Belinostat_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.189023
CANX calnexin 0.118178
MCL1 myeloid cell leukemia 1 0.11739
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0802118
GDA guanine deaminase 0.0766078
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0728474
NAMPT nicotinamide phosphoribosyltransferase 0.0703411
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0639846
IGFBP3 insulin-like growth factor binding protein 3 0.0627383
ELL2 elongation factor, RNA polymerase II, 2 0.0605111
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0584188
TMX4 thioredoxin-related transmembrane protein 4 0.0567627
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0566823
PYGL phosphorylase, glycogen, liver 0.0541003
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0528447
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517213
PGK1 phosphoglycerate kinase 1 0.0510562
SAMD4A sterile alpha motif domain containing 4A 0.0505118
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0486865
PCBP2 poly(rC) binding protein 2 0.0476018
TM4SF1 transmembrane 4 L six family member 1 0.0472095
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0454736
VIM vimentin 0.0448019
BASP1 brain abundant, membrane attached signal protein 1 0.0447199
OGA O-GlcNAcase 0.0442844
TGFBR1 transforming growth factor, beta receptor 1 0.0428816
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.042336
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0420346
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0418241
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0417571
ITPRID2 ITPR interacting domain containing 2 0.0414966
CTSL cathepsin L 0.0411706
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.040593
ESYT2 extended synaptotagmin-like protein 2 0.0404749
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0391826
FLNB filamin B, beta 0.0389556
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0389385
PDGFA platelet-derived growth factor alpha polypeptide 0.0382995
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0379187
RTN4 reticulon 4 0.0368795
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0365117
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0352763
EIF1 eukaryotic translation initiation factor 1 0.0345966
LDHA lactate dehydrogenase A 0.0342067
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0341383
EZR ezrin 0.0340905
STC1 stanniocalcin 1 0.0339047
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0335927
CD109 CD109 molecule 0.033521
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330119
AVL9 AVL9 homolog (S. cerevisiase) 0.0329396
APLP2 amyloid beta (A4) precursor-like protein 2 0.0326068
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0322153
LAMB1 laminin, beta 1 0.0319254
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0306091
NPAS2 neuronal PAS domain protein 2 0.030416
TGFBI transforming growth factor, beta-induced, 68kDa 0.0302498
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0299781
MSN moesin 0.029744
SFTPA2 surfactant protein A2 0.0293719
COL5A2 collagen, type V, alpha 2 0.0290721
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0289807
COPA coatomer protein complex, subunit alpha 0.0289131
MFF mitochondrial fission factor 0.0286205
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0283781
FNDC3A fibronectin type III domain containing 3A 0.0279367
KRT19 keratin 19, type I 0.0278882
LIMCH1 LIM and calponin homology domains 1 0.0277842
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0277472
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0274933
ZEB2 zinc finger E-box binding homeobox 2 0.027483
CSNK1A1 casein kinase 1, alpha 1 0.0274334
FNIP1 folliculin interacting protein 1 0.027053
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0269016
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0267378
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0266156
BPTF bromodomain PHD finger transcription factor 0.0264309
DGKD diacylglycerol kinase, delta 130kDa 0.0263056
SLC38A2 solute carrier family 38, member 2 0.026214
TFPI2 tissue factor pathway inhibitor 2 0.026089
BZW1 basic leucine zipper and W2 domains 1 0.025678
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0253943
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0251137
KMT2E lysine (K)-specific methyltransferase 2E 0.0249
YBX3 Y box binding protein 3 0.0247051
USP34 ubiquitin specific peptidase 34 0.0238325
AKAP13 A kinase (PRKA) anchor protein 13 0.0234427
IQGAP1 IQ motif containing GTPase activating protein 1 0.0233346
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231626
DOCK4 dedicator of cytokinesis 4 0.0231021
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.022941
EFNA5 ephrin-A5 0.0228407
SOD2 superoxide dismutase 2, mitochondrial 0.0227365
HDLBP high density lipoprotein binding protein 0.0224157
CTSC cathepsin C 0.0223761
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0223299
