Belinostat_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belinostat perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belinostat_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.338201
CANX calnexin 0.189072
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.141763
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.131513
P4HB prolyl 4-hydroxylase, beta polypeptide 0.108785
APLP2 amyloid beta (A4) precursor-like protein 2 0.0861831
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0799742
SQSTM1 sequestosome 1 0.0771773
CXCL8 chemokine (C-X-C motif) ligand 8 0.0637221
TPR translocated promoter region, nuclear basket protein 0.0634134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0619416
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0523021
SOD2 superoxide dismutase 2, mitochondrial 0.0506286
SFTPA2 surfactant protein A2 0.050277
OGA O-GlcNAcase 0.0494265
FTH1 ferritin, heavy polypeptide 1 0.0492155
SEC31A SEC31 homolog A (S. cerevisiae) 0.0479262
SUCO SUN domain containing ossification factor 0.0434347
CALU calumenin 0.0432896
CALR calreticulin 0.0420317
ADIPOR2 adiponectin receptor 2 0.0404138
BASP1 brain abundant, membrane attached signal protein 1 0.0402291
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0397861
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0395173
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0392306
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0373383
BZW1 basic leucine zipper and W2 domains 1 0.0364329
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0360243
SPAG9 sperm associated antigen 9 0.0356092
SEC23A Sec23 homolog A (S. cerevisiae) 0.0352685
TTC3 tetratricopeptide repeat domain 3 0.0350464
LCORL ligand dependent nuclear receptor corepressor-like 0.034018
KDM3A lysine (K)-specific demethylase 3A 0.0339565
ACBD3 acyl-CoA binding domain containing 3 0.0336798
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0335491
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0335424
RAD21 RAD21 homolog (S. pombe) 0.0335306
BIRC6 baculoviral IAP repeat containing 6 0.0333149
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0330721
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0319224
FN1 fibronectin 1 0.0318965
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0317
TM9SF3 transmembrane 9 superfamily member 3 0.0314832
KDM5B lysine (K)-specific demethylase 5B 0.0309751
COPA coatomer protein complex, subunit alpha 0.0304791
MARCHF6 membrane associated ring-CH-type finger 6 0.0303383
HMGB3 high mobility group box 3 0.0298781
WAC WW domain containing adaptor with coiled-coil 0.0286642
YBX3 Y box binding protein 3 0.0284836
SDCBP syndecan binding protein (syntenin) 0.0283695
APP amyloid beta (A4) precursor protein 0.0279988
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0279946
CD109 CD109 molecule 0.027875
ANKRD17 ankyrin repeat domain 17 0.0277211
ZSWIM6 zinc finger, SWIM-type containing 6 0.0272532
PELO pelota homolog (Drosophila) 0.0270241
AFDN afadin, adherens junction formation factor 0.0267829
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0266194
RICTOR RPTOR independent companion of MTOR, complex 2 0.0265746
TMED2 transmembrane emp24 domain trafficking protein 2 0.0265222
WDR45B WD repeat domain 45B 0.0263516
TENT2 terminal nucleotidyltransferase 2 0.0262675
RC3H1 ring finger and CCCH-type domains 1 0.0260527
SPTBN1 spectrin, beta, non-erythrocytic 1 0.025881
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0257919
GOLGA4 golgin A4 0.0255733
YTHDC1 YTH domain containing 1 0.0250243
ZCCHC7 zinc finger, CCHC domain containing 7 0.0250182
HDLBP high density lipoprotein binding protein 0.0249275
ANKRD28 ankyrin repeat domain 28 0.0244024
RAB6A RAB6A, member RAS oncogene family 0.0243346
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.024263
FOS FBJ murine osteosarcoma viral oncogene homolog 0.024007
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0239218
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0238016
LIFR leukemia inhibitory factor receptor alpha 0.0231879
DNM1L dynamin 1-like 0.0229253
RAB1A RAB1A, member RAS oncogene family 0.0228155
KLHL24 kelch-like family member 24 0.0226476
ETNK1 ethanolamine kinase 1 0.0224265
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0222776
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0222319
AKAP9 A kinase (PRKA) anchor protein 9 0.0221926
SMOX spermine oxidase 0.0221819
FAT1 FAT atypical cadherin 1 0.0221518
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0221382
IQGAP1 IQ motif containing GTPase activating protein 1 0.0220003
ANKHD1 ankyrin repeat and KH domain containing 1 0.0215477
PICALM phosphatidylinositol binding clathrin assembly protein 0.0214585
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0214568
YY1AP1 YY1 associated protein 1 0.0208485
ARRDC3 arrestin domain containing 3 0.0206611
ASXL1 additional sex combs like transcriptional regulator 1 0.0204924
PELI1 pellino E3 ubiquitin protein ligase 1 0.0204804
