Belinostat_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.153054
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107891
APLP2 amyloid beta (A4) precursor-like protein 2 0.0817052
CANX calnexin 0.065432
TSC22D2 TSC22 domain family, member 2 0.0605127
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0514035
GRB10 growth factor receptor-bound protein 10 0.0501934
MYH9 myosin, heavy chain 9, non-muscle 0.05004
PCBP2 poly(rC) binding protein 2 0.0481884
AKAP13 A kinase (PRKA) anchor protein 13 0.0436567
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0436007
FNDC3B fibronectin type III domain containing 3B 0.0384931
SPAG9 sperm associated antigen 9 0.0381359
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0374864
TPM3 tropomyosin 3 0.0369392
FLNB filamin B, beta 0.0364701
UBA6 ubiquitin-like modifier activating enzyme 6 0.0354014
LIMCH1 LIM and calponin homology domains 1 0.0347852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0340524
VEGFA vascular endothelial growth factor A 0.0339058
DSCAM Down syndrome cell adhesion molecule 0.0336728
ADAM9 ADAM metallopeptidase domain 9 0.0328392
CALR calreticulin 0.0320563
KDM6A lysine (K)-specific demethylase 6A 0.0318491
PTK2 protein tyrosine kinase 2 0.0308822
COPA coatomer protein complex, subunit alpha 0.0306825
YTHDC1 YTH domain containing 1 0.0305309
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0294691
RCOR1 REST corepressor 1 0.0294049
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0292784
FAM13A family with sequence similarity 13, member A 0.0284633
MARCHF6 membrane associated ring-CH-type finger 6 0.0282647
HSPA8 heat shock 70kDa protein 8 0.0280765
FXR1 fragile X mental retardation, autosomal homolog 1 0.0276248
ZFAND3 zinc finger, AN1-type domain 3 0.0276017
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0275568
KMT2C lysine (K)-specific methyltransferase 2C 0.0274083
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0267768
TUFT1 tuftelin 1 0.0266059
PDLIM5 PDZ and LIM domain 5 0.0265763
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0265162
IGFBP3 insulin-like growth factor binding protein 3 0.0256335
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0251381
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0249981
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0246782
GOLGA4 golgin A4 0.024479
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0242886
CD109 CD109 molecule 0.0242355
BZW1 basic leucine zipper and W2 domains 1 0.0241419
IRF6 interferon regulatory factor 6 0.0239515
WAC WW domain containing adaptor with coiled-coil 0.023695
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0235952
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0231524
UBE2H ubiquitin-conjugating enzyme E2H 0.0229777
CERT1 ceramide transporter 1 0.0227965
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0226564
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0225308
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0223604
GPBP1 GC-rich promoter binding protein 1 0.0222412
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0221158
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.021996
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0219577
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0219519
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0217555
TRIO trio Rho guanine nucleotide exchange factor 0.0214536
CCNL1 cyclin L1 0.0213586
SSBP2 single-stranded DNA binding protein 2 0.0211895
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0205671
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203267
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0202968
PLEC plectin 0.0202551
USP9X ubiquitin specific peptidase 9, X-linked 0.0202548
APP amyloid beta (A4) precursor protein 0.020163
CHD1 chromodomain helicase DNA binding protein 1 0.0200537
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0200059
SEC23A Sec23 homolog A (S. cerevisiae) 0.0198895
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0196874
KDM5B lysine (K)-specific demethylase 5B 0.0196476
NUP58 nucleoporin 58 0.0196241
EPS8 epidermal growth factor receptor pathway substrate 8 0.01957
SLMAP sarcolemma associated protein 0.0195447
ANXA2 annexin A2 0.0192493
ITCH itchy E3 ubiquitin protein ligase 0.0190958
ZNF148 zinc finger protein 148 0.0190952
TENT2 terminal nucleotidyltransferase 2 0.0190792
TOP1 topoisomerase (DNA) I 0.0189926
ARRDC3 arrestin domain containing 3 0.0188877
SETD5 SET domain containing 5 0.0187211
TPR translocated promoter region, nuclear basket protein 0.0186992
OGA O-GlcNAcase 0.018577
MYO10 myosin X 0.0185625
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0185378
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0184472
HELZ helicase with zinc finger 0.0184166
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0183411
