| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.365688 |
| VIM | vimentin | 0.175987 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.164999 |
| AREG | amphiregulin | 0.144774 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.14067 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.139994 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.137025 |
| HMGA2 | high mobility group AT-hook 2 | 0.123271 |
| MMP12 | matrix metallopeptidase 12 | 0.118984 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.100621 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0933662 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0915586 |
| ANKRD12 | ankyrin repeat domain 12 | 0.082528 |
| YAP1 | Yes-associated protein 1 | 0.0778331 |
| ANXA1 | annexin A1 | 0.077714 |
| DST | dystonin | 0.0776648 |
| NLGN1 | neuroligin 1 | 0.074704 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0745899 |
| VMP1 | vacuole membrane protein 1 | 0.0693366 |
| TMEM41B | transmembrane protein 41B | 0.0689685 |
| PDGFC | platelet derived growth factor C | 0.0674703 |
| PTMA | prothymosin, alpha | 0.0673359 |
| TENM3 | teneurin transmembrane protein 3 | 0.0657846 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0657543 |
| PCDH7 | protocadherin 7 | 0.0637776 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0631974 |
| MKI67 | marker of proliferation Ki-67 | 0.0626973 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0622091 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0606284 |
| MGAT4C | MGAT4 family, member C | 0.0593062 |
| CALR | calreticulin | 0.0579489 |
| CDK6 | cyclin-dependent kinase 6 | 0.0571645 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0567505 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0556745 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0550825 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0537923 |
| TPM3 | tropomyosin 3 | 0.0534334 |
| ENO1 | enolase 1, (alpha) | 0.0525338 |
| EHBP1 | EH domain binding protein 1 | 0.0522023 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0512248 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0507602 |
| TUBA1B | tubulin, alpha 1b | 0.0502116 |
| NEBL | nebulette | 0.0499696 |
| UBC | ubiquitin C | 0.0478819 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0470767 |
| HDAC9 | histone deacetylase 9 | 0.0468949 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0466657 |
| USP34 | ubiquitin specific peptidase 34 | 0.0465907 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0464658 |
| CENPF | centromere protein F, 350/400kDa | 0.046452 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0463747 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0462061 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0445637 |
| CCN2 | cellular communication network factor 2 | 0.0441946 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0434547 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0431146 |
| ACTG1 | actin gamma 1 | 0.0424037 |
| JMJD1C | jumonji domain containing 1C | 0.0423438 |
| AXIN2 | axin 2 | 0.0422893 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0414535 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0406978 |
| PCDH9 | protocadherin 9 | 0.0402987 |
| EGR1 | early growth response 1 | 0.039272 |
| ADIPOR2 | adiponectin receptor 2 | 0.0385635 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0375901 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0374917 |
| RPL4 | ribosomal protein L4 | 0.0364004 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0362728 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0361332 |
| GOLGB1 | golgin B1 | 0.0359532 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0354013 |
| CEP112 | centrosomal protein 112kDa | 0.0349732 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0341529 |
| BPTF | bromodomain PHD finger transcription factor | 0.0341398 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0331748 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0324836 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0324292 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0320549 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0305914 |
| FNIP1 | folliculin interacting protein 1 | 0.0302724 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030245 |
| RRM2 | ribonucleotide reductase M2 | 0.030224 |
| RAB10 | RAB10, member RAS oncogene family | 0.0300243 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0293536 |
| LMO7 | LIM domain 7 | 0.0286629 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0278865 |
| EDARADD | EDAR-associated death domain | 0.0277463 |
| BRD2 | bromodomain containing 2 | 0.0277146 |
| EPHA6 | EPH receptor A6 | 0.0277138 |
| MPG | N-methylpurine-DNA glycosylase | 0.0269556 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0266586 |
| SYT1 | synaptotagmin I | 0.0266197 |
| TGM2 | transglutaminase 2 | 0.0265636 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0263627 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0262635 |
| MED13L | mediator complex subunit 13-like | 0.0262146 |
| GCG | glucagon | 0.0261353 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0260171 |
| LDHB | lactate dehydrogenase B | 0.0259413 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.0255792 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0594478 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.051837 |
