Belinostat_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.1614
TXNRD1 thioredoxin reductase 1 0.119627
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103214
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0970374
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0821093
RBM39 RNA binding motif protein 39 0.076423
TM4SF1 transmembrane 4 L six family member 1 0.0762417
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0754961
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0693752
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0680899
ERBIN erbb2 interacting protein 0.066531
RICTOR RPTOR independent companion of MTOR, complex 2 0.0658344
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0626054
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.062529
FGB fibrinogen beta chain 0.0600623
WDR43 WD repeat domain 43 0.0589047
PCBP2 poly(rC) binding protein 2 0.0573903
ZFAND3 zinc finger, AN1-type domain 3 0.0569643
FTH1 ferritin, heavy polypeptide 1 0.0568766
MCL1 myeloid cell leukemia 1 0.0559773
HDAC9 histone deacetylase 9 0.0552847
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0550149
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0541159
PTK2 protein tyrosine kinase 2 0.0531526
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0528734
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0503542
WAC WW domain containing adaptor with coiled-coil 0.0500001
ZNF207 zinc finger protein 207 0.0495254
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0494006
TPM3 tropomyosin 3 0.0489056
APP amyloid beta (A4) precursor protein 0.0488767
ADAM17 ADAM metallopeptidase domain 17 0.0475739
BCLAF1 BCL2-associated transcription factor 1 0.0474524
EIF1 eukaryotic translation initiation factor 1 0.046539
COPA coatomer protein complex, subunit alpha 0.0464069
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.045951
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.045416
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0452296
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0433032
NOP58 NOP58 ribonucleoprotein 0.0431818
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0425547
TRA2A transformer 2 alpha homolog (Drosophila) 0.0423907
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0419697
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0419168
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0418318
DSCAM Down syndrome cell adhesion molecule 0.0409561
APLP2 amyloid beta (A4) precursor-like protein 2 0.0408505
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0404131
PDIA6 protein disulfide isomerase family A, member 6 0.0403692
FAM168A family with sequence similarity 168, member A 0.0403368
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0401321
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0398196
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0397917
ECT2 epithelial cell transforming 2 0.0393481
FXR1 fragile X mental retardation, autosomal homolog 1 0.0387628
SETD5 SET domain containing 5 0.038729
NUP58 nucleoporin 58 0.0384865
TPM4 tropomyosin 4 0.0384548
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0380644
ANKRD11 ankyrin repeat domain 11 0.0375373
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0374926
CSNK1A1 casein kinase 1, alpha 1 0.0374893
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0374664
USP3 ubiquitin specific peptidase 3 0.0373993
DENND4A DENN/MADD domain containing 4A 0.0373964
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.037324
TFG TRK-fused gene 0.0367332
ZNF292 zinc finger protein 292 0.0366883
TPD52 tumor protein D52 0.0365985
KMT2E lysine (K)-specific methyltransferase 2E 0.036216
INO80 INO80 complex subunit 0.0356883
HDGF hepatoma-derived growth factor 0.0354651
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0353737
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0351771
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.035005
CANX calnexin 0.0349453
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0346599
CCNL1 cyclin L1 0.0346346
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0343177
MARCHF6 membrane associated ring-CH-type finger 6 0.0342563
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0339895
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0338776
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0338532
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0337634
YAP1 Yes-associated protein 1 0.0337446
RBM25 RNA binding motif protein 25 0.033631
MYOF myoferlin 0.0336282
FAM107B family with sequence similarity 107, member B 0.0335704
PDLIM5 PDZ and LIM domain 5 0.0333356
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0332339
YBX1 Y box binding protein 1 0.0331438
RAB1A RAB1A, member RAS oncogene family 0.0331235
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0326442
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.032616
PUM1 pumilio RNA-binding family member 1 0.0320554
CSDE1 cold shock domain containing E1, RNA-binding 0.0319238
