Belinostat_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0840577
PTGES2 prostaglandin E synthase 2 0.0839555
OGA O-GlcNAcase 0.0769588
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0739823
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0679861
COG5 component of oligomeric golgi complex 5 0.0645148
TASP1 taspase, threonine aspartase, 1 0.0643288
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0633416
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0596958
SMYD3 SET and MYND domain containing 3 0.0590318
KDM4B lysine (K)-specific demethylase 4B 0.0580502
RYBP RING1 and YY1 binding protein 0.0570075
TOP1 topoisomerase (DNA) I 0.0559423
VCL vinculin 0.0558805
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0553817
MRTFA myocardin related transcription factor A 0.0553002
NUP58 nucleoporin 58 0.055088
KDM3A lysine (K)-specific demethylase 3A 0.0549276
OSBPL9 oxysterol binding protein-like 9 0.0548453
PIBF1 progesterone immunomodulatory binding factor 1 0.0524132
FN1 fibronectin 1 0.052017
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0506805
RASA2 RAS p21 protein activator 2 0.0503902
TPR translocated promoter region, nuclear basket protein 0.0502152
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0500998
NGLY1 N-glycanase 1 0.0497173
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0489395
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0484348
TSC22D2 TSC22 domain family, member 2 0.0483529
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0482257
RB1CC1 RB1-inducible coiled-coil 1 0.0481469
NEBL nebulette 0.0477737
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0476684
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0470124
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0468308
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0467434
ACTN4 actinin, alpha 4 0.0462672
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0456156
GSK3B glycogen synthase kinase 3 beta 0.0450651
MAPK8 mitogen-activated protein kinase 8 0.0444591
GMDS GDP-mannose 4,6-dehydratase 0.0443694
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.044056
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0437952
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0437304
CALU calumenin 0.0429168
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.042431
TFG TRK-fused gene 0.0423809
BRWD1 bromodomain and WD repeat domain containing 1 0.0420731
TAOK3 TAO kinase 3 0.0420329
SLC38A1 solute carrier family 38, member 1 0.0420286
TM9SF3 transmembrane 9 superfamily member 3 0.0410831
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0408866
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0408049
NCOA3 nuclear receptor coactivator 3 0.0405873
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.040518
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0398982
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0394156
UBA6 ubiquitin-like modifier activating enzyme 6 0.0389448
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0388061
MCTP1 multiple C2 domains, transmembrane 1 0.0386311
SDCBP syndecan binding protein (syntenin) 0.0382753
INSIG1 insulin induced gene 1 0.0376855
PDLIM5 PDZ and LIM domain 5 0.0371597
RPL13A ribosomal protein L13a 0.0369458
TTC3 tetratricopeptide repeat domain 3 0.0368307
CTNND1 catenin (cadherin-associated protein), delta 1 0.0368093
TUSC3 tumor suppressor candidate 3 0.0367866
SAMD4A sterile alpha motif domain containing 4A 0.036519
IRS2 insulin receptor substrate 2 0.0360718
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0360662
MYO10 myosin X 0.0360211
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.035839
BRD4 bromodomain containing 4 0.0352872
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0350179
ZSWIM6 zinc finger, SWIM-type containing 6 0.0349505
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0339342
ZFAND6 zinc finger, AN1-type domain 6 0.0336932
VEZT vezatin, adherens junctions transmembrane protein 0.0336344
FAR1 fatty acyl CoA reductase 1 0.0334529
ADAM9 ADAM metallopeptidase domain 9 0.0333741
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0333108
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033234
KIAA1217 KIAA1217 0.0329456
PDE8A phosphodiesterase 8A 0.0326984
JAK1 Janus kinase 1 0.0326654
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0325315
USP15 ubiquitin specific peptidase 15 0.0323338
DTNA dystrobrevin, alpha 0.0320929
AFF1 AF4/FMR2 family, member 1 0.0320293
SNX1 sorting nexin 1 0.0318508
OSBPL8 oxysterol binding protein-like 8 0.0317695
CSDE1 cold shock domain containing E1, RNA-binding 0.0315544
LIMS1 LIM and senescent cell antigen-like domains 1 0.0315457
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0310755
RNMT RNA (guanine-7-) methyltransferase 0.0310127
FAM13A family with sequence similarity 13, member A 0.0308879
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0307517
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0307397
