Belinostat_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP9 A kinase (PRKA) anchor protein 9 0.105055
COL6A3 collagen, type VI, alpha 3 0.104423
STC1 stanniocalcin 1 0.0973281
ELL2 elongation factor, RNA polymerase II, 2 0.0789947
B2M beta-2-microglobulin 0.0775108
ZBTB20 zinc finger and BTB domain containing 20 0.0676843
DSCAM Down syndrome cell adhesion molecule 0.0675649
HDLBP high density lipoprotein binding protein 0.0645681
EXT1 exostosin glycosyltransferase 1 0.0637684
GOLGA4 golgin A4 0.0615494
UBA6 ubiquitin-like modifier activating enzyme 6 0.0599323
SEC31A SEC31 homolog A (S. cerevisiae) 0.0587052
FUS FUS RNA binding protein 0.0583996
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0583469
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0583002
RAB1A RAB1A, member RAS oncogene family 0.0567291
NRXN3 neurexin 3 0.0531267
AFF4 AF4/FMR2 family, member 4 0.0517557
MYH9 myosin, heavy chain 9, non-muscle 0.0504649
HOOK2 hook microtubule-tethering protein 2 0.0495517
ESYT2 extended synaptotagmin-like protein 2 0.0492303
CANX calnexin 0.0488564
RARS1 arginyl-tRNA synthetase 1 0.0482153
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0479699
IGFBP5 insulin-like growth factor binding protein 5 0.0476102
COPB1 coatomer protein complex, subunit beta 1 0.0466631
ANXA2 annexin A2 0.0464796
TOM1L2 target of myb1-like 2 (chicken) 0.0448755
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0436056
TTC3 tetratricopeptide repeat domain 3 0.0429211
SDC4 syndecan 4 0.0425845
FNDC3B fibronectin type III domain containing 3B 0.0416503
CFDP1 craniofacial development protein 1 0.0413516
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0411278
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0402409
FN1 fibronectin 1 0.0397946
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0397396
COG5 component of oligomeric golgi complex 5 0.0395976
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0371641
ZCCHC7 zinc finger, CCHC domain containing 7 0.0369041
HPCAL1 hippocalcin-like 1 0.0362011
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0360184
RLF rearranged L-myc fusion 0.0358294
ITCH itchy E3 ubiquitin protein ligase 0.0355779
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0354428
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0354302
COG6 component of oligomeric golgi complex 6 0.035312
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0349351
ANLN anillin, actin binding protein 0.0346579
STK4 serine/threonine kinase 4 0.034227
SSR1 signal sequence receptor, alpha 0.0337823
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0335945
PTMA prothymosin, alpha 0.0333884
KDM3A lysine (K)-specific demethylase 3A 0.0330148
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0327435
MORF4L2 mortality factor 4 like 2 0.0325175
ADM adrenomedullin 0.0322948
RTN4 reticulon 4 0.0320903
CTNND1 catenin (cadherin-associated protein), delta 1 0.0318087
NAMPT nicotinamide phosphoribosyltransferase 0.0318078
CARD16 caspase recruitment domain family, member 16 0.031771
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0317257
DPYD dihydropyrimidine dehydrogenase 0.0315626
ACBD3 acyl-CoA binding domain containing 3 0.0310943
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0309188
LONP2 lon peptidase 2, peroxisomal 0.030866
THRAP3 thyroid hormone receptor associated protein 3 0.03086
IQGAP1 IQ motif containing GTPase activating protein 1 0.0306126
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0305346
ARRDC3 arrestin domain containing 3 0.0304291
HLA-C major histocompatibility complex, class I, C 0.0301934
CHD9 chromodomain helicase DNA binding protein 9 0.0299048
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.02979
LGALS1 lectin, galactoside-binding, soluble, 1 0.0297097
ACTN4 actinin, alpha 4 0.029553
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0294062
ARF4 ADP-ribosylation factor 4 0.029337
TRA2A transformer 2 alpha homolog (Drosophila) 0.0287576
PMM2 phosphomannomutase 2 0.0287009
GPR107 G protein-coupled receptor 107 0.0284571
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0283327
NOTCH2 notch 2 0.0283241
PRSS23 protease, serine, 23 0.0283043
CAMKMT calmodulin-lysine N-methyltransferase 0.0278347
CLIC4 chloride intracellular channel 4 0.0275665
MAP2K1 mitogen-activated protein kinase kinase 1 0.0274467
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0273958
CTSB cathepsin B 0.027327
FOXO3 forkhead box O3 0.0271831
HBS1L HBS1-like translational GTPase 0.0271443
YME1L1 YME1-like 1 ATPase 0.0271157
LMAN1 lectin, mannose-binding, 1 0.0270487
SEC13 SEC13 homolog (S. cerevisiae) 0.0268863
CSDE1 cold shock domain containing E1, RNA-binding 0.0268369
MBD5 methyl-CpG binding domain protein 5 0.0268182
USP53 ubiquitin specific peptidase 53 0.0266628
WTAP Wilms tumor 1 associated protein 0.0266052
C1R complement component 1, r subcomponent 0.0265487
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0264558
