a -0.0227667
RPL8 ribosomal protein L8 -0.022607
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0225219
RPS16 ribosomal protein S16 -0.0224041
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0222845
LAMA4 laminin, alpha 4 -0.0222401
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.022153
HMGB1 high mobility group box 1 -0.0220873
RPS4X ribosomal protein S4, X-linked -0.0220585
RPS27A ribosomal protein S27a -0.0218309
RACK1 receptor for activated C kinase 1 -0.0217784
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0214197
VCL vinculin -0.0211623
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0208863
RPL37 ribosomal protein L37 -0.0207885
RPS13 ribosomal protein S13 -0.0207354
RPS5 ribosomal protein S5 -0.020334
CYB5R3 cytochrome b5 reductase 3 -0.0203309
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0201863
PKM pyruvate kinase, muscle -0.0199569
RPS29 ribosomal protein S29 -0.0199141
RPS23 ribosomal protein S23 -0.019584
ISG15 ISG15 ubiquitin-like modifier -0.0195625
AGR2 anterior gradient 2 -0.0192109
ATP5F1B ATP synthase F1 subunit beta -0.0190664
MT1X metallothionein 1X -0.0190367
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0188153
RPS10 ribosomal protein S10 -0.0185612
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0183448
RPL27A ribosomal protein L27a -0.0182727
GSTP1 glutathione S-transferase pi 1 -0.0181653
F3 coagulation factor III (thromboplastin, tissue factor) -0.0179666
RPL5 ribosomal protein L5 -0.0177039
KLK10 kallikrein-related peptidase 10 -0.0175827
LOC102724023 ES1 protein homolog, mitochondrial -0.0175625
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0175319
RPL38 ribosomal protein L38 -0.0174742
CCND1 cyclin D1 -0.0173888
MYL12B myosin, light chain 12B, regulatory -0.0172386
RPL15 ribosomal protein L15 -0.0172206
RPL4 ribosomal protein L4 -0.0171103
PRSS3 protease, serine, 3 -0.0170331
RPS20 ribosomal protein S20 -0.0167357
IGFBP4 insulin-like growth factor binding protein 4 -0.016722
RPL19 ribosomal protein L19 -0.0165291
GNAS GNAS complex locus -0.0163484