Belinostat_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.17003
FN1 fibronectin 1 0.144856
MYH9 myosin, heavy chain 9, non-muscle 0.0784892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0692627
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0665247
PDE10A phosphodiesterase 10A 0.0619778
SFTPA2 surfactant protein A2 0.0603009
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0597702
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0584437
FNDC3B fibronectin type III domain containing 3B 0.0582883
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0559496
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0520895
VEGFA vascular endothelial growth factor A 0.050726
MYOF myoferlin 0.050379
HDAC9 histone deacetylase 9 0.0499585
OGA O-GlcNAcase 0.0481342
NAV2 neuron navigator 2 0.0457303
CDK19 cyclin-dependent kinase 19 0.0452075
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0450841
ARRDC3 arrestin domain containing 3 0.0445802
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0441452
APLP2 amyloid beta (A4) precursor-like protein 2 0.0433687
PCBP2 poly(rC) binding protein 2 0.0431536
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0421118
RB1CC1 RB1-inducible coiled-coil 1 0.0415168
MSN moesin 0.0413141
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0408015
ELL2 elongation factor, RNA polymerase II, 2 0.0397024
GOLGA4 golgin A4 0.039699
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0380069
CANX calnexin 0.0377266
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0373081
ANXA2 annexin A2 0.0363066
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.035094
DSCAM Down syndrome cell adhesion molecule 0.0350779
TNIP1 TNFAIP3 interacting protein 1 0.0344696
FLNB filamin B, beta 0.0344584
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0337697
JMJD1C jumonji domain containing 1C 0.0329482
ZNF292 zinc finger protein 292 0.032241
USP9X ubiquitin specific peptidase 9, X-linked 0.0320186
APP amyloid beta (A4) precursor protein 0.031784
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0311989
SMAD3 SMAD family member 3 0.0306784
PRELID2 PRELI domain containing 2 0.0305997
TRIO trio Rho guanine nucleotide exchange factor 0.0302099
ATXN1 ataxin 1 0.0286713
SERINC1 serine incorporator 1 0.0280216
WDFY1 WD repeat and FYVE domain containing 1 0.0279237
YEATS2 YEATS domain containing 2 0.0276331
FNIP1 folliculin interacting protein 1 0.0274042
PNISR PNN-interacting serine/arginine-rich protein 0.027178
SNX9 sorting nexin 9 0.0269673
DIAPH3 diaphanous-related formin 3 0.0269309
CEP250 centrosomal protein 250kDa 0.026817
RICTOR RPTOR independent companion of MTOR, complex 2 0.0252651
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251428
PPARD peroxisome proliferator-activated receptor delta 0.0250826
OPTN optineurin 0.025001
STAG2 stromal antigen 2 0.0247376
SP100 SP100 nuclear antigen 0.0244654
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0244493
HDLBP high density lipoprotein binding protein 0.0240631
ITCH itchy E3 ubiquitin protein ligase 0.0239815
BASP1 brain abundant, membrane attached signal protein 1 0.0238793
SCAF8 SR-related CTD-associated factor 8 0.0236062
NAMPT nicotinamide phosphoribosyltransferase 0.0236052
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0235636
TENT5A terminal nucleotidyltransferase 5A 0.0230515
AKAP9 A kinase (PRKA) anchor protein 9 0.0230446
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0230143
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0229903
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0229046
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0227323
KLF6 Kruppel-like factor 6 0.022617
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0225221
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0224164
UBA6 ubiquitin-like modifier activating enzyme 6 0.0223588
ADM adrenomedullin 0.0222327
EEF2 eukaryotic translation elongation factor 2 0.0222073
LDHA lactate dehydrogenase A 0.0220688
BPTF bromodomain PHD finger transcription factor 0.0218745
MKI67 marker of proliferation Ki-67 0.0218471
ADAR adenosine deaminase, RNA-specific 0.0218449
SDCBP syndecan binding protein (syntenin) 0.0216919
SENP6 SUMO1/sentrin specific peptidase 6 0.0216773
ASXL1 additional sex combs like transcriptional regulator 1 0.0214314
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0212619
ESYT2 extended synaptotagmin-like protein 2 0.0211619
LOXL2 lysyl oxidase-like 2 0.0211371
MORF4L2 mortality factor 4 like 2 0.0210597
ANLN anillin, actin binding protein 0.020879
MX1 MX dynamin-like GTPase 1 0.0207327
RAP1B RAP1B, member of RAS oncogene family 0.020731
NDRG1 N-myc downstream regulated 1 0.0205604
VMP1 vacuole membrane protein 1 0.0203165
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0203128
KDM3A lysine (K)-specific demethylase 3A 0.0202058
