Belinostat_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

147 genes differentially expressed following the Belinostat_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.227957
AKAP12 A kinase (PRKA) anchor protein 12 0.168371
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.151235
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122114
NF1 neurofibromin 1 0.121768
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120093
DTNA dystrobrevin, alpha 0.117606
NAP1L1 nucleosome assembly protein 1-like 1 0.110178
APLP2 amyloid beta (A4) precursor-like protein 2 0.107652
NALF1 NALCN channel auxiliary factor 1 0.106691
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.103802
ATP13A3 ATPase type 13A3 0.0984582
PTK2 protein tyrosine kinase 2 0.0978769
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0969669
MYH9 myosin, heavy chain 9, non-muscle 0.0920088
WNK1 WNK lysine deficient protein kinase 1 0.0890922
PGK1 phosphoglycerate kinase 1 0.0855914
ADAM9 ADAM metallopeptidase domain 9 0.0855245
NKD1 naked cuticle homolog 1 (Drosophila) 0.0847185
SBF2 SET binding factor 2 0.0810208
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0805726
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0755869
GRB10 growth factor receptor-bound protein 10 0.0749393
ACTG1 actin gamma 1 0.0745085
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0712977
CMIP c-Maf inducing protein 0.0705449
RPS6 ribosomal protein S6 0.0698246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0686899
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0683443
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0633959
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0612727
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0577482
RPL39 ribosomal protein L39 0.0574905
PTMA prothymosin, alpha 0.0556631
ATP11B ATPase, class VI, type 11B 0.0551314
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0539052
RAB1A RAB1A, member RAS oncogene family 0.0522923
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0522135
DSCAM Down syndrome cell adhesion molecule 0.0500745
MTF2 metal response element binding transcription factor 2 0.0496412
SPAG9 sperm associated antigen 9 0.0494045
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0445537
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0442254
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0427163
MED13 mediator complex subunit 13 0.0416745
OGA O-GlcNAcase 0.0397393
FNDC3B fibronectin type III domain containing 3B 0.0395725
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0387341
CFDP1 craniofacial development protein 1 0.0377851
AKAP13 A kinase (PRKA) anchor protein 13 0.037772
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.036922
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0365691
RUNX1 runt-related transcription factor 1 0.0359605
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.0334113
PAWR PRKC, apoptosis, WT1, regulator 0.0324814
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.02828
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0275801
ZSWIM6 zinc finger, SWIM-type containing 6 0.0275088
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0255803
TFG TRK-fused gene 0.0237233
ACTN4 actinin, alpha 4 0.0222719
ERRFI1 ERBB receptor feedback inhibitor 1 0.0193182
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0192075
ZBTB20 zinc finger and BTB domain containing 20 0.017539
ANXA2 annexin A2 0.0152367
PEAK1 pseudopodium-enriched atypical kinase 1 0.0145377
EGFR epidermal growth factor receptor 0.0142545
JMJD1C jumonji domain containing 1C 0.01276
SLC38A1 solute carrier family 38, member 1 0.0119773
TUT4 terminal uridylyl transferase 4 0.0113604
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0082011
ARID4B AT rich interactive domain 4B (RBP1-like) 0.00634158
TM9SF3 transmembrane 9 superfamily member 3 0.00594949
SND1 staphylococcal nuclease and tudor domain containing 1 0.00430145
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00183896
ZFAND3 zinc finger, AN1-type domain 3 0.00177535

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.242682
HMGA2 high mobility group AT-hook 2 -0.198672
IGFBP3 insulin-like growth factor binding protein 3 -0.192115
EXT1 exostosin glycosyltransferase 1 -0.190349
TPT1 tumor protein, translationally-controlled 1 -0.183929
MT2A metallothionein 2A -0.139391
CDH13 cadherin 13 -0.135782
CXCL8 chemokine (C-X-C motif) ligand 8 -0.133633
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.127642
PDE10A phosphodiesterase 10A -0.120067
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.109879
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.107154
PSD3 pleckstrin and Sec7 domain containing 3 -0.105379
RPS25 ribosomal protein S25 -0.0991507
RPS12 ribosomal protein S12 -0.0962975
MCL1 myeloid cell leukemia 1 -0.0933044
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0895063
IGF2 insulin-like growth factor 2 -0.0874054
MYO1E myosin IE -0.084299
RPS19 ribosomal protein S19 -0.0828763
RB1CC1 RB1-inducible coiled-coil 1 -0.0770716
PRKCA protein kinase C, alpha -0.0710302
VCL vinculin -0.0709479
RPL23 ribosomal protein L23 -0.0693423
NAV2 neuron navigator 2 -0.0655584
ATP11A ATPase, class VI, type 11A -0.065471
NDRG1 N-myc downstream regulated 1 -0.0654336
LDHA lactate dehydrogenase A -0.0627682
TMSB10 thymosin beta 10 -0.0601013
FTL ferritin, light polypeptide -0.059975
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.053649
STC1 stanniocalcin 1 -0.0524575
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0460811
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0447419
GOLGA4 golgin A4 -0.042675
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0417312
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.04161
ENO1 enolase 1, (alpha) -0.0403537
EFNA5 ephrin-A5 -0.036702
ANKRD17 ankyrin repeat domain 17 -0.0361893
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.034011
DST dystonin -0.0337497
FN1 fibronectin 1 -0.03339
SMYD3 SET and MYND domain containing 3 -0.032278
FRMD5 FERM domain containing 5 -0.0302654
GMDS GDP-mannose 4,6-dehydratase -0.0301781
GSK3B glycogen synthase kinase 3 beta -0.0294632
ASPH aspartate beta-hydroxylase -0.0289271
INTS6 integrator complex subunit 6 -0.0241027
DOCK4 dedicator of cytokinesis 4 -0.0226437
RPL34 ribosomal protein L34 -0.0218202
SPDYA speedy/RINGO cell cycle regulator family member A -0.0217688
ETNK1 ethanolamine kinase 1 -0.0195636
OXR1 oxidation resistance 1 -0.0168605
MT1X metallothionein 1X -0.0162424
STAU1 staufen double-stranded RNA binding protein 1 -0.0161448
GOLGB1 golgin B1 -0.0155389
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0153388
KMT2C lysine (K)-specific methyltransferase 2C -0.0152445
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0142653
ATXN1 ataxin 1 -0.012956
CNKSR3 CNKSR family member 3 -0.0127889
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0124623
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0111886
PEG10 paternally expressed 10 -0.00554237
STK24 serine/threonine kinase 24 -0.00261197
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.00244542
RPS8 ribosomal protein S8 -0.00158642
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -7.73627E-4
LCOR ligand dependent nuclear receptor corepressor -3.50038E-4
VIM vimentin -7.79283E-5