| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Belumosudil (mesylate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Belumosudil (mesylate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | 0.114944 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0963206 |
| SMAD3 | SMAD family member 3 | 0.0962168 |
| LMO7 | LIM domain 7 | 0.0940136 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0688532 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0625668 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0523445 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0522271 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0510578 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0510076 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0504154 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0437597 |
| PLSCR2 | phospholipid scramblase 2 | 0.0434198 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0387509 |
| EFNB2 | ephrin-B2 | 0.0378933 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0366944 |
| MCU | mitochondrial calcium uniporter | 0.0343617 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0341222 |
| FNIP1 | folliculin interacting protein 1 | 0.0325854 |
| VCL | vinculin | 0.0317496 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0309146 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0307239 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0298246 |
| YAP1 | Yes-associated protein 1 | 0.0295711 |
| PDZD8 | PDZ domain containing 8 | 0.029492 |
| MAP7 | microtubule-associated protein 7 | 0.0293738 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0292515 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284209 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0280558 |
| HKDC1 | hexokinase domain containing 1 | 0.0265437 |
| NABP1 | nucleic acid binding protein 1 | 0.0257127 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0257101 |
| FNIP2 | folliculin interacting protein 2 | 0.0254528 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0252638 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0249829 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0245981 |
| TOX3 | TOX high mobility group box family member 3 | 0.0240879 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0230767 |
| MYO1E | myosin IE | 0.0230282 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0218907 |
| DUSP10 | dual specificity phosphatase 10 | 0.0214782 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0208477 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0207528 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0204283 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0203026 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0201028 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0199672 |
| HOMER1 | homer scaffolding protein 1 | 0.0199341 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0194649 |
| SLK | STE20-like kinase | 0.0194051 |
| EREG | epiregulin | 0.0193472 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0189301 |
| SIK3 | SIK family kinase 3 | 0.0188993 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0185821 |
| TRIM2 | tripartite motif containing 2 | 0.0178888 |
| MED13 | mediator complex subunit 13 | 0.0176333 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0173862 |
| FBXO39 | F-box protein 39 | 0.0172315 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0172125 |
| TRIB1 | tribbles pseudokinase 1 | 0.0169629 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0168798 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0168779 |
| ATXN1 | ataxin 1 | 0.0166261 |
| ZNF292 | zinc finger protein 292 | 0.0165747 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0164229 |
| UBAP2 | ubiquitin associated protein 2 | 0.0162104 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0160096 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0158733 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0157554 |
| UBAP1 | ubiquitin associated protein 1 | 0.0157446 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0157174 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0155725 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0155676 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0154105 |
| TLE4 | transducin-like enhancer of split 4 | 0.0151 |
| RUNX1 | runt-related transcription factor 1 | 0.0150705 |
| TMEM65 | transmembrane protein 65 | 0.0150567 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0150437 |
| CUL3 | cullin 3 | 0.0149887 |
| SUSD1 | sushi domain containing 1 | 0.0149729 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0147435 |
| KYNU | kynureninase | 0.0147212 |
| DST | dystonin | 0.0146495 |
| SEPTIN9 | septin 9 | 0.0146033 |
| GLRX3 | glutaredoxin 3 | 0.0141535 |
| GK | glycerol kinase | 0.01406 |
| PRSS22 | protease, serine, 22 | 0.0138286 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0138068 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0137305 |
| SON | SON DNA binding protein | 0.0137096 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0134881 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0132616 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0132005 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.0131481 |
| VMP1 | vacuole membrane protein 1 | 0.0130796 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0130336 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0129712 |
| SPAG9 | sperm associated antigen 9 | 0.0128995 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0128891 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.012805 |
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | -0.192309 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.160001 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.138731 |
| HLA-B | major histocompatibility complex, class I, B | -0.126777 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.123714 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108922 |
| PTMA | prothymosin, alpha | -0.101045 |
| LCN2 | lipocalin 2 | -0.0885494 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0868907 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0847677 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0792562 |
| LYZ | lysozyme | -0.0742427 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0654437 |
| SQSTM1 | sequestosome 1 | -0.0637398 |
| MT2A | metallothionein 2A | -0.0600164 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0566239 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0553572 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0552919 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0549661 |
| XAF1 | XIAP associated factor 1 | -0.0542165 |
| TMSB10 | thymosin beta 10 | -0.0535526 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0534137 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0526116 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0518999 |
| HLA-E | major histocompatibility complex, class I, E | -0.0509683 |
| NDRG1 | N-myc downstream regulated 1 | -0.0503016 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0497354 |
| RPL35A | ribosomal protein L35a | -0.0487036 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0479365 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0476394 |
| TXNIP | thioredoxin interacting protein | -0.0474353 |
| ACTG1 | actin gamma 1 | -0.0473976 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0470209 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0469785 |
| NPSR1 | neuropeptide S receptor 1 | -0.0468784 |
| HLA-C | major histocompatibility complex, class I, C | -0.0467772 |
| PGK1 | phosphoglycerate kinase 1 | -0.0467048 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0456329 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0453091 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0451492 |
| TPM4 | tropomyosin 4 | -0.044823 |
| HLA-A | major histocompatibility complex, class I, A | -0.0447237 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0442256 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0427628 |
| FTL | ferritin, light polypeptide | -0.042686 |
| RIGI | RNA sensor RIG-I | -0.0423736 |
| MX2 | MX dynamin-like GTPase 2 | -0.0422243 |
| EPCAM | epithelial cell adhesion molecule | -0.0410723 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0410707 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0405761 |
| MX1 | MX dynamin-like GTPase 1 | -0.0398646 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.039647 |
| CANX | calnexin | -0.0389051 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0385223 |
| RNF213 | ring finger protein 213 | -0.0382842 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0381538 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0376616 |
| ANXA4 | annexin A4 | -0.0374704 |
| MUC20 | mucin 20, cell surface associated | -0.0370323 |
| PTGR1 | prostaglandin reductase 1 | -0.0369233 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0365872 |
| EGR1 | early growth response 1 | -0.0363885 |
| SSH2 | slingshot protein phosphatase 2 | -0.0360952 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0359751 |
| S100A6 | S100 calcium binding protein A6 | -0.0357474 |
| PKM | pyruvate kinase, muscle | -0.0357101 |
| KRT19 | keratin 19, type I | -0.0352049 |
| ITGA6 | integrin, alpha 6 | -0.0348635 |
| RPL34 | ribosomal protein L34 | -0.0345152 |
| S100P | S100 calcium binding protein P | -0.0342149 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0336941 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0335918 |
| JUN | jun proto-oncogene | -0.0327494 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0326169 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.031971 |
| APOL1 | apolipoprotein L, 1 | -0.0315765 |
| RRBP1 | ribosome binding protein 1 | -0.0315446 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0313924 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0310204 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0307744 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0306445 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0304929 |
| ABLIM1 | actin binding LIM protein 1 | -0.0303016 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0303006 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -0.0302594 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0299745 |
| RPL37A | ribosomal protein L37a | -0.0299679 |
| SP100 | SP100 nuclear antigen | -0.0299537 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0294784 |
| ENO1 | enolase 1, (alpha) | -0.0292011 |
| RPL31 | ribosomal protein L31 | -0.0291705 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0291149 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0291072 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0290719 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0289268 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0286603 |
| TXNRD1 | thioredoxin reductase 1 | -0.028469 |
| RPS12 | ribosomal protein S12 | -0.0278331 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0277754 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0277045 |
