| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Belumosudil (mesylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.125151 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.103501 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0949909 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0927402 |
| EFNA5 | ephrin-A5 | 0.0926661 |
| AHNAK | AHNAK nucleoprotein | 0.076611 |
| EGFR | epidermal growth factor receptor | 0.0714468 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0671539 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.066321 |
| RPL4 | ribosomal protein L4 | 0.0643958 |
| UBC | ubiquitin C | 0.0632496 |
| MYO1E | myosin IE | 0.0622033 |
| EHBP1 | EH domain binding protein 1 | 0.0613132 |
| VIM | vimentin | 0.0605037 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0576041 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0556819 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0543806 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0485253 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0482998 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0464669 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0463255 |
| CCDC88A | coiled-coil domain containing 88A | 0.0461696 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0443072 |
| PRKCA | protein kinase C, alpha | 0.0441679 |
| SP100 | SP100 nuclear antigen | 0.0437104 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0434676 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0431779 |
| BPTF | bromodomain PHD finger transcription factor | 0.0429782 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0422379 |
| HMGA2 | high mobility group AT-hook 2 | 0.0415948 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0413972 |
| GOLGB1 | golgin B1 | 0.0390763 |
| KYNU | kynureninase | 0.0390586 |
| LMO7 | LIM domain 7 | 0.0389675 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0377931 |
| LMNA | lamin A/C | 0.0376746 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0374289 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0372087 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0367679 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0355626 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0352975 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.035074 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0336424 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0329965 |
| RHCG | Rh family, C glycoprotein | 0.0321117 |
| NRG1 | neuregulin 1 | 0.0320197 |
| RND3 | Rho family GTPase 3 | 0.0314832 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0313778 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0308035 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0307301 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0306561 |
| CUX1 | cut-like homeobox 1 | 0.0305104 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0299714 |
| BICC1 | BicC family RNA binding protein 1 | 0.0298962 |
| INTS6 | integrator complex subunit 6 | 0.0298812 |
| H1-0 | H1.0 linker histone | 0.0297423 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0295444 |
| MYADM | myeloid-associated differentiation marker | 0.0295289 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0294097 |
| MCU | mitochondrial calcium uniporter | 0.0287736 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.028343 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0278673 |
| TNS3 | tensin 3 | 0.0271618 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0270508 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0267058 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0265149 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0264226 |
| ACTN4 | actinin, alpha 4 | 0.0261432 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0261292 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0260243 |
| FNIP1 | folliculin interacting protein 1 | 0.025753 |
| RSPO3 | R-spondin 3 | 0.0255698 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0255308 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0255181 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.025515 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0252109 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0246313 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0244808 |
| CP | ceruloplasmin (ferroxidase) | 0.0239679 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0238829 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0237514 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0237431 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0236726 |
| EXOC4 | exocyst complex component 4 | 0.0226507 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0226343 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0225791 |
| PALLD | palladin, cytoskeletal associated protein | 0.022575 |
| TCF12 | transcription factor 12 | 0.0222021 |
| ERBIN | erbb2 interacting protein | 0.0221902 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.022162 |
| S100A10 | S100 calcium binding protein A10 | 0.0220644 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.02166 |
| MED13L | mediator complex subunit 13-like | 0.0215006 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0214985 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0214235 |
| CAVIN1 | caveolae associated protein 1 | 0.0211581 |
| SQSTM1 | sequestosome 1 | 0.0209108 |
| AUTS2 | autism susceptibility candidate 2 | 0.0207094 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0203263 |
| CREBBP | CREB binding protein | 0.0201925 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.154898 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.108284 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.085685 |
| MT2A | metallothionein 2A | -0.0824458 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0793697 |
| SMAD3 | SMAD family member 3 | -0.079256 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0784245 |
| SPAG9 | sperm associated antigen 9 | -0.076368 |
| TXNRD1 | thioredoxin reductase 1 | -0.0650278 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0622255 |
| USP3 | ubiquitin specific peptidase 3 | -0.0548954 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0539033 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0536981 |
| PDE10A | phosphodiesterase 10A | -0.0522608 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0521011 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0517853 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0515153 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0509147 |
| RPS2 | ribosomal protein S2 | -0.0494941 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0491411 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0470998 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0467185 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0460964 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.045894 |
| RPL37A | ribosomal protein L37a | -0.0445872 |
| NAV2 | neuron navigator 2 | -0.0433471 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0423753 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0422434 |
| RPS19 | ribosomal protein S19 | -0.0405688 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0381745 |
| RTN4 | reticulon 4 | -0.0381665 |
| HELZ | helicase with zinc finger | -0.0380572 |
| NUP58 | nucleoporin 58 | -0.0365865 |
| MSN | moesin | -0.0360791 |
| GOLGA4 | golgin A4 | -0.0360078 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0352139 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0339774 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0339169 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0336371 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0324204 |
| RPL7 | ribosomal protein L7 | -0.0321154 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0308882 |
| ZNF292 | zinc finger protein 292 | -0.0298828 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0297311 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0294928 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.029483 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0292932 |
| STC1 | stanniocalcin 1 | -0.0284479 |
| PCBP2 | poly(rC) binding protein 2 | -0.0282087 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0280243 |
| RPS16 | ribosomal protein S16 | -0.0279069 |
| NBAS | neuroblastoma amplified sequence | -0.0274493 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0273775 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0270742 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0267991 |
| FLNB | filamin B, beta | -0.0266616 |
| XPO1 | exportin 1 | -0.0265834 |
| CLTC | clathrin, heavy chain (Hc) | -0.0264295 |
| RPL26 | ribosomal protein L26 | -0.0260657 |
| RASA2 | RAS p21 protein activator 2 | -0.026014 |
| RPS29 | ribosomal protein S29 | -0.0259663 |
| RPL38 | ribosomal protein L38 | -0.0257053 |
| NGLY1 | N-glycanase 1 | -0.0256928 |
| RPS5 | ribosomal protein S5 | -0.0256374 |
| CLINT1 | clathrin interactor 1 | -0.0254967 |
| MCL1 | myeloid cell leukemia 1 | -0.0254766 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0254743 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -0.0254485 |
| SP3 | Sp3 transcription factor | -0.0253851 |
| WDR43 | WD repeat domain 43 | -0.0253397 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0252647 |
| MYO1B | myosin IB | -0.0251774 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0249563 |
| CANX | calnexin | -0.0245992 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0243502 |
| PGK1 | phosphoglycerate kinase 1 | -0.0242646 |
| GRAMD1B | GRAM domain containing 1B | -0.0242156 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0239428 |
| RPL11 | ribosomal protein L11 | -0.0239263 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0235117 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0234656 |
| DUSP5 | dual specificity phosphatase 5 | -0.0234278 |
| RPLP1 | ribosomal protein, large, P1 | -0.0233646 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0232299 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0231586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0230935 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0230012 |
| APP | amyloid beta (A4) precursor protein | -0.0228311 |
| TGM2 | transglutaminase 2 | -0.0228256 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0222344 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0220677 |
| AFDN | afadin, adherens junction formation factor | -0.021797 |
| RNF24 | ring finger protein 24 | -0.0217766 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0217731 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0216154 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0215342 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.021491 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0212374 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0211281 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.0211091 |