AVL9 AVL9 homolog (S. cerevisiase) 0.0264332

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.195866
VIM vimentin -0.0832735
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0801069
LMNA lamin A/C -0.0681563
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0635547
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.060697
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0481785
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0438831
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.043653
TRIO trio Rho guanine nucleotide exchange factor -0.0434888
TMSB10 thymosin beta 10 -0.0430881
TGFBI transforming growth factor, beta-induced, 68kDa -0.0403858
NAV1 neuron navigator 1 -0.0398669
RPL28 ribosomal protein L28 -0.0391649
ENO1 enolase 1, (alpha) -0.0375818
PKM pyruvate kinase, muscle -0.037484
RHEB Ras homolog enriched in brain -0.0374825
BSG basigin (Ok blood group) -0.0360839
COL1A1 collagen, type I, alpha 1 -0.0345736
DDIT4 DNA-damage-inducible transcript 4 -0.0339324
POTEF POTE ankyrin domain family, member F -0.0336124
RPL37A ribosomal protein L37a -0.0333888
MYL12B myosin, light chain 12B, regulatory -0.0330144
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0328208
BZW2 basic leucine zipper and W2 domains 2 -0.032095
CALD1 caldesmon 1 -0.0319637
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0319473
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0317765
PURB purine-rich element binding protein B -0.0317329
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0309349
RPL32 ribosomal protein L32 -0.0309054
USP47 ubiquitin specific peptidase 47 -0.0308778
EIF5B eukaryotic translation initiation factor 5B -0.0307611
DSTN destrin (actin depolymerizing factor) -0.0306964
FBXO11 F-box protein 11 -0.0304265
ZEB1 zinc finger E-box binding homeobox 1 -0.029273
AAK1 AP2 associated kinase 1 -0.0287608
H3-3B H3.3 histone B -0.0286018
SPAG9 sperm associated antigen 9 -0.0285182
SMAD3 SMAD family member 3 -0.0282051
WNT5A wingless-type MMTV integration site family, member 5A -0.0279976
PDE4D phosphodiesterase 4D, cAMP-specific -0.0279834
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0278448
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.027586
EFNA5 ephrin-A5 -0.027556
PDS5B PDS5 cohesin associated factor B -0.0273699
DPYSL2 dihydropyrimidinase-like 2 -0.0272408
RPL36A ribosomal protein L36a -0.0269214
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0268174
ETV6 ets variant 6 -0.0267745
ADAM9 ADAM metallopeptidase domain 9 -0.0262186
RPL23 ribosomal protein L23 -0.0260733
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0255549
NDRG1 N-myc downstream regulated 1 -0.0254967
KIAA0319L KIAA0319-like -0.025496
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0254394
KDM6A lysine (K)-specific demethylase 6A -0.0253543
COL6A1 collagen, type VI, alpha 1 -0.0251699
PEAK1 pseudopodium-enriched atypical kinase 1 -0.024855
IGF1R insulin-like growth factor 1 receptor -0.0248396
KMT2C lysine (K)-specific methyltransferase 2C -0.0248339
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0248138
TRIM9 tripartite motif containing 9 -0.0248042
ATXN2 ataxin 2 -0.0248034
NT5C2 5'-nucleotidase, cytosolic II -0.0246786
UBTD2 ubiquitin domain containing 2 -0.0246427
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0245572
PUM1 pumilio RNA-binding family member 1 -0.0245051
RPS10 ribosomal protein S10 -0.0244043
NHSL1 NHS-like 1 -0.0242467
ARF6 ADP-ribosylation factor 6 -0.0240042
LOX lysyl oxidase -0.0239132
RAB10 RAB10, member RAS oncogene family -0.0238761
MAPK8 mitogen-activated protein kinase 8 -0.0238498
CERT1 ceramide transporter 1 -0.0238498
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0237033
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit -0.0236919
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.023557
ANKHD1 ankyrin repeat and KH domain containing 1 -0.023491
MAP4 microtubule-associated protein 4 -0.0234416
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0234302
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0234142
PDZD2 PDZ domain containing 2 -0.0234131
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.023358
CAPN2 calpain 2, (m/II) large subunit -0.0232566
ARHGAP17 Rho GTPase activating protein 17 -0.0230796
MON2 MON2 homolog (S. cerevisiae) -0.0230184
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0229254
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0228762
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0228382
SQSTM1 sequestosome 1 -0.0227783
EGFR epidermal growth factor receptor -0.0227752
FTL ferritin, light polypeptide -0.0227102
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0225534
NPAS2 neuronal PAS domain protein 2 -0.0224821
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0224051
TPI1 triosephosphate isomerase 1 -0.0222642
MORC3 MORC family CW-type zinc finger 3 -0.0222253
RAI1 retinoic acid induced 1 -0.02214
MXI1 MAX interactor 1, dimerization protein -0.021854