TFPI2 tissue factor pathway inhibitor 2 0.0317686
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.03173
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0316618
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0315309

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.144682
TMSB10 thymosin beta 10 -0.089984
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0796006
MT2A metallothionein 2A -0.0677647
RPLP1 ribosomal protein, large, P1 -0.0632145
ACTG1 actin gamma 1 -0.0615498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0519832
RPL23 ribosomal protein L23 -0.0512894
STC1 stanniocalcin 1 -0.0509787
RPS21 ribosomal protein S21 -0.043126
DST dystonin -0.0428425
CAVIN1 caveolae associated protein 1 -0.0425764
ATP5F1E ATP synthase F1 subunit epsilon -0.042018
RPL36 ribosomal protein L36 -0.0394298
IER3 immediate early response 3 -0.0388475
RPS29 ribosomal protein S29 -0.0364486
RPL35A ribosomal protein L35a -0.0358082
FTL ferritin, light polypeptide -0.0357576
EIF5B eukaryotic translation initiation factor 5B -0.0334529
BASP1 brain abundant, membrane attached signal protein 1 -0.0323236
EXT1 exostosin glycosyltransferase 1 -0.0321982
RPL28 ribosomal protein L28 -0.0314627
ATXN1 ataxin 1 -0.030963
ARHGAP26 Rho GTPase activating protein 26 -0.0309021
RPS19 ribosomal protein S19 -0.0308238
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0307366
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0306276
AREG amphiregulin -0.0298547
EHBP1 EH domain binding protein 1 -0.0298208
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0279709
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0271259
FLNB filamin B, beta -0.0263924
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.026356
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0261731
COTL1 coactosin-like F-actin binding protein 1 -0.0260552
RPL9 ribosomal protein L9 -0.0257491
RPL31 ribosomal protein L31 -0.025741
NEBL nebulette -0.0256827
LMNA lamin A/C -0.0254943
EFNA5 ephrin-A5 -0.0240869
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0238882
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0237739
CNKSR3 CNKSR family member 3 -0.0237605
THSD4 thrombospondin, type I, domain containing 4 -0.0237251
TRIO trio Rho guanine nucleotide exchange factor -0.0235496
NEGR1 neuronal growth regulator 1 -0.0231663
RPS8 ribosomal protein S8 -0.0230886
RPS15 ribosomal protein S15 -0.0230877
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.022948
EPAS1 endothelial PAS domain protein 1 -0.0228973
RPL8 ribosomal protein L8 -0.0226403
EGFR epidermal growth factor receptor -0.0223267
RPS3 ribosomal protein S3 -0.022083
RPS16 ribosomal protein S16 -0.0220677
BICC1 BicC family RNA binding protein 1 -0.0214482
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0207886
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.020328
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0200798
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.0200218
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0199839
PTPRM protein tyrosine phosphatase, receptor type, M -0.0199486
S100A10 S100 calcium binding protein A10 -0.0199084
RPL36AL ribosomal protein L36a-like -0.0197661
RPL34 ribosomal protein L34 -0.0197618
RPS24 ribosomal protein S24 -0.0197147
TPT1 tumor protein, translationally-controlled 1 -0.0196563
ZBTB20 zinc finger and BTB domain containing 20 -0.0195125
RPS20 ribosomal protein S20 -0.0194795
RPL19 ribosomal protein L19 -0.0193577
FLNA filamin A, alpha -0.019326
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0192812
UBL5 ubiquitin-like 5 -0.0190649
RPS6 ribosomal protein S6 -0.0190617
RPL38 ribosomal protein L38 -0.0186452
CA8 carbonic anhydrase VIII -0.0185938
PRKCA protein kinase C, alpha -0.0185208
SLC35F3 solute carrier family 35, member F3 -0.0184829
RPL18 ribosomal protein L18 -0.0183439
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0183091
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0179586
RPS23 ribosomal protein S23 -0.0177539
PDE10A phosphodiesterase 10A -0.0175083
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0174482
RAD51B RAD51 paralog B -0.0171901
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0169003
ROMO1 reactive oxygen species modulator 1 -0.0168584
MT1X metallothionein 1X -0.0167751
AHR aryl hydrocarbon receptor -0.0166138
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0163224
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0163066
SMYD3 SET and MYND domain containing 3 -0.0163002
MAML3 mastermind-like 3 (Drosophila) -0.0161897
RPLP2 ribosomal protein, large, P2 -0.0161329
RPL32 ribosomal protein L32 -0.015632
RACK1 receptor for activated C kinase 1 -0.015333
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0151625
RPS5 ribosomal protein S5 -0.0149744
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0149407
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0147905
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0147724