| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.210035 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.143127 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.116017 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0893051 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0861137 |
| MT2A | metallothionein 2A | 0.0514182 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0482435 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0449699 |
| NDRG1 | N-myc downstream regulated 1 | 0.0443788 |
| UBC | ubiquitin C | 0.0400289 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.037752 |
| DCLK2 | doublecortin-like kinase 2 | 0.0368597 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0360865 |
| CENPF | centromere protein F, 350/400kDa | 0.0328354 |
| PTMA | prothymosin, alpha | 0.0320316 |
| MSN | moesin | 0.0300485 |
| PLAT | plasminogen activator, tissue | 0.0298136 |
| POTEF | POTE ankyrin domain family, member F | 0.0296911 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0290828 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0287761 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0280756 |
| FOSL1 | FOS-like antigen 1 | 0.0276819 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.027397 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0269344 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0269006 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0266962 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0265463 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0262565 |
| TPM3 | tropomyosin 3 | 0.0261473 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0261067 |
| RUNX1 | runt-related transcription factor 1 | 0.0256465 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0245823 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0239148 |
| PFN1 | profilin 1 | 0.0234526 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0229192 |
| HSPB1 | heat shock 27kDa protein 1 | 0.022819 |
| COPA | coatomer protein complex, subunit alpha | 0.0222722 |
| TLE4 | transducin-like enhancer of split 4 | 0.0217743 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.021748 |
| HDAC9 | histone deacetylase 9 | 0.021679 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0216397 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0209044 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0197523 |
| SEC24A | SEC24 family member A | 0.019739 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0194865 |
| PKM | pyruvate kinase, muscle | 0.0193718 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.018675 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0183414 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0182873 |
| TGFB1 | transforming growth factor, beta 1 | 0.0181905 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0181821 |
| MSI2 | musashi RNA-binding protein 2 | 0.0180084 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0179292 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0179111 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.017443 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0173173 |
| CDK6 | cyclin-dependent kinase 6 | 0.0172055 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0171932 |
| S100A10 | S100 calcium binding protein A10 | 0.0171499 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0167009 |
| SUCNR1 | succinate receptor 1 | 0.0166107 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0163672 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0162514 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0161905 |
| RRM2 | ribonucleotide reductase M2 | 0.016078 |
| MEIS2 | Meis homeobox 2 | 0.0157738 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0157417 |
| CD44 | CD44 molecule (Indian blood group) | 0.0156959 |
| PCBP2 | poly(rC) binding protein 2 | 0.0155361 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0154828 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.015446 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0154356 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0153562 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0153177 |
| INTS6 | integrator complex subunit 6 | 0.0148729 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0144872 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0144125 |
| CMIP | c-Maf inducing protein | 0.0142088 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0141235 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0140427 |
| ACLY | ATP citrate lyase | 0.0140283 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0138243 |
| TPX2 | TPX2, microtubule-associated | 0.0137816 |
| BAG3 | BCL2-associated athanogene 3 | 0.013691 |
| SON | SON DNA binding protein | 0.0136747 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0135978 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.013569 |
| UBXN4 | UBX domain protein 4 | 0.0135449 |
| MB21D2 | Mab-21 domain containing 2 | 0.0135328 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0135153 |
| FAM162A | family with sequence similarity 162, member A | 0.0134265 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0133265 |
| MKI67 | marker of proliferation Ki-67 | 0.0132838 |
| SEPTIN7 | septin 7 | 0.0132759 |
| PRKCA | protein kinase C, alpha | 0.0128354 |
| ZNF148 | zinc finger protein 148 | 0.0127393 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0127338 |
| CENPE | centromere protein E, 312kDa | 0.0125694 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0125603 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0125275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.252538 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.199552 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.131785 |
| LOX | lysyl oxidase | -0.115759 |
| VIM | vimentin | -0.112977 |
| TMSB10 | thymosin beta 10 | -0.0970522 |
| AHNAK | AHNAK nucleoprotein | -0.0934496 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.089978 |
| CSTB | cystatin B (stefin B) | -0.0854184 |
| THBS2 | thrombospondin 2 | -0.0788383 |
| HLA-B | major histocompatibility complex, class I, B | -0.0760963 |
| LOXL2 | lysyl oxidase-like 2 | -0.0725973 |
| FBN1 | fibrillin 1 | -0.0672636 |
| FN1 | fibronectin 1 | -0.0566273 |
| CANX | calnexin | -0.056188 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0527007 |
| COL5A2 | collagen, type V, alpha 2 | -0.0511776 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0495394 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0487671 |
| AUTS2 | autism susceptibility candidate 2 | -0.0453043 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0449712 |
| GPC6 | glypican 6 | -0.0447343 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0442667 |
| SQSTM1 | sequestosome 1 | -0.0437476 |
| B2M | beta-2-microglobulin | -0.043303 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0429462 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.042431 |
| HLA-C | major histocompatibility complex, class I, C | -0.0416398 |
| SLFN5 | schlafen family member 5 | -0.0407168 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0407086 |
| NIBAN1 | niban apoptosis regulator 1 | -0.038673 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0381681 |
| ANXA2 | annexin A2 | -0.0380087 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0375727 |
| RIGI | RNA sensor RIG-I | -0.0371804 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0370301 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0363449 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0355199 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0355186 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0351909 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0347993 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0345083 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0344471 |
| COL5A1 | collagen, type V, alpha 1 | -0.0332969 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0319642 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0319485 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0314453 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0296945 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0293262 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0290843 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0290277 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0289774 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.0285145 |
| MX2 | MX dynamin-like GTPase 2 | -0.0283841 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0277484 |
| SFTPA2 | surfactant protein A2 | -0.0277275 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0274037 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.0265783 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0260916 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0259441 |
| MYOF | myoferlin | -0.0258072 |
| AFF3 | AF4/FMR2 family, member 3 | -0.025762 |
| OGA | O-GlcNAcase | -0.0255043 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0254385 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.025238 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0251609 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0251293 |
| TMSB4X | thymosin beta 4, X-linked | -0.0248637 |
| RNF213 | ring finger protein 213 | -0.0246981 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0242455 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.022895 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0228902 |
| ANK2 | ankyrin 2, neuronal | -0.0224617 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0221698 |
| APP | amyloid beta (A4) precursor protein | -0.0217578 |
| CTSB | cathepsin B | -0.0217491 |
| CAVIN1 | caveolae associated protein 1 | -0.0213556 |
| MAP4 | microtubule-associated protein 4 | -0.0212681 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0210371 |
| S100A11 | S100 calcium binding protein A11 | -0.0209166 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0208782 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0207458 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0206507 |
| SYT1 | synaptotagmin I | -0.0203188 |
| S100A6 | S100 calcium binding protein A6 | -0.0201706 |
| NAV2 | neuron navigator 2 | -0.0198978 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0198496 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0197215 |
| DSPP | dentin sialophosphoprotein | -0.0196736 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.019657 |
| VCL | vinculin | -0.0196481 |
| OSMR | oncostatin M receptor | -0.0196175 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0189737 |
| TPM4 | tropomyosin 4 | -0.0188416 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0187746 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0185534 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0185526 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0185438 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0184714 |
| PODXL | podocalyxin-like | -0.0183306 |
