| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.269368 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0874646 |
| PTMA | prothymosin, alpha | 0.0785164 |
| CDH18 | cadherin 18, type 2 | 0.0738179 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0651632 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0616529 |
| CENPF | centromere protein F, 350/400kDa | 0.0541169 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0487857 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.045511 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0438052 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0425657 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0407313 |
| MKI67 | marker of proliferation Ki-67 | 0.0336616 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0335478 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0324707 |
| RPS6 | ribosomal protein S6 | 0.0323878 |
| RPL4 | ribosomal protein L4 | 0.0322324 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0316221 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0298323 |
| EMP1 | epithelial membrane protein 1 | 0.0298045 |
| DEK | DEK proto-oncogene | 0.0296337 |
| GNAS | GNAS complex locus | 0.0296218 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0289901 |
| MAGEA4 | melanoma antigen family A4 | 0.0281963 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0281882 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0280787 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0268911 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0264302 |
| RPLP1 | ribosomal protein, large, P1 | 0.0261041 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.0257473 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0255979 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0250829 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0246158 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0245579 |
| NFIA | nuclear factor I/A | 0.0245046 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0237625 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0235049 |
| HMGB1 | high mobility group box 1 | 0.0234754 |
| ACTG1 | actin gamma 1 | 0.0233394 |
| RPS8 | ribosomal protein S8 | 0.0231767 |
| PCNX4 | pecanex 4 | 0.0225059 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0222933 |
| DCDC2 | doublecortin domain containing 2 | 0.0214687 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0213988 |
| MLEC | malectin | 0.0205115 |
| STXBP4 | syntaxin binding protein 4 | 0.0203052 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.0202933 |
| CCDC138 | coiled-coil domain containing 138 | 0.0198096 |
| RRM2 | ribonucleotide reductase M2 | 0.0197818 |
| KLF6 | Kruppel-like factor 6 | 0.0197363 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0197291 |
| CENPE | centromere protein E, 312kDa | 0.0195925 |
| SYAP1 | synapse associated protein 1 | 0.019414 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0191611 |
| FAM193A | family with sequence similarity 193, member A | 0.0186787 |
| RPS4X | ribosomal protein S4, X-linked | 0.0186498 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.0183429 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0182736 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0181931 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.017956 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0178983 |
| UBAP2 | ubiquitin associated protein 2 | 0.0178114 |
| TOB2 | transducer of ERBB2, 2 | 0.0175481 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0173458 |
| ECT2 | epithelial cell transforming 2 | 0.0170052 |
| SMC4 | structural maintenance of chromosomes 4 | 0.016928 |
| SIK2 | salt-inducible kinase 2 | 0.0166377 |
| MLIP | muscular LMNA-interacting protein | 0.0165709 |
| RPL18 | ribosomal protein L18 | 0.0164819 |
| RPS28 | ribosomal protein S28 | 0.0164612 |
| RPLP0 | ribosomal protein, large, P0 | 0.0164071 |
| BNC2 | basonuclin 2 | 0.016357 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0162221 |
| MTREX | Mtr4 exosome RNA helicase | 0.0161796 |
| PBRM1 | polybromo 1 | 0.0160233 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0159956 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.015967 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0159317 |
| TENM3 | teneurin transmembrane protein 3 | 0.0159028 |
| ATP11A | ATPase, class VI, type 11A | 0.0158236 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0158133 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0158031 |
| PFN1 | profilin 1 | 0.0157549 |
| CDCA2 | cell division cycle associated 2 | 0.015709 |
| USP34 | ubiquitin specific peptidase 34 | 0.0155441 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0154734 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0153872 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0153753 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0153242 |
| CBX3 | chromobox homolog 3 | 0.0152775 |
| WLS | wntless Wnt ligand secretion mediator | 0.0152562 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0151706 |
| TOX | thymocyte selection-associated high mobility group box | 0.015126 |
| HELZ | helicase with zinc finger | 0.015124 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0151029 |
| STMN1 | stathmin 1 | 0.0150778 |
| HDAC9 | histone deacetylase 9 | 0.0148508 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0147853 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0146878 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0146769 |
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | -0.083848 |
| CADM2 | cell adhesion molecule 2 | -0.069268 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0677224 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0675765 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0660406 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0652241 |
| RIGI | RNA sensor RIG-I | -0.0632533 |
| RPS27A | ribosomal protein S27a | -0.0580655 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0573122 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0535469 |
| ENO1 | enolase 1, (alpha) | -0.0530649 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0517364 |
| LDHA | lactate dehydrogenase A | -0.0502432 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0499497 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0489207 |
| RAD51B | RAD51 paralog B | -0.0484703 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0478372 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0475323 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0469317 |
| RPS12 | ribosomal protein S12 | -0.045215 |
| NUP58 | nucleoporin 58 | -0.0437857 |
| PCBP2 | poly(rC) binding protein 2 | -0.0431487 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0430621 |
| XPOT | exportin, tRNA | -0.0424573 |
| EXOC6B | exocyst complex component 6B | -0.0415645 |
| AUTS2 | autism susceptibility candidate 2 | -0.0402539 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0400904 |
| ANK2 | ankyrin 2, neuronal | -0.0391148 |
| EFNA5 | ephrin-A5 | -0.0382238 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0380534 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0362939 |
| APP | amyloid beta (A4) precursor protein | -0.0360558 |
| MCL1 | myeloid cell leukemia 1 | -0.0359242 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0356328 |
| RPL23 | ribosomal protein L23 | -0.0354873 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0354092 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0352503 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0342718 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0336581 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.0332786 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0330159 |
| MAP1B | microtubule-associated protein 1B | -0.0324781 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0320677 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0316878 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.031489 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0304573 |
| TRIM25 | tripartite motif containing 25 | -0.03004 |
| RTN4 | reticulon 4 | -0.0300259 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0298956 |
| YBX1 | Y box binding protein 1 | -0.029584 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0294479 |
| PGK1 | phosphoglycerate kinase 1 | -0.0294156 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0291899 |
| MEF2A | myocyte enhancer factor 2A | -0.0287757 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0285221 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0283547 |
| VGLL4 | vestigial-like family member 4 | -0.0282892 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0280974 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0279979 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0277637 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | -0.0276483 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -0.0276017 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0275741 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0272576 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -0.0271116 |
| TNPO1 | transportin 1 | -0.026884 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.026767 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0266365 |
| AARS1 | alanyl-tRNA synthetase 1 | -0.0262908 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.0260714 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0259066 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0258271 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0258129 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0255261 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0253139 |
| SESN2 | sestrin 2 | -0.0253052 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0249727 |
| YAP1 | Yes-associated protein 1 | -0.0248945 |
| PUS7 | pseudouridylate synthase 7 (putative) | -0.0248885 |
| COL5A2 | collagen, type V, alpha 2 | -0.024802 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0247929 |
| DENND5A | DENN/MADD domain containing 5A | -0.0247445 |
| RPL26 | ribosomal protein L26 | -0.0245645 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0242145 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0240384 |
| TMEM41B | transmembrane protein 41B | -0.0239259 |
| PREPL | prolyl endopeptidase-like | -0.0238355 |
| IWS1 | IWS1 homolog (S. cerevisiae) | -0.0238313 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0237565 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0237469 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0236941 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.0235122 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.023475 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | -0.0232054 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0230848 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0230643 |
| ATF3 | activating transcription factor 3 | -0.023061 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | -0.0228778 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0228455 |
| RPL37A | ribosomal protein L37a | -0.0227953 |