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.020162
BBX bobby sox homolog (Drosophila) 0.0201151

decreased expression

Symbol Name Standardized Value
IER3 immediate early response 3 -0.0656953
VIM vimentin -0.0504531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0476818
GLIS3 GLIS family zinc finger 3 -0.0440966
TMSB10 thymosin beta 10 -0.0423065
FTL ferritin, light polypeptide -0.0400893
RPLP2 ribosomal protein, large, P2 -0.0391658
RPL35A ribosomal protein L35a -0.0377897
TPT1 tumor protein, translationally-controlled 1 -0.0376778
IGFBP3 insulin-like growth factor binding protein 3 -0.0376771
RPS6 ribosomal protein S6 -0.0342357
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0334651
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0319696
RPL37A ribosomal protein L37a -0.0313287
UGCG UDP-glucose ceramide glucosyltransferase -0.0312345
RPLP1 ribosomal protein, large, P1 -0.0296694
RPL36 ribosomal protein L36 -0.0294565
BICC1 BicC family RNA binding protein 1 -0.0288228
RPS24 ribosomal protein S24 -0.0287757
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0274896
RPS3 ribosomal protein S3 -0.027362
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0270606
SFRP1 secreted frizzled-related protein 1 -0.026642
RPS13 ribosomal protein S13 -0.0260092
KMT2C lysine (K)-specific methyltransferase 2C -0.0256166
RPS8 ribosomal protein S8 -0.0249488
SLC38A1 solute carrier family 38, member 1 -0.0248305
RPL23 ribosomal protein L23 -0.0236682
ACTG1 actin gamma 1 -0.0236046
ENAH enabled homolog (Drosophila) -0.0227489
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0224149
RPL9 ribosomal protein L9 -0.0221883
EIF5B eukaryotic translation initiation factor 5B -0.0219171
RPL38 ribosomal protein L38 -0.0218549
EGR1 early growth response 1 -0.0212323
RPL26 ribosomal protein L26 -0.0207066
RPL34 ribosomal protein L34 -0.0206286
INHBA inhibin, beta A -0.0204678
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0203195
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0201972
RPS23 ribosomal protein S23 -0.0190515
CD44 CD44 molecule (Indian blood group) -0.0189552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0189533
PTMA prothymosin, alpha -0.0188497
HMGA1 high mobility group AT-hook 1 -0.0187896
RPS19 ribosomal protein S19 -0.0187371
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0186392
RPS21 ribosomal protein S21 -0.0185356
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0183526
ARL4C ADP-ribosylation factor-like 4C -0.0183231
EXT1 exostosin glycosyltransferase 1 -0.0182715
RPS29 ribosomal protein S29 -0.0181453
RPL35 ribosomal protein L35 -0.0181365
RPL18 ribosomal protein L18 -0.0181166
ASPH aspartate beta-hydroxylase -0.0180302
RPL32 ribosomal protein L32 -0.0174771
MT2A metallothionein 2A -0.0174614
RPL36A ribosomal protein L36a -0.0172822
LOC102724023 ES1 protein homolog, mitochondrial -0.0172157
SAMD3 sterile alpha motif domain containing 3 -0.0172112
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0171605
SOX4 SRY (sex determining region Y)-box 4 -0.0171322
RPL7A ribosomal protein L7a -0.0170501
RPL12 ribosomal protein L12 -0.0168065
QKI QKI, KH domain containing, RNA binding -0.0165534
RPS10 ribosomal protein S10 -0.0164289
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0159192
LMNA lamin A/C -0.0158223
RPS25 ribosomal protein S25 -0.0158122
NAV1 neuron navigator 1 -0.0157738
RPL28 ribosomal protein L28 -0.0157319
RPL27 ribosomal protein L27 -0.0156324
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0152776
RPL37 ribosomal protein L37 -0.0151067
TXNRD1 thioredoxin reductase 1 -0.0146764
GPHN gephyrin -0.0145639
RPL10A ribosomal protein L10a -0.014275
RPS20 ribosomal protein S20 -0.0142631
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0141943
EGFR epidermal growth factor receptor -0.0141282
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0140687
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0140087
CAVIN1 caveolae associated protein 1 -0.0139809
FAM162A family with sequence similarity 162, member A -0.0138916
RPL11 ribosomal protein L11 -0.013798
NPR2 natriuretic peptide receptor 2 -0.0137938
PA2G4 proliferation-associated 2G4, 38kDa -0.0136734
SSBP2 single-stranded DNA binding protein 2 -0.0131727
SRPK2 SRSF protein kinase 2 -0.0131064
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.012974
RRBP1 ribosome binding protein 1 -0.0129113
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0127857
AUTS2 autism susceptibility candidate 2 -0.0127656
CRY1 cryptochrome circadian clock 1 -0.0127472
RPS12 ribosomal protein S12 -0.012743
PRSS23 protease, serine, 23 -0.0126889
RPS15 ribosomal protein S15 -0.012628
LSAMP limbic system-associated membrane protein -0.0124836
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0122651
COTL1 coactosin-like F-actin binding protein 1 -0.0121472