ERBIN erbb2 interacting protein 0.0182959
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0182259
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0182089
PPARD peroxisome proliferator-activated receptor delta 0.0179871
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0179055

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.279575
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223092
TMSB10 thymosin beta 10 -0.214283
RPL35A ribosomal protein L35a -0.126111
NDRG1 N-myc downstream regulated 1 -0.118905
ACTG1 actin gamma 1 -0.116997
TPT1 tumor protein, translationally-controlled 1 -0.10799
RPLP1 ribosomal protein, large, P1 -0.106684
MT2A metallothionein 2A -0.0959686
PTMA prothymosin, alpha -0.0954285
LAMB3 laminin, beta 3 -0.0931609
RPS19 ribosomal protein S19 -0.0888716
RPLP2 ribosomal protein, large, P2 -0.0848676
S100A10 S100 calcium binding protein A10 -0.0823443
S100A6 S100 calcium binding protein A6 -0.0786653
RPL34 ribosomal protein L34 -0.0770708
EIF1 eukaryotic translation initiation factor 1 -0.0769685
RPS23 ribosomal protein S23 -0.0662739
HMGA1 high mobility group AT-hook 1 -0.0661189
RPS29 ribosomal protein S29 -0.064588
RPL32 ribosomal protein L32 -0.062455
ISG15 ISG15 ubiquitin-like modifier -0.0620731
RPS8 ribosomal protein S8 -0.0605678
RPL8 ribosomal protein L8 -0.0602927
RPL23 ribosomal protein L23 -0.05813
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0563241
IFITM3 interferon induced transmembrane protein 3 -0.0552098
IFI27 interferon, alpha-inducible protein 27 -0.0532568
RPS3 ribosomal protein S3 -0.0531573
RPS6 ribosomal protein S6 -0.0528704
RPL37A ribosomal protein L37a -0.0528101
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0483243
RPL31 ribosomal protein L31 -0.048016
RPS13 ribosomal protein S13 -0.0473539
RPL9 ribosomal protein L9 -0.0469266
RPL28 ribosomal protein L28 -0.0458728
RPL36 ribosomal protein L36 -0.0455765
HLA-B major histocompatibility complex, class I, B -0.0449346
RPL37 ribosomal protein L37 -0.044814
KRT7 keratin 7, type II -0.0425321
RACK1 receptor for activated C kinase 1 -0.0417922
G0S2 G0/G1 switch 2 -0.0417856
S100A9 S100 calcium binding protein A9 -0.0407282
IFI6 interferon, alpha-inducible protein 6 -0.0400185
RPS14 ribosomal protein S14 -0.0396739
RPL19 ribosomal protein L19 -0.0396425
RPS21 ribosomal protein S21 -0.0372786
C15ORF48 chromosome 15 open reading frame 48 -0.0367831
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0366686
RPS24 ribosomal protein S24 -0.0363039
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0359152
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0354458
RPL30 ribosomal protein L30 -0.0344275
RPL12 ribosomal protein L12 -0.0337427
RPS15 ribosomal protein S15 -0.0336155
RPS16 ribosomal protein S16 -0.0335953
RPL11 ribosomal protein L11 -0.0329485
RPS10 ribosomal protein S10 -0.0329327
RPL36A ribosomal protein L36a -0.0328679
S100A11 S100 calcium binding protein A11 -0.0328425
SLC38A1 solute carrier family 38, member 1 -0.0327084
CSTB cystatin B (stefin B) -0.0324187
RPS27A ribosomal protein S27a -0.0324112
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.032388
TUBB4B tubulin, beta 4B class IVb -0.0323774
RPL38 ribosomal protein L38 -0.0318213
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0318116
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0317246
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0314211
RPS25 ribosomal protein S25 -0.030883
UPP1 uridine phosphorylase 1 -0.030775
RPS12 ribosomal protein S12 -0.0304469
GNAS GNAS complex locus -0.0303053
RPL15 ribosomal protein L15 -0.0299809
IFITM1 interferon induced transmembrane protein 1 -0.0298857
NPC2 Niemann-Pick disease, type C2 -0.0296567
RPS17 ribosomal protein S17 -0.029583
RPS27 ribosomal protein S27 -0.0290273
RPL5 ribosomal protein L5 -0.0288672
RPL7A ribosomal protein L7a -0.0284941
RPL18 ribosomal protein L18 -0.0279305
TACSTD2 tumor-associated calcium signal transducer 2 -0.0279194
RPL35 ribosomal protein L35 -0.0277074
RPS5 ribosomal protein S5 -0.0268281
BHLHE40 basic helix-loop-helix family, member e40 -0.0267301
RPL27 ribosomal protein L27 -0.0264518
VIM vimentin -0.0257448
RPS4X ribosomal protein S4, X-linked -0.025718
PLAUR plasminogen activator, urokinase receptor -0.0256519
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0255734
RPS11 ribosomal protein S11 -0.0251668
TM4SF1 transmembrane 4 L six family member 1 -0.0250972
FBXO32 F-box protein 32 -0.0248694
ATP5F1E ATP synthase F1 subunit epsilon -0.0246876
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0246792
MDK midkine (neurite growth-promoting factor 2) -0.0245597
SDC4 syndecan 4 -0.0242657
GPX4 glutathione peroxidase 4 -0.0242301
IFI16 interferon, gamma-inducible protein 16 -0.0240916
KLF6 Kruppel-like factor 6 -0.0236316