Belinostat_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Belinostat_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0834181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.075531
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0653499
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0588928
OLA1 Obg-like ATPase 1 0.0538634
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0535476
ZFAND3 zinc finger, AN1-type domain 3 0.0456993
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0373372
TPM3 tropomyosin 3 0.0372272
ADAM9 ADAM metallopeptidase domain 9 0.0339107
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0335041
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0323576
THBS1 thrombospondin 1 0.0320528
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0315752
ENAH enabled homolog (Drosophila) 0.0314906
H1-0 H1.0 linker histone 0.0314494
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0311624
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0307157
MEMO1 mediator of cell motility 1 0.0300372
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0299809
STAU1 staufen double-stranded RNA binding protein 1 0.0297324
SRP54 signal recognition particle 54kDa 0.0292753
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0292352
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0283934
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0279595
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0278844
MYH9 myosin, heavy chain 9, non-muscle 0.0276967
USP15 ubiquitin specific peptidase 15 0.0276009
MTF2 metal response element binding transcription factor 2 0.0275266
WDR43 WD repeat domain 43 0.0272436
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0269332
APP amyloid beta (A4) precursor protein 0.0268945
FXR1 fragile X mental retardation, autosomal homolog 1 0.0267594
NUP153 nucleoporin 153kDa 0.0263538
SERINC1 serine incorporator 1 0.0263075
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0262749
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.025999
FUS FUS RNA binding protein 0.0258825
GLS2 glutaminase 2 (liver, mitochondrial) 0.025879
GRB2 growth factor receptor-bound protein 2 0.025469
KIDINS220 kinase D-interacting substrate, 220kDa 0.0253727
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0251905
CRY1 cryptochrome circadian clock 1 0.0248886
MRTFA myocardin related transcription factor A 0.0245741
NCKAP1 NCK-associated protein 1 0.0241183
ORC4 origin recognition complex, subunit 4 0.0239005
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0234002
UBQLN1 ubiquilin 1 0.0231283
KAT6A K(lysine) acetyltransferase 6A 0.0230958
TPX2 TPX2, microtubule-associated 0.0227353
IFRD1 interferon-related developmental regulator 1 0.0225713
ECT2 epithelial cell transforming 2 0.0225417
PTGES2 prostaglandin E synthase 2 0.0224705
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0223099
TMSB4X thymosin beta 4, X-linked 0.0222693
ELOVL5 ELOVL fatty acid elongase 5 0.0221171
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.022003
USP33 ubiquitin specific peptidase 33 0.0217141
APLP2 amyloid beta (A4) precursor-like protein 2 0.0216887
SSB Sjogren syndrome antigen B (autoantigen La) 0.0213053
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 0.0212345
FGFR1OP2 FGFR1 oncogene partner 2 0.0210882
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0210305
SPAG9 sperm associated antigen 9 0.0210224
PGAP1 post-GPI attachment to proteins 1 0.0209815
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0208974
OSBPL9 oxysterol binding protein-like 9 0.0208866
ATAD2 ATPase family, AAA domain containing 2 0.0207247
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0207084
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0206798
GXYLT1 glucoside xylosyltransferase 1 0.0206498
KDM1A lysine (K)-specific demethylase 1A 0.020417
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0202144
USP9X ubiquitin specific peptidase 9, X-linked 0.0201927
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0201349
HMGB2 high mobility group box 2 0.0198617
ANXA5 annexin A5 0.0197989
IQGAP1 IQ motif containing GTPase activating protein 1 0.0197501
ARHGAP12 Rho GTPase activating protein 12 0.0196772
MRPS30 mitochondrial ribosomal protein S30 0.0196562
HDAC2 histone deacetylase 2 0.019512
MYO10 myosin X 0.0193994
RACGAP1 Rac GTPase activating protein 1 0.0193227
AHCTF1 AT hook containing transcription factor 1 0.0192081
RTN4 reticulon 4 0.0189152
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0188402
LMTK2 lemur tyrosine kinase 2 0.0187233
ARHGAP26 Rho GTPase activating protein 26 0.0186789
ANLN anillin, actin binding protein 0.0185649
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0183192
PCBP2 poly(rC) binding protein 2 0.0180902
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0180739
CTNNBL1 catenin, beta like 1 0.0180593
ARL13B ADP-ribosylation factor-like 13B 0.0180123
