| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSF1 | colony stimulating factor 1 (macrophage) | 0.118086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.114967 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.107073 |
| GPC6 | glypican 6 | 0.100775 |
| UBC | ubiquitin C | 0.0790811 |
| TPM3 | tropomyosin 3 | 0.0788225 |
| MSN | moesin | 0.0687892 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0682039 |
| POTEF | POTE ankyrin domain family, member F | 0.0677536 |
| RPS8 | ribosomal protein S8 | 0.0672337 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0559862 |
| RND3 | Rho family GTPase 3 | 0.0533168 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0519217 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0492145 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0485735 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0453061 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0431034 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0419607 |
| IFI44L | interferon-induced protein 44-like | 0.0410763 |
| NAV2 | neuron navigator 2 | 0.0406547 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.039816 |
| RPL4 | ribosomal protein L4 | 0.0390544 |
| DSTN | destrin (actin depolymerizing factor) | 0.0379937 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0376106 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0362799 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0355576 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0352027 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0346205 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0341489 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0338476 |
| MYADM | myeloid-associated differentiation marker | 0.0325829 |
| SEPTIN9 | septin 9 | 0.0321634 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0314833 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0302782 |
| NOTCH2 | notch 2 | 0.0297713 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0295433 |
| HDAC9 | histone deacetylase 9 | 0.0290962 |
| GOLGB1 | golgin B1 | 0.0290743 |
| RPL21 | ribosomal protein L21 | 0.0288369 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0278799 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0278752 |
| RPS12 | ribosomal protein S12 | 0.0277077 |
| ATF3 | activating transcription factor 3 | 0.0276939 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0275918 |
| GPC5 | glypican 5 | 0.0273888 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0271732 |
| KYNU | kynureninase | 0.0270536 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0270454 |
| BRD2 | bromodomain containing 2 | 0.0266387 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0265434 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0264757 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0260132 |
| HDGF | hepatoma-derived growth factor | 0.0257867 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0257076 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0251018 |
| PFN1 | profilin 1 | 0.0250353 |
| TMF1 | TATA element modulatory factor 1 | 0.0244997 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0242723 |
| FAM114A1 | family with sequence similarity 114, member A1 | 0.0241794 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0240837 |
| ENO1 | enolase 1, (alpha) | 0.0240631 |
| RUNX1 | runt-related transcription factor 1 | 0.0238034 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0237725 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0237639 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0234406 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0230424 |
| PGM3 | phosphoglucomutase 3 | 0.0229979 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0228778 |
| PAX8 | paired box 8 | 0.0227685 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0227212 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.022689 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.022479 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0224328 |
| AHNAK | AHNAK nucleoprotein | 0.0223646 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0223304 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0220639 |
| CRY1 | cryptochrome circadian clock 1 | 0.0219104 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0218878 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0217516 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0216958 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0216424 |
| SDC4 | syndecan 4 | 0.0215022 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0212028 |
| RPS6 | ribosomal protein S6 | 0.0210959 |
| RPS2 | ribosomal protein S2 | 0.0210012 |
| MYOF | myoferlin | 0.0209526 |
| HM13 | histocompatibility (minor) 13 | 0.0205766 |
| ZFP36 | ZFP36 ring finger protein | 0.020282 |
| PKM | pyruvate kinase, muscle | 0.0202398 |
| VEGFA | vascular endothelial growth factor A | 0.0200946 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0200023 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0198607 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0198381 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0197977 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0196718 |
| ACLY | ATP citrate lyase | 0.0196177 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0196025 |
| CDK6 | cyclin-dependent kinase 6 | 0.01944 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0194099 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0194054 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185671 |
| ASPH | aspartate beta-hydroxylase | -0.151813 |
| VIM | vimentin | -0.121633 |
| HLA-B | major histocompatibility complex, class I, B | -0.105204 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.102287 |
| TMSB10 | thymosin beta 10 | -0.0986779 |
| FRMD4A | FERM domain containing 4A | -0.0894909 |
| GLIS3 | GLIS family zinc finger 3 | -0.0855877 |
| VCL | vinculin | -0.0663771 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.064707 |
| RPL35A | ribosomal protein L35a | -0.0646802 |
| TGFA | transforming growth factor, alpha | -0.0638169 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0557293 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0553353 |
| PALLD | palladin, cytoskeletal associated protein | -0.0551975 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0544589 |
| RAI14 | retinoic acid induced 14 | -0.0512541 |
| LOXL2 | lysyl oxidase-like 2 | -0.0511133 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0491065 |
| TXNRD1 | thioredoxin reductase 1 | -0.0490089 |
| GDF15 | growth differentiation factor 15 | -0.0489957 |
| ARF1 | ADP-ribosylation factor 1 | -0.048067 |
| RRBP1 | ribosome binding protein 1 | -0.0472721 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0471082 |
| NDRG1 | N-myc downstream regulated 1 | -0.0468721 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0452276 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0441818 |
| CP | ceruloplasmin (ferroxidase) | -0.0421253 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0411167 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0401071 |
| RBM39 | RNA binding motif protein 39 | -0.0399366 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0392108 |
| HLA-C | major histocompatibility complex, class I, C | -0.0373665 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0360628 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0356707 |
| RAD21 | RAD21 homolog (S. pombe) | -0.035553 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.035493 |
| HPCAL1 | hippocalcin-like 1 | -0.0353181 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0344325 |
| GNAS | GNAS complex locus | -0.0344139 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.034383 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0343404 |
| ATP13A3 | ATPase type 13A3 | -0.0343218 |
| SMAD3 | SMAD family member 3 | -0.0340183 |
| RHEB | Ras homolog enriched in brain | -0.0335527 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0335496 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.033441 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0330581 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0330434 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0325032 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0320002 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0316858 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0316224 |
| ANXA2 | annexin A2 | -0.0314631 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0314077 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0313746 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.031322 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0311466 |
| NF1 | neurofibromin 1 | -0.0309786 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0307488 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0302166 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0302097 |
| RAB10 | RAB10, member RAS oncogene family | -0.0301004 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0300702 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.030057 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0299503 |
| MTDH | metadherin | -0.0299456 |
| CAVIN1 | caveolae associated protein 1 | -0.0298863 |
| ANLN | anillin, actin binding protein | -0.0297951 |
| SRPK2 | SRSF protein kinase 2 | -0.0297325 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0296716 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0293614 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0292192 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0290797 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0289171 |
| GLG1 | golgi glycoprotein 1 | -0.0289065 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0289058 |
| GOLGA3 | golgin A3 | -0.0288822 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0288217 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0287421 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0286867 |
| STK17A | serine/threonine kinase 17a | -0.0285827 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0281685 |
| ANXA5 | annexin A5 | -0.0278702 |
| CDK13 | cyclin-dependent kinase 13 | -0.0276352 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0276313 |
| PXDN | peroxidasin | -0.0276264 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0275749 |
| QKI | QKI, KH domain containing, RNA binding | -0.0275025 |
| AOPEP | aminopeptidase O (putative) | -0.0273256 |
| CA12 | carbonic anhydrase XII | -0.0273111 |
| HLA-E | major histocompatibility complex, class I, E | -0.0272791 |
| TPM4 | tropomyosin 4 | -0.0271683 |
| CD82 | CD82 molecule | -0.026885 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0259628 |
| RRM2 | ribonucleotide reductase M2 | -0.0259519 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | -0.0259389 |
| SDCBP | syndecan binding protein (syntenin) | -0.0258027 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0257581 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0257442 |