JMJD1C jumonji domain containing 1C 0.0221151
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0220054
RAI1 retinoic acid induced 1 0.0219435
CEP350 centrosomal protein 350kDa 0.0218771

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.26977
NALF1 NALCN channel auxiliary factor 1 -0.106305
PSD3 pleckstrin and Sec7 domain containing 3 -0.0649647
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0598805
TRIO trio Rho guanine nucleotide exchange factor -0.057168
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0521326
TXNRD1 thioredoxin reductase 1 -0.0419005
PTPRM protein tyrosine phosphatase, receptor type, M -0.0386061
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0372121
LSAMP limbic system-associated membrane protein -0.0367974
PTMA prothymosin, alpha -0.0367955
PDE10A phosphodiesterase 10A -0.0353098
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0352061
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0332725
P3H2 prolyl 3-hydroxylase 2 -0.0328801
RPS21 ribosomal protein S21 -0.032525
RPL26 ribosomal protein L26 -0.0302548
EIF5B eukaryotic translation initiation factor 5B -0.029769
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0294363
RPLP1 ribosomal protein, large, P1 -0.029173
RPL36 ribosomal protein L36 -0.0289692
ATP5F1E ATP synthase F1 subunit epsilon -0.0287157
RPS6 ribosomal protein S6 -0.0285609
TMSB10 thymosin beta 10 -0.0281558
LMNA lamin A/C -0.0279349
AUTS2 autism susceptibility candidate 2 -0.0270976
SRGN serglycin -0.0270031
RPL38 ribosomal protein L38 -0.0269646
DST dystonin -0.0269413
RPL35 ribosomal protein L35 -0.0267703
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.026547
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262084
COL8A1 collagen, type VIII, alpha 1 -0.0254139
RPL37A ribosomal protein L37a -0.0247164
RPLP2 ribosomal protein, large, P2 -0.024258
CADM2 cell adhesion molecule 2 -0.0235601
ACTG1 actin gamma 1 -0.0235522
PRDX1 peroxiredoxin 1 -0.0227873
RPL35A ribosomal protein L35a -0.0226485
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224047
RPL34 ribosomal protein L34 -0.0221706
PDE4B phosphodiesterase 4B, cAMP-specific -0.0220177
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.021773
PM20D1 peptidase M20 domain containing 1 -0.0216198
RPL9 ribosomal protein L9 -0.0214882
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0212367
PRKN parkin RBR E3 ubiquitin protein ligase -0.0210467
IGF1R insulin-like growth factor 1 receptor -0.0208107
PBX1 pre-B-cell leukemia homeobox 1 -0.0207742
AKR1C1 aldo-keto reductase family 1, member C1 -0.0206543
RPS25 ribosomal protein S25 -0.0206062
NCKAP5 NCK-associated protein 5 -0.0196646
RPS24 ribosomal protein S24 -0.0194811
RPL12 ribosomal protein L12 -0.0194354
RPL27 ribosomal protein L27 -0.018673
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0185286
RPS8 ribosomal protein S8 -0.0182619
RPL18 ribosomal protein L18 -0.0181739
RPS29 ribosomal protein S29 -0.0179518
GREM2 gremlin 2, DAN family BMP antagonist -0.0179381
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0178324
PA2G4 proliferation-associated 2G4, 38kDa -0.0176587
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0175053
RPS3 ribosomal protein S3 -0.0172817
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0162764
GPHN gephyrin -0.0158939
CHSY3 chondroitin sulfate synthase 3 -0.01547
EPHA5 EPH receptor A5 -0.0153871
RPL13A ribosomal protein L13a -0.0151889
PALLD palladin, cytoskeletal associated protein -0.0150993
RPL32 ribosomal protein L32 -0.0150837
MYL12B myosin, light chain 12B, regulatory -0.0150506
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0149828
KMT2C lysine (K)-specific methyltransferase 2C -0.0147814
RPL28 ribosomal protein L28 -0.0147633
MT2A metallothionein 2A -0.0144673
RPL37 ribosomal protein L37 -0.0143839
AFG2A AFG2 AAA ATPase homolog A -0.0143064
NCOA7 nuclear receptor coactivator 7 -0.0141176
KIAA0825 KIAA0825 -0.0140968
RPS16 ribosomal protein S16 -0.0140705
BZW2 basic leucine zipper and W2 domains 2 -0.0140332
S100A10 S100 calcium binding protein A10 -0.0139072
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0137788
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0134187
DSTN destrin (actin depolymerizing factor) -0.0131623
NOP58 NOP58 ribonucleoprotein -0.0131335
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0129628
RPS10 ribosomal protein S10 -0.0129411
CHML choroideremia-like (Rab escort protein 2) -0.0126822
RPS12 ribosomal protein S12 -0.0126355
POMP proteasome maturation protein -0.0124855
GMDS GDP-mannose 4,6-dehydratase -0.0122987
TTC28 tetratricopeptide repeat domain 28 -0.0121561
FTL ferritin, light polypeptide -0.0118653
NDUFA4 NDUFA4, mitochondrial complex associated -0.0117832
TLE4 transducin-like enhancer of split 4 -0.0116711
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0115851
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0115568
TMEM178B transmembrane protein 178B -0.0115242