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0203608
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0203278
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0201604
COG5 component of oligomeric golgi complex 5 0.0200492
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0199454
WDFY1 WD repeat and FYVE domain containing 1 0.0199206

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.196959
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133813
HMGA2 high mobility group AT-hook 2 -0.113384
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.111161
ASPH aspartate beta-hydroxylase -0.106292
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0967926
TMSB10 thymosin beta 10 -0.0866556
IFI27 interferon, alpha-inducible protein 27 -0.083269
MT2A metallothionein 2A -0.0766583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.057432
TMEM156 transmembrane protein 156 -0.0569819
RPS6 ribosomal protein S6 -0.0541842
FNDC3B fibronectin type III domain containing 3B -0.0534268
FTL ferritin, light polypeptide -0.0515282
TRIO trio Rho guanine nucleotide exchange factor -0.0498306
NAMPT nicotinamide phosphoribosyltransferase -0.0489325
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0455379
S100A6 S100 calcium binding protein A6 -0.0449747
SYT1 synaptotagmin I -0.0444331
RPL37A ribosomal protein L37a -0.0432519
PTK2 protein tyrosine kinase 2 -0.042867
MAP1B microtubule-associated protein 1B -0.0412175
IFI44L interferon-induced protein 44-like -0.0407636
NDRG1 N-myc downstream regulated 1 -0.0405211
DST dystonin -0.0400572
ACTG1 actin gamma 1 -0.039687
KMT2E lysine (K)-specific methyltransferase 2E -0.0396461
NTN4 netrin 4 -0.0393455
RPL35A ribosomal protein L35a -0.0375936
POTEF POTE ankyrin domain family, member F -0.0373451
B2M beta-2-microglobulin -0.0368297
LRMDA leucine rich melanocyte differentiation associated -0.0364415
PTMA prothymosin, alpha -0.0356948
S100A10 S100 calcium binding protein A10 -0.034803
RPS12 ribosomal protein S12 -0.0344927
ETV1 ets variant 1 -0.0341115
ENO2 enolase 2 (gamma, neuronal) -0.0329699
LY6E lymphocyte antigen 6 complex, locus E -0.032899
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0326151
RPL9 ribosomal protein L9 -0.0324976
ZMYND8 zinc finger, MYND-type containing 8 -0.0320991
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0316697
RPS19 ribosomal protein S19 -0.0312059
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0310242
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0307583
FOXP1 forkhead box P1 -0.0303644
KLHL5 kelch-like family member 5 -0.0298465
RAD51B RAD51 paralog B -0.0290976
TSC22D1 TSC22 domain family, member 1 -0.029062
RPL31 ribosomal protein L31 -0.0286854
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0278699
ZBTB20 zinc finger and BTB domain containing 20 -0.0270826
OSMR oncostatin M receptor -0.026957
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0269039
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.026891
RPS25 ribosomal protein S25 -0.0268406
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0268375
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0266233
SEPTIN9 septin 9 -0.0264151
TMEM165 transmembrane protein 165 -0.0263505
TSHZ2 teashirt zinc finger homeobox 2 -0.0262706
ELL2 elongation factor, RNA polymerase II, 2 -0.0262151
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0257054
IFI6 interferon, alpha-inducible protein 6 -0.025605
RPL28 ribosomal protein L28 -0.0255439
STC2 stanniocalcin 2 -0.0255361
MAML2 mastermind-like 2 (Drosophila) -0.0254461
NRP1 neuropilin 1 -0.0244865
AKAP12 A kinase (PRKA) anchor protein 12 -0.0244267
SOX4 SRY (sex determining region Y)-box 4 -0.0244177
MT1X metallothionein 1X -0.0243541
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0241493
SOX5 SRY (sex determining region Y)-box 5 -0.0238923
PKM pyruvate kinase, muscle -0.0238708
RPS20 ribosomal protein S20 -0.0238601
HMGA1 high mobility group AT-hook 1 -0.0237497
RPLP1 ribosomal protein, large, P1 -0.0232568
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0231441
RPS16 ribosomal protein S16 -0.0227542
EFNA5 ephrin-A5 -0.0224353
RPLP2 ribosomal protein, large, P2 -0.0223873
RPS23 ribosomal protein S23 -0.0221681
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0220557
GLIS3 GLIS family zinc finger 3 -0.0217308
BABAM2 BRISC and BRCA1 A complex member 2 -0.0217017
RPS24 ribosomal protein S24 -0.021515
RNF213 ring finger protein 213 -0.0213453
LOC102724023 ES1 protein homolog, mitochondrial -0.0211998
NALF1 NALCN channel auxiliary factor 1 -0.0210778
GPC6 glypican 6 -0.0207342
RPL18 ribosomal protein L18 -0.020517
TTC28 tetratricopeptide repeat domain 28 -0.0204145
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0203138
MAP4 microtubule-associated protein 4 -0.0201628
SVIL supervillin -0.0200637
RBM39 RNA binding motif protein 39 -0.0198243
UGCG UDP-glucose ceramide glucosyltransferase -0.0198022
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.019709
RPL8 ribosomal protein L8 -0.0196541
IER3 immediate early response 3 -0.0194072