RTTN rotatin 0.0180019
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0179203
ACVR2A activin A receptor, type IIA 0.0177774
NUP58 nucleoporin 58 0.0177407
SMC5 structural maintenance of chromosomes 5 0.0177017
SCAF4 SR-related CTD-associated factor 4 0.0176864

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163121
VIM vimentin -0.142926
TMSB10 thymosin beta 10 -0.130704
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.116206
CDH10 cadherin 10, type 2 (T2-cadherin) -0.114623
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0907518
PTMA prothymosin, alpha -0.0740929
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.072948
PHIP pleckstrin homology domain interacting protein -0.0636562
RPS16 ribosomal protein S16 -0.0621489
CADM2 cell adhesion molecule 2 -0.0601903
PCLO piccolo presynaptic cytomatrix protein -0.0599094
RPS8 ribosomal protein S8 -0.0575369
RPS6 ribosomal protein S6 -0.0575041
RPL35A ribosomal protein L35a -0.055673
ACTG1 actin gamma 1 -0.0556684
ADGRL2 adhesion G protein-coupled receptor L2 -0.0552075
RAD51B RAD51 paralog B -0.055186
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0524582
RPLP1 ribosomal protein, large, P1 -0.0506473
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.050176
FTL ferritin, light polypeptide -0.0499695
ANKRD12 ankyrin repeat domain 12 -0.0487645
PCDH9 protocadherin 9 -0.048736
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0472051
PARD3B par-3 family cell polarity regulator beta -0.0462509
RPL37A ribosomal protein L37a -0.0461832
GNAS GNAS complex locus -0.0440358
TENM3 teneurin transmembrane protein 3 -0.0434846
HDAC9 histone deacetylase 9 -0.0432972
MDK midkine (neurite growth-promoting factor 2) -0.0424122
RPS27A ribosomal protein S27a -0.0417561
RPL37 ribosomal protein L37 -0.0412399
PDE4D phosphodiesterase 4D, cAMP-specific -0.0410963
RPLP2 ribosomal protein, large, P2 -0.0409453
RPS19 ribosomal protein S19 -0.0405435
NTM neurotrimin -0.0398814
ITGAV integrin, alpha V -0.0391569
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0388228
KMT2C lysine (K)-specific methyltransferase 2C -0.0381098
RPL19 ribosomal protein L19 -0.0377585
TRPS1 trichorhinophalangeal syndrome I -0.0376604
COL11A1 collagen, type XI, alpha 1 -0.0372413
PBX3 pre-B-cell leukemia homeobox 3 -0.0371951
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0369283
RPL31 ribosomal protein L31 -0.0366274
RPL30 ribosomal protein L30 -0.0366242
RPS3 ribosomal protein S3 -0.0362977
ENO1 enolase 1, (alpha) -0.0339583
MEIS2 Meis homeobox 2 -0.0332563
RPS12 ribosomal protein S12 -0.0332047
PLPP1 phospholipid phosphatase 1 -0.0330037
RPL28 ribosomal protein L28 -0.0327448
RPL11 ribosomal protein L11 -0.0326921
NCAM2 neural cell adhesion molecule 2 -0.0325191
CDH19 cadherin 19, type 2 -0.0310896
MT2A metallothionein 2A -0.0309119
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0302557
COL5A2 collagen, type V, alpha 2 -0.0297969
EIF1 eukaryotic translation initiation factor 1 -0.0296912
FOXP2 forkhead box P2 -0.0294714
PCDH7 protocadherin 7 -0.0293077
RPS13 ribosomal protein S13 -0.0292847
POTEF POTE ankyrin domain family, member F -0.0289128
ADGRL3 adhesion G protein-coupled receptor L3 -0.0283748
RPL23 ribosomal protein L23 -0.0282424
LRRC4C leucine rich repeat containing 4C -0.0277977
TPT1 tumor protein, translationally-controlled 1 -0.0277004
EEF2 eukaryotic translation elongation factor 2 -0.0271236
MKI67 marker of proliferation Ki-67 -0.0270132
AKAP9 A kinase (PRKA) anchor protein 9 -0.0269134
RPL12 ribosomal protein L12 -0.0267133
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0265848
RPL5 ribosomal protein L5 -0.0262011
PFN1 profilin 1 -0.0259119
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0258841
LOC102724023 ES1 protein homolog, mitochondrial -0.0258628
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0257089
ATP5F1B ATP synthase F1 subunit beta -0.0255582
SRRM2 serine/arginine repetitive matrix 2 -0.025454
TAS2R14 taste receptor, type 2, member 14 -0.025351
HSPB1 heat shock 27kDa protein 1 -0.0253013
PRTG protogenin -0.0250477
NHSL1 NHS-like 1 -0.0250064
RPS23 ribosomal protein S23 -0.0248781
JMJD1C jumonji domain containing 1C -0.0248328
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0247017
KMT2E lysine (K)-specific methyltransferase 2E -0.0246589
PGK1 phosphoglycerate kinase 1 -0.0244788
RPL36 ribosomal protein L36 -0.0243587
ANKRD33B ankyrin repeat domain 33B -0.0243304
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0243243
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0241931
RPL36A ribosomal protein L36a -0.0235656
RPL9 ribosomal protein L9 -0.0235298
RPS15 ribosomal protein S15 -0.0235238
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0233994
MBD5 methyl-CpG binding domain protein 5 -0.0231932
RPL7A ribosomal protein L7a -0.0229918
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0229866