Belinostat_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.137591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.134457
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.116673
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.11398
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0829738
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0711225
CANX calnexin 0.0680236
TPX2 TPX2, microtubule-associated 0.062365
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0617176
CALU calumenin 0.0589341
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0581393
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0572149
APLP2 amyloid beta (A4) precursor-like protein 2 0.0539982
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0537138
TXNRD1 thioredoxin reductase 1 0.0514256
RPL23 ribosomal protein L23 0.0512907
SMC4 structural maintenance of chromosomes 4 0.0487573
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0482912
CENPF centromere protein F, 350/400kDa 0.047285
GOLGA4 golgin A4 0.0465539
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0464582
SETD5 SET domain containing 5 0.0444453
PCBP2 poly(rC) binding protein 2 0.0424425
GOLGB1 golgin B1 0.0410839
NUP58 nucleoporin 58 0.0404515
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0403116
RPLP1 ribosomal protein, large, P1 0.039968
KIAA1958 KIAA1958 0.0388489
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0384145
RPL12 ribosomal protein L12 0.0379386
ANLN anillin, actin binding protein 0.0376503
MTDH metadherin 0.0368757
HSPA8 heat shock 70kDa protein 8 0.0363644
KIF5B kinesin family member 5B 0.0362239
MKI67 marker of proliferation Ki-67 0.0361032
RPL26 ribosomal protein L26 0.0360689
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0360468
CEP295 centrosomal protein 295kDa 0.0357074
RBM39 RNA binding motif protein 39 0.0354432
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0353498
SPAG9 sperm associated antigen 9 0.0335665
PIBF1 progesterone immunomodulatory binding factor 1 0.0324691
DEK DEK proto-oncogene 0.0319215
RB1CC1 RB1-inducible coiled-coil 1 0.0316284
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0312474
TNPO1 transportin 1 0.0310309
DIAPH3 diaphanous-related formin 3 0.031027
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0309296
COG5 component of oligomeric golgi complex 5 0.030813
FNIP1 folliculin interacting protein 1 0.0307552
GOLGA2 golgin A2 0.030506
ZNF292 zinc finger protein 292 0.0305034
RARS1 arginyl-tRNA synthetase 1 0.0303978
CLTC clathrin, heavy chain (Hc) 0.0295802
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0295468
PHIP pleckstrin homology domain interacting protein 0.0294091
LCORL ligand dependent nuclear receptor corepressor-like 0.0291479
PTMA prothymosin, alpha 0.0290881
YBX1 Y box binding protein 1 0.0290261
CEP250 centrosomal protein 250kDa 0.0290183
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0288195
ARL15 ADP-ribosylation factor-like 15 0.0281571
TMEM123 transmembrane protein 123 0.0280076
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0279081
WDPCP WD repeat containing planar cell polarity effector 0.0278544
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0278518
SQSTM1 sequestosome 1 0.0277982
RPS8 ribosomal protein S8 0.0268925
EEF2 eukaryotic translation elongation factor 2 0.0268337
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0265833
CLINT1 clathrin interactor 1 0.0264187
MRE11 MRE11 homolog, double strand break repair nuclease 0.026366
CHD1 chromodomain helicase DNA binding protein 1 0.0262597
CALR calreticulin 0.0262012
IARS1 isoleucyl-tRNA synthetase 1 0.0261861
BASP1 brain abundant, membrane attached signal protein 1 0.0259801
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0259345
HJURP Holliday junction recognition protein 0.0258415
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0252411
RPS3 ribosomal protein S3 0.0252349
TPR translocated promoter region, nuclear basket protein 0.0252293
TENT2 terminal nucleotidyltransferase 2 0.0252116
NAP1L1 nucleosome assembly protein 1-like 1 0.0250144
GOLT1B golgi transport 1B 0.0250089
KLHL24 kelch-like family member 24 0.0249722
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.024947
SRP54 signal recognition particle 54kDa 0.0247672
CCDC88A coiled-coil domain containing 88A 0.0247119
WAC WW domain containing adaptor with coiled-coil 0.0246459
RAB10 RAB10, member RAS oncogene family 0.024606
GPHN gephyrin 0.0246019
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0244211
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0243214
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0241871
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0241781
ANKRD28 ankyrin repeat domain 28 0.0241578
HELZ helicase with zinc finger 0.0240366
UBQLN1 ubiquilin 1 0.0238866
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0238706
RPLP2 ribosomal protein, large, P2 0.0235116

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.140201