| RPL35A | ribosomal protein L35a | -0.046994 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0445165 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0379355 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0377572 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0375964 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0367917 |
| RPS12 | ribosomal protein S12 | -0.032896 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0328044 |
| RPL36 | ribosomal protein L36 | -0.031521 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0312836 |
| RPS29 | ribosomal protein S29 | -0.0308679 |
| RPS27A | ribosomal protein S27a | -0.0305715 |
| OGA | O-GlcNAcase | -0.0303938 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0295468 |
| HMGA1 | high mobility group AT-hook 1 | -0.0284384 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.028234 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0275124 |
| RPS19 | ribosomal protein S19 | -0.0271458 |
| RPL26 | ribosomal protein L26 | -0.0269895 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0269226 |
| RPL37A | ribosomal protein L37a | -0.0255309 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0242742 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0237155 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0214667 |
| RPL38 | ribosomal protein L38 | -0.0214415 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0213783 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213083 |
| RPL11 | ribosomal protein L11 | -0.0206037 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0204364 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0191972 |
| RPLP2 | ribosomal protein, large, P2 | -0.0189947 |
| RPL8 | ribosomal protein L8 | -0.0188746 |
| RPL12 | ribosomal protein L12 | -0.0186326 |
| RPS24 | ribosomal protein S24 | -0.0184476 |
| TNPO1 | transportin 1 | -0.0177682 |
| FOXN2 | forkhead box N2 | -0.0174296 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0174149 |
| GHITM | growth hormone inducible transmembrane protein | -0.0173242 |
| RPL37 | ribosomal protein L37 | -0.0172799 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0172396 |
| RPS20 | ribosomal protein S20 | -0.0168893 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0168026 |
| RPS21 | ribosomal protein S21 | -0.0168 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0167979 |
| RPS6 | ribosomal protein S6 | -0.016706 |
| RPS23 | ribosomal protein S23 | -0.0163851 |
| YEATS2 | YEATS domain containing 2 | -0.0156975 |
| CDV3 | CDV3 homolog (mouse) | -0.0156869 |
| RIOK3 | RIO kinase 3 | -0.0156745 |
| NUP58 | nucleoporin 58 | -0.0156489 |
| RPLP1 | ribosomal protein, large, P1 | -0.0156281 |
| RPL9 | ribosomal protein L9 | -0.0156062 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0152395 |
| TCEA1 | transcription elongation factor A (SII), 1 | -0.0152075 |
| RAD51B | RAD51 paralog B | -0.0151936 |
| ANXA2 | annexin A2 | -0.0150609 |
| RPL19 | ribosomal protein L19 | -0.0150326 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0145521 |
| RPL36A | ribosomal protein L36a | -0.0145059 |
| PCBP2 | poly(rC) binding protein 2 | -0.014478 |
| ZNF217 | zinc finger protein 217 | -0.0144413 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0142104 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0141458 |
| SEPHS2 | selenophosphate synthetase 2 | -0.0141154 |
| S100A11 | S100 calcium binding protein A11 | -0.0137922 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0136785 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0136614 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0136517 |
| NABP1 | nucleic acid binding protein 1 | -0.0135159 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.013493 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0133415 |
| RPL13A | ribosomal protein L13a | -0.013256 |
| RPL23 | ribosomal protein L23 | -0.0132262 |
| ABI1 | abl-interactor 1 | -0.0131963 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0131647 |
| H3-3B | H3.3 histone B | -0.0130174 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.012658 |
| AEBP2 | AE binding protein 2 | -0.012582 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0124436 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0123976 |
| RBM25 | RNA binding motif protein 25 | -0.0122241 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0121381 |
| RNF130 | ring finger protein 130 | -0.0121271 |
| ELP2 | elongator acetyltransferase complex subunit 2 | -0.0121259 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.012094 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0120125 |
| RPS16 | ribosomal protein S16 | -0.0119736 |
| RPS5 | ribosomal protein S5 | -0.0119703 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.011945 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.011924 |
| CFAP73 | cilia and flagella associated protein 73 | -0.0118779 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0118199 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0117954 |
| MAP4 | microtubule-associated protein 4 | -0.0117832 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0117401 |
| YBX3 | Y box binding protein 3 | -0.0116662 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.011648 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.011539 |