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0307391
PRKCA protein kinase C, alpha 0.0304657

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.140862
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135397
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.114798
FTL ferritin, light polypeptide -0.110325
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0989903
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0902703
MYO1E myosin IE -0.0860337
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0847355
TMSB10 thymosin beta 10 -0.0833016
ASPH aspartate beta-hydroxylase -0.0813316
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0752868
IGF2 insulin-like growth factor 2 -0.0731459
GPC6 glypican 6 -0.0717145
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0700251
GRB10 growth factor receptor-bound protein 10 -0.0668303
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0647344
BACE2 beta-site APP-cleaving enzyme 2 -0.0645921
VIM vimentin -0.0635693
ZBTB20 zinc finger and BTB domain containing 20 -0.0623266
CEMIP cell migration inducing protein, hyaluronan binding -0.0594887
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0583985
PDE4D phosphodiesterase 4D, cAMP-specific -0.0568509
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.055421
FMNL2 formin-like 2 -0.0544629
PKM pyruvate kinase, muscle -0.0540693
RPL11 ribosomal protein L11 -0.0536855
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0534546
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0518657
MACF1 microtubule-actin crosslinking factor 1 -0.0514524
RPS19 ribosomal protein S19 -0.0504383
AKAP12 A kinase (PRKA) anchor protein 12 -0.0496799
ERBIN erbb2 interacting protein -0.0480843
LAMB3 laminin, beta 3 -0.0477608
SEPTIN10 septin 10 -0.0456839
EGFR epidermal growth factor receptor -0.045378
RNF213 ring finger protein 213 -0.0451707
EFNA5 ephrin-A5 -0.0447872
S100A6 S100 calcium binding protein A6 -0.0444469
NCOR2 nuclear receptor corepressor 2 -0.043313
DOCK5 dedicator of cytokinesis 5 -0.0430322
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0423739
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0423047
LMNA lamin A/C -0.0413171
SSH2 slingshot protein phosphatase 2 -0.0410385
SMAD3 SMAD family member 3 -0.0404523
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0398133
RPL37A ribosomal protein L37a -0.0389806
SEPTIN7 septin 7 -0.0389493
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0389331
FTH1 ferritin, heavy polypeptide 1 -0.0387311
MBNL1 muscleblind-like splicing regulator 1 -0.0383567
TFPI2 tissue factor pathway inhibitor 2 -0.0382204
VEGFA vascular endothelial growth factor A -0.0379877
NDRG1 N-myc downstream regulated 1 -0.0378335
FBF1 Fas (TNFRSF6) binding factor 1 -0.037515
RPS10 ribosomal protein S10 -0.0372062
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0368378
RTN4 reticulon 4 -0.0367404
NALF1 NALCN channel auxiliary factor 1 -0.0364852
MUC16 mucin 16, cell surface associated -0.0359775
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0358899
TPI1 triosephosphate isomerase 1 -0.0345268
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.034459
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0344414
ANKHD1 ankyrin repeat and KH domain containing 1 -0.034323
UBL3 ubiquitin-like 3 -0.0340694
PDE10A phosphodiesterase 10A -0.0338995
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0335424
LPP LIM domain containing preferred translocation partner in lipoma -0.0329289
CD109 CD109 molecule -0.0324875
LOC112694756 uncharaterized LOC112694756 -0.0324673
BCAS3 breast carcinoma amplified sequence 3 -0.0322706
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0320302
FNDC3B fibronectin type III domain containing 3B -0.0316254
ZMYND8 zinc finger, MYND-type containing 8 -0.0316017
DIAPH3 diaphanous-related formin 3 -0.0312371
RHOBTB3 Rho-related BTB domain containing 3 -0.0309919
B2M beta-2-microglobulin -0.0307612
IGFBP3 insulin-like growth factor binding protein 3 -0.0307316
NF1 neurofibromin 1 -0.0305889
AKAP9 A kinase (PRKA) anchor protein 9 -0.0299242
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0298155
EZR ezrin -0.0297706
MAML2 mastermind-like 2 (Drosophila) -0.0295155
ANO6 anoctamin 6 -0.0293985
RPS16 ribosomal protein S16 -0.029203
KIF13A kinesin family member 13A -0.0292002
PBX3 pre-B-cell leukemia homeobox 3 -0.0287881
HOOK2 hook microtubule-tethering protein 2 -0.0284622
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0283997
AHNAK AHNAK nucleoprotein -0.0278771
PTPRM protein tyrosine phosphatase, receptor type, M -0.0278299
NRDC nardilysin convertase -0.0273502
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0270476
PARD3 par-3 family cell polarity regulator -0.0269687
WNK1 WNK lysine deficient protein kinase 1 -0.0267507
CLIP2 CAP-GLY domain containing linker protein 2 -0.026735
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0265825
VGF VGF nerve growth factor inducible -0.026458
RIGI RNA sensor RIG-I -0.0263397