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0933825
TMSB10 thymosin beta 10 -0.0854076
CD44 CD44 molecule (Indian blood group) -0.0758078
ANGPTL4 angiopoietin-like 4 -0.0623166
DST dystonin -0.0612132
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0601248
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0575742
HMGA2 high mobility group AT-hook 2 -0.0560649
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0524723
POTEF POTE ankyrin domain family, member F -0.0506083
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0494832
PRSS23 protease, serine, 23 -0.0494646
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0482255
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0476016
FMNL2 formin-like 2 -0.0475039
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0469509
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0453353
MACF1 microtubule-actin crosslinking factor 1 -0.0445428
NALCN sodium leak channel, non selective -0.0441848
ZBTB20 zinc finger and BTB domain containing 20 -0.0431976
RAI14 retinoic acid induced 14 -0.0410935
SVIL supervillin -0.0409518
THSD4 thrombospondin, type I, domain containing 4 -0.0404282
NDRG1 N-myc downstream regulated 1 -0.0400028
OSMR oncostatin M receptor -0.0399515
PRR16 proline rich 16 -0.0397066
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0394484
EGFR epidermal growth factor receptor -0.0376566
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0373986
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0371663
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0370018
FTH1 ferritin, heavy polypeptide 1 -0.0365727
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0363844
RIGI RNA sensor RIG-I -0.0353867
NAV3 neuron navigator 3 -0.0347141
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0339994
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0328656
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0323088
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0322022
FLNB filamin B, beta -0.0313831
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0309066
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0306014
IGFBP3 insulin-like growth factor binding protein 3 -0.0297457
PRKCA protein kinase C, alpha -0.0297011
PODXL podocalyxin-like -0.0293753
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0290489
PLEK2 pleckstrin 2 -0.0282557
ENO2 enolase 2 (gamma, neuronal) -0.0277423
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0276164
PARD3 par-3 family cell polarity regulator -0.0275961
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0271507
PCED1B PC-esterase domain containing 1B -0.0267364
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0263069
TPT1 tumor protein, translationally-controlled 1 -0.0262011
DPYD dihydropyrimidine dehydrogenase -0.0257748
FMN1 formin 1 -0.0257553
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0256226
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0250751
FNDC3A fibronectin type III domain containing 3A -0.0244932
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0242485
CDCP1 CUB domain containing protein 1 -0.0236408
ZFHX3 zinc finger homeobox 3 -0.0234997
LDHA lactate dehydrogenase A -0.0234621
IGF2 insulin-like growth factor 2 -0.0233713
CUX1 cut-like homeobox 1 -0.0230415
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0229944
NT5E 5'-nucleotidase, ecto (CD73) -0.022894
PTPRG protein tyrosine phosphatase, receptor type, G -0.022894
S100A10 S100 calcium binding protein A10 -0.0228359
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0226508
RSF1 remodeling and spacing factor 1 -0.0221829
NPAS2 neuronal PAS domain protein 2 -0.0220725
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0219665
JMJD1C jumonji domain containing 1C -0.0217986
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0217378
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0217226
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0216854
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0212427
PTK2 protein tyrosine kinase 2 -0.0211383
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0210968
EFNA5 ephrin-A5 -0.0210376
AKAP13 A kinase (PRKA) anchor protein 13 -0.0210039
BTG1 B-cell translocation gene 1, anti-proliferative -0.0209525
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0209258
DTNA dystrobrevin, alpha -0.0207662
WARS1 tryptophanyl-tRNA synthetase 1 -0.0206756
LAMA5 laminin, alpha 5 -0.0206265
S100A6 S100 calcium binding protein A6 -0.0205228
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.020498
SH3KBP1 SH3-domain kinase binding protein 1 -0.0203236
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0203213
ITGAV integrin, alpha V -0.0202848
AKAP12 A kinase (PRKA) anchor protein 12 -0.0202711
MYOF myoferlin -0.0201879
ZBTB7A zinc finger and BTB domain containing 7A -0.0201634
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0200446
BCAR3 breast cancer anti-estrogen resistance 3 -0.0198528
ACTG1 actin gamma 1 -0.019822
B2M beta-2-microglobulin -